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  1. 1044941
    “…METHODS: EBO was administered once daily at 8 different doses to HFS-MAC replicates for 28 days to achieve a half-life (t½) of 10.4h and the 0-24h area under the concentration-time curves (AUC(0-24)) that cover the observed AUC values in humans. …”
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    1697. Dose-response Studies of the Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, Epetraborole, in the Intracellular Hollow Fiber System Model of Mycobacterium avium complex Lung Disease
  2. 1044942
    “…Children < 18 years of age seen in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and mid-turbinate nasal +/- throat swabs were tested using multiplex respiratory pathogen assays or real time polymerase chain reaction (PCR) test for AdV, respiratory syncytial virus (RSV), human metapneumovirus, rhinovirus/enterovirus (RV), influenza, parainfluenza viruses, and endemic coronaviruses. …”
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    2196. Frequencies of Adenovirus Types in U.S. Children with Acute Respiratory Illness, 2016–2019
  3. 1044943
    “…Population-based studies examining the outcomes associated with various management processes of occiput posterior position at the time of labor or delivery are lacking. OBJECTIVE: This study aimed to describe the current management of term singleton occiput posterior deliveries in British Columbia, Canada and to examine the association between different management strategies and adverse outcomes by describing the rates of: occiput posterior malposition; and spontaneous vaginal delivery, operative vaginal delivery, and cesarean delivery from occiput posterior malposition. …”
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    Labor and delivery outcomes by delivery method in term deliveries in occiput posterior position: a population-based retrospective cohort study
  4. 1044944
    “…This modified operation not only retains the integrity of the posterior superior retinacular artery of the femoral head but also reduces the difficulty of the operation and shortens the surgical time, which is of great clinical significance.…”
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    A modified surgical method for the treatment of ONFH: quadratus femoris muscle pedicle bone grafting with preservation of the posterior superior retinacular artery
  5. 1044945
    “…However, almost all patients treated with ICIs and with disease progression over time died (mortality in the case of disease progression 95% vs. 62.5% in the cohort without ICIs). …”
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    Predictive Value of Baseline FDG-PET/CT for the Durable Response to Immune Checkpoint Inhibition in NSCLC Patients Using the Morphological and Metabolic Features of Primary Tumors
  6. 1044946
    “…Reproductive performance data including total number of piglets born (TB), number of piglets born alive (BA), percentage of stillborn piglets (SB) and percentage of mummified foetuses (MF) per litter, farrowing duration, piglet expulsion interval, time from onset of farrowing to the last placental expulsion, piglet preweaning mortality rate, percentage of piglets crushed by sows and number of piglets at weaning were analysed. …”
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    Pen Versus Crate: A Comparative Study on the Effects of Different Farrowing Systems on Farrowing Performance, Colostrum Yield and Piglet Preweaning Mortality in Sows under Tropical Conditions
  7. 1044947
    por Mlecnik, Bernhard, Lugli, Alessandro, Bindea, Gabriela, Marliot, Florence, Bifulco, Carlo, Lee, Jiun-Kae Jack, Zlobec, Inti, Rau, Tilman T., Berger, Martin D., Nagtegaal, Iris D., Vink-Börger, Elisa, Hartmann, Arndt, Geppert, Carol I., Kolwelter, Julie, Merkel, Susanne, Grützmann, Robert, Van den Eynde, Marc, Jouret-Mourin, Anne, Kartheuser, Alex, Léonard, Daniel, Remue, Christophe, Wang, Julia, Bavi, Prashant, Roehrl, Michael H. A., Ohashi, Pamela S., Nguyen, Linh T., Han, SeongJun, MacGregor, Heather L., Hafezi-Bakhtiari, Sara, Wouters, Bradly G., Masucci, Giuseppe V., Andersson, Emilia K., Zavadova, Eva, Vocka, Michal, Spacek, Jan, Petruzelka, Lubos, Konopasek, Bohuslav, Dundr, Pavel, Skalova, Helena, Nemejcova, Kristyna, Botti, Gerardo, Tatangelo, Fabiana, Delrio, Paolo, Ciliberto, Gennaro, Maio, Michele, Laghi, Luigi, Grizzi, Fabio, Fredriksen, Tessa, Buttard, Bénédicte, Lafontaine, Lucie, Maby, Pauline, Majdi, Amine, Hijazi, Assia, El Sissy, Carine, Kirilovsky, Amos, Berger, Anne, Lagorce, Christine, Paustian, Christopher, Ballesteros-Merino, Carmen, Dijkstra, Jeroen, van de Water, Carlijn, Vliet, Shannon van Lent-van, Knijn, Nikki, Mușină, Ana-Maria, Scripcariu, Dragos-Viorel, Popivanova, Boryana, Xu, Mingli, Fujita, Tomonobu, Hazama, Shoichi, Suzuki, Nobuaki, Nagano, Hiroaki, Okuno, Kiyotaka, Torigoe, Toshihiko, Sato, Noriyuki, Furuhata, Tomohisa, Takemasa, Ichiro, Patel, Prabhu, Vora, Hemangini H., Shah, Birva, Patel, Jayendrakumar B., Rajvik, Kruti N., Pandya, Shashank J., Shukla, Shilin N., Wang, Yili, Zhang, Guanjun, Kawakami, Yutaka, Marincola, Francesco M., Ascierto, Paolo A., Fox, Bernard A., Pagès, Franck, Galon, Jérôme
    Publicado 2023
    “…METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM). The time to recurrence (TTR) was the primary endpoint. …”
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    Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
  8. 1044948
    “…Participant inclusion required at least 1 geocoded residential address and anthropometric measure (taken at the same time or after the address date) from birth through adolescence. …”
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    Associations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children
  9. 1044949
    por Rabie, Amgad M., Eltayb, Wafa A.
    Publicado 2023
    “…Further experimental evaluation proved for the first time, utilizing the in vitro anti-RdRp/ExoN and anti-SARS-CoV-2 bioassays, that ChloViD2022, CoViTris2022, and Taroxaz-26 could effectively inhibit the replication of the new virulent strains of SARS-CoV-2 with extremely minute in vitro anti-RdRp and anti-SARS-CoV-2 EC(50) values of 0.17 and 0.41 μM for ChloViD2022, 0.21 and 0.69 μM for CoViTris2022, and 0.23 and 0.73 μM for Taroxaz-26, respectively, transcending the anti-COVID-19 drug molnupiravir. …”
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    Potent Dual Polymerase/Exonuclease Inhibitory Activities of Antioxidant Aminothiadiazoles Against the COVID-19 Omicron Virus: A Promising In Silico/In Vitro Repositioning Research Study
  10. 1044950
    “…Compared with priming and subsequently boosting with BBIBP-CorV, all participants who were primed with BBIBP-CorV and subsequently boosted with BNT162b2 had ≥median concentration of anti-S and neutralizing IgG antibodies and 14.6-time increased odds of having a T-cell response (aOR, 14.63; 95% CI: 1.78–120.5). …”
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    Evaluation of post-vaccination immunoglobulin G antibodies and T-cell immune response after inoculation with different types and doses of SARS-CoV-2 vaccines: A retrospective cohort study
  11. 1044951
    por Arraes de Alencar Ximenes, Ricardo, de Barros Miranda-Filho, Demócrito, Brickley, Elizabeth B., Barreto de Araújo, Thalia Velho, Montarroyos, Ulisses Ramos, Abtibol-Bernardino, Marília Rosa, Mussi-Pinhata, Marisa M., Duarte, Geraldo, Coutinho, Conrado Milani, Biason de Moura Negrini, Silvia Fabiana, Alecrim, Maria das Graças Costa, Albuquerque de Almeida Peixoto, Lucíola de Fátima, Lopes Moreira, Maria Elisabeth, Zin, Andrea, Pereira Júnior, José Paulo, Nielsen-Saines, Karin, Turchi Martelli, Celina Maria, Rodrigues, Laura Cunha, Vieira de Souza, Wayner, Ventura, Liana O., Silva de Oliveira, Consuelo, de Matos, Haroldo, Furtado Serra, Emilene Monteiro, Souza Gomes, Luna Thais, Nogueira, Maurício L., Estofolete, Cassia, Vaz-Oliani, Denise Cristina, Passos, Saulo Duarte, Moron, Antonio, Duarte Rodrigues, Maria Manoela, Pereira Sarmento, Stéphanno Gomes, Turchi, Marília Dalva, Pela Rosado, Luiza Emylce, de Sene Amâncio Zara, Ana Laura, Franco Gomes, Maria Bárbara, Schuler-Faccini, Lavínia, Herrero-Silva, Juliana, Amorim, Melania M., Melo, Adriana Oliveira, Ledo Alves da Cunha, Antônio José, Prata-Barbosa, Arnaldo, Amim, Joffre, Rezende-Filho, Jorge, Calcagno, Juan Ignacio, Júnior Alcântara, Luiz Carlos, Lima de Almeida, Breno, Hofer, Cristina Barroso, Machado, Elizabeth S., de Siqueira, Isadora Cristina, Martinez-Espinosa, Flor Ernestina, Brasil, Patrícia
    Publicado 2022
    “…For other abnormalities, the absolute risks were: 2.6% for microcephaly at birth or first evaluation, 4.0% for microcephaly at any time during follow-up, 7.9% for neuroimaging abnormalities, 18.7% for functional neurological abnormalities, 4.0% for ophthalmic abnormalities, 6.4% for auditory abnormalities, 0.6% for arthrogryposis, and 1.5% for dysphagia. …”
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    Risk of adverse outcomes in offspring with RT-PCR confirmed prenatal Zika virus exposure: an individual participant data meta-analysis of 13 cohorts in the Zika Brazilian Cohorts Consortium
  12. 1044952
    “…DISCLAIMER: This guideline represents the views of ESHRE, which were achieved after careful consideration of the scientific evidence available at the time of preparation. In the absence of scientific evidence on certain aspects, a consensus between the relevant ESHRE stakeholders has been obtained. …”
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    ESHRE guideline: medically assisted reproduction in patients with a viral infection/disease
  13. 1044953
    por Villar, Jose, Soto Conti, Constanza P, Gunier, Robert B, Ariff, Shabina, Craik, Rachel, Cavoretto, Paolo I, Rauch, Stephen, Gandino, Serena, Nieto, Ricardo, Winsey, Adele, Menis, Camilla, Rodriguez, Gabriel B, Savasi, Valeria, Tug, Niyazi, Deantoni, Sonia, Fabre, Marta, Martinez de Tejada, Begoña, Rodriguez-Sibaja, Maria Jose, Livio, Stefania, Napolitano, Raffaele, Maiz, Nerea, Sobrero, Helena, Peterson, Ashley, Deruelle, Philippe, Giudice, Carolina, Teji, Jagjit S, Casale, Roberto A, Salomon, Laurent J, Prefumo, Federico, Cheikh Ismail, Leila, Gravett, Michael G, Vale, Marynéa, Hernández, Valeria, Sentilhes, Loïc, Easter, Sarah R, Capelli, Carola, Marler, Emily, Cáceres, Daniela M, Albornoz Crespo, Guadalupe, Ernawati, Ernawati, Lipschuetz, Michal, Takahashi, Ken, Vecchiarelli, Carmen, Hubka, Teresa, Ikenoue, Satoru, Tavchioska, Gabriela, Bako, Babagana, Ayede, Adejumoke I, Eskenazi, Brenda, Thornton, Jim G, Bhutta, Zulfiqar A, Kennedy, Stephen H, Papageorghiou, Aris T
    Publicado 2023
    “…METHODS: INTERCOVID-2022 is a large, prospective, observational study, involving 41 hospitals across 18 countries. Each woman with real-time PCR or rapid test, laboratory-confirmed COVID-19 in pregnancy was compared with two unmatched women without a COVID-19 diagnosis who were recruited concomitantly and consecutively in pregnancy or at delivery. …”
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    Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study
  14. 1044954
    “…Sampling and 12-lead electrocardiogram were performed at different time points as follows: immediately after TICU admission and at 24 h and 48 h after trauma. …”
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    Serum pro-B-type natriuretic peptide levels and cardiac index as adjunctive tools of blunt cardiac injury
  15. 1044955
    “…We retrieved data on RSV-associated hospital admissions from the Danish National Patient Registry and demographic and clinical details of children who received mechanical ventilation through prospective real-time data collection in 2021–22 and retrospective data collection for the 2016–17 to 2019–20 RSV seasons from all eight paediatric and neonatal intensive care units in Denmark. …”
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    Hospital admissions and need for mechanical ventilation in children with respiratory syncytial virus before and during the COVID-19 pandemic: a Danish nationwide cohort study
  16. 1044956
    “…After a median follow-up time of 8 years, 154 women in the gonadotrophin group had a live birth (83.7%) versus 150 women in the CC group (78.9%) (relative risk (RR) 1.06, 95% CI 0.96–1.17). …”
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    Long-term outcomes of switching to gonadotrophins versus continuing with clomiphene citrate, with or without intrauterine insemination, in women with normogonadotropic anovulation and clomiphene failure: follow-up study of a factorial randomized clinical trial
  17. 1044957
    por Harrison, C, Gameiro, S, Boivin, J
    Publicado 2023
    “…HCPs perceived implementation of the TPCI Checklist to be challenging in its current length due to time pressures and clinic workload. Suggestions for enhancing the TPCI Checklist and App were provided, but none required critical changes to its core components or activities. …”
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    Qualitative evaluation of the acceptability and feasibility among healthcare professionals and patients of an ART multi-cycle treatment planning and continuation intervention prototype
  18. 1044958
    “…WIDER IMPLICATIONS OF THE FINDINGS: In the largest study of its kind, our analysis of singleton siblings, corrected for unmeasured, non-time varying maternal factors, confirms the previously reported association between blastocyst transfer and LGA babies, and shows a reduced risk of congenital anomaly following blastocyst transfer. …”
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    A comparison of perinatal outcomes following fresh blastocyst or cleavage stage embryo transfer in singletons and twins and between singleton siblings
  19. 1044959
    “…ICA induced in C57BL/6 and DBA/1 mice did cause irreversible cartilage damage at later time points, indicating that immune complexes and FcγRs play an important role in inducing irreversible cartilage damage. …”
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    FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)
  20. 1044960
    “…The analysis was conducted using a healthcare perspective. A 100 age-year time horizon was used. A 3% discount rate was applied to both the costs and effects in the model. …”
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    2412 Cost effectiveness analysis of operative Versus antibiotic management for uncomplicated appendicitis
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