“…Each admission involved 2 nights of unfragmented sleep [8-h time-in-bed (TIB)] followed by 3 nights of sleep fragmentation, induced by auditory stimuli distributed across the night, producing 1-hr of cumulative wakefulness while enabling equal sleep opportunity (9-h TIB). …”
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“…There was an increase in the time during which interstitial glucose levels were between 3.0 and 3.9 mmol/l in the POWER2DM group, but no increase in clinically relevant hypoglycaemia (interstitial glucose level below 3.0 mmol/l). …”
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“…In addition, The CTRP9 promoter in the Hcy group showed hypermethylation. At the same time as Hcy intervention, overexpression of DNMT1 increases the methylation level of the CTRP9 promoter, while 5-Azc can reduce the methylation level of the CTRP9 promoter. …”
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“…None of the subjects in the study experienced any adverse effects associated with this study, nor increases in MCC time. Bioburden reduction (A) and mucociliary clearance assessment (B) [Figure: see text] A) Data is expressed as mean ± SEM CFU log10 reduction, from baseline bioburden. …”
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“…Proportions of RSV hospitalizations over all-cause hospitalizations over time, and intensive care unit (ICU) admissions, prolonged admissions (≥ 7-days) and mortality proportions were calculated, overall and by age groups and regions. …”
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“…S1-palivizumab/S2-palivizumab recipients had ∼10-fold lower levels of nAbs over the S2 PK model-predicted time course to D151 compared with participants receiving S2-nirsevimab. …”
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“…PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 1487 clinics offering ART services in 40 countries reported, for the second time, a total of more than 1 million (1 077 813) treatment cycles, including 160 782 with IVF, 427 980 with ICSI, 335 744 with FET, 64 089 with preimplantation genetic testing (PGT), 82 373 with egg donation (ED), 546 with IVM of oocytes, and 6299 cycles with frozen oocyte replacement (FOR). …”
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“…It suggests that loss of PTEN function may not exclusively be caused by genetic alterations, yet at the same time links the low expression of PTEN to a phenotype of cells that have been shown to invade cartilage aggressively. …”
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“…On the other hand, the leptospiras mixed with normal rabbit serum lived well and multiplied during the same period of time and under otherwise identical conditions (at 28°C.) …”
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“…Gels removed from their glass supports after apparent swelling equilibrium, when placed in dilute buffer, begin to swell gradually in all three dimensions and the double refraction decreases slowly, though it persists for a long time. But the double refraction per unit change in dimension and per unit concentration still remains the same as before, thus proving that the internal elastic stress as indicated by the double refraction is brought about by the resistance of the gel itself to deformation. …”
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“…BACKGROUND: Coronary heart disease (CHD) is a common and potentially fatal malady with a life time prevalence of over 20%. For Germany, the mortality attributable to chronic ischemic heart disease or acute myocardial infarction is estimated at 140,000 deaths per year. …”
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“…SUMMARY ANSWER: This study identifies, for the first time, the prevalence of Ca(2+) store defects in sperm from research donors, IVF and ICSI patients. …”
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“…Because current protection efforts seem to be failing, it is time to evaluate, discuss, and test alternatives to the present policy. …”
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“…Xpert® MTB/RIF assay (Xpert) is a rapid, automated test that can detect both TB and rifampicin resistance, within two hours after starting the test, with minimal hands-on technical time, but is more expensive than conventional sputum microscopy. …”
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“…All patients’ puncture was performed by a full-time doctor. The operation was performed under epidural anesthesia. …”
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“…FR and MR delayed gastric emptying (Time(50%): type 2 diabetes, FR 83.2 ± 7.2 min, MR 82.3 ± 6.4 min, RF 29.8 ± 3.9 min [p < 0.05 for FR vs RF and MR vs RF]; healthy, FR 66.3 ± 5.5 min, MR 74.4 ± 7.6 min, RF 32.4 ± 4.5 min [p < 0.05 for FR vs RF and MR vs RF]), which is associated with amelioration of postprandial glucose excursion (AUC(−15–120 min)-glucose: type 2 diabetes, r = −0.746, p < 0.05; healthy, r = −0.433, p < 0.05) and glucose variability (SD(−15–240 min)-glucose: type 2 diabetes, r = −0.578, p < 0.05; healthy, r = −0.526, p < 0.05), as well as with increasing GLP-1 (AUC(−15–120 min)-GLP-1: type 2 diabetes, r = 0.437, p < 0.05; healthy, r = 0.300, p = 0.107) and glucagon (AUC(−15–120 min)-glucagon: type 2 diabetes, r = 0.399, p < 0.05; healthy, r = 0.471, p < 0.05). …”
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“…(R) • Antibiotics should be administered up to 60 minutes before skin incision, as close to the time of incision as possible. (R) • Antibiotic regimes longer than 24 hours have no additional benefit in clean-contaminated head and neck surgery. …”
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“…SELECTION CRITERIA: Randomised trials, non‐randomised trials, interrupted time series studies, or controlled before‐after studies. …”
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“…After confirmation of a case of Ebola virus disease, we definitively enumerated on a list a ring (cluster) of all their contacts and contacts of contacts including named contacts and contacts of contacts who were absent at the time of the trial team visit. The list was archived, then we randomly assigned clusters (1:1) to either immediate vaccination or delayed vaccination (21 days later) of all eligible individuals (eg, those aged ≥18 years and not pregnant, breastfeeding, or severely ill). …”
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“…Additionally, we examined whether subtypes of suicidality can be identified based on mental state at the time of high SI and identified four potential subtypes: high anxiety, low mood, combined and non-affective (psychotic). …”
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