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1044161por Godino, Job G., Golaszewski, Natalie M., Norman, Greg J., Rock, Cheryl L., Griswold, William G., Arredondo, Elva, Marshall, Simon, Kolodziejczyk, Julie, Dillon, Lindsay, Raab, Fred, Jain, Sonia, Crawford, Maggie, Merchant, Gina, Patrick, Kevin“…BACKGROUND: Weight loss interventions based solely on text messaging (short message service [SMS]) have been shown to be modestly effective for short periods of time and in some populations, but limited evidence is available for positive longer-term outcomes and for efficacy in Hispanic populations. …”
Publicado 2019
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1044162“…However, she developed complications from treatment, in form of worsening cataract and recurrent urinary tract infections. At the time of article submission, her GCA and RA remain in remission while her prednisolone had been tapered to 9 mg daily. …”
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1044163por Humam, Ali Merzza, Loh, Teck Chwen, Foo, Hooi Ling, Samsudin, Anjas Asmara, Mustapha, Noordin Mohamed, Zulkifli, Idrus, Izuddin, Wan Ibrahim“…However, the extensive use of antibiotics as growth promoters for a long time leads to the development of antibiotic-resistant bacteria and the possibility of antibiotic-resistant genes being transferred among organisms. …”
Publicado 2019
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1044164por Kleiner, David E., Brunt, Elizabeth M., Wilson, Laura A., Behling, Cynthia, Guy, Cynthia, Contos, Melissa, Cummings, Oscar, Yeh, Matthew, Gill, Ryan, Chalasani, Naga, Neuschwander-Tetri, Brent A., Diehl, Anna Mae, Dasarathy, Srinivasan, Terrault, Norah, Kowdley, Kris, Loomba, Rohit, Belt, Patricia, Tonascia, James, Lavine, Joel E., Sanyal, Arun J.“…OBJECTIVE: To evaluate the histologic evolution of NAFLD and the factors associated with changes in disease severity over time. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort substudy from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) NAFLD Database study, a noninterventional registry, was performed at 8 university medical research centers. …”
Publicado 2019
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1044165por Zhang, Jing, Guo, Ming, Huang, Zhi-Xiang, Bao, Rong, Yu, Qian, Dai, Ming, Wang, Xin, Rao, Yan“…To investigate the expression of inflammatory cytokines and anti-microbial peptide genes, we determined the transcriptional levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), mouse β-defensin-2 (mBD2), and cathelicidin LL-37 through real-time quantitative polymerase chain reaction. The protein levels of IFN-γ were detected by enzyme-linked immunosorbent assay. …”
Publicado 2019
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1044166por Jiang, Wei-Wei, Wang, Yi-Meng, Wang, Xiao-Yu, Zhang, Qian, Zhu, Si-Man, Zhang, Chun-Lei“…RESULTS: Cell proliferation inhibition was seen in HaCaT cells with treatment of matrine in a dose- and time-dependent manner (P < 0.01, respectively). Cell cycle G0/G1 phase arrest was observed in a dose-dependent way (P < 0.01). …”
Publicado 2019
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1044167por Schinke, Carolina, Boyle, Eileen, Ashby, Cody, Wang, Yan, Christopher Wardell, Davies, Thanendrarajan, Sharmilan, Zangari, maurizio, van Rhee, Frits, Morgan, Gareth, Walker, Brian“…CD34+ sorted cells, taken at the time of stem cell harvest from the same 19 patients, were used as controls. …”
Publicado 2019
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1044168por Novak, Laurie L., George, Sheba, Wallston, Kenneth, Vaughn, Yolanda, Israel, Tiffany, Joosten, Yvonne, Williams, Neely, Wilkins, Consuelo, Richmond, Al“…Stories were defined as narratives with (a) at least one actor (b) action that unfolds over time, and (c) a realization, destination, or conflict resolution (i.e., a point of the story). …”
Publicado 2018
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10441693573 Critical Barriers to Effective Community-Academic Research Partnerships and Potential Solutionspor Woolford, Susan J, Buyuktur, Ayse G., Piechowski, Patricia, Doshi, Aalap, Marsh, Erica E.“…This was closely linked to the need for additional funding to help foster and strengthen relationships by allowing partners to spend time together to both work and socialize informally, preferably in face-to-face settings. …”
Publicado 2019
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1044170“…Finally, we must measure the cost to the clinician of implementing our model in an ICU, specifically how it impacts their time to accomplish the task of selecting an intervention for the hemodynamically unstable patient. …”
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1044171por Wang, Hui-Yan, She, Guang-Tong, Sun, Li-Zhou, Lu, Hao, Wang, Yin-Pin, Miao, Jun, Liu, Ke-Zhuo, Sun, Cai-Feng, Ju, Hui-Hui“…VDR and PPARγ messenger RNA (mRNA) transcript levels in these adipose tissues were quantified by real-time polymerase chain reaction. The differences between the levels of PPARγ protein and phosphorylated PPARγ Ser273 were detected by Western blotting. …”
Publicado 2019
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1044172“…Articles only eligible for meta-analysis were those that reported either or both high (> 2.5 m·s(−2)) and very high (> 3.5 m·s(−2)) intensity accelerations and decelerations concurrently using global positioning system devices (sampling rate: ≥ 5 Hz) during elite able-bodied (mean age: ≥ 18 years) team sports competitive match play (match time: ≥ 75%). Separate inverse random-effects meta-analyses were conducted to compare: (1) standardised mean differences (SMDs) in the frequency of high and very high intensity accelerations and decelerations occurring during match play, and (2) SMDs of temporal changes in high and very high intensity accelerations and decelerations across first and second half periods of match play. …”
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1044173por Mayoral, Karina, Rajmil, Luis, Murillo, Marta, Garin, Olatz, Pont, Angels, Alonso, Jordi, Bel, Joan, Perez, Jacobo, Corripio, Raquel, Carreras, Gemma, Herrero, Javier, Mengibar, Jose-Maria, Rodriguez-Arjona, Dolors, Ravens-Sieberer, Ulrike, Raat, Hein, Serra-Sutton, Vicky, Ferrer, Montse“…Reliability was assessed with the intraclass correlation coefficient and responsiveness by testing changes over time and calculating the effect size. Reliability and responsiveness were tested among the stable and improved subsamples defined by a KIDSCREEN-10 index change of <4.5 points or ≥4.5 points, respectively, from the first to the fourth visit. …”
Publicado 2019
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1044174por Panula, Sarita, Kurek, Magdalena, Kumar, Pankaj, Albalushi, Halima, Padrell Sánchez, Sara, Damdimopoulou, Pauliina, Olofsson, Jan I, Hovatta, Outi, Lanner, Fredrik, Stukenborg, Jan-Bernd“…SUMMARY ANSWER: Our results demonstrate for the first time that KS-derived hiPSCs show similar XCI behavior to female hPSCs in culture and show biological relevance to KS genotype-related clinical features. …”
Publicado 2019
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1044175por Clamp, Andrew R, James, Elizabeth C, McNeish, Iain A, Dean, Andrew, Kim, Jae-Weon, O'Donnell, Dearbhaile M, Hook, Jane, Coyle, Christopher, Blagden, Sarah, Brenton, James D, Naik, Raj, Perren, Tim, Sundar, Sudha, Cook, Adrian D, Gopalakrishnan, Gosala S, Gabra, Hani, Lord, Rosemary, Dark, Graham, Earl, Helena M, Hall, Marcia, Banerjee, Susana, Glasspool, Rosalind M, Jones, Rachel, Williams, Sarah, Swart, Ann Marie, Stenning, Sally, Parmar, Mahesh, Kaplan, Richard, Ledermann, Jonathan A“…No significant progression-free survival increase was observed with either weekly regimen (restricted mean survival time 24·4 months [97·5% CI 23·0–26·0] in group 1, 24·9 months [24·0–25·9] in group 2, 25·3 months [23·9–26·9] in group 3; median progression-free survival 17·7 months [IQR 10·6–not reached] in group 1, 20·8 months [11·9–59·0] in group 2, 21·0 months [12·0–54·0] in group 3; log-rank p=0·35 for group 2 vs group 1; group 3 vs 1 p=0·51). …”
Publicado 2019
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1044176“…Via giving intragastric administration of Soybean oligosaccharide (SBOS) at the low dose (50/(kg·BW)/d), the middle dose (200 mg/(kg·BW)/d) and the high dose (500 mg/(kg·BW)/d) partly once a day, which is also 28 days in a row. At the same time, (SBOS) mice in the drug group and (CG) mice in the positive control group were given intraabdominal injection of CTX (200 mg/kg/d).The immunosuppressive mouse model (CY) was established after 72 h in the model group and the positive control group (CG) was given intragastric administration of levamisole hydrochloric acid (LMS) for 3 days, with the data of 80ug/kg/d after injection of CTX (for actually 72 h). …”
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1044177por Moody, Emily C., Cantoral, Alejandra, Tamayo-Ortiz, Marcela, Pizano-Zárate, Ma. Luisa, Schnaas, Lourdes, Kloog, Itai, Oken, Emily, Coull, Brent, Baccarelli, Andrea, Téllez-Rojo, Martha M., Wright, Robert O., Just, Allan C.“…The mean (range) age of the children was 4.8 (4.0-6.4) years at visit 1, and 6.7 (6.0-9.7) years at visit 2. At the time of delivery, the mean (range) age of the mothers was 27.7 (18.3-44.4) years, with a mean (range) prepregnancy body mass index of 26.4 (18.5-43.5). …”
Publicado 2019
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1044178“…RESULTS: There were no significant differences in age, weight, height, body mass index, age, and time of menopause between the two groups. There were a total of 71 cases (35.0%) in group A (60–70 years), 80 cases (39.4%) in group B (71–80 years), and 52 cases (25.6%) in group C (81–90 years). …”
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1044179por Liegeon, Geoffroy, Antoni, Guillemette, Pialoux, Gilles, Capitant, Catherine, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cécile, Cua, Eric, Senneville, Eric, Raffi, François, Meyer, Laurence, Molina, Jean‐Michel, Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P, Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon‐Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C, Diallo, A, Gibowski, S, Delfraissy, J F, Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Molina, Jean‐Michel, Wainberg, Mark A, Trottier, Benoit, Tremblay, Cécile, Baril, Jean‐Guy, Pialoux, Gilles, Cotte, Laurent, Chéret, Antoine, Pasquet, Armelle, Cua, Eric, Hall, Nolwenn, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand‐Zaleski, Isabelle, Meyer, Laurence, Aboulker, Jean‐Pierre, Spire, Bruno, Suzan‐Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Capitant, Catherine, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie‐Christine, Charreau, Isabelle, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, Rabian, Cecile“…Using linear mixed model, we evaluated the mean eGFR decline from baseline over time and determined risks factors associated with eGFR decline during the study. …”
Publicado 2020
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1044180por Jackson, Graham H, Davies, Faith E, Pawlyn, Charlotte, Cairns, David A, Striha, Alina, Collett, Corinne, Waterhouse, Anna, Jones, John R, Kishore, Bhuvan, Garg, Mamta, Williams, Cathy D, Karunanithi, Kamaraj, Lindsay, Jindriska, Wilson, Jamie N, Jenner, Matthew W, Cook, Gordon, Kaiser, Martin F, Drayson, Mark T, Owen, Roger G, Russell, Nigel H, Gregory, Walter M, Morgan, Gareth J“…We aimed to assess response-adapted intensification treatment with cyclophosphamide, bortezomib, and dexamethasone (CVD) versus no intensification treatment in patients with newly diagnosed multiple myeloma who had a suboptimal response to initial immunomodulatory triplet treatment which was standard of care in the UK at the time of trial design. METHODS: The Myeloma XI trial was an open-label, randomised, phase 3, adaptive design trial done at 110 National Health Service hospitals in the UK. …”
Publicado 2019
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