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1044341por Nickels, Stefanie, Edwards, Matthew D, Poole, Sarah F, Winter, Dale, Gronsbell, Jessica, Rozenkrants, Bella, Miller, David P, Fleck, Mathias, McLean, Alan, Peterson, Bret, Chen, Yuanwei, Hwang, Alan, Rust-Smith, David, Brant, Arthur, Campbell, Andrew, Chen, Chen, Walter, Collin, Arean, Patricia A, Hsin, Honor, Myers, Lance J, Marks Jr, William J, Mega, Jessica L, Schlosser, Danielle A, Conrad, Andrew J, Califf, Robert M, Fromer, Menachem“…BACKGROUND: Although effective mental health treatments exist, the ability to match individuals to optimal treatments is poor, and timely assessment of response is difficult. One reason for these challenges is the lack of objective measurement of psychiatric symptoms. …”
Publicado 2021
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1044342por Burkart, Katrin G, Brauer, Michael, Aravkin, Aleksandr Y, Godwin, William W, Hay, Simon I, He, Jaiwei, Iannucci, Vincent C, Larson, Samantha L, Lim, Stephen S, Liu, Jiangmei, Murray, Christopher J L, Zheng, Peng, Zhou, Maigeng, Stanaway, Jeffrey D“…Changes in both exposures and the composition of causes of death drove changes in risk over time. Steady increases in exposure to the risk of high temperature are of increasing concern for health. …”
Publicado 2021
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1044343por Hippisley-Cox, Julia, Patone, Martina, Mei, Xue W, Saatci, Defne, Dixon, Sharon, Khunti, Kamlesh, Zaccardi, Francesco, Watkinson, Peter, Shankar-Hari, Manu, Doidge, James, Harrison, David A, Griffin, Simon J, Sheikh, Aziz, Coupland, Carol A C“…CONCLUSION: Increased risks of haematological and vascular events that led to hospital admission or death were observed for short time intervals after first doses of the ChAdOx1 nCoV-19 and BNT162b2 mRNA vaccines. …”
Publicado 2021
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1044344por Mukkada, Sheena, Bhakta, Nickhill, Chantada, Guillermo L, Chen, Yichen, Vedaraju, Yuvanesh, Faughnan, Lane, Homsi, Maysam R, Muniz-Talavera, Hilmarie, Ranadive, Radhikesh, Metzger, Monika, Friedrich, Paola, Agulnik, Asya, Jeha, Sima, Lam, Catherine, Dalvi, Rashmi, Hessissen, Laila, Moreira, Daniel C, Santana, Victor M, Sullivan, Michael, Bouffet, Eric, Caniza, Miguela A, Devidas, Meenakshi, Pritchard-Jones, Kathy, Rodriguez-Galindo, Carlos“…Factors associated with treatment modification included upper-middle-income country status (OR 0·5 [95% CI 0·3–0·7]; p=0·0004), primary diagnosis of other haematological malignancies (0·5 [0·3–0·8]; p=0·0088), the presence of one of more COVID-19 symptoms at the time of presentation (1·8 [1·3–2·4]; p=0·0002), and the presence of one or more comorbidities (1·6 [1·1–2·3]; p=0·020). …”
Publicado 2021
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1044345por Huang, Lixue, Yao, Qun, Gu, Xiaoying, Wang, Qiongya, Ren, Lili, Wang, Yeming, Hu, Ping, Guo, Li, Liu, Min, Xu, Jiuyang, Zhang, Xueyang, Qu, Yali, Fan, Yanqing, Li, Xia, Li, Caihong, Yu, Ting, Xia, Jiaan, Wei, Ming, Chen, Li, Li, Yanping, Xiao, Fan, Liu, Dan, Wang, Jianwei, Wang, Xianguang, Cao, Bin“…The median age of patients was 59·0 years (IQR 49·0–67·0) and 681 (53%) were men. The median follow-up time was 185·0 days (IQR 175·0–198·0) for the 6-month visit and 349·0 days (337·0–361·0) for the 12-month visit after symptom onset. …”
Publicado 2021
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1044346por Treppiedi, Donatella, Barbieri, Anna Maria, Di Muro, Genesio, Marra, Giusy, Mangili, Federica, Catalano, Rosa, Esposito, Emanuela, Ferrante, Emanuele, Serban, Andreea Liliana, Locatelli, Marco, Lania, Andrea Gerardo, Spada, Anna, Arosio, Maura, Peverelli, Erika, Mantovani, Giovanna“…SIMPLE SUMMARY: Cushing’s Disease (CD) is a rare but severe endocrine disorder due to an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, and pathogenetics remained a puzzling issue for a long time. The recent identification of somatic mutations in the 14-3-3 protein binding motif of ubiquitin specific peptidase 8 gene (USP8), present in a consistent subgroup of ACTH-secreting pituitary tumors, have represented a major advance in the understanding of CD pathogenesis. …”
Publicado 2021
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1044347por Hollis, Jenna L., Kocanda, Lucy, Seward, Kirsty, Collins, Clare, Tully, Belinda, Hunter, Mandy, Foureur, Maralyn, Lawrence, Wendy, MacDonald-Wicks, Lesley, Schumacher, Tracy“…Data were summarised using descriptive statistics, and differences between TDF domain scores at the specific time points were analysed using Wilcoxon matched-pairs signed-rank tests. …”
Publicado 2021
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1044348por Keller, Franziska Maria, Dahmen, Alina, Derksen, Christina, Kötting, Lukas, Lippke, Sonia“…Further, a longitudinal study was conducted making use of the internet among a second study sample of psychosomatic rehabilitation patients at two measurement time points—before (N=1719) and after (n=738) rehabilitation—between July 2020 and April 2021. …”
Publicado 2021
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1044349por Pillay, Thillagavathie, Clarke, Lynsey, Abbott, Lee, Surana, Pinki, Shenvi, Asha, Deshpande, Sanjeev, Cookson, Joanne, Nash, Matthew, Fawke, Joe, Rasiah, Vishna, Cusack, Jonathan“…A consultant focus was adopted to promote a long-term engagement between units around shared care. There were four time points for this neonatal networking during the course of the day. …”
Publicado 2021
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1044350“…The use of rapid diagnostic tests at or near the point‐of‐care (POC) can increase access to early diagnosis of HIV infection in infants and children less than 18 months of age and timely initiation of antiretroviral therapy (ART). …”
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1044351por Kamau, Edwin, Yates, Adam, Maisiba, Risper, Singoei, Valentine, Opot, Benjamin, Adeny, Rose, Arima, Cornel O., Otieno, Victor, Sumbi, Catherine S., Okoth, Raphael O., Abdi, Farid, Mwalo, Maurine, Ochola, Jew, Otieno, June, Ake, Julie, Imbach, Michelle, Turley, Hannah A., Juma, Dennis, Akala, Hoseah M., Owuoth, John, Andagalu, Ben, Crowell, Trevor A., Nwoga, Chiaka, Cowden, Jessica, Polyak, Christina S.“…The presence of malaria parasites was determined using microscopy and real-time-PCR, and schistosomiasis infection by urine antigen analysis (CCA). …”
Publicado 2021
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1044352por Cuénod, Aline, Wüthrich, Daniel, Seth-Smith, Helena M. B., Ott, Chantal, Gehringer, Christian, Foucault, Frédéric, Mouchet, Roxanne, Kassim, Ali, Revathi, Gunturu, Vogt, Deborah R., von Felten, Stefanie, Bassetti, Stefano, Tschudin-Sutter, Sarah, Hettich, Timm, Schlotterbeck, Götz, Homberger, Christina, Casanova, Carlo, Moran-Gilad, Jacob, Sagi, Orli, Rodríguez-Sánchez, Belén, Müller, Franco, Aerni, Martina, Gaia, Valeria, van Dessel, Helke, Kampinga, Greetje A., Müller, Claudia, Daubenberger, Claudia, Pflüger, Valentin, Egli, Adrian“…We then re-analysed over 22,000 Matrix-Assisted Laser Desorption Ionization - Time Of Flight (MALDI-TOF) mass spectra routinely acquired at eight healthcare institutions in four countries looking for these species-specific markers. …”
Publicado 2021
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1044353por Li, Jing, Zhang, Xiao-Bo, Wang, Jing-Jing, Jin, Lu-Jia, Shan, Hu-Sheng, Zhang, Xiao, Ma, Li, Xue, Xiao-Dong, Zhang, Xin, Zhang, Zhong-Liang, Meng, Liang-Liang, Yuan, Fei, Xiao, Yue-Yong“…RESULTS: Higher Ve was seen in IRE zone than in H-FIRE zone (0.14 ± 0.02 vs. 0.08 ± 0.05, t = 2.408, P = 0.043) on day 4, but no significant difference was seen in Ktrans or Kep between IRE and H-FIRE zones at all time points (all P > 0.05). For IRE zone, the greatest Ktrans was seen on day 7, which was significantly higher than that on day 1 (P = 0.033). …”
Publicado 2021
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1044354por Molteni, Erika, Sudre, Carole H, Canas, Liane S, Bhopal, Sunil S, Hughes, Robert C, Antonelli, Michela, Murray, Benjamin, Kläser, Kerstin, Kerfoot, Eric, Chen, Liyuan, Deng, Jie, Hu, Christina, Selvachandran, Somesh, Read, Kenneth, Capdevila Pujol, Joan, Hammers, Alexander, Spector, Tim D, Ourselin, Sebastien, Steves, Claire J, Modat, Marc, Absoud, Michael, Duncan, Emma L“…Reassuringly, symptom burden in these children did not increase with time, and most recovered by day 56. Some children who tested negative for SARS-CoV-2 also had persistent and burdensome illness. …”
Publicado 2021
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1044355“…A subgroup analysis of patients who underwent primary THA in 2008 was performed to adjust for the effect of comorbidities on mortality, as American Society of Anesthesiologists (ASA) scores became available in the SHAR at that time. For the PROM analysis, we identified three controls matched by age, gender, indication for surgery, and year of operation to each living PJI patient. …”
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1044356por Liu, Tongtong, Li, Ting, Chen, Xuhui, Li, Zuofan, Feng, Miaomiao, Yao, Wenlong, Wan, Li, Zhang, Chuanhan, Zhang, Yue“…The use of these agents within a proper time window could not only curtail further nerve injury but also produce an analgesic effect.…”
Publicado 2021
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1044357por Tumwebaze, Patrick K, Katairo, Thomas, Okitwi, Martin, Byaruhanga, Oswald, Orena, Stephen, Asua, Victor, Duvalsaint, Marvin, Legac, Jennifer, Chelebieva, Sevil, Ceja, Frida G, Rasmussen, Stephanie A, Conrad, Melissa D, Nsobya, Samuel L, Aydemir, Ozkan, Bailey, Jeffrey A, Bayles, Brett R, Rosenthal, Philip J, Cooper, Roland A“…These results suggest that additional changes will be seen over time and continued surveillance of susceptibility to key ACT components is warranted. …”
Publicado 2021
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1044358por Eriksson, L. S. E., Nastic, D., Lindqvist, P. G., Imboden, S., Järnbert‐Pettersson, H., Carlson, J. W., Epstein, E.“…RESULTS: Median follow‐up time from surgery was 58 months (interquartile range, 48–71 months; range, 0–102 months). …”
Publicado 2021
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1044359por Revollo, Boris, Blanco, Ignacio, Soler, Pablo, Toro, Jessica, Izquierdo-Useros, Nuria, Puig, Jordi, Puig, Xavier, Navarro-Pérez, Valentí, Casañ, Cristina, Ruiz, Lidia, Perez-Zsolt, Daniel, Videla, Sebastià, Clotet, Bonaventura, Llibre, Josep M“…Nasopharyngeal specimens used for Ag-RDT screening were analysed by real-time reverse-transcriptase PCR (RT-PCR) and cell culture (Vero E6 cells). 8 days after the event, a nasopharyngeal swab was collected and analysed by Ag-RDT, RT-PCR, and a transcription-mediated amplification test (TMA). …”
Publicado 2021
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1044360“…Immunisation delay was reported by 21.3% [18.0, 25.1] of mothers, but a majority (67.0%) were caused by the infant’s sickness at the time of vaccination, while a minority (6.1%) due to mothers’ concerns about vaccine safety and side effects. …”
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