“…Together, this approach enabled us to assess both the intra- and inter-sample differences in peptide signal response and retention time. RESULTS: Despite differences in sample preparation, quantitative MS approaches and patient samples, 25 proteins, including Tau, had a consistent and significant change in AD in both the discovery and replication cohorts. …”
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“…After a median follow up time of 12 months in each cohort, the adjusted 1-year rate of local control and incidence of radiation necrosis was 91% (95% CI 86–96%) and 85% (95% CI 75–95%) (p = 0.26) and 10% (95% CI 5–15%) and 7% (95% CI 0.1–14%) (p = 0.73) for SF-SRS and HF-SRS, respectively. …”
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“…PARTICIPANTS/MATERIALS, SETTING, METHODS: The levels of UPR sensor proteins and UPR-related genes were measured in cumulus cells from PCOS and control patients by real-time quantitative PCR (qPCR) and western blot. The ovaries, oocytes, GCs and COCs were collected from PCOS mice treated with metformin and controls. …”
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“…Patients in the anakinra group were treated with subcutaneous anakinra (100 mg twice a day for 72 h, then 100 mg daily for 7 days) as well as the standard treatments at the institution at the time. Patients in the historical group received standard treatments and supportive care. …”
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“…Geometric least-squares mean ratios were used for between-treatment comparisons of baseline (day 0)-adjusted area under the plasma concentration versus time curves (AUC(0–24)) and maximum plasma concentrations (C(max)) for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). …”
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“…Annual mean concentrations of particulate matter (PM) with a diameter [Formula: see text] ([Formula: see text]), [Formula: see text] , nitrogen dioxide ([Formula: see text]), and nitrogen oxides ([Formula: see text]) at the nurses’ residences since 1990 ([Formula: see text] and [Formula: see text]) or 1970 ([Formula: see text] and [Formula: see text]) were estimated using the Danish Eulerian Hemispheric Model/Urban Background Model/AirGIS (DEHM/UBM/AirGIS) dispersion model. We used time-varying Cox regression models to examine the association between 1- and 3-y running means of these pollutants, as well as 23-y running means of [Formula: see text] and [Formula: see text] , with both overall and fatal incident MI. …”
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“…Particular attention is warranted among men who inject drugs to improve timely HIV diagnosis, drug interaction management, and retention in treatment. …”
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“…The expression of PD-L1 in mononuclear cells (MCs) was analyzed using real time PCR. PD-L1 immunohistochemical analysis was prepared on TC and IC. …”
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“…The serum inflammatory markers were determined by commercial kits and the expression of molecules in TLR4/MyD88 signaling pathway in liver by real-time PCR and western blotting. The recruitments of TLR4 and MyD88 into lipid rafts of live tissue lysates were detected by sucrose gradient ultracentrifugation and western blotting. …”
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“…A total of 442 of 457 eligible patients (Compliance = 96,7%) have thus far completed the 12 months follow-up time point. RESULTS: All mean KOOS, OKS, KSS and VAS scores improved significantly 1 year after surgery (p<0.05). …”
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“…MAIN OUTCOMES: Primary: Time for clinical improvement and lung CT score changes 14 days after treatment. …”
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“…Concomitant cannabidiol led to a small increase in stiripentol exposure (17% increase in maximum observed plasma concentration [C(max)]; 30% increase in area under the concentration–time curve over the dosing interval [AUC(tau)]). …”
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“…CV safety assessments included proportion of patients with and exposure-adjusted rates of on-treatment CV adverse events of special interest (CVAESI) and major adverse cardiac events (MACE), as well as time-to-first (TTF) CVAESI, and TTF CVAESI resulting in hospitalization/prolonged hospitalization or death. …”
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“…MAIN OUTCOMES AND MEASURES: Serial assessment of 13 biochemical parameters at 12 time points for up to 5 years after bariatric procedure. …”
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“…Plasma small polar metabolites were measured by gas chromatography and time-of-flight mass spectrometry. Lipids were measured by ultra-HPLC and quadrupole mass spectrometry. …”
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“…After accounting for the time to seroconversion, we estimated that for every reported confirmed case, there were 11·6 infections in the community. …”
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“…Their ability of providing unique capabilities in continuous, real-time, and non-invasive tracking of the physiological markers of users can provide insights into the performance and health of individuals. …”
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“…Array comparative genomic hybridization (aCGH) was then performed to detect CNVs in the other four families, F2-F5. Quantitative real-time polymerase chain reaction (qPCR) was used to validate and determine the extent of identified CNVs containing HMX1-ECR region. …”
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“…It is shown for the first time that the effect is dependent on RNA polymerase II-mediated transcription, but not on de novo biosynthesis of cholesterol or fatty acids, and therefore is not a generalized metabolic response to ethanol exposure. …”
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“…The median whole slide image file size was 1.3 GB; scan time/slide averaged 90 s; and scanned tissue area averaged 612 mm(2). …”
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