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1041081“…Such platform enabled the operation of an optimised workflow to obtain comprehensive maps of the carbon flux distribution in the central carbon metabolism in a parallel-automated manner, thereby accelerating the time-consuming strain characterization step in the design-build-test-learn cycle for metabolic engineering of P. pastoris. …”
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1041082por Ekblom-Bak, Elin, Bojsen-Møller, Emil, Wallin, Peter, Paulsson, Sofia, Lindwall, Magnus, Rundqvist, Helene, Bolam, Kate A.“…During a mean (SD) follow-up time of 9.6 (5.5) years, a total of 499 incident cases of colon, 283 of lung, and 1918 of prostate cancer occurred, as well as 152 deaths due to colon cancer, 207 due to lung cancer, and 141 deaths due to prostate cancer. …”
Publicado 2023
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1041083por Werkman, Nikki C. C., Driessen, Johanna H. M., Stehouwer, Coen D. A., Vestergaard, Peter, Schaper, Nicolaas C., van den Bergh, Joop P., Nielen, Johannes T. H.“…The date of the first prescription defined the start of follow-up. Time-varying Cox proportional hazards models estimated the hazard ratios (HRs) of LLA and DFU with current SGLT2-I use and GLP1-RA use versus current SU use. …”
Publicado 2023
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1041084por Pescarini, Julia M., Cardoso, Andrey M., Santos, Ricardo Ventura, Scaff, Priscila F., Paixao, Enny S., Ranzani, Otavio T., Cerqueira-Silva, Thiago, Boaventura, Viviane S., Bertoldo-Junior, Juracy, de Oliveira, Vinicius A., Werneck, Guilherme L., Barreto, Mauricio L., Barral-Netto, Manoel“…CONCLUSIONS: Lower coverage but similar Covid-19 VE among indigenous people than overall Brazilians suggest the need to expand access, timely vaccination, and urgently offer booster doses to achieve a great level of protection among this group. …”
Publicado 2023
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1041085por Firoozabadi, Mahdieh Ghanbari, Mirzaei, Masoud, Grace, Sherry L, Vafaeinasab, Mohammadreza, Dehghani-Tafti, Maryam, Sadeghi, Abbas, Asadi, Zohre, Basirinezhad, Mohammad Hasan“…Men rated “already exercise at home or in community” (2.69; ES = 0.23, CI:0.1–0.36; P = 0.001), time constraints (2.18; ES = 0.15, CI:0.07–0.23; P < 0.001) and work responsibilities (2.24; ES = 0.16, CI:0.07–0.25; P = 0.001) as greater CR barriers than women. …”
Publicado 2023
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1041086por Zhang, Lian, Holmes, Jason M., Liu, Zhengliang, Vora, Sujay A., Sio, Terence T., Vargas, Carlos E., Yu, Nathan Y., Keole, Sameer R., Schild, Steven E., Bues, Martin, Li, Sheng, Liu, Tianming, Shen, Jiajian, Wong, William W., Liu, Wei“…Dose volume histogram (DVH) indices, 3D Gamma passing rates with a criterion of 3%/3mm/10%, and dice coefficients for the structures enclosed by the iso-dose lines between the predicted and the ground truth doses were used as the evaluation metrics. The calculation time for each proton dose prediction was recorded to evaluate the method’s efficiency. …”
Publicado 2023
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1041087por Nikulin, Pavel, Zschaeck, Sebastian, Maus, Jens, Cegla, Paulina, Lombardo, Elia, Furth, Christian, Kaźmierska, Joanna, Rogasch, Julian M. M., Holzgreve, Adrien, Albert, Nathalie L., Ferentinos, Konstantinos, Strouthos, Iosif, Hajiyianni, Marina, Marschner, Sebastian N., Belka, Claus, Landry, Guillaume, Cholewinski, Witold, Kotzerke, Jörg, Hofheinz, Frank, van den Hoff, Jörg“…Including evaluation of lymph node metastases can further increase the prognostic value of PET but accurate manual delineation and classification of all lesions is time-consuming and prone to interobserver variability. …”
Publicado 2023
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1041088por Li, Lu, Chen, Lu, Yan, Lu, Guo, Yueqian, Li, Fang, Fan, Ming, Lan, Mei, Lai, Xin, Zhou, Jie, Huang, Yecai, Xu, Peng, Lang, Jinyi, Feng, Mei“…RESULTS: 40 R/M HNSCC patients were enrolled in our stuty. The median follow up time was 14 months. 22 patients had recurrent disease only, 16 patients had metastatic disease only, and 2 patients had both recurrence and metastasis disease. …”
Publicado 2023
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1041089por Drechsel, Katja C E, Pilon, Maxime C F, Stoutjesdijk, Francis, Meivis, Salena, Schoonmade, Linda J, Wallace, William Hamish B, van Dulmen-den Broeder, Eline, Beishuizen, Auke, Kaspers, Gertjan J L, Broer, Simone L, Veening, Margreet A“…In this review, we make a recommendation on reproductive markers that could be assessed and the timing of (repeated) measurements.…”
Publicado 2023
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1041090por Fagbamigbe, Omon Stellamaris, Olaseinde, Olugbenga Sunday, Bello, Oluwasomidoyin O., Setlhare, Vincent, Nyaberi, Jackline Mosinya, Wegbom, Anthony Ike, Adebowale, Ayo Stephen, Fagbamigbe, Adeniyi Francis“…While most studies focused on the time of initiation and number of ANC contacts, emphasis was rarely placed on the components of ANC offered to women. …”
Publicado 2023
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1041091por Witlox, Willem, Grimm, Sabine, Howick, Jeremy, Armstrong, Nigel, Ahmadu, Charlotte, McDermott, Kevin, Otten, Thomas, Noake, Caro, Wolff, Robert, Joore, Manuela“…In the QUAZAR AML-001 trial, oral azacitidine significantly improved overall survival (OS) versus placebo: median OS gain of 9.9 months (24.7 months versus 14.8 months; hazard ratio (HR) 0.69 (95% CI 0.55–0.86), p < 0.001). The median time to relapse was also better for oral azacitidine, and the incidences of TEAEs were similar for the two arms. …”
Publicado 2023
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1041092por Chandra, Sidhanth, Di Meco, Antonio, Dodiya, Hemraj B., Popovic, Jelena, Cuddy, Leah K., Weigle, Ian Q., Zhang, Xiaoqiong, Sadleir, Katherine, Sisodia, Sangram S., Vassar, Robert“…CONCLUSIONS: We show for the first time, in the context of amyloidosis, that the GMB plays an important role in controlling reactive astrocyte induction, morphology, and astrocyte recruitment to Aβ plaques. …”
Publicado 2023
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1041093por Hillary, Robert F., McCartney, Daniel L., Smith, Hannah M., Bernabeu, Elena, Gadd, Danni A., Chybowska, Aleksandra D., Cheng, Yipeng, Murphy, Lee, Wrobel, Nicola, Campbell, Archie, Walker, Rosie M., Hayward, Caroline, Evans, Kathryn L., McIntosh, Andrew M., Marioni, Riccardo E.“…Incident cases were identified using linkage to Scottish primary (Read 2) and secondary (ICD-10) care records, and the censoring date was set to October 2020. The mean time-to-diagnosis ranged from 5.0 years (for chronic pain) to 11.7 years (for Coronavirus Disease 2019 (COVID-19) hospitalisation). …”
Publicado 2023
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1041094por Zhang, Sihui, Wang, Chao, Liu, Bei, Lu, Qing-Bin, Shang, Jia, Zhou, Yihua, Jia, Jidong, Xu, Xiaoyuan, Rao, Huiying, Han, Bingfeng, Zhao, Tianshuo, Chen, Linyi, Xie, Mingzhu, Cui, Jiahao, Du, Juan, zeng, Jing, huang, Ninghua, Liu, Yaqiong, Zhang, Lei, Zhuang, Hui, Cui, Fuqiang“…FINDINGS: Besides the status quo, we finally simulated 135 treatment-expanding scenarios based on the cross combination of different thresholds of ALT, treatment coverages, population's age groups and implementation time. For the status quo, a cumulative incidence of 16,038–42,691 HBV-related complications and 3116–18,428 related deaths will happened between 2030 and 2050. …”
Publicado 2023
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1041095por Racca, Annalisa, Santos-Ribeiro, Samuel, Drakopoulos, Panagiotis, De Coppel, Joran, Van Landuyt, Lisbet, Tournaye, Herman, Blockeel, Christophe“…CONCLUSIONS: In a frozen embryo transfer cycle, performed with artificial preparation of the endometrium, 7 versus 14 days of oestrogen priming are comparable, in terms of clinical pregnancy rate; the advantages of a seven-day protocol include the shorter time to pregnancy, reduced exposure to oestrogens, and more flexibility of scheduling and programming, and less probability to recruit a follicle and have a spontaneous LH surge. …”
Publicado 2023
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1041096“…METHODS: The study included a cohort of stable CAD patients undergoing PCI who had experienced two naturally occurring modes of CR program after hospital discharge at two time periods, January 2019 to December 2019 (in-person CR program) and May 2020 to May 2021 (remote CR program). …”
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1041097por Hutton, Paul, Kelly, James, Taylor, Christopher D. J., Williams, Brian, Emsley, Richard, Alexander, Candy Ho, Vikram, Anvita, Saddington, David, McCann, Andrea, Burke, Joseph, Eliasson, Emma, Harper, Sean, Karatzias, Thanos, Taylor, Peter J., Watson, Andrew, Dougall, Nadine, Stavert, Jill, O’Rourke, Suzanne, Glasgow, Angela, Murphy, Regina, Palmer, Karen, Zaidi, Nosheen, Bidwell, Polly, Pritchard, Jemma, Carr, Lucy, Woodrow, Amanda“…Our aim is to accelerate their development by testing, for the first time in mental healthcare, the feasibility, acceptability and safety of running an ‘Umbrella’ trial. …”
Publicado 2023
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1041098por Bersanelli, Melissa, Verzoni, Elena, Cortellini, Alessio, Giusti, Raffaele, Calvetti, Lorenzo, Ermacora, Paola, Di Napoli, Marilena, Catino, Annamaria, Guadalupi, Valentina, Guaitoli, Giorgia, Scotti, Vieri, Mazzoni, Francesca, Veccia, Antonello, Guglielmini, Pamela Francesca, Perrone, Fabiana, Maruzzo, Marco, Rossi, Ernesto, Casadei, Chiara, Montesarchio, Vincenzo, Grossi, Francesco, Rizzo, Mimma, Travagliato Liboria, Maria Grazia, Mencoboni, Manlio, Zustovich, Fable, Fratino, Lucia, Accettura, Caterina, Cinieri, Saverio, Camerini, Andrea, Sorarù, Mariella, Zucali, Paolo Andrea, Ricciardi, Serena, Russo, Antonio, Negrini, Giorgia, Banzi, Maria Chiara, Lacidogna, Gaetano, Fornarini, Giuseppe, Laera, Letizia, Mucciarini, Claudia, Santoni, Matteo, Mosillo, Claudia, Bonetti, Andrea, Longo, Lucia, Sartori, Donata, Baldini, Editta, Guida, Michele, Iannopollo, Mauro, Bordonaro, Roberto, Morelli, Maria Francesca, Tagliaferri, Pierosandro, Spada, Massimiliano, Ceribelli, Anna, Silva, Rosa Rita, Nolè, Franco, Beretta, Giordano, Giovanis, Petros, Santini, Daniele, Luzi Fedeli, Stefano, Nanni, Oriana, Maiello, Evaristo, Labianca, Roberto, Pinto, Carmine, Clemente, Alberto, Tognetto, Michele, De Giorgi, Ugo, Pignata, Sandro, Di Maio, Massimo, Buti, Sebastiano, Giannarelli, Diana“…The trial's primary endpoint was the time-adjusted incidence of influenza-like illness (ILI) until April 30, 2020, the results of which were reported previously. …”
Publicado 2023
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1041099por Costello, Ruth E., Tazare, John, Piehlmaier, Dominik, Herrett, Emily, Parker, Edward P.K., Zheng, Bang, Mansfield, Kathryn E., Henderson, Alasdair D., Carreira, Helena, Bidulka, Patrick, Wong, Angel Y.S., Warren-Gash, Charlotte, Hayes, Joseph F., Quint, Jennifer K., MacKenna, Brian, Mehrkar, Amir, Eggo, Rosalind M., Katikireddi, Srinivasa Vittal, Tomlinson, Laurie, Langan, Sinéad M., Mathur, Rohini“…We grouped ethnicity (exposure), into five categories: White, Asian, Black, Other, and Mixed. We used interrupted time-series regression to estimate ethnic differences in clinical monitoring frequency (blood pressure and Hba1c measurements, chronic obstructive pulmonary disease and asthma annual reviews) before and after March 23, 2020. …”
Publicado 2023
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1041100por Trickey, Adam, Bivegete, Sandra, Duffell, Erika, McNaughton, Anna L., Nerlander, Lina, Walker, Josephine G., Fraser, Hannah, Hickman, Matthew, Vickerman, Peter, Brooks-Pollock, Ellen, Christensen, Hannah“…We included data on adults from the general population, pregnant women, first time blood donors (FTBD), men who have sex with men (MSM), prisoners, people who inject drugs (PWID), and migrants from 2001 to 2021, with three exceptions made for pre-2001 estimates. …”
Publicado 2023
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