“…MC3353 displayed dose- and time-dependent antiproliferative activity in several cancer cell types, inducing cell death and affecting EMT through E-cadherin and MMP2 modulation. …”
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“…INTERPRETATION: The persistently high prevalence of late-stage breast cancer at diagnosis across all ethnoracial and social strata in Brazil, although more substantially among the most disadvantaged populations, implies that early detection policies might have had little effect on breast cancer mortality so far, and highlights the need to focus primarily on timely diagnosis of symptomatic breast cancer rather than on screening for asymptomatic disease. …”
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“…The risk of loss to club-based care was higher among participants assigned to community-based clubs than among those assigned to clinic-based clubs (adjusted hazard ratio 1.38, 95% CI 1.02–1.87, p = 0.032), after accounting for sex, age, nationality, time on ART, baseline CD4 count, and employment status. …”
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“…BACKGROUND: Ecological momentary assessments (EMAs) administered via text messaging facilitate real-time data collection. With widespread cell phone access, EMAs are becoming more available to even the most disenfranchised communities, such as those living with HIV. …”
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“…In intervention studies where touch points decrease over time, there is even more of an adherence challenge. …”
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“…Differences between GHQ-28 scores for structured and usual care callers will be tested using a generalized linear mixed model with fixed effects for intervention and each time period. The trial will recruit 1512 callers. …”
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“…These should be considered for patients with both DM and obesity. POC A1c is a time-efficient tool to identify those with or at-risk of DM.…”
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“…To understand these relationships, we performed standardized mixed-meal tolerance tests (MMTT) with timed blood sampling for determination of plasma glucose, insulin and C-peptide in non-diabetic adolescents and young adults with pancreatic insufficient CF (PI-CF). …”
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“…As F has pulsatile secretion and diurnal variation, integrating blood concentrations (IC) over time has been recommended as the most accurate estimate of tissue exposure to circulating hormones. …”
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“…CC genotype of rs2282679 (PR 1.74; 95%CI 1.30;2.24; p<0.001), GC2 isoform (PR 1.66; 95%CI 1.17; 2.38; p=0.005), time since menopause (PR 1.02; 95%CI 1.003;1.03, p= 0.016) and HOMA-IR (PR 1.02; 95%CI 1.01;1.03, p= 0.004) were associated with higher prevalence ratios for 25(OH)D deficiency. …”
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“…Conclusion: We show for the first time that a novel SSTR2 analog (86)Y-EB-TATE is characterized by superior tumor uptake compared to (68)Ga-DOTATATE and (68)Ga-DOTA-JR11 in TC mice models. …”
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“…ERRγ1 mRNA and Aro mRNA variants were analyzed by Real-time RT-PCR with primers for total (TotAro, Ex2-Ex3), and active (ActAro, Ex9-Ex10)Aro. …”
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“…The total period of subsequent BP exposure (TOTPERIOD) was determined by the time between the first and last prescriptions, inclusive of all treatment gaps. …”
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“…Mean ± SE histomorphometric values for the 8/10 subjects with osteomalacia at baseline were 20.4 ± 4.2 µm for osteoid thickness (OT), 23.0 ± 7.2% for osteoid volume/bone volume (OV/BV), and 66.1 ± 10.6% for osteoid surface/bone surface (OS/BS); baseline median (Q1, Q3) for mineralization lag time (MLT) was 1672 (1102, 2929) days. At W48, histomorphometric indices improved as shown by mean percentage changes in OT (37%), OV/BV (40%), OS/BS (-5%), and MLT (median percentage change -78%). …”
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“…Patients initially received 25 or 50 µg/day of rhPTH(1-84) subcutaneously, once daily, with stepwise dose adjustments of 25 µg (up or down) to a maximum of 100 µg/day. rhPTH(1-84) could be titrated and oral calcium (Ca) and calcitriol doses adjusted at any time during the study to maintain albumin-corrected serum Ca levels in the target range of 8.0-9.0 mg/dL. …”
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“…To study the dynamic profile of Plasma Glucose (PG) and plasma Insulin (PI) values at time 0,1 and 2 hour during an OGTT b. to assess whether degree of insulin resistance in Hispanic children and adolescents can be predict an abnormal I hr glucose level. …”
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“…Data after 64 weeks of treatment will be available at the time of presentation. In this randomized Phase 3 trial, burosumab resulted in increases in growth and mobility, and significantly greater improvements in rickets than Pi/D in 1-12 year-old children with XLH.…”
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“…We here describe, for the first time, four case series of CAEBV/EBV-HLH patients who carried the hypomorphic variants of XLP-related genes. …”
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“…CHVs’ home visits had no statistically significant effect on diarrhea or fever prevalence at either time point. After a follow-up of 12 months, the prevalence of diarrhea and fever was 7.0% (55/784) and 18.4% (144/784), respectively, in the control communities and 4.5% (37/825) and 14.7% (121/825), respectively, in the intervention communities (12-month RR adjusted for clustering and stratification: diarrhea, RR 0.73, 95% CI 0.37–1.45, p = 0.37; fever, RR 0.76, 95% CI 0.51–1.14, p = 0.20). …”
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“…To evaluate motion interplay effects, simulated delivered doses were calculated for each plan by sorting spots into corresponding respiratory phases using spot delivery time recorded in the log files by the beam delivery system to calculate each phase dose and accumulate dose to the T50 CTs. …”
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