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1043981Increased serine synthesis in cumulus cells of young infertile women with diminished ovarian reservepor Lu, Xinmei, Lv, Xiaolong, Dong, Xi, Li, Yulin, Turathum, Bongkoch, Liu, Suying, Wang, Xuemei, Shi, Huijuan, Liu, Yubing“…The transcript and protein levels of key enzymes involved in serine synthesis were verified in additional samples using quantitative real-time PCR (qRT-PCR) (n = 10) and capillary western blotting (n = 36). …”
Publicado 2023
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1043982por Sharma, Gunjan, Tran, Tiffany M., Bansal, Ishu, Beg, Mohammad Sabique, Bhardwaj, Ruchi, Bassi, Jaspal, Tan, Yuande, Jaiswal, Amit Kumar, Tso, Christine, Jain, Ayushi, Singh, Jay, Chattopadhyay, Parthaprasad, Singh, Archna, Chopra, Anita, Bakhshi, Sameer, Casero, David, Rao, Dinesh S., Palanichamy, Jayanth Kumar“…METHODS: Gene expression was analyzed from patient bone marrow RNA using Real Time RT-qPCR. Knockout cell lines were created using CRISPR-Cas9 based lentiviral vectors. …”
Publicado 2023
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1043983por Jin, Aina, Kan, Zhaobo, Tan, Qiushi, Shao, Jing, Han, Qi, Chang, Yashan, An, Nan, Yi, Muqing“…The cyclists completed a one-day pattern protocol that consisted of intraday fasting, 30 min of sitting still, 85 min of prolonged exercise plus a 5-min sprint (PE), a short recovery period of 60 min, a 20-min time trial (TT), and recovery till next morning. …”
Publicado 2023
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1043984por Bulgay, Celal, Cepicka, Ladislav, Dalip, Metin, Yıldırım, Selin, Ceylan, Halil İ., Yılmaz, Özlem Ö., Ulucan, Korkut, Badicu, Georgian, Cerit, Mesut“…Genotyping was conducted using real-time PCR. To assess the pre- and post-test performance differences of soccer players, the Wilcoxon Signed Rank test was employed. …”
Publicado 2023
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1043985por Yaskolka Meir, Anat, Keller, Maria, Hoffmann, Anne, Rinott, Ehud, Tsaban, Gal, Kaplan, Alon, Zelicha, Hila, Hagemann, Tobias, Ceglarek, Uta, Isermann, Berend, Shelef, Ilan, Blüher, Matthias, Stumvoll, Michael, Li, Jun, Haange, Sven-Bastian, Engelmann, Beatrice, Rolle-Kampczyk, Ulrike, von Bergen, Martin, Hu, Frank B., Stampfer, Meir J., Kovacs, Peter, Liang, Liming, Shai, Iris“…Adherence to the Green-MED diet was assessed by questionnaire and urine polyphenols metabolomics (high-performance liquid chromatography quadrupole time of flight). RESULTS: Baseline chronological age (51.3 ± 10.6 years) was significantly correlated with all methylation age (mAge) clocks with correlations ranging from 0.83 to 0.95; p < 2.2e − 16 for all. …”
Publicado 2023
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1043986“…Multiple DNA double-strand breaks (DSBs) were detected in SK-BR-3 cells exposed to [(225)Ac]Ac-DOTA-trastuzumab by γ-H2AX immunofluorescence microscopy. The time-integrated activity of [(111)In]In-DOTA-trastuzumab in SK-BR-3 cells was measured and used to estimate the absorbed doses from [(225)Ac]Ac-DOTA-trastuzumab by Monte Carlo N-Particle simulation for correlation with the SF. …”
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1043987“…The main perceived public health advantage of telehealth clinics was the shorter traveling and waiting time (526/664, 79.2%), while the main concern was legal issues from wrong diagnosis and treatment (511/664, 77.4%). …”
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1043988“…BACKGROUND: Timely and appropriate treatment for childhood illness saves the lives of millions of children. …”
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1043989por Moreno-Perez, Oscar, Guillen-Morote, Cristina, Argüello, Thalía, Soriano, Carmen, SantaCruz, Elisa, Lopez-Mondejar, Pedro, Navarro-Hoyas, Clara, Sanchez-Ortiga, Ruth, Sanchez-Pacheco, Myriam, Modrego-Pardo, Ines, Miguel Pico, Antonio“…The oSEMA provider specialties were mainly: endocrinology (ENDO) 39.2%, primary physician (PCare) 35.7% and cardiology (CAR) 20.9%. At the time of this analysis, the maintenance dose was 7 mg in 98.4% of patients. …”
Publicado 2023
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1043990por Paparodis, Rodis D, Bantouna, Dimitra, Karvounis, Evangelos, Livadas, Sarantis, Angelopoulos, Nicholas G, Zoupas, Ioannis, Imam, Shahnawaz, Jaume, Juan Carlos“…We assessed the percentage of patients reaching vitamin D adequacy (>30ng/ml) (VDA) by year and month of testing, by the use of VDS: in low dose (≤1200IU daily) (LD), medium dose (1201-3000IU daily) (MD) and high dose (>3000IU daily) (HD), by duration of use: short use (<12 months) and long term (≥12 months) (LT), by the timing of use: current use (CU), former use (stopped at least 2 months) (FU) and never use (NU). …”
Publicado 2023
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1043991por Abel, Brent, Minich, Waldemar, Schwiebert, Christian, Welsink, Tim, Seemann, Petra, Schomburg, Lutz, Brown, Rebecca J“…By easing diagnosis and monitoring of TBIR, the new assay for InsR-aAb quantification should enhance access to timely and effective treatment for TBIR. Presentation: Thursday, June 15, 2023…”
Publicado 2023
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1043992por Vidana Gamage, Hashni Epa, Shahoei, Sayyed Hamed, Albright, Samuel, Nguyen, Tiffany, Farmer, Rachel Elizabeth, Weisser, Erin, Bautista Rivas, Rafael Ovidio, Schane, Claire P, Wang, Yu, Nelczyk, Adam, Ma, Liqian, Tiwari, Srishti, Gupta, Anasuya Das, Bendre, Shruti, Apetoh, Lionel, Hergenrother, Paul, Nelson, Erik Russell“…Mining clinical data, we have found that high tumoral expression of NR0B2 is associated with an increased time to recurrence. Single cell RNA-sequencing indicates that NR0B2 is expressed within the myeloid cells of normal breast tissue. …”
Publicado 2023
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1043993por Bunnell, Mary A, Lin, Patrick, Zhou, Sherry, Park, Chan Jin, Wang, Shuangqi, Hu, Qinan, Marzbanabbasabadi, Behrokh, Oh, Ji Eun, Wang, Bensen, Laws, Mary, Fletcher, Endia, Liu, Zhengde, Joo, Erica, Qiao, Huanyu, Flaws, Jodi, Ko, Chemyong“…Pregnant CD-1 dams (n=5-6/treatment/time point) were orally administered an environmentally relevant phthalate mixture (20 μg/Kg/day) or vehicle daily from embryonic day (ED) 10.5 until birth. …”
Publicado 2023
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1043994por De Andrade, Nathalia Liberatoscioli Menezes, de Assis Funari, Mariana Ferreira, Malaquias, Alexsandra, Branco Dantas, Naiara Castelo, Rezende, Raissa, de Polli Cellin, Laurana, Homma, Thais Kataoka, Lerario, Antonio Marcondes, Arnhold, Ivo J, Vasques, Gabriela Andrade, Lima Jorge, Alexander Augusto“…Conclusion: The diagnostic yield of a multigene sequencing approach was three time higher in patients with syndromic SS than those with isolated SS. …”
Publicado 2023
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1043995por Liu, Anna, Brar, Sukhman, McKenzie, Kate, Beaton, Melanie, Lapier, Heather, Hramiak, Irene, Brahmania, Mayur, Spaic, Tamara, Clemens, Kristin K“…Microvascular complications were present in 6 (55%) with T1D and in 83 (50%) T2D patients. At the time of their NAFLD diagnosis, mean BMI of those with T1D was 31.7±5.8 kg/m(2) vs 35.8±10 kg/m(2) in T2D patients. …”
Publicado 2023
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1043996por Handelsman, David J, Grossmann, Mathis, Yeap, Bu Beng, Stuckey, Bronwyn G A, Shankara-Narayana, Nandini, Conway, Ann J, Inder, Warrick, McLachlan, Robert I, Allan, Carolyn A, Jenkins, Alicia, Jesudason, David R, Bracken, Karen, Robledo, Kristy, Wittert, Gary A“…Participants in follow-up survey were similar to non-participants in 23 anthropometric and demographic variables at entry to T4DM, but more in follow-up study were randomized to T (53 vs 46%%, p=0.038), had lower entry weight (107 vs 109 kg, p=0.026) and older school leaving age (16.7 vs 16.5 years, p=0.026) but remaining well matched for work status (46% retired, 35% full-time work, p=0.60), alcohol intake (69% nil or light, 3% heavy; p=0.12) and smoking (3% smoking, p=0.61). …”
Publicado 2023
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1043997por Puglisi, Soraya, Calabrese, Anna, Basile, Vittoria, Kimpel, Otilia, Altieri, Barbara, Angelousi, Anna, Kaltsas, Gregory, Ambroziak, Urszula, Appetecchia, Maria Luisa, Arosio, Maura, Berruti, Alfredo, Cosentini, Deborah, Canu, Letizia, Ceccato, Filippo, Di Dalmazi, Guido, Bouys, Lucas, Libè, Rossella, Nowak, Karolina, Papierska, Lucyna, Pittaway, James, Kienitz, Tina, Quinkler, Marcus, Elhassan, Yasir, Ronchi, Cristina, Saiegh, Leonard, Stigliano, Antonio, Dusek, Tina, Kastelan, Darko, Fassnacht, Martin, Terzolo, Massimo“…We have recently proposed a new method analogous to what is established for the anticoagulant warfarin, the time in target range (TTR). We aimed to evaluate whether the TTR is a factor influencing recurrence-free survival (RFS) in patients with ACC on adjuvant mitotane. …”
Publicado 2023
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1043998por Foss de Freitas, Maria Cristina, Rosenberg, Drake Stanton, Guler, Merve Celik, Yosef, Matheos, Khalatbari, Shoukoufeh, Carman, Richison, DillGomes, Anabela, Ashmus, Michelle, Spino, Cathie, Akinci, Baris, Brown, Rebecca J, Oral, Elif A“…The pain severity score (PSS) calculated from the BPI was positively associated with depression (PHQ9; p<0.0001) and anxiety (GAD-7; p=0.0003) adjusted for follow-up time. Patients with mild/moderate pain (PSS ≤4) showed a significant positive association with several Quality of Life (QoL) scores, such as physical functioning, limitation to physical health, limitation with emotional problems, and lack of energy/fatigue, social functioning, and general health (p<0.001 for all associations). …”
Publicado 2023
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1043999por Alcantara, Jonanlis Ramirez, Grant, Natalie, Stanley, Takara Leah, Eichler, Florian, Tritos, Nicholas A“…The median [IQR] TT level was 200 [143,240] ng/dL at the time of hypogonadism diagnosis. In patients with normal TT, the median [IQR] TT level was 498 [445,615] ng/dL. …”
Publicado 2023
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1044000por Domé, Laila, Riaño Gomez, Juan Manuel, Marta Bonaventura, María, Olga Fernandez, Marina, Daniel Montaner, Alejandro, Adela Lux-Lantos, Victoria, Silvia Bianchi, Maria“…NF-Gly did not vary with time in SD and HFD mice (day 12 vs day 1), while it significantly diminished with IMT [NF-Gly (mg/dl): repeated measures ANOVA: interaction, p<0.05; IMT6: Day1 vs Day12, p<0.02; IMT20: Day1 vs Day12, p<0.02]. …”
Publicado 2023
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