“…CONCLUSIONS: KEY SCIENTIFIC CONCEPTS AND RECOMMENDATIONS FOR PRECISION MEDICINE: Our metabolomics community believes that inclusion of metabolomics data in precision medicine initiatives is timely and will provide an extremely valuable layer of data that compliments and informs other data obtained by these important initiatives. …”
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“…METHODS: Consecutive patients admitted in 26 French ED for dyspnea suspected to be the consequence of AHF, prior to in hospital diagnostic test, were prospectively included at the time of their admission in the DeFSSICA Survey. Clinical characteristics at admission were recorded by the ED physicians. …”
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“…For each patient, formalin embedded biopsy samples of the duodenum referred to the period of ME diagnosis were retrieved. Real-time polymerase chain reaction (RT-PCR) was used to detect the amount of mRNA coding for tTG2, IFNγ, TLR2 and MyD88, and the quantity was expressed as fold change compared to controls. …”
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“…FINDINGS: Median follow-up at the time of this report was 11 1 months (interquartile range 6·7–15·2). …”
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“…We briefly discuss the origins of these large neurogenic genes, as they relate to the remarkable diversity of metazoan behaviors, and highlight key consequences on both behavioral traits and neurogenic disease across, respectively, evolutionary and ontogenetic time scales. TESTING THE HYPOTHESIS: Current approaches to studying the genetic mechanisms underlying rapid phenotypic change primarily focus on identifying signatures of Darwinian selection in protein-coding regions. …”
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“…A DNA barcode dataset with 3205 barcodes is made public at the same time, providing DNA barcodes of ca. 779 species, of which 2563 are identified as belonging to 444 validly published species. …”
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“…Using our targeted sequencing approach, endometrial driver mutations were identified in all seven women who received a cancer diagnosis based on classic histopathology of tissue curettage obtained at the time of hysteroscopy. In addition, relatively high allele fraction driver mutations were identified in the lavage fluid of approximately half of the women without a cancer diagnosis. …”
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“…AIM: To assess the prevalence of depressed heart rate variability (HRV) after an acute myocardial infarction (MI), and to evaluate its prognostic significance in the present era of immediate reperfusion. METHODS: Time-domain HRV (obtained from 24-h Holter recordings) was assessed in 326 patients (63.5 ± 12.1 years old; 80% males), two weeks after a complicated MI treated by early reperfusion: 208 ST-elevation myocardial infarction (STEMI) patients (in which reperfusion was successfully obtained within 6 h of symptoms in 94% of cases) and 118 non-ST-elevation myocardial infarction (NSTEMI) patients (percutaneous coronary intervention was performed within 24 h and successful in 73% of cases). …”
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“…Routine methods for identification include PCR-based analysis, western blotting, or crude activity screening, all of which are time-consuming techniques. To simplify this screening, we have adapted the 2A peptide system from the foot-and-mouth disease virus (FMDV) to T. reesei to express a readily screenable marker protein that is co-translated with a target protein. …”
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“…This was an in-person intervention, which could be a barrier for people without the time, flexibility, transportation, social support, and/or financial resources to attend. …”
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“…Even accounting for SP resistance, extending IPTp-SP to all women attending ANC, as well as long-lasting insecticidal net distribution targeted towards first-time mothers, would have a sizeable impact upon maternal and infant health in almost all malaria-endemic settings in sub-Saharan Africa.…”
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“…After the trial, 162 intervention and 172 control group children were reenrolled in a follow-up study at 13 y of age (December 2012–June 2014). At this time, DNA collected from 279 children (134 intervention and 145 control) was genotyped for a common serotonin transporter polymorphism. …”
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“…A primary barrier to this reporting is timely and easy access to data. It is possible that expanded adoption of electronic health record and laboratory reporting systems will improve access to this data and reduce reporting the burden. …”
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“…METHODS AND FINDINGS: We adapted an empirically calibrated dynamic compartmental model and used it to assess the discounted costs (in 2015 US dollars), health outcomes (HIV infections averted, change in HIV prevalence, and discounted quality-adjusted life years [QALYs]), and incremental cost-effectiveness ratios (ICERs) of the four prevention programs, considered singly and in combination over a 20-y time horizon. We obtained epidemiologic, economic, and health utility parameter estimates from the literature, previously published models, and expert opinion. …”
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“…In the test group the treatment duration was tailored according to the virus load tested by real time PCR into 8 weeks for patients who had undetectable HCV RNA level in their serum by the end of the second week of treatment (vRVR)), or 12 weeks for those who did not show vRVR. …”
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“…This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. FINDINGS: Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. …”
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“…ACL-QOL scores increased significantly from baseline over time for all groups (p=0.000). There was no difference in mean ACL-QOL score at 5-years (p=0.548): PT=82.5 (SD 17.9, 95% CI 79.0-86.0); HT=83.9 (SD 18.2, 95% CI 80.3-87.4); DB=81.1 (SD 19.3, 95% CI 77.4-84.8). …”
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“…All damaged cartilage displayed elevated cell death, especially in the superficial layer at all time points (Group 3; 56.4 ± 20.0%, 44.5 ± 11.5%, and 57.6 ± 16.3%, Group 5; 14.8 ± 5.3, 12.8 ± 13.2%, and 20.1 ± 4.1%, respectively). …”
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“…The parameters were measured as follows for the ACL injury group and control group respectively: height, 161.3 ± 6.7 and 162.0 ± 5.7 cm, P = 0.63; body weight, 57.5 ± 7.8 and 55.4 ± 6.2kg, P = 0.22; body mass index, 22.1 ± 1.8 and 20.1 ± 2.7, P= 0.17; anterior knee laxity, 4.0 ± 1.0 and 3.8 ± 1.1 mm, P = 0.54;, general joint laxity, 1.8 ± 1.3 and 2.7 ± 2.2 points, P = 0.03; femoral anteversion, 16.2 ± 3.7 and 16.7 ± 3.3 degree, P = 0.60; navicular drop, 8.5 ± 6.2 and 8.0 ± 3.3 mm, P = 0.78; muscle strength of knee flexion, 0.97 ± 0.27 and 0.89 ± 0.20 Nm/kg, P = 0.17; muscle strength of knee extension, 1.73 ± 0.39 and 1.58 ± 0.35 Nm, P = 0.14; muscle strength of hip abduction, 1.42 ± 0.32 and 1.26 ± 0.24 N, P = 0.02; locus length per time, 1.35 ± 0.39 and 1.16 ± 0.26 cm/s, P = 0.09; and environmental area, 2.62 ± 1.64 and 2.20 ± 1.22 cm(2), P = 0.37 (Table 1). …”
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“…The primary endpoint was overall survival, defined as time from randomisation until death from any cause, analysed by modified intention-to-treat. …”
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