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  1. 1043121
    “…Individuals with COVID-19 who clinically deteriorated (ie, who met the primary outcome) showed an early blunted respiratory interferon response and pronounced and persistent Th2 inflammation, mediated by CC chemokine ligand (CCL)-24, compared with those with COVID-19 who did not clinically deteriorate. Over time, the natural course of COVID-19 showed persistently high respiratory interferon concentrations and elevated concentrations of the eosinophil chemokine, CCL-11, despite clinical symptom improvement. …”
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    Online Artículo Texto
    Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis
  2. 1043122
    “…In contrast, the stage of disease, the therapeutic regimen, the ECOG status, and the time from initial diagnosis did not correlate with the presence of any type of advance directive. …”
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    Advance directives in patients with head and neck cancer - status quo and factors influencing their creation
  3. 1043123
    “…Ten out of 24 models for time-to-event outcomes accounted for censoring (42%). …”
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    Methodological conduct of prognostic prediction models developed using machine learning in oncology: a systematic review
  4. 1043124
    “…However, uncertainty remains over how long primary vaccination series remain effective, the ideal timing for booster doses, and the safety of heterologous booster regimens. …”
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    Online Artículo Texto
    COVID-19 vaccine waning and effectiveness and side-effects of boosters: a prospective community study from the ZOE COVID Study
  5. 1043125
    “…Secondary endpoints encompassed variation in monthly analgesic intake (MAI), Numerical Rating Scale (NRS), HIT-6 and MIDAS scores, and ≥ 50%, ≥ 75% and 100% responder rates at the same time intervals. RESULTS: Sixty-seventh number migraine patients had received ≥ 1 subcutaneous fremanezumab dose and were considered for safety analysis, while 53 patients completed 12 weeks of treatment and were included also in the effectiveness analysis. …”
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    Online Artículo Texto
    Fremanezumab in the prevention of high-frequency episodic and chronic migraine: a 12-week, multicenter, real-life, cohort study (the FRIEND study)
  6. 1043126
    “…Utility values (‘utilities’) are used in health economic analyses to incorporate individual or societal perspectives regarding the desirability of health outcomes such as a certain health state or change in health states over time. OBJECTIVES: The primary objective of this systematic literature review (SLR) was to identify published utilities associated with patients with SMA and their caregivers and to determine the extent to which Health Technology Assessment (HTA) requirements of methods used to generate utilities are met. …”
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    Systematic Literature Review to Identify Utility Values in Patients with Spinal Muscular Atrophy (SMA) and Their Caregivers
  7. 1043127
    “…Similar proportions of patients showed recovery from diarrhea over the 120 h after randomization (97.0% in the B. clausii group [n = 227]; 98.0% on placebo [n = 227]). Median time to recovery was also similar: 42.83 (95% CI: 40.90–44.90) hours for B. clausii and 42.13 (95% CI: 39.80–43.87) hours for placebo. …”
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    Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration therapy (ORT) and zinc in acute diarrhea in children: a randomized, double-blind, placebo-controlled study in India
  8. 1043128
    “…Different blood cell counts and HIs were calculated at three time-points: baseline (pre steroid), pre chemoimmunotherapy (post steroid) and post chemoimmunotherapy. …”
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    A Prognostic Model Using Post-Steroid Neutrophil-Lymphocyte Ratio Predicts Overall Survival in Primary Central Nervous System Lymphoma
  9. 1043129
    “…CONCLUSIONS: General and abdominal obesity begin at an early age and increase over time, showing an inverse correlation with socioeconomic status. …”
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    Tracking and risk of abdominal and general obesity in children between 4 and 9 years of age. The Longitudinal Childhood Obesity Study (ELOIN)
  10. 1043130
    por Price, Ashley M., Olson, Samantha M., Newhams, Margaret M., Halasa, Natasha B., Boom, Julie A., Sahni, Leila C., Pannaraj, Pia S., Irby, Katherine, Bline, Katherine E., Maddux, Aline B., Nofziger, Ryan A., Cameron, Melissa A., Walker, Tracie C., Schwartz, Stephanie P., Mack, Elizabeth H., Smallcomb, Laura, Schuster, Jennifer E., Hobbs, Charlotte V., Kamidani, Satoshi, Tarquinio, Keiko M., Bradford, Tamara T., Levy, Emily R., Chiotos, Kathleen, Bhumbra, Samina S., Cvijanovich, Natalie Z., Heidemann, Sabrina M., Cullimore, Melissa L., Gertz, Shira J., Coates, Bria M., Staat, Mary A., Zinter, Matt S., Kong, Michele, Chatani, Brandon M., Hume, Janet R., Typpo, Katri V., Maamari, Mia, Flori, Heidi R., Tenforde, Mark W., Zambrano, Laura D., Campbell, Angela P., Patel, Manish M., Randolph, Adrienne G.
    Publicado 2022
    “…We estimated vaccine effectiveness by comparing the odds of antecedent full vaccination (two doses of BNT162b2 messenger RNA vaccine) at least 14 days before illness among case patients and controls, according to time since vaccination for patients 12 to 18 years of age and in periods coinciding with circulation of B.1.617.2 (delta) (July 1, 2021, to December 18, 2021) and omicron (December 19, 2021, to February 17, 2022) among patients 5 to 11 and 12 to 18 years of age. …”
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    BNT162b2 Protection against the Omicron Variant in Children and Adolescents
  11. 1043131
    “…Uptake of HTS among AYP visiting hubs for the first time after COVID-19-related closures was higher (73.2%) compared to uptake before adaptations (65.9%; adjOR=1.24 95%CI 0.99, 1.56, p=0.06). …”
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    Adapting community-based sexual and reproductive health services for adolescents and young people aged 15-24 years in response to COVID-19 in Lusaka, Zambia: the implications on the uptake of HIV testing services
  12. 1043132
    “…BACKGROUND: Limitations of life-sustaining interventions in intensive care units (ICUs) exhibit substantial changes over time, and large, contemporary variation across world regions. …”
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    Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill
  13. 1043133
    “…RESULTS: There were no statistically significant differences in the MAP, HR and SpO2 among three groups at each observation time point (P>0.05). At T2 and T3, the levels of serum IL-6, TNF-α and IL-8 were obviously decreased in group D1 and D2 compared with those in group C (P<0.05), and the decreases in group D1 were overtly larger than those in group D2, and the decreases at T3 were markedly greater than those at T2 (P<0.05). …”
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    One-lung ventilation patients: Clinical context of administration of different doses of dexmedetomidine
  14. 1043134
    “…These findings suggest the safety of third vaccination doses in individuals who were eligible for booster vaccination at the time of this study.…”
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    Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records
  15. 1043135
    “…All cancer patients who developed a fever at the time of hospital visit were included in this study, and their socio-demographic and clinical data were collected using a structured questionnaire. …”
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    Bacterial profile and antimicrobial susceptibility patterns in cancer patients
  16. 1043136
    “…Schools should promote girl’s empowerment and awareness and, at the same time, reinforce boy’s role in fatherhood and shared responsibilities. …”
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    Adolescent pregnancy in Sao Tome and Principe: a cross-sectional hospital-based study
  17. 1043137
    “…No evidence of association with HbA1c was found for this dietary pattern at other time-periods. Decreases in ‘obesogenic’ dietary pattern score were associated with weight loss (β = − 0.77 [− 1.31, − 0.23] kg/SD) but not independently with HbA1c during any period. …”
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    Is glycaemic control associated with dietary patterns independent of weight change in people newly diagnosed with type 2 diabetes? Prospective analysis of the Early-ACTivity-In-Diabetes trial
  18. 1043138
    “…To optimize the assays, we first determined the minimum blood volume sufficient for detection of PvLAP5 and Pv18SrRNA using P. vivax infected Aotus blood that was preserved in RNAp and kept either at ambient temperature for up to 8 days before freezing or was snap-frozen at -80° Celsius at the time of bleeding. We then compared the mean differences in gametocyte detection rates of both qRT-PCR assays to LM and performed a multivariate correlation analysis of study variables. …”
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    Comparison of PvLAP5 and Pvs25 qRT-PCR assays for the detection of Plasmodium vivax gametocytes in field samples preserved at ambient temperature from remote malaria endemic regions of Panama
  19. 1043139
    “…The primary outcome is the time to first major vascular event (composite of non-fatal MI, non-fatal stroke and cardiovascular death [excluding confirmed intracranial haemorrhage and other fatal cardiovascular haemorrhage]). …”
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    Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
  20. 1043140
    “…Difference-in-differences models were used to compare these changes between respondents in the state of Victoria who were exposed to lockdown at the time of the 2020 interviews (treatment group) and respondents living elsewhere in Australia (who were living relatively free of restrictions; control group). …”
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    Effect of lockdown on mental health in Australia: evidence from a natural experiment analysing a longitudinal probability sample survey
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