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  1. 1042341
    “…METHODS: Primary pancreatic cancer cells of patient-derived xenografts (PDXs) were cultured in adherent or CSC-enriching sphere conditions to determine the role of glutathione metabolism in stemness. Real-time polymerase chain reaction (PCR) was used to validate RNAseq results involving glutathione metabolism genes in adherent vs spheres, as well as the expression of pluripotency-related genes following treatment. …”
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    Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells
  2. 1042342
    “…The changes in NMR over time varied across the sites. Even among babies born ≥ 2500 g, lower gestational age and birthweight were largely associated with increased risk of mortality. …”
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    Neonatal deaths in infants born weighing ≥ 2500 g in low and middle-income countries
  3. 1042343
    “…We report maternal characteristics and outcomes in relationship to the inter-delivery interval (IDI, time from previous delivery [live or stillborn] to the delivery of the index birth), by category of 6–17 months (short), 18–36 months (reference), 37–60 months, and 61–180 months (long). …”
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    The relationship between birth intervals and adverse maternal and neonatal outcomes in six low and lower-middle income countries
  4. 1042344
    “…A descriptive analysis was conducted using tables, interquartile ranges and median. The time to development of surgical site infection was estimated using Kaplan-Meier method. …”
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    Incidence and predictors of surgical site infection following cesarean section in North-west Ethiopia: a prospective cohort study
  5. 1042345
    “…Secondary data analysis on three time points during 2015 through 2018 revealed a rising trend of HIV among attendees of the ICTCs (ICTC-Hasanganj, ICTC-Unnao district hospital and ICTC- Nawabganj) catering to the entire district of Unnao. …”
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    Unsterile injection equipment associated with HIV outbreak and an extremely high prevalence of HCV—A case-control investigation from Unnao, India
  6. 1042346
    “…DM patients have a significantly higher death rate (20.5% versus 12.3%; p = 0.04) and lower survival time (p = 0.016) than non-DM. Multivariate cox proportional hazards regression model revealed that age [Hazards ratio, HR 3.0 (95% confidence interval, CI 1.7–5.3); p < 0.001], congestive heart failure [adjusted HR 3.5 (CI 1.4–8.3); p = 0.006], smoking [adjusted HR 5.8 (CI 2.0–17.2); p < 0.001], β-blocker use [adjusted HR 1.7 (CI 1.0–2.9); p = 0.04], bilateral lung infiltrates [adjusted HR 1.9 (CI 1.1–3.3); p = 0.02], creatinine > 90 µmol/l [adjusted HR 2.1 (CI 1.3–3.5); p = 0.004] and 25(OH)D < 12.5 nmol/l [adjusted HR 7.0 (CI 1.7–28.2); p = 0.007] were significant predictors of mortality among hospitalized Covid-19 patients. …”
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    Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study
  7. 1042347
    “…In addition, we used quantitative real-time polymerase chain reaction (RT-qPCR) and Western blotting to determine FN1 expression in bladders with different grades of fibrosis. …”
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    MicroRNA-219c-5p regulates bladder fibrosis by targeting FN1
  8. 1042348
    “…BACKGROUND: Long-term care facilities (LTCFs) are vulnerable to outbreaks of coronavirus disease 2019 (COVID-19). Timely epidemiological surveillance is essential for outbreak response, but is complicated by a high proportion of silent (non-symptomatic) infections and limited testing resources. …”
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    Optimizing COVID-19 surveillance in long-term care facilities: a modelling study
  9. 1042349
    “…These sequences will be prepared by an independent statistician and will be kept in opaque, sealed, numbered envelopes which will be opened only at the time of enrollment. The allocation ratio in intervention and control groups is 1:1. …”
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    Effects of curcumin-piperine co-supplementation on clinical signs, duration, severity, and inflammatory factors in patients with COVID-19: a structured summary of a study protocol for a randomised controlled trial
  10. 1042350
    “…This systematic review and meta-analysis of either published or preprint observational studies or randomized control trials (RCT) aimed to assess mortality rate, duration of hospital stay, need for mechanical ventilation (MV), virologic cure rate (VQR), time to a negative viral polymerase chain reaction (PCR), radiological progression, experiencing drug side effects, and clinical worsening. …”
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    A systematic review and meta-analysis on chloroquine and hydroxychloroquine as monotherapy or combined with azithromycin in COVID-19 treatment
  11. 1042351
    “…MAIN OUTCOMES AND MEASURES: The primary end point was PFS, considering the time from the initiation of therapy to the date of recurrence, confirmed disease progression, or death. …”
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    Development and Validation of a Machine Learning Model to Explore Tyrosine Kinase Inhibitor Response in Patients With Stage IV EGFR Variant–Positive Non–Small Cell Lung Cancer
  12. 1042352
    “…We included clinics with ≥50 patients contributing to person-time-at risk in each study year. PARTICIPANTS: Patients aged 19–64 with ≥1 ambulatory visit in the study period were included. …”
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    New hypertension and diabetes diagnoses following the Affordable Care Act Medicaid expansion
  13. 1042353
    “…Although it is not feasible to increase the number of mental health care providers or hours they work in the short term, improving their time efficiency may be a viable solution. Virtually and digitally delivering psychotherapy, which has been shown to be efficient and clinically effective, might be a good method for addressing this growing demand. …”
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    Using the Online Psychotherapy Tool to Address Mental Health Problems in the Context of the COVID-19 Pandemic: Protocol for an Electronically Delivered Cognitive Behavioral Therapy Program
  14. 1042354
    “…CONCLUSIONS: Based on these results, we suggest that face-to-face health education requires integration of home health care provision and more relevant and timely interactive SMS text messages to increase the effectiveness of the intervention. …”
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    Awareness Development and Usage of Mobile Health Technology Among Individuals With Hypertension in a Rural Community of Bangladesh: Randomized Controlled Trial
  15. 1042355
    “…Inflammation was evaluated by gross ear thickness, histopathology, the infiltration of inflammatory cells (CD3(+) T cells and neutrophils) using immunofluorescence, and the expression of cytokine production using real-time quantitative polymerase chain reaction. The obtained data were statistically evaluated by unpaired t-tests and a one-way analysis of variance. …”
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    Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis
  16. 1042356
    “…OBJECTIVE: To evaluate the changes over time in alcohol use and unhealthy alcohol use from 2 years before to 8 years after a bariatric surgical procedure among individuals with or without preoperative unhealthy alcohol use. …”
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    Association of Bariatric Surgical Procedures With Changes in Unhealthy Alcohol Use Among US Veterans
  17. 1042357
    por Roth, Gregory A., Mensah, George A., Johnson, Catherine O., Addolorato, Giovanni, Ammirati, Enrico, Baddour, Larry M., Barengo, Noël C., Beaton, Andrea Z., Benjamin, Emelia J., Benziger, Catherine P., Bonny, Aimé, Brauer, Michael, Brodmann, Marianne, Cahill, Thomas J., Carapetis, Jonathan, Catapano, Alberico L., Chugh, Sumeet S., Cooper, Leslie T., Coresh, Josef, Criqui, Michael, DeCleene, Nicole, Eagle, Kim A., Emmons-Bell, Sophia, Feigin, Valery L., Fernández-Solà, Joaquim, Fowkes, Gerry, Gakidou, Emmanuela, Grundy, Scott M., He, Feng J., Howard, George, Hu, Frank, Inker, Lesley, Karthikeyan, Ganesan, Kassebaum, Nicholas, Koroshetz, Walter, Lavie, Carl, Lloyd-Jones, Donald, Lu, Hong S., Mirijello, Antonio, Temesgen, Awoke Misganaw, Mokdad, Ali, Moran, Andrew E., Muntner, Paul, Narula, Jagat, Neal, Bruce, Ntsekhe, Mpiko, Moraes de Oliveira, Glaucia, Otto, Catherine, Owolabi, Mayowa, Pratt, Michael, Rajagopalan, Sanjay, Reitsma, Marissa, Ribeiro, Antonio Luiz P., Rigotti, Nancy, Rodgers, Anthony, Sable, Craig, Shakil, Saate, Sliwa-Hahnle, Karen, Stark, Benjamin, Sundström, Johan, Timpel, Patrick, Tleyjeh, Imad M., Valgimigli, Marco, Vos, Theo, Whelton, Paul K., Yacoub, Magdi, Zuhlke, Liesl, Murray, Christopher, Fuster, Valentin
    Publicado 2020
    “…GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. …”
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    Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study
  18. 1042358
    “…Costs were from a health care sector perspective, and the time horizon was 4 months, from April to August 2020. …”
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    Clinical Outcomes, Costs, and Cost-effectiveness of Strategies for Adults Experiencing Sheltered Homelessness During the COVID-19 Pandemic
  19. 1042359
    “…We aimed to determine whether reduced antenatal growth velocity from the time of routine mid-trimester ultrasound is associated with antenatal, intrapartum and postnatal indicators of placental insufficiency among term AGA infants. …”
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    Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight
  20. 1042360
    “…In normal cells, activation of NRF2 by a thiol-reactive stressor helps prevent, for a limited period of time, the initiation of cancer by chemical carcinogens through induction of genes encoding drug-metabolising enzymes. …”
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    NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
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