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  1. 1041741
    “…We quantified regional binding using six methods (12 variants), some of which were region-based (applied to the average time-activity curve within a region) and others were voxel-based: 1) Models requiring arterial ppIFs – regional reversible compartmental models with one and two tissue compartments (2kbv and 4kbv); 2) Regional and voxelwise Logan’s graphical analyses (Logan et al., 1990), which required arterial ppIFs; 3) Model-free regional and voxelwise (exponential) spectral analyses (SA; (Cunningham and Jones, 1993)), which also required arterial ppIFs; 4) methods not requiring arterial ppIFs – voxelwise standardised uptake values (Kenney et al., 1941), and regional and voxelwise simplified reference tissue models (SRTM/SRTM2) using brainstem or alternatively cerebellum as pseudo-reference regions (Lammertsma and Hume, 1996; Gunn et al., 1997). …”
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    Test-retest reproducibility of quantitative binding measures of [(11)C]Ro15-4513, a PET ligand for GABA(A) receptors containing alpha5 subunits
  2. 1041742
    “…Instead, we found evidence of time-varying effects of somatic mutation load on PFS in this cohort (n = 25, p = 0.044). …”
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    Online Artículo Texto
    Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis
  3. 1041743
    Publicado 2017
    “…However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. …”
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    Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
  4. 1041744
    “…The study was conducted through a Web-based platform consisting of a landing Web page and capabilities to administer study measures at different time points. Web-based measurements were self-assessed at baseline and 4 weeks, and EMAs were collected repeatedly at regular weekly intervals or ad hoc when participants interacted with the study platform. …”
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    Online Artículo Texto
    Efficacy of a Web-Based Guided Recommendation Service for a Curated List of Readily Available Mental Health and Well-Being Mobile Apps for Young People: Randomized Controlled Trial
  5. 1041745
    “…Estimates for the proportion of children younger than 5 years with a fever within the previous 14 days and P falciparum infection assessed by RDT who received an ACT were incorporated in a generalised additive mixed model, including data on ACT distributions, to estimate coverage across all countries and time periods. We did random effects meta-analyses to examine individual, household, and community effects associated with ACT coverage. …”
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    Population coverage of artemisinin-based combination treatment in children younger than 5 years with fever and Plasmodium falciparum infection in Africa, 2003–2015: a modelling study using data from national surveys
  6. 1041746
    “…Gene expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) was assessed by quantitative real-time polymerase chain reaction (qPCR), and the levels of signal transducers and activators of transcription 3 (stat3) and phosphor-stat3 (p-stat3) were also analyzed by Western blotting. …”
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    Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury
  7. 1041747
    “…We did a within-trial cost-effectiveness analysis using person-level data and modelled outcomes over a 25-year time horizon using microsimulation. This study is registered with Current Controlled Trials, number ISRCTN82857232. …”
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    Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial
  8. 1041748
    “…Corticosteroids may reduce the time to resolution of pleural effusion. Risk of residual pleural effusion on chest X‐ray was reduced by 45% at eight weeks (RR 0.54, 95% CI 0.37 to 0.78; 237 participants, 2 trials, low certainty evidence), and 65% at 24 weeks (RR 0.35, 95% CI 0.18 to 0.66; 237 participants, 2 trials, low certainty evidence). …”
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    Corticosteroids for tuberculous pleurisy
  9. 1041749
    “…With further improvement in sequence throughput and error rate reduction, this platform shows great promise for precise real-time analysis of the composition and structure of more complex microbial communities.…”
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    MinION™ nanopore sequencing of environmental metagenomes: a synthetic approach
  10. 1041750
    “…Thirty-five of 90 had never used a biologic for Juvenile DM at that time. Fifty-five of 91 (denominators vary) had used biologics for JDM in their practice with 32%, 5%, and 4% using rituximab, etanercept, and infliximab, respectively, and 17% having used more than one of the three drugs. …”
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    Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America
  11. 1041751
    “…Ratio of CT(1000μm nasal to fovea)/SFCT (0.90±0.06;range:0.66,1.23) and ratio of CT(2500μm nasal to fovea)/SFCT (0.70±0.13;range:0.28,1.23) decreased with older age (P = 0.01;and P = 0.001, respectively), while ratio of CT(1000μm temporal to fovea)/SFCT (1.02±0.06;range:0.56,1.37) and ratio of CT(2500μm temporal to fovea)/SFCT (0.99±0.11;range:0.54,1.84) increased with older age (both P<0.001). Time spent outdoors or indoors was not significantly associated with CT-related parameter in multivariate analysis. …”
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    Choroidal thickness in school children: The Gobi Desert Children Eye Study
  12. 1041752
    “…CONCLUSIONS: There were no statistically significant differences between groups for the secondary outcomes once age, gender, time since diagnosis and type of MS were accounted for. …”
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    Effect of exercising at minimum recommendations of the multiple sclerosis exercise guideline combined with structured education or attention control education – secondary results of the step it up randomised controlled trial
  13. 1041753
    “…Demographic characteristics were inversely related to HRQL (r = −0.419, p = 0.007), but have a significant impact on health literacy (r = 0.675, p = 0.029) and self-management efficacy (r = 0.379, p = 0.029). At the same time, self-management efficacy was positively correlated to health literacy (r = 0.413, p < 0.01). …”
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    The effect of health literacy and self-management efficacy on the health-related quality of life of hypertensive patients in a western rural area of China: a cross-sectional study
  14. 1041754
    “…The participants were classified according to the Chinese University Prognostic Index (CUPI), the Cancer of the Liver Italian Program (CLIP), Japan Integrated Staging (JIS), China Integrated Score (CIS) systems, Barcelona Clinic Liver Cancer (BCLC), Okuda and tumor-node-metastasis (TNM) staging systems at the time of diagnosis and during patient follow-up. The sensitivity and specificity of the predictive value of each staging system for 3- and 6-month mortality were analyzed by relative operating characteristic (ROC) curve analysis with a non-parametric test being used to compare the area under curve (AUC) of the ROC curves. …”
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    Validation and ranking of seven staging systems of hepatocellular carcinoma
  15. 1041755
    por Sewell, J, Daskalopoulou, M, Nakagawa, F, Lampe, FC, Edwards, S, Perry, N, Wilkins, E, O'Connell, R, Jones, M, Collins, S, Speakman, A, Phillips, AN, Rodger, AJ, Johnson, Margaret, McDonnell, Jeff, Aderonke, Adebiyi, Gilson, Richard, Haddow, Lewis, Gilson, Simon, Broussard, Christina, Pralat, Robert, Wayal, Sonali, Fisher, Martin, Pollard, Alex, Fedele, Serge, Kerr, Louise, Heald, Lisa, Hadley, Wendy, Hobbs, Kerry, Williams, Julia, Youssef, Elaney, Richardson, Celia, Groth, Sean, Clowes, Yvonne, Cullie, Jennifer, Murphy, Cynthia, Martin, Christina, George, Valerie, Thompson, Andrew, Anderson, Jane, Mguni, Sifiso, Awosika, Damilola, Scourse, Rosalind, Aderogba, Kazeem, Osborne, Caron, Cross, Sue, Whinney, Jacqueline, Tawana, Cheryl, Lascar, Monica, Maseko, Zandile, Townsend, Gemma, Theodore, Vera, Sagoo, Jas, Miners, Alec, Hart, Graham, Geretti, Anna‐Maria, Burman, Bill, Partridge, Nick, Orton, Kay, Nardone, Anthony, Sullivan, Ann
    Publicado 2016
    “…In analyses adjusted for gender/sexual orientation, ethnicity, age and time since starting ART, factors strongly associated with inaccurate self‐report of VL (including “don't know”) included socioeconomic disadvantage [prevalence ratio (95% CI) for “not” vs. …”
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    Accuracy of self‐report of HIV viral load among people with HIV on antiretroviral treatment
  16. 1041756
    “…Of the 5 major themes identified in open narratives, 3 were related to healthcare providers—lack of timely attention, poor skills (knowledge or implementation), and reluctance to deliver a dead baby. …”
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    Identification of factors associated with stillbirth in the Indian state of Bihar using verbal autopsy: A population-based study
  17. 1041757
    “…A mixed-model ANOVA (group x time) was used for all statistical comparisons with an a priori α =.05. …”
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    Femoral Nerve Blockade versus Adductor Canal Nerve Blockade with Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized Clinical Trial
  18. 1041758
    “…Of the 231 patients, 201 returned to play (87.0%) at a mean time of 10.1 months. Mean pre-operative outcome scores on the IKDC, Lysholm, SF-12 PCS and SF-12 MCS were 50.1, 61.2, 41.5, and 53.6 respectively. …”
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    Pre-operative Short Form Survey is Predictive of Return to Play and Minimal Clinically Important Difference after Anterior Cruciate Ligament Reconstruction
  19. 1041759
    “…Tukey’s correction was used to adjust for multiple group comparisons, and two independent t-tests: 1- between rabbits receiving hydrogel alone vs. their respective controls; 2- between rabbits receiving hydrogel / MSCs vs. their respective controls; for both ICRS and O’Driscoll scores, being a total of six statistical analyses. RESULTS: At time of euthanasia, all hydrogels remained in place. …”
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    Cartilage Repair with Mesenchymal Stem Cells (MSCs) Delivered in a Novel Chondroitin Sulfate / Polyethylene Glycol Hydrogel in a Rabbit Animal Model”
  20. 1041760
    “…For the revision cohort, the average age at primary ACLR was 21.1 years (range 13-47 years) (Table 1). Time between primary and revision ACLR was an average of 2.2 years (0.23-8.72 years). …”
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    Primary Anterolateral Ligament Rupture in Patients Requiring Revision Anterior Cruciate Ligament Reconstruction: A Retrospective Magnetic Resonance Imaging Review
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