“…The presence of two types of adipose tissue, which have the opposing function, has been known for a long time. White adipose tissue (WAT) is the tissue of energy expenditure storage, while Brown adipose tissue (BAT) is characterized to dissipates energy as heat and is required for non-shivering thermoregulation, presents a high thermogenesis capacity, regulating systemic metabolism and participating of the glycemic homeostasis, and displayed a high metabolic activity, which is due the presence of UCP1 (uncoupling protein-1) and through this the ability to dissipate energy, to burn away (extra) food, and it had been a proposal as a potential target to obesity treatment. …”
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“…He was 177 cm tall at the age of 19. At the time he presented to our clinic, he weighed 95.3 kg and was 183 cm tall. …”
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“…Subsequent monitoring of serum calcium levels showed improvement with time, along with improvement in polyphagia and polyuria. …”
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“…Our result reveals for the first time that inhibiting elevated microRNAs may be a more effective therapeutic approach than gene transfer to improve blood flow and muscle function in type 2 DM and PAD.…”
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“…The median (range) age at the time of diagnosis was 38 years (6-83). Total thyroidectomy was performed in 719 pts (96.4%) while the other 27 pts had partial thyroid surgery. …”
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“…Peptides were also analysed by real-time cellular impedance assays (xCELLigence) to measure unbiased receptor stimulation. xCELLigence assays showed PTH1-34, PTHrP1-34 and Abaloparatide had the highest potencies (3.7 nM,1.4 nM,1.7nM respectively) while Tyr(1)PTH1-34 and PTH2-34 had significantly decreased potencies (64nM and 130nM), the β-arrestin biased agonist, D-Trp(12)Tyr(34)PTH7–34, had no effect. …”
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“…Conclusion:The weight loss in the SG group, as compared to controls, lessened over time remaining statistically significant until yr 6. …”
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“…VMS reductions were significantly greater with the 2 higher NT-814 doses at most time-points, as early as the first week of treatment. …”
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“…Sex differences include the timing of adrenal fetal zone (X-zone) regression, which occurs during male mouse puberty but only after pregnancy or advanced age in females. …”
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“…Although a statistically significant difference was seen between IGF-1 levels at 6 weeks and 3–6 months, the mean difference between these time points was small (20 ng/mL, P=<0.001). There was a greater percent reduction in IGF-1 at 6 weeks following surgery in those who had a normal IGF-1 at 3–6 months compared to those who did not (63% vs 35%, P=<0.01). …”
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“…In an initial study, heterozygous POMC-KO mice with an established pituitary tumor of approx. 10mm(3) (mean volume 8.9±0.3), as determined by MRI, were treated with a range of TBR-760 doses (0.125 to 12.5mg/kg, sc, QD) for 60 days. During that time, tumors in vehicle-treated mice increased in size by 890±0.7%, whereas all doses of TBR-760 tested resulted in a nearly complete inhibition of tumor growth from treatment initiation. …”
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“…The majority of OSG members were females who were not full-time employees and with varied levels of education. …”
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“…Although similar clinical outcomes following MIS- and Open-TLIF were reported essentially at the early postoperative time, the comparison of local balance variables after these two different techniques was lack. …”
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“…OBJECTIVE: The objectives were to (1) evaluate changes in frailty status, level of independence, mood, cognition, and quality of life (QoL) over a 12-month period and (2) explore the relationship between frailty status and level of independence, mood, cognition, and QoL at 2 different time points (at baseline and at 1 year). DESIGN: This is a prospective cohort study involving 100 prevalent HD patients. …”
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“…BACKGROUND: Dual tasking constitutes a large portion of most activities of daily living; in real-life situations, people need to not only maintain balance and mobility skills, but also perform other cognitive or motor tasks at the same time. Interest toward dual-task training (DTT) is increasing as traditional interventions may not prepare patients to adequately face the challenges of most activities of daily living. …”
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“…Men comprised a smaller proportion of individuals starting ART (37.2% versus 62.8%), tended to be older (median age 37 versus 33 years), and tended to have lower CD4 counts (median 220 versus 289 cells/μl) at the time of ART initiation compared to women. The overall rate of mortality among men was 10.3 (95% CI 8.2–12.4) deaths/100 person-years (PYs), compared to 5.5 (95% CI 4.3–6.8) deaths/100 PYs among women (difference +4.7 [95% CI 2.3–7.2] deaths/100 PYs; p < 0.001). …”
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“…The participants were asked about their musculoskeletal pain (low back and limb pain) and lifestyle factors: use of evacuation shelters or temporary housing at any point of time, job loss after the disaster, decreased income after the disaster, current smoking status, current drinking status, lack of sleep, regular exercise, and participation in recreational or community activities. …”
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“…The advanced ARIMA model was used for predicting future data based on time series data. The ARIMA model provides a weight to past values and error values to correct the model prediction, so it is better than other basic regression and exponential methods. …”
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“…In other variables such as cell morphology and cellularity score, there were no significant differences between LR-PRP and LP-PRP groups in any time points. Flow cytometric findings showed that recruitment of GFP-positive MPs in the LR and LP-PRP groups were significantly increased from postoperative day 4 compared with control group without PRP treatment (P < 0.001). …”
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“…Across both disorders, impairments in social cognition persist over time, drive disability, and predict functional outcome. …”
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