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1044121por Torretta, Silvia, Rampino, Antonio, Pergola, Giulio, Pennuto, Maria, Basso, Manuela, Carlo, Pasquale Di, Masellis, Rita, Blasi, Giuseppe, Bertolino, Alessandro“…Biological validation experiments were performed in primary mouse cortical neurons. By real-time PCR analysis we measured the mRNA transcript levels of a group of genes included in the DRD2 co-expression module in basal conditions and upon viral vector-mediated overexpression (OE) and knockdown (KD) of the predicted TFs. …”
Publicado 2018
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1044122por Mullany, Luke C., van Boetzelaer, Elburg W., Gutman, Julie R., Steinhardt, Laura C., Ngoy, Pascal, Barbera Lainez, Yolanda, Wittcoff, Alison, Harvey, Steven A., Ho, Lara S.“…Among 4,434 enrolled children, 4,141 (93.4%) met the per-protocol definition of receipt of the arm-specific advice from the CHW and a timely day 8 assessment (universal follow-up group: 2,210; conditional follow-up group: 1,931). …”
Publicado 2018
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1044123por Källander, Karin, Alfvén, Tobias, Funk, Tjede, Abebe, Ayalkibet, Hailemariam, Abreham, Getachew, Dawit, Petzold, Max, Steinhardt, Laura C., Gutman, Julie R.“…Few children sought care from another provider after their initial visit to the CHW: 3.0% (59/1,993) in the conditional follow-up arm and 1.1% (22/1,953) in the universal follow-up arm, on average 3.2 and 3.4 days later, respectively, with no significant difference between arms (risk difference 1.79%, 95% CI −1.23%, 4.82%, p = 0.244). The mean travel time to another provider was 2.2 hours (95% CI 0.01, 5.3) in the conditional follow-up arm and 2.6 hours (95% CI 0.02, 4.5) in the universal follow-up arm (p = 0.82); the mean cost for seeking care after visiting the CHW was 26.5 birr (95% CI 7.8, 45.2) and 22.8 birr (95% CI 15.6, 30.0), respectively (p = 0.69). …”
Publicado 2018
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1044124“…RNA was extracted from decidual tissue and subjected to Illumina HT-12v4.0 BeadChip expression microarrays (TNL, n = 11; TL, n = 8; PTNL, n = 7; PTL, n = 10). Quantitative real-time PCR (qRT-PCR) was used to validate the microarray results. …”
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1044125por Gong, Shan-Shan, Fan, Yi-Hong, Wang, Shi-Yi, Han, Qing-Qing, Lv, Bin, Xu, Yi, Chen, Xi, He, Yao-Er“…The expression levels of inflammation cytokines IL-6, TNF-α and CXCL-1 were examined in colon tissues using real-time PCR and ELISA kits. RESULTS: Compared with the DSS group, mice treated with the CRH-R2 antagonist Ast2B showed greater loss of body weight, shorter colon lengths (4.90 ± 0.32 vs 6.21 ± 0.34 cm, P < 0.05), and higher DAI (3.61 ± 0.53 vs 2.42 ± 0.32, P < 0.05) and histological scores (11.50 ± 1.05 vs 8.33 ± 1.03, P < 0.05). …”
Publicado 2018
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1044126por Lyu, Jing-Jun, Mehta, Jawahar L, Li, Yi, Ye, Lu, Sun, Sheng-Nan, Sun, Hong-Shuang, Li, Jia-Chang, Zhang, Dong-Mei, Wei, Jie“…Compared with C57BL/6 mice, phos-ULK1 (Ser(327)) expression was significantly lower at 2 h and 12 h after CPR (2 h after CPR: 1.88 ± 0.36 vs. 1.12 ± 0.11, t = −1.36, P < 0.01 and 12 h after CPR: 1.52 ± 0.16 vs. 1.05 ± 0.12, t = −0.33, P < 0.01), whereas phos-ULK1 (Ser(757)) expression was significantly higher at 2 h and 12 h after CPR in NOD/SCID mice (2 h after CPR: 1.28 ± 0.12 vs. 1.69 ± 0.14, t = 1.7, P < 0.01 and 12 h after CPR: 1.33 ± 0.10 vs. 1.94 ± 0.13, t = 2.75, P < 0.01). (3) Furthermore, NLRP3 inflammasome/caspase-1 activation in the pulmonary tissues occurred early and for only a short time in C57BL/6 mice, but this phenomenon was sustained in NOD/SCID mice. …”
Publicado 2018
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1044127“…Some biological observations (relationship with mites, moulting) are recorded for the first time. Complete illustrations of external morphological characters, an identification key, and distribution maps of all species are provided.…”
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1044128“…Inclusion criteria were skeletally mature patients at the time of arthroscopy, signs and symptoms consistent with a diagnosis of FAI. …”
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1044129“…There was no difference over time in both survivors and nonsurvivors (all P > 0.05). …”
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1044130por Feng, QiPing, Wei, Wei-Qi, Chung, Cecilia P., Levinson, Rebecca T., Sundermann, Alexandra C., Mosley, Jonathan D., Bastarache, Lisa, Ferguson, Jane F., Cox, Nancy J., Roden, Dan M., Denny, Joshua C., Linton, MacRae F., Edwards, Digna R. Velez, Stein, C. Michael“…The analysis plan for the validation phase was constructed at the time of the design of that component of the study. …”
Publicado 2018
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1044131por Al-Shahi Salman, Rustam, Frantzias, Joseph, Lee, Robert J, Lyden, Patrick D, Battey, Thomas W K, Ayres, Alison M, Goldstein, Joshua N, Mayer, Stephan A, Steiner, Thorsten, Wang, Xia, Arima, Hisatomi, Hasegawa, Hitoshi, Oishi, Makoto, Godoy, Daniel A, Masotti, Luca, Dowlatshahi, Dar, Rodriguez-Luna, David, Molina, Carlos A, Jang, Dong-Kyu, Davalos, Antonio, Castillo, José, Yao, Xiaoying, Claassen, Jan, Volbers, Bastian, Kazui, Seiji, Okada, Yasushi, Fujimoto, Shigeru, Toyoda, Kazunori, Li, Qi, Khoury, Jane, Delgado, Pilar, Sabín, José Álvarez, Hernández-Guillamon, Mar, Prats-Sánchez, Luis, Cai, Chunyan, Kate, Mahesh P, McCourt, Rebecca, Venkatasubramanian, Chitra, Diringer, Michael N, Ikeda, Yukio, Worthmann, Hans, Ziai, Wendy C, d'Esterre, Christopher D, Aviv, Richard I, Raab, Peter, Murai, Yasuo, Zazulia, Allyson R, Butcher, Kenneth S, Seyedsaadat, Seyed Mohammad, Grotta, James C, Martí-Fàbregas, Joan, Montaner, Joan, Broderick, Joseph, Yamamoto, Haruko, Staykov, Dimitre, Connolly, E Sander, Selim, Magdy, Leira, Rogelio, Moon, Byung Hoo, Demchuk, Andrew M, Di Napoli, Mario, Fujii, Yukihiko, Anderson, Craig S, Rosand, Jonathan“…Multivariable models of patients with data on antiplatelet therapy use, data on anticoagulant therapy use, and assessment of CT angiography spot sign at symptom onset showed that time from symptom onset to baseline imaging (odds ratio 0·50, 95% CI 0·36–0·70; p<0·0001), intracerebral haemorrhage volume on baseline imaging (7·18, 4·46–11·60; p<0·0001), antiplatelet use (1·68, 1·06–2·66; p=0·026), and anticoagulant use (3·48, 1·96–6·16; p<0·0001) were independent predictors of intracerebral haemorrhage growth (C-index 0·78, 95% CI 0·75–0·82). …”
Publicado 2018
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1044132por Gossec, Laure, Berenbaum, Francis, Chauvin, Pierre, Hudry, Christophe, Cukierman, Gabrielle, de Chalus, Thibault, Dreuillet, Caroline, Saulot, Vincent, Tong, Sabine, Russo-Marie, Françoise, Joubert, Jean-Michel, Saraux, Alain“…The QuAD may facilitate this dialogue, and may also be useful in population studies to standardize the assessment and evolution of beliefs over time. People with long-term inflammatory conditions such as rheumatoid arthritis (RA; inflammation of the joints) and axial spondyloarthritis (axSpA; inflammation of the spine) may hold a number of beliefs about their disease, including some that are not supported by current scientific evidence (e.g., “I think that my disease was triggered by a vaccination”). …”
Publicado 2018
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1044133“…Course evaluation highlighted the need for clarity on the organizations involved in the PMI, and leaving time for student-student interaction. Conclusions: While some student responses during the exercise were terse, an evolution was detectable over the three course components in student ability to suggest tangible policies and steps for implementation. …”
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1044134por Li, Yan-Feng, Zhu, Tong, Zhang, Yong, Luo, Yong, Li, Ke, Liu, Xu-Dong, Zhou, Bo, Li, Zhong-Tai, Jiang, Jun“…RESULTS: The mean follow-up time was 15.9 (range 2–40) months. Twenty-six patients treated with pulsatile GnRH infusion were followed over 2 years, 41 cases were followed over 1 year, 45 cases were followed over one-half year, 5 cases were followed for 3 months to one-half year, and 4 cases were followed for under 3 months. …”
Publicado 2018
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1044135por Merga Duffa, Yamirot, Terfa Kitila, Kumera, Mamuye Gebretsadik, Dereje, Bitew, Adane“…CONCLUSION: This study determined the prevalence of urinary tract infection in pediatric patients and highlighted the major bacterial uropathogens involved in UTI for the first time in the country. Furthermore, bacterial pathogen species and their frequency was consistent with the usually reported pattern, with E. coli being the most common organism isolated in cases of urinary tract infections followed by Klebsiella spp. …”
Publicado 2018
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1044136por Konda, Manikyeswara Rao, Alluri, Krishnaraju Venkata, Janardhanan, Prason Kumar, Trimurtulu, Golakoti, Sengupta, Krishanu“…RESULTS: GMCT-300 mice showed significant improvement in swimming time (GMCT: 395.3 ± 81.70 s vs. CMC: 271.6 ± 56.86 s; p = 0.0166), distance (GMCT: 341.22 ± 65.88 m vs. …”
Publicado 2018
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1044137por Prasad, G. V. Ramesh, Yan, Andrew T., Nash, Michelle M., Kim, S. Joseph, Wald, Ron, Wald, Rachel, Lok, Charmaine, Gunaratnam, Lakshman, Karur, Gauri R., Kirpalani, Anish, Connelly, Philip W.“…Limited intrapatient biomarker sampling and CMR measurements precluded constructing dose-response curves of biomarkers to LV mass and function. The CMR timing in relation to dialysis was not standardized. …”
Publicado 2018
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1044138por Henderson, Heather, Cober, Eric, Richter, Sandra S, Salata, Robert, Kalayjian, Robert, Watkins, Richard, Doi, Yohei, Kaye, Keith, Evans, Scott R, Fowler, Vance G, Bonomo, Robert, Duin, David Van“…Each patient with CRE infection was included once at the time of the last positive culture episode. Infections were distinguished from colonization using established definitions. …”
Publicado 2018
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1044139por Oh, Timothy S, Peacock, James E, Le, Katherine, Sohail, M Rizwan, Baddour, Larry M, Vikram, Holenarasipur R, Miro, Jose M, Prutkin, Jordan M, Greenspon, Arnold J, Carrillo, Roger G, Danik, Stephan B, Naber, Christoph K, Blank, Elisabeth, Tseng, Chi-Hong, Uslan, Daniel Z“…Fourteen cases of IE (78%) were definite by the modified Duke criteria. Median time from last device procedure to infection was 510 days (range 37–2,952 days). …”
Publicado 2018
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1044140por Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C“…Factors including species, formulation, concentration, dose, volume, and number of injections were examined for the effect on systemic exposure over time. GS-CA2 plasma concentrations in dogs (Figure 1) were maintained above the human plasma protein binding-adjusted EC(95) (4 nM) for the entire study duration (16 weeks). …”
Publicado 2018
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