“…Most income loss was associated with hospitalization and time for picking up TB drugs. Most TB patients (85.9%) reported worsening financial situations due to TB, and over fifty percent (53.0%) borrowed money or sold assets to finance TB treatment. …”
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“…Knee outcome measures included the Knee injury and Osteoarthritis Outcome Score (KOOS) pain, symptoms, activities of daily living (ADL), sports and recreation function, and knee-related quality of life subscales, and total KOOS score were assessed from baseline to 2 years. Missing data at each time point were replaced with multiple imputation under the assumption of missing at random. …”
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“…Hemoglobin A1c levels and specific DM therapies administered were collected. Time elapsed from the first diagnosis of DM was not collected and, therefore, was not included in the analyses. …”
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“…Weight loss-induced improvements in the QoL and particularly the physical health status were maintained in MUO until the end of the trial, while benefits disappeared over time in MHO. Group allocation by HOMA-IR and ISI(Clamp) revealed higher benefits for MUO mainly in parameters of the glucose metabolism and QoL. …”
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“…Meta-analysis revealed that whole-body vibration with strengthening exercises has a significant treatment effect on pain score (standardized mean difference (SMD) = 0.46 points, 95% confidence interval (95% CI) = 0.20–0.71, p = 0.0004), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC-function) (SMD = 0.51 points, 95% CI = 0.27–0.75, p < 0.0001), Timed Up and Go (TUG) test (SMD = 0.82 points, 95% CI = 0.46–1.18, p < 0.00001), extensor isokinetic peak torque (SMD = 0.65 points, 95% CI = 0.00–1.29, p = 0.05), peak power (SMD = 0.68 points, 95% CI = 0.26–1.10, p = 0.001), and extensor isometric strength (SMD = 0.44 points, 95% CI = 0.13–0.75, p = 0.006). …”
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“…One hundred and twelve (61.5%) of patients continued baricitinib at data collection time; mean persistence was 14.1 (0.5) months. Overall treatment persistence was 79.7/64.8/59.1% at 6/12/18 months. …”
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“…Overall, in our primary analysis including all diagnosed tuberculosis cases, a time-varying association was identified between LTBI testing and treatment and lower risk of incident tuberculosis (hazard ratio [HR] 0·76 [95% CI 0·63–0·91]) when compared with no testing. …”
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“…Besides their lack of training about these conditions, family physicians also described difficulties when trying to access timely specialized services for their patients. Physicians can experience moral distress when they know that their patients need higher level care, but there are systemic barriers to specialized programs that block their patients from getting the care they need when they need it. …”
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“…Among 3524 patients [including 1252 (35.53%) very elderly patients] who completed the entire study, 2897 (82.21%) patients had a CHA(2)DS(2)-VASc score ≥ 2, 2274 (64.53%) had HAS-BLED score < 3, and 1659 (47.08%) had both of the above. The follow-up time was 3.80 (median, interquartile range 1.89–6.56) years. …”
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“…Subsequently, the disease duration, prognosis of disease, time of negative nucleic acid and the cytokines levels in serum were used to assess the efficacy of treatment with LS in patients. …”
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“…Overall, 9365 patients (17.5%) developed fractures after initial receipt of ADT. The median time to first fracture was 31 months (IQR, 15-56 months). …”
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“…The expression patterns of sEV miRNAs in the benign, adenocarcinoma in situ/minimally invasive adenocarcinoma, and invasive adenocarcinoma subgroups were found to gradually change with the increase in aggressiveness for the first time. Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients. …”
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“…METHODS: RNA sequencing and quantitative real-time PCR (qRT-PCR) assays were applied to screen for circRNAs differentially expressed in LSCC tissues and cell lines. …”
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“…METHODS: We investigated the relationship between appendicular skeletal lean mass/height(2) (ALM/HT(2)) (kg/m(2)) assessed by DXA and SARC‐F in a subset of 1538 (778 men and 760 women) participants in the Multiethnic Cohort (MEC) Study after adjustment for race/ethnicity, age, and body mass index (BMI) at the time of DXA measurement. We then investigated the association between SARC‐F and mortality among 71 283 (41 757 women and 29 526 men) participants in the MEC, who responded to the five SARC‐F questions on a mailed questionnaire as part of the MEC follow‐up in 2012–2016. …”
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“…The total effective rate［overall response rate（ORR）］was 66.7％（58/87）. ③The ORR of the classic and late aGVHD groups was 77.8％（42/54）and 48.5％（16/33）, respectively. ④The median（range）follow-up time was 154（4–1813）days, the 6-month overall survival（OS）rate of the 87 patients was 44.8％（95％ CI 39.5％-50.1％）and the 1-year OS was 39.4％（95％ CI 34.2％–44.3％）. ⑤After treatment with basiliximab, the 6-month OS in the CR（35 cases）, PR（23 cases）, and NR（29 cases）groups was 80.0％（95％ CI 73.2％–86.8％）, 39.1％（95％ CI 28.9％–49.3％）, and 6.9％（95％ CI 2.2％–11.6％）, respectively（χ(2)＝34.679, P<0.001）, and the 1-year OS was 74.3％（95％ CI 66.9％–81.7％）, 30.4％（95％ CI 20.8％–40.0％）, and 3.4％（95％ CI 0％–6.8％）, respectively（χ(2)＝43.339, P<0.001）. …”
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“…First, in elderly patients with late-stage CKD, antibody titers tended to be lower in the G5D group than in the G4 and G5 groups despite the shorter time since vaccination; therefore, CKD stage progression might cause a decline in antibody titers. …”
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“…RESULTS: Generally, active treatment led to significant improvements from baseline in FACIT-F total, and MOS-SS and SF-36 composite/domain scores vs placebo, observed by M1 and maintained through M6 (last placebo-controlled time point). Through M6, more patients achieved improvements from baseline ≥ MCID and achieved scores ≥ population normative values in FACIT-F total and SF-36 domain scores with tofacitinib vs placebo. …”
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“…Limitations of the analysis are the relatively few studies contributing to symptom severity estimates and inconsistent use of PROMs (different measures and time points) across the included literature, which hindered interpretation. …”
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“…Regarding cognition on the 8 core knowledge of TB, the overall awareness rate among the freshmen is 73.3%(3,420/4,664); the awareness rate of the knowledge that “guarantee adequate sleep, reasonable diet, and strengthen physical exercise can reduce the incidence of TB” among them was the highest at 88.7% (517/583); and the awareness rate of the knowledge that “coughing or sputum expectoration occurred for more than 2 weeks should be suspected of infecting TB and seeking medical treatment in time” among them was the lowest at 47.5% (277/583). …”
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“…Mechanistic studies using time-resolved IR and electrochemical measurements provided molecular architecture for constructing efficient supramolecular photocatalysts. …”
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