“…RESULTS: A non-parametric longitudinal voxel-based analysis limited to the fornix revealed a time x treatment interaction which reached significance in the body of the fornix (corrected p<.04) with NAC patients showing an increase in gFA over 6-month of treatment. …”
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“…The mean increase in body weight from baseline to Week 52 was 2.6kg (observed cases [OC]) and 19.6% of patients had a weight increase ≥7% at any time during the study. There were no clinically relevant findings for either metabolic parameters (lipids and glucose), or for events related to ECGs, vital signs, extrapyramidal symptoms, or prolactin. …”
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“…Furthermore, no studies have examined the putative effect of PRS for Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive Disorder (MDD) on previously identified general and specific symptom dimensions. At the same time, only one study has investigated how symptoms vary according to epidemiological factors such as living in urban neighbourhoods. …”
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“…Considering that the clinically high-risk (CHR) status can be defined as a late phase of risk,6 the accumulation of risk indicators in childhood, including PRS and risk endophenotypes, document this early life period as the optimal timing for early intervention approaches. REFERENCES: 1. …”
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“…We present interim analyses of 3 month data with general linear and logistic regression models, clustered by centre and adjusted for baseline scores and demographics. RESULTS: Recruitment time, now finished, was extended to reach target sample size, so 12 month data are incomplete. 258 were allocated to PSI or TAU. 18 dropped-out before baseline assessment: 240 entered the modified intention to treat analysis (PSI 121, TAU 119). …”
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“…Horyzons is safe and engaging (over prolonged periods of time) and may improve depression and social connectedness in FEP patients.…”
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“…Percent change in CDI positively correlated with percent change in AHRS from pre-RCT to post-RCT time-point for the entire sample (N=13; ρ=0.55, p=0.05). …”
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“…Although we cannot draw definite conclusions, we identified different patterns of longitudinal course for different cognitive domains with attention, shot-term memory, working memory, visual-spatial ability and executive functions presenting a decline over time; whereas other domains, such as visual memory, visual perception, learning memory, verbal comprehension, motor function, remaining stable in patient through patients’ 4th and 5th decades of life.…”
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“…In the model, we included a random intercept for each patient and, as fixed effects, we entered sex, time (days from baseline measurement), waist circumference and antipsychotic use at each assessment point, and baseline cigarette smoking. …”
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“…Using this data, we fitted growth mixture models to identify latent trajectory classes that accounted for heterogeneity in patterns of change in psychotic symptoms over time. RESULTS: We had sufficient data on occurrence of psychotic symptoms throughout the follow up on 326 (~ 60%) patients. …”
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“…The daily dose of vitamin D was calculated based on the concentration of vitamin D in the product used and the reported amount of the product consumed. At the time when cohort was born, the recommended dose of vitamin D was 2000 IU/day. …”
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“…Trained interviewers administered the Composite International Diagnostic Interview (CIDI) at three time points in a representative general population sample, with N=4.596 individuals who completed all assessments. …”
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“…After adjustment for potential confounders (age, follow-up time, sex, BMI, and pubertal status), the CAR continued to show significant associations with both depression (p=0.006) and PQ negative symptoms (p=0.007) whilst only a statistical trend was observed for the relationship between diurnal cortisol levels and positive symptoms (p=0.055). …”
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“…Data were processed with CMTK using a 68 regions parcellation according to a state-of-the-art pipeline. Time series were averaged over the Freesurfer regions and Pearson’s correlation was used as FC measure. …”
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“…METHODS: Forty-six FES patients, 41 non-psychotic FDRs of patients with chronic schizophrenia (unrelated to the FES group) and 54 HCs were studied. Pro-social time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance were assessed with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). …”
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“…The levels of sVCAM-1 dramatically decreased after 8 weeks of liraglutide treatment (503 ± 182 vs 382 ± 131 ng/ml, P = 0.046) compared to that of the metformin treatment group. At the same time, the differences before and after liraglutide treatment in 120 min of NEFA (− 32 [− 96, − 5] vs 5 [− 35, 38] µmol/L, P = 0.033) and AUCins (738 [451, 1118] vs 594 [357, 1216] mIU/L, P = 0.014) were remarkably enhanced compared to that of the metformin therapy. …”
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“…CONCLUSION: Evidence from conversion time courses together with results of activity measurements for pfLDH and PDC show that in IBB14LA1 the distribution of fluxes at the pyruvate branching point is carbon source and oxygen dependent. …”
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“…The structures of the full channel in the open and closed states were compared for the first time using the recent Cryo-EM resolved structure for full open hERG channel and an homology model for the closed state, based on the highly homolog EAG1 channel. …”
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“…Growing granddaughters and grandsons of controls had greater decreases in cortical volumetric BMD than grandchildren of individuals with OA (time-by-group [T(*)G] based on mixed model [± standard error] -9.7 ± 4.3 versus -0.8 ± 4.4 mg/cm(3)/year, respectively, for granddaughters, difference of 9.0 [95% CI, 2.4-15.5] mg/cm(3)/year, p = 0.007 and -6.8 ± 3.3 versus 4.5 ± 3.4 mg/cm(3)/year, respectively, for grandsons, difference of 11.3 [95% CI, 4.3-18.3] mg/cm(3)/year, p = 0.002). …”
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“…In the 2L setting, OS rates for the same time periods were 40%, 22% and 8%, respectively. …”
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