“…Results were consistent in subgroups defined by vaccination status, disease severity at baseline, and timing of randomisation in relation to onset of symptoms. …”
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“…We calculated the trend of HRs (and 95% CI) by time of observation (calendar year) to indicate trends in inequalities. …”
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“…METHODS: A cross-sectional study was conducted to describe the pattern of perioperative surgical patient care, equipment handling and operating room management during the COVID-19 pandemic at JMC, using five-point Likert scales (0, not at all; 1, rarely; 2, sometimes; 3, most of the time; 4, frequently). A total of 90 respondents [35 patients (five patients from each of seven surgical departments) and 55 healthcare providers (six professionals from each of nine units, including the center of sterility room and anesthesia)] who were available during the study period, selected by a convenience sampling technique with multistage clustering, participated in the study. …”
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“…The results from the COALA study were compared with data from COVID-19 surveillance cases (CATS) for the same age group and time period. In Germany, SARS-CoV‑2 cases are reported to the local health authorities by physicians and laboratories. …”
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“…Individuals were exact matched (1:1) by sex, 10-year age group, nationality, comorbidity count, and timing of primary infection or first-dose vaccination. …”
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“…Other than the previously suggested risk factors, our algorithms showed a positive correlation between the incidence of VTE and smoking (OR=2.09, p<0.001), age <55 y/o (p=0.001), open fracture (OR=2.49, p<0.001), male sex (OR=1.98, p<0.001), surgical versus nonoperative treatment (OR=1.88, p=0.001), and multiple fractures at the time of trauma (OR=1.9, p=0.001). Factors that showed negative correlation with VTE include statins use (OR=0.36, p<0.001), hypertension (OR=0.53, p=0.001), vitamin D (OR=0.43, 0.002), calcium supplementation (OR= 0.43, p= 0.01), hyperlipidemia (OR=0.55, p=0.006), cataract (OR=0.19, p=0.01), osteoporosis (OR=0.36, p=0.02), cardiovascular diseases (OR=0.54, p=0.02), hypokalemia (OR=0.26, p=0.03), and proton pump inhibitor use (OR=0.5, p=0.03). …”
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“…Intraoperative ventilatory parameters (lung compliance and plateau airway pressure) were recorded at five specific timepoints: after induction of anesthesia, after carbon dioxide (CO(2)) insufflation, one-hour, and two-hours into surgery and at the end of surgery. At the same time, arterial and end-tidal CO(2) values were noted and arterial to end-tidal CO(2) gradient was calculated. …”
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“…We analyzed the region, time and population distribution characteristics of obstetric infection, compared the epidemiological factors of obstetric infection before and after the Universal Two-Child Policy, and analyzed the relevant risk factors of obstetric infection. …”
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“…The triple inhibition with an anti-PD-L1 monoclonal antibody, the MEK inhibitor and the Ido-1 inhibitor demonstrated significant antiproliferative and proapoptotic activity on ex-vivo NSCLC samples; at the same time the triple combination kept increased the levels of pro-inflammatory cytokines produced by both PBMCs and tumor spheroids in order to sustain the immune response and simultaneously decreased the expression of other checkpoint (such as CTLA-4, Ido-1 and TIM-3) thus promoting an immune-reactive and inflamed micro-environment. …”
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“…The repeated measures ANCOVA tested the variations (time) of the locomotor profile of players while considering the baseline as covariable and the group as a factor. …”
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“…METHODS: C. striatum isolates were identified using VITEK-2 ANC card, matrix-assisted laser desorption/ionization-time of flight mass spectrometry and 16S rRNA sequencing. …”
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“…Noninvasive screening for severe aortic valve stenosis (AS) may result in early cardiac diagnostic leading to an appropriate and timely medical intervention. PURPOSE: The aims of this study were 1) to develop an artificial intelligence to detect severe AS based on heart sounds and 2) to build an application to screen patients using electronic stethoscope and smartphones, which will provide an efficient diagnostic workflow for screening as a complementary tool in daily clinical practice. …”
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“…Computational intelligence method based on ant colony optimization was used to develop a time-to-first-event risk prediction model for HHF. …”
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“…The esketamine dose and VRS score during propofol injection were significantly different between the two groups (P < 0.05), whereas surgical duration, emergence time, visual analogue scale (VAS) score of postoperative uterine contraction pain, and Riker sedation/anxiety scale (SAS) score were not significantly different. …”
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“…The common reasons for unmet healthcare needs were cost of treatment, lack of health facilities, lack of/conflicting time, health problem not viewed as serious, and mistrust/fear of provider. …”
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“…SUMMARY ANSWER: Our study reveals for the first time that the oocyte maturation potential gradually decreases with a reduction of maternal MTHFR activity determined by combined C677T/A1298C polymorphisms, while embryo quality was worse in women with intermediate MTHFR activity. …”
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“…Primary outcomes were annual rates of change in global cognition and cognitive domain scores over time until final follow-up within each cohort study analysed by use of an individual participant data meta-analysis. …”
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“…No relevant changes were observed in the placebo group at any time point. Pre-existing Ad26 VNAs did not appear to impact RSV-specific immune response durability. …”
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“…Antibody decline over time was comparable in YA and OA cohorts. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: mRNA-1345 is well-tolerated in YA and OA. …”
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“…McLeroth, MD, Labcorp: Full time employee|Labcorp: Stocks/Bonds Mary Beth Dorr, PhD, Merck: Past employee|Merck: Stocks/Bonds|Pfizer: Stocks/Bonds|Venatorx: Employee Aaron Dane, MSc, Amplyx: Advisor/Consultant|AN2 therapeutics: Advisor/Consultant|Artizan: Advisor/Consultant|Cidara: Advisor/Consultant|ContraFect: Advisor/Consultant|Correvio: Advisor/Consultant|Davolterra: Advisor/Consultant|Destiny Pharma: Advisor/Consultant|Entasis: Advisor/Consultant|F2G Limited: Advisor/Consultant|GSK: Advisor/Consultant|Humanigen: Advisor/Consultant|Kymab: Advisor/Consultant|Modis: Advisor/Consultant|Orca: Advisor/Consultant|Pfizer: Advisor/Consultant|Phico: Advisor/Consultant|Pled Pharma: Advisor/Consultant|Rare Thyroid: Advisor/Consultant|Roche: Advisor/Consultant|Scynexis: Advisor/Consultant|Sinovent: Advisor/Consultant|Spero Therapeutics: Advisor/Consultant|Transcrip: Advisor/Consultant|Venatorx: Advisor/Consultant Tim Henkel, MD, PhD, Venatorx Pharmaceuticals: Stocks/Bonds.…”
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