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1044741por Nadkarni, Abhijit, Weobong, Benedict, Weiss, Helen A, McCambridge, Jim, Bhat, Bhargav, Katti, Basavaraj, Murthy, Pratima, King, Michael, McDaid, David, Park, A-La, Wilson, G Terence, Kirkwood, Betty, Fairburn, Christopher G, Velleman, Richard, Patel, Vikram“…We excluded patients who needed emergency medical treatment or inpatient admission, who were unable to communicate clearly, and who were intoxicated at the time of screening. Participants were randomly allocated (1:1) by trained health assistants based at the primary health centres to enhanced usual care (EUC) alone or EUC combined with CAP, in randomly sized blocks of four to six, stratified by primary health centre, and allocation was concealed with use of sequential numbered opaque envelopes. …”
Publicado 2017
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1044742“…In the other two bigger trials, serum vitamin D concentrations were elevated in the intervention group for most of the trial duration but not at the end of supplementation. This may be due to time elapsed at measurement from the last dose, incomplete compliance, or increased need of vitamin D with infant age. …”
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1044743por Coghill, David R., Banaschewski, Tobias, Nagy, Peter, Otero, Isabel Hernández, Soutullo, César, Yan, Brian, Caballero, Beatriz, Zuddas, Alessandro“…TEAEs that were reported by ≥5% of participants and considered by investigators as related to LDX were decreased appetite (49.4%), weight decrease (18.2%), insomnia (13.1%), initial insomnia (8.9%), irritability (8.6%), nausea (6.7%), headache (5.7%), and tic (5.1%). The median time to first onset and duration, respectively, of TEAEs of special interest were as follows: decreased appetite, 13.5 and 169.0 days; weight decrease, 29.0 and 225.0 days; insomnia, 17.0 and 42.8 days; and headache, 22.0 and 2.0 days. …”
Publicado 2017
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1044744por Prasad, Hari A., Pasha, Naveed, Hilal, Mohammed, Amarnath, G. S., Kundapur, Vinaya, Anand, M, Singh, Sumeet“…Heat treatments were performed at a starting temperature of 500°C, heating rate of 100°c/ min, ending at a temperature of 1000°C and 15 minutes holding time without vacuum for the specimens in the group 4, 5, 9 and 10. …”
Publicado 2017
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1044745por Domb, Benjamin G., Kenney, Raymond James, Cook, Christopher, LaReau, Justin M., Childs, Sean, Chaharbakhshi, Edwin, Giordano, Brian D.“…RESULTS: Prospectively collected data was reviewed for 91 patients who underwent Hip Arthroscopy and 34 patients who underwent HA/PAO. Average age at the time of surgery was 32 years old (range 14-62) for arthroscopy and 31 years old (range 15-51) for combined surgery. …”
Publicado 2017
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1044746por Wasan, Harpreet S, Gibbs, Peter, Sharma, Navesh K, Taieb, Julien, Heinemann, Volker, Ricke, Jens, Peeters, Marc, Findlay, Michael, Weaver, Andrew, Mills, Jamie, Wilson, Charles, Adams, Richard, Francis, Anne, Moschandreas, Joanna, Virdee, Pradeep S, Dutton, Peter, Love, Sharon, Gebski, Val, Gray, Alastair, van Hazel, Guy, Sharma, Ricky A“…There was no difference in overall survival (hazard ratio [HR] 1·04, 95% CI 0·90–1·19; p=0·61). The median survival time in the FOLFOX plus SIRT group was 22·6 months (95% CI 21·0–24·5) compared with 23·3 months (21·8–24·7) in the FOLFOX alone group. …”
Publicado 2017
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1044747por Wiysonge, Charles S, Ntsekhe, Mpiko, Thabane, Lehana, Volmink, Jimmy, Majombozi, Dumisani, Gumedze, Freedom, Pandie, Shaheen, Mayosi, Bongani M“…Further research may help evaluate percutaneous drainage of the pericardium under local anaesthesia, the timing of pericardiectomy in tuberculous constrictive pericarditis, and new antibiotic regimens. 2 April 2019 Up to date All studies incorporated from most recent search All eligible published studies found in the last search (27 Mar, 2017) were included and one ongoing study was identified (see 'Characteristics of ongoing studies' section)…”
Publicado 2017
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1044748por Yu, Qin Ping, Feng, Ding Yuan, He, Xiao Jun, Wu, Fan, Xia, Min Hao, Dong, Tao, Liu, Yi Hua, Tan, Hui Ze, Zou, Shi Geng, Zheng, Tao, Ou, Xian Hua, Zuo, Jian Jun“…Isoforms of MyHC gene expression were detected by real-time quantitative polymerase chain reaction. RESULTS: The final body weight and carcass weight of finishing pigs were increased by TCMF1 (p<0.05), while the psoas major muscle cross-sectional area was increased by TCMF (p<0.05). …”
Publicado 2017
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1044749por Mytton, Oliver T., Jackson, Christopher, Steinacher, Arno, Goodman, Anna, Langenberg, Claudia, Griffin, Simon, Wareham, Nick, Woodcock, James“…We simulated a population of adults in England aged 40–45 years and followed until age 100 years, using data from the Health Survey of England (2009–2012) and the English Longitudinal Study of Aging (1998–2012), to simulate changes in risk factors for simulated individuals over time. We used recent programme data to describe uptake of NHS Health Checks and of 4 associated interventions (statin medication, antihypertensive medication, smoking cessation, and weight management). …”
Publicado 2018
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1044750“…Western blot analyses were run in duplicate using the following antibodies optimized for postmortem brain: MCT1, LDH, LDHA, LDHB, HXK1, glucose transporter 3 (GLUT3). We performed real time quantitative polymerase chain reaction (RT-qPCR) using TaqMan PCR assays (MCT1, MCT4, HXK1, HXK2, LDHA, LDHB, PFK1, GLUT1, and GLUT3) in duplicate on cDNA samples in 96-well optical plates on a Stratagene MX3000P (Stratagene, La Jolla, California). …”
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1044751por Wu, Shinyi, Ell, Kathleen, Jin, Haomiao, Vidyanti, Irene, Chou, Chih-Ping, Lee, Pey-Jiuan, Gross-Schulman, Sandra, Sklaroff, Laura Myerchin, Belson, David, Nezu, Arthur M, Hay, Joel, Wang, Chien-Ju, Scheib, Geoffrey, Di Capua, Paul, Hawkins, Caitlin, Liu, Pai, Ramirez, Magaly, Wu, Brian W, Richman, Mark, Myers, Caitlin, Agustines, Davin, Dasher, Robert, Kopelowicz, Alex, Allevato, Joseph, Roybal, Mike, Ipp, Eli, Haider, Uzma, Graham, Sharon, Mahabadi, Vahid, Guterman, Jeffrey“…Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers. OBJECTIVE: The aim of this study was to compare 6-month outcomes of a technology-facilitated care model with a usual care model and a supported care model that involved team-based collaborative depression care for safety-net primary care adult patients with type 2 diabetes. …”
Publicado 2018
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1044752por Guillory, Jamie, Wiant, Kristine F, Farrelly, Matthew, Fiacco, Leah, Alam, Ishrat, Hoffman, Leah, Crankshaw, Erik, Delahanty, Janine, Alexander, Tesfa N“…BACKGROUND: Tobacco public education campaigns focus increasingly on hard-to-reach populations at higher risk for smoking, prompting campaign creators and evaluators to develop strategies to reach hard-to-reach populations in virtual and physical spaces where they spend time. OBJECTIVE: The aim of this study was to describe two novel recruitment strategies (in-person intercept interviews in lesbian, gay, bisexual, and transgender [LGBT] social venues and targeted social media ads) and compares characteristics of participants recruited via these strategies for the US Food and Drug Administration’s This Free Life campaign evaluation targeting LGBT young adults who smoke cigarettes occasionally. …”
Publicado 2018
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1044753por Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, Njølstad, Pål R“…Excellent glycaemic control was maintained for patients for whom we had paired data on HbA(1c) and sulfonylurea at all time points (ie, pre-transfer [for HbA(1c)], year 1, and most recent follow-up; n=64)—median HbA(1c) was 8·1% (IQR 7·2–9·2; 65·0 mmol/mol [55·2–77·1]) before transfer to sulfonylureas, 5·9% (5·4–6·5; 41·0 mmol/mol [35·5–47·5]; p<0·0001 vs pre-transfer) at 1 year, and 6·4% (5·9–7·3; 46·4 mmol/mol [41·0–56·3]; p<0·0001 vs year 1) at most recent follow-up (median 10·3 years [IQR 9·2–10·9]). …”
Publicado 2018
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1044754“…The propensity score summarizes the many patient and surgical factors that were used in the matching process (including sex, age, type of primary arthroplasty, time to revision surgery, and details about the revision procedure performed such as the approach, specific components revised, femoral head size, bearing surface, and use of bone graft) using one single score for each revised hip. …”
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1044755por Perry, William, Lacritz, Laura, Roebuck-Spencer, Tresa, Silver, Cheryl, Denney, Robert L, Meyers, John, McConnel, Charles E, Pliskin, Neil, Adler, Deb, Alban, Christopher, Bondi, Mark, Braun, Michelle, Cagigas, Xavier, Daven, Morgan, Drozdick, Lisa, Foster, Norman L, Hwang, Ula, Ivey, Laurie, Iverson, Grant, Kramer, Joel, Lantz, Melinda, Latts, Lisa, Ling, Shari M, Lopez, Ana Maria, Malone, Michael, Martin-Plank, Lori, Maslow, Katie, Melady, Don, Messer, Melissa, Most, Randi, Norris, Margaret P, Shafer, David, Silverberg, Nina, Thomas, Colin M, Thornhill, Laura, Tsai, Jean, Vakharia, Nirav, Waters, Martin, Golden, Tamara“…Key learning points of the summit included: recognizing the importance of educating patients and healthcare providers about the value of assessing current and baseline cognition; emphasizing that any screening tool must be appropriately normalized and validated in the population in which it is used to obtain accurate information, including considerations of language, cultural factors, and education; and recognizing the great potential, with appropriate caveats, of electronic health records to augment cognitive screening and tracking of changes in cognitive health over time. Summit Participants Deb Adler(1), Christopher Alban, MD, MBA(2), Mark Bondi, PhD(3), Michelle Braun, PhD(4), Xavier Cagigas, PhD(5), Morgan Daven(6), Robert L. …”
Publicado 2018
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1044756por Landovitz, Raphael J., Li, Sue, Grinsztejn, Beatriz, Dawood, Halima, Liu, Albert Y., Magnus, Manya, Hosseinipour, Mina C., Panchia, Ravindre, Cottle, Leslie, Chau, Gordon, Richardson, Paul, Marzinke, Mark A., Hendrix, Craig W., Eshleman, Susan H., Zhang, Yinfeng, Tolley, Elizabeth, Sugarman, Jeremy, Kofron, Ryan, Adeyeye, Adeola, Burns, David, Rinehart, Alex R., Margolis, David, Spreen, William R., Cohen, Myron S., McCauley, Marybeth, Eron, Joseph J.“…One HIV infection occurred in a participant 48 weeks after last injection of CAB LA: CAB was not detectable in plasma both at the time of first reactive HIV test and at the study visit 12 weeks prior to the first reactive test. …”
Publicado 2018
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1044757por Marty, Francisco M, Ljungman, Per, Chemaly, Roy F, Wan, Hong, Teal, Valerie L, Butterton, Joan, Yeh, Wendy W, Leavitt, Randi Y, Badshah, Cyrus“…By HCT Week 14, CS-CMVi occurred in 15 (31.3%) LET-treated patients and 17 (77.3%) PBO patients; CS-CMVi with imputed events were 22 (45.8%) in LET group and 20 (90.9%) in PBO group (difference –44.8%; 95% CI, –64.7% to –24.8%; P < 0.0001). Median CMV VL at time of PET was 413 c/mL (range, 150–31,847) and was similar between groups. …”
Publicado 2018
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1044758por Kityo, Cissy, Szubert, Alexander J., Siika, Abraham, Heyderman, Robert, Bwakura-Dangarembizi, Mutsa, Lugemwa, Abbas, Mwaringa, Shalton, Griffiths, Anna, Nkanya, Immaculate, Kabahenda, Sheila, Wachira, Simon, Musoro, Godfrey, Rajapakse, Chatu, Etyang, Timothy, Abach, James, Spyer, Moira J., Wavamunno, Priscilla, Nyondo-Mipando, Linda, Chidziva, Ennie, Nathoo, Kusum, Klein, Nigel, Hakim, James, Gibb, Diana M., Walker, A. Sarah, Pett, Sarah L.“…CONCLUSIONS: Although 12 weeks of raltegravir intensification was well tolerated and reduced HIV viraemia significantly faster than standard triple-drug ART during the time of greatest risk for early death, this strategy did not reduce mortality or clinical events in this group and is not warranted. …”
Publicado 2018
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1044759por Mortimer, Duncan, Bosch, Marije, Mckenzie, Joanne E., Turner, Simon, Chau, Marisa, Ponsford, Jennie L., Knott, Jonathan C., Gruen, Russell L., Green, Sally E.“…Methods: Trial-based economic evaluations from a health sector perspective, with time horizons set to coincide with the final follow-up for the NET sample (2 months post-intervention) and to 1-month post-discharge for the NET-Plus sample. …”
Publicado 2018
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1044760por Deng, Qinfang, Xie, Boxiong, Wu, Leilei, Ji, Xianxiu, Li, Chao, Feng, Li, Fang, Qiyu, Bao, Yuchen, Li, Jialu, Jin, Shengnan, Ding, Chunming, Li, Yixue, Zhou, Songwen“…Using in-depth integration and analysis of ctDNA genomic mutation data and clinical data at multiple time points during the treatment of 53 NSCLC patients, we described the resistance mechanisms of 1(st) EGFR TKIs treatment more comprehensively and dynamically. …”
Publicado 2018
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