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1042361por Muessig, Kathryn Elizabeth, Golinkoff, Jesse M, Hightow-Weidman, Lisa B, Rochelle, Aimee E, Mulawa, Marta I, Hirshfield, Sabina, Rosengren, A Lina, Aryal, Subhash, Buckner, Nickie, Wilson, M Skye, Watson, Dovie L, Houang, Steven, Bauermeister, José Arturo“…We will also explore whether participant engagement, as measured by paradata (data collected as users interact with an mHealth intervention, eg, time spent using the intervention), mediates stigma- and HIV care–related outcomes. …”
Publicado 2020
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1042362por Bhaskaran, Krishnan, Rentsch, Christopher T, MacKenna, Brian, Schultze, Anna, Mehrkar, Amir, Bates, Chris J, Eggo, Rosalind M, Morton, Caroline E, Bacon, Sebastian C J, Inglesby, Peter, Douglas, Ian J, Walker, Alex J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Forbes, Harriet J, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen J W, Smeeth, Liam, Goldacre, Ben“…Interaction terms were added to assess effect modification by age, sex, ethnicity, comorbidities, and calendar time. RESULTS: 17 282 905 adults were included, of whom 27 480 (0·16%) had HIV recorded. …”
Publicado 2021
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1042363por Kim, Joon Hyung, Johnson, Robert, Kovac, Martina, Cunningham, Anthony L, Emmadi, Srikanth, Sullivan, Keith, Dagnew, Alemnew F, Curran, Desmond, Schuind, Anne“…Martina Kovac, MD, GSK (Other Financial or Material Support, I was an employee of GSK at the time of the study) Anthony L. Cunningham, MBBS, MD, FRACP, FRCPA, GSK (Consultant) Srikanth Emmadi, MSc, GSK (Employee) Keith Sullivan, MD, FASTCT, GSK (Consultant) Alemnew F. …”
Publicado 2020
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1042364por Glidden, David V, Dunn, David T, Das, Moupali, Ebrahimi, Ramin, Zhong, Lijie, Stirrup, Oliver T, Anderson, Peter L“…Of the 11 on F/TDF, 10 had low, 0 had medium, and 1 had high TFV-DP levels; among HIV-negative controls, 5% of the person-time had low, 9% had medium, and 86% had high TFV-DP levels. …”
Publicado 2020
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1042365por Reekie, Joanne, Khurana, Mark P, Lodding, Isabelle P, Ekenberg, Christina, Gustafsson, Finn, Helleberg, Marie, Mocroft, Amanda, Perch, Michael, Rasmussen, Allan, Sørensen, Søren S, Lundgren, Jens“…Figure 3 Risk of recurrent CMV infection in the 6 months following clearance and stopping of treatment for the first CMV infection (N=99), stratified by CMV serostatus at the time of transplant [Image: see text] Figure 4 Factors associated with recurrent CMV infection within 6 months of stopping treatment for the first CMV infection [Image: see text] CONCLUSION: Recurrent CMV infection remains a significant complication among SOT recipients, especially in those with high risk CMV IgG serostatus. …”
Publicado 2020
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1042366por Baker, Arthur W, Maged, Ahmed, Haridy, Salah, Stout, Jason E, Seidelman, Jessica L, Lewis, Sarah S, Anderson, Deverick J“…Traditional surveillance detection was defined as the time of outbreak detection by routine infection control procedures. …”
Publicado 2020
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1042367por Petigara, Tanaz, Chen, Ya-Ting, Liu, Zhiwen, Goveia, Michelle, Johnson, David, Marshall, Gary S“…A previous analysis found variability in the timing of HepB doses in infants receiving DTaP-IPV/Hib. …”
Publicado 2020
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1042368por Ison, Michael G, Chao, Nelson, Marty, Francisco M, Moon, Seung Hyun, Zhang, Zhiji, Chandak, Aastha“…We also used a generalized linear model to determine adjusted TR stratified by the presence or absence of any acute or chronic graft-versus-host diseases (GVHD) after adjusting for age, health plan, underlying disease, stem cell source, number of comorbidities, baseline costs, and follow-up time. RESULTS: The study included 13,363 patients, representing 22% of HCTs reported to CIBMTR for the study period, of which 1,368 (10%) were coded with an RVI in the year following HCT: 578 (4%) RSV, 687 (5%) influenza, 166 (1%) PIV, and 181 (1%) HMPV. …”
Publicado 2020
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1042369por Mathur, Poonam, Kaplan, Roman, Theppote, Amanda, Kottilil, Shyam, Wilson, Eleanor“…Correlates such as the ASCVD score should be considered in the timing of HCV treatment, in order to reduce the long-term risk of CVD. …”
Publicado 2020
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1042370por Katsube, Takayuki, Kawaguchi, Nao, Matsunaga, Yuko, Ariyasu, Mari, Den Nagata, Tsutae, Portsmouth, Simon, Paterson, David, Paterson, David, Satlin, Michael J, Zeitlinger, Markus, Echols, Roger, Wajima, Toshihiro“…METHODS: Sparse pharmacokinetic (PK) samples at steady state from critically ill patients with pneumonia, bloodstream infection/sepsis, or complicated urinary tract infection receiving CFDC in two Phase 3 studies were analyzed. Percent time of dosing interval of free drug concentration exceeding the minimum inhibitory concentration (MIC) in plasma and epithelial lining fluid (ELF) (%fT(>MIC) and %fT(>MIC,ELF), respectively) were determined for 60 (CREDIBLE-CR; NCT02714595) and 97 patients (APEKS-NP; NCT03032380), using a 3-compartment population PK model. …”
Publicado 2020
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1042371por Brenes-Chacon, Helena, Garcia-Maurino, Cristina, Moore-Clingenpeel, Melissa, Mertz, Sara, Ye, Fang, Cohen, Daniel M, Ramilo, Octavio, Mejias, Asuncion“…[Image: see text] METHODS: Previously healthy children < 2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and nasopharyngeal swabs were obtained for RSV typing and quantitation by real-time PCR. Patients were stratified by age (0-< 3, 3-6, and >6-24 months) and multivariable analyses were performed to identify clinical and viral factors associated with severe disease. …”
Publicado 2020
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1042372por Viehman, J Alex, Nguyen, M Hong, Garner, Will, Apostolopoulou, Anna, Harris, Gavin H, Lucas, Aaron, Jagadeesan, Vidya, Butler, Sharlay, Rapinski, Glen J, McCreary, Erin K, Arbulu, Ricardo, Ganchuk, Steven, Yang, Anne, Avasarala, Amitha, Trificante, Rosalie, Bollam, Rahul, Zou, Richard H, Moghbeli, Kaveh, Darwish, Malik, Hemadri, Amit, Weslander, Erin, Campfield, Brian T, Michaels, Marian G, Haidar, Ghady, Daley, Jesssica, Martin, Elise, Bariola, J Ryan“…Guidelines changed over time. Hydroxychloroquine (HCQ) was unrestricted during phase 1, then restricted by pharmacy outside of a randomized clinical trial (RCT) during phase 2 (excepting those ineligible for RCTs). …”
Publicado 2020
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1042373por Li, Se, Kuter, Barbara J, Schmidt, Elvira, Richardson, Elizabeth, Saldutti, Louise P, Monika, Neumann, Koller, Linnea, Agrawal, Manica, Pawaskar, Manjiri D“…More effectiveness studies are warranted to further address questions on the relationship of VE and time since vaccination as well as the effectiveness of a third dose of M-M-R(®) II for measles or mumps outbreak control. …”
Publicado 2020
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1042374por Pinho, Rafaela Tonholli, Tanure, Luciana Coelho, Lopes, Joice Ribeiro, Pires, Bárbara Caldeira, de Souza, Flávio Henrique Batista, Couto, Braulio Roberto Gonçalves Marinho, Starling, Carlos Ernesto Ferreira, Silva, Estevão Urbano, MICHELI, Thais, GUIMARAES, Míriam, Couto, Renato C, ARAÚJO, Marina, FRANCISCO, Sheila, EVANGELISTA, Neila, Messias, Glauco, Santos, Leonardo, Pessoa, Jussara“…For many hospitals, SSI surveillance has three main objectives: to feedback surgeons with their SSI rates; to evaluate SSI rates over time, identifying outbreaks; and to compare data among different institutions. …”
Publicado 2020
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1042375por Gutierrez, Ramiro L, Burns, Daniel, Lalani, Tahaniyat, Bennett-Carter, Denise, Fraser, Jamie, Riddle, Mark, Connor, Patrick, Porter, Chad, Troth, Thomas, Ruck, Richard, Barton, Jerry, Tilley, Drake H, Kunz, Anjali, Fairchok, Mary, Yun, Heather, Alvarez, Bryan, Higgins, Robert, Mitra, Indrani, Stewart, Laveta, Rahman, Azizur, Rimmer, JoAnna, Hutley, Emma, Swierczewski, Brett, Tabberer, Bethany, Tribble, David“…Diaries were reviewed with subjects on return. Primary endpoint was time to first unformed stool (TFUS) in a TD episode. …”
Publicado 2020
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1042376por Hu, Tianyan, Sarpong, Eric, Song, Yan, Done, Nicolae, Orvis, Eli, Signorovitch, James, Petigara, Tanaz“…RESULTS: AOM IRs declined over time among commercially and Medicaid-insured children in all age groups < 18 years old. …”
Publicado 2020
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1042377por Sederdahl, Bethany K, Weinberg, Geoffrey A, Campbell, Angela P, Selvarangan, Rangaraj, Schuster, Jennifer E, Harrison, Christopher J, Rha, Brian, Lively, Joana Y, Patel, Manish, Shu, Bo, Boom, Julie A, Avadhanula, Vasanthi, Halasa, Natasha B, Stewart, Laura S, Szilagyi, Peter G, Hickey, Robert, Michaels, Marian G, Williams, John V“…Nasal/throat swabs were collected from emergency department (ED) or inpatient children with ARI, or healthy controls in clinic, between 12/05/2016-10/31/2019 and tested by real-time RT-PCR for ICV and other respiratory viruses. …”
Publicado 2020
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1042378por Varsavsky, Thomas, Graham, Mark S, Canas, Liane S, Ganesh, Sajaysurya, Capdevila Pujol, Joan, Sudre, Carole H, Murray, Benjamin, Modat, Marc, Jorge Cardoso, M, Astley, Christina M, Drew, David A, Nguyen, Long H, Fall, Tove, Gomez, Maria F, Franks, Paul W, Chan, Andrew T, Davies, Richard, Wolf, Jonathan, Steves, Claire J, Spector, Tim D, Ourselin, Sebastien“…We used three datasets to validate our models: the Office for National Statistics (ONS) Community Infection Survey, the Real-time Assessment of Community Transmission (REACT-1) study, and UK Government testing data. …”
Publicado 2021
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1042379por Sanchez, Katherine, Kim, Isaac, Chun, Brie, Pucilowska, Joanna, Redmond, William L., Urba, Walter J., Martel, Maritza, Wu, Yaping, Campbell, Mary, Sun, Zhaoyu, Grunkemeier, Gary, Chang, Shu Ching, Bernard, Brady, Page, David B.“…Hierarchical linear modeling was utilized to compare pre- and post-treatment immune cell expression, account for correlation of time-dependent measurement, variation across high-powered magnification views within each subject, and variation between subjects. …”
Publicado 2021
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1042380por Rau, Matthias, Thiele, Kirsten, Hartmann, Niels-Ulrik Korbinian, Schuh, Alexander, Altiok, Ertunc, Möllmann, Julia, Keszei, András P., Böhm, Michael, Marx, Nikolaus, Lehrke, Michael“…Treatment with empagliflozin had no effect on the primary endpoint of systemic vascular resistance index, nor on cardiac index, stroke volume index or pulse rate at any time point. In addition, echocardiography showed no difference in left ventricular systolic function as assessed by left ventricular ejections fraction and strain analysis. …”
Publicado 2021
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