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  1. 1044301
    por Villar, José, Ariff, Shabina, Gunier, Robert B., Thiruvengadam, Ramachandran, Rauch, Stephen, Kholin, Alexey, Roggero, Paola, Prefumo, Federico, do Vale, Marynéa Silva, Cardona-Perez, Jorge Arturo, Maiz, Nerea, Cetin, Irene, Savasi, Valeria, Deruelle, Philippe, Easter, Sarah Rae, Sichitiu, Joanna, Soto Conti, Constanza P., Ernawati, Ernawati, Mhatre, Mohak, Teji, Jagjit Singh, Liu, Becky, Capelli, Carola, Oberto, Manuela, Salazar, Laura, Gravett, Michael G., Cavoretto, Paolo Ivo, Nachinab, Vincent Bizor, Galadanci, Hadiza, Oros, Daniel, Ayede, Adejumoke Idowu, Sentilhes, Loïc, Bako, Babagana, Savorani, Mónica, Cena, Hellas, García-May, Perla K., Etuk, Saturday, Casale, Roberto, Abd-Elsalam, Sherief, Ikenoue, Satoru, Aminu, Muhammad Baffah, Vecciarelli, Carmen, Duro, Eduardo A., Usman, Mustapha Ado, John-Akinola, Yetunde, Nieto, Ricardo, Ferrazi, Enrico, Bhutta, Zulfiqar A., Langer, Ana, Kennedy, Stephen H., Papageorghiou, Aris T.
    Publicado 2021
    “…Among women who tested positive (98.1% by real-time polymerase chain reaction), 54 (13%) of their neonates tested positive. …”
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    Online Artículo Texto
    Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study
  2. 1044302
    “…Smartphones and other technologies have the potential to increase access to therapeutic strategies that enhance self-management while simultaneously providing real-time user feedback and provider alerts to augment care. …”
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    Online Artículo Texto
    A Smartphone-Based Self-management Intervention for Bipolar Disorder (LiveWell): User-Centered Development Approach
  3. 1044303
    “…BACKGROUND: Global randomised controlled trials of the anti-IL-6 receptor antibody tocilizumab in patients admitted to hospital with COVID-19 have shown conflicting results but potential decreases in time to discharge and burden on intensive care. Tocilizumab reduced progression to mechanical ventilation and death in a trial population enriched for racial and ethnic minorities. …”
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    Online Artículo Texto
    Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial
  4. 1044304
    “…Participants were tested for vitamin D metabolites (25(OH)D3, 1,25(OH)2D3, 3-epi-25(OH)D3, 24,25(OH)2D3 and D3) by UPLC-MS/MS, free 25(OH)D and vitamin D-binding protein by ELISA, as well as PTH by electrochemiluminescence immunoassay and routine biochemical parameters of blood serum (calcium, phosphorus, albumin) at the time of admission. Results: patients had in general very low 25()D3 levels - median 10.9 ng/mL [6.9; 15.6], corresponding to a pronounced vitamin D deficiency in half of the patients. …”
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    Vitamin D Metabolism Is Significantly Impaired in COVID-19 Inpatients
  5. 1044305
    “…All TW were non-gonadectomized subjects and were in estrogen [transdermal estradiol (n=2), oral estradiol (n=3) and conjugated estrogen (n=3)], plus cyproterone acetate (n=8) therapy in an average time of 15.6 ±8.7 years. Body composition was assessed by InBody 720, and participants’ level of physical activity by IPAQ (International Physical Activity Questionnaire) short form. …”
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    First Evidence of Cardiopulmonary Adaptation to Physical Effort in Transgender Women After Long-Term Hormone Therapy: A Cross-Sectional Study
  6. 1044306
    “…At W36, 81% (95% CI 69.9-89.1) of osilodrostat recipients had mUFC ≤ULN (key secondary endpoint). Median time to first controlled mUFC response was 35 days (95% CI 34‒52) for pts randomized to osilodrostat. …”
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    Osilodrostat Is an Effective and Well-Tolerated Treatment for Cushing’s Disease (CD): Results From a Phase III Study With an Upfront, Randomized, Double-Blind, Placebo-Controlled Phase (LINC 4)
  7. 1044307
    “…Expression alterations were examined via microarray, RNA sequencing and reverse transcription quantitative real-time PCR (qRT-PCR), proteins were analysed by western blotting and immunostaining, and insulin secretion was quantified in static incubations. …”
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    The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells
  8. 1044308
    “…Viral RNA was extracted from the environmental samples. Real-time RT-PCR assays for influenza A, H5, H7 and H9 subtypes were performed on all the samples to identify subtypes of influenza virus. …”
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    Distribution of avian influenza viruses according to environmental surveillance during 2014–2018, China
  9. 1044309
    “…CONCLUSIONS: Refractory hypoxaemia remains a major association with mortality, yet evidence based ARDS interventions, in particular prone positioning, were not implemented and had delayed application with an associated reduced responsiveness. Real-time service evaluation techniques offer opportunities to assess the delivery of care and improve protocolised implementation of evidence-based ARDS interventions, which might be associated with improvements in survival. …”
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    Online Artículo Texto
    Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom
  10. 1044310
    “…CONCLUSIONS AND RELEVANCE: This study found that infants born extremely preterm were at increased risk of mortality and morbidity in China, with a survival rate that improved over time and a major morbidity rate that increased. These findings suggest that more active and effective treatment strategies are needed, especially for infants born at gestational age 25 to 27 weeks.…”
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    Online Artículo Texto
    Mortality and Morbidity of Infants Born Extremely Preterm at Tertiary Medical Centers in China From 2010 to 2019
  11. 1044311
    “…At least one AGA, defined in real time by our molecular tumor board, was found in 393/550 patients (71%, two-sided 90%CI 68–75%). …”
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    Prospective high-throughput genome profiling of advanced cancers: results of the PERMED-01 clinical trial
  12. 1044312
    “…MAIN OUTCOME MEASURES: Participants were asked ‘What is your best guess as to the percent chance that John actually had COVID-19 at the time of his test, given his result?’; questions about their feelings of trustworthiness in the result, their perceptions of the quality of the underlying evidence and what action they felt ‘John’ should take in the light of his result. …”
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    Online Artículo Texto
    How do the UK public interpret COVID-19 test results? Comparing the impact of official information about results and reliability used in the UK, USA and New Zealand: a randomised controlled trial
  13. 1044313
    “…This, compounded with the time that has taken to organise these trials as compared to the rapid development of COVID-19 vaccines, has rendered these trials of marginal importance. …”
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    Chemoprophylaxis trial designs in epidemics: insights from a systematic review of COVID-19 study registrations
  14. 1044314
    por Groner, Rudolf, Kasneci, Enkelejda
    Publicado 2021
    “…In this context, Niu, Gao, Xue, Zhang & Yang (8) conducted two experiments to explore the optimum target size and gaze-triggering dwell time in ECI. Their results have an exemplary application value for future interface design. …”
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    Online Artículo Texto
    Eye movements in real and simulated driving and navigation control – Foreword to the Special Issue
  15. 1044315
    “…Overall 65% (85/130) of P. falciparum infections had Pfkelch13 propeller mutations which increased over time and recrudescence occurred almost exclusively in them; risk ratio 9.42 (95% CI 1.30–68.29). …”
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    A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border
  16. 1044316
    “…Secondary outcomes were pregnancy loss (analysed per clinical pregnancy), cancelled cycles (analysed pCC), total drug usage per oocyte retrieved and time-to-live birth (TTLB; per calendar week and per cycle). …”
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    Comparative effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) versus highly purified urinary human menopausal gonadotropin (hMG HP) in assisted reproductive technology (ART) treatments: a non-interventional study in Germany
  17. 1044317
    “…LIMITATIONS, REASONS FOR CAUTION: Our study is limited by lack of details regarding mode, frequency and timing of PC consumption. Moreover, we were not able to adequately assess the effect of PCs on immediate or long-term clinical outcomes, due to the small sample size and the lack of follow up. …”
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    Online Artículo Texto
    Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche
  18. 1044318
    “…Modified Poisson regression models were used to assess the risk of infertility diagnosis (relative risk, RR) adjusted for income quintile and further stratified by parity at the time of cancer diagnosis (nulliparous and parous). …”
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    Risk of infertility in female adolescents and young adults with cancer: a population-based cohort study
  19. 1044319
    “…CONCLUSIONS AND RELEVANCE: This cohort study found mental health disparities in TGD youth relative to cisgender youth, with worse scores observed across assessment time points. For all participants, primary clinical outcome measures were significantly lower at treatment discharge than at entry, with no significant differences between discharge and 1-month follow-up. …”
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    Clinical Outcomes Following Acute Residential Psychiatric Treatment in Transgender and Gender Diverse Adolescents
  20. 1044320
    “…Culturally sensitive web-based interventions that enhance family communication and understanding of genetic cancer risk are timely. This collaboration creates a research infrastructure between Switzerland and Korea that can be scaled up to cover other hereditary cancer syndromes. …”
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    Using a Tailored Digital Health Intervention for Family Communication and Cascade Genetic Testing in Swiss and Korean Families With Hereditary Breast and Ovarian Cancer: Protocol for the DIALOGUE Study
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