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1045321Tocilizumab au cours du COVID-19 : le plus tôt serait le mieux ? Une analyse exploratoire de cohortepor Jachiet, V., Richier, Q., Carrat, F., Abisror, N., Dhôte, R., Jerome, P., Marc, G., Maurier, F., Olivier, H., Michel, M., Godeau, B., Boris, B., Cloé, C., Cacoub, P., Mahévas, T., Chasset, F., Adedjouma, A., Fain, O., Lacombe, K., Mekinian, A.“…L’hétérogénéité des résultats concernant l’efficacité du TCZ pourrait être expliquée par des différences dans le timing d’injection : défavorable si trop précoce ou inefficace si trop tardive. …”
Publicado 2021
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1045322por Keats, Emily C., Oh, Christina, Chau, Tamara, Khalifa, Dina S., Imdad, Aamer, Bhutta, Zulfiqar A.“…LMIC were defined by the World Bank Group at the time of the search for this review. While the aim was to include healthy pregnant women, it is likely that these populations had one or more micronutrient deficiencies at baseline; women were not excluded on this basis. …”
Publicado 2021
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1045323por Frantz, Travis, Ulrich, Marisa, Everhart, Joshua, Mundy, Andrew, Barlow, Jonathan, Neviaser, Andrew, Jones, Grant, Bishop, Julie, Cvetanovich, Gregory“…One SCR patient and 3 rTSA patients were deceased within the follow-up time period. Multivariate analysis demonstrated no independent predictors of revision surgery, and the only independent predictors of patient satisfaction to be improved pre-op active ER ROM (0.03) and strength (p=0.048). …”
Publicado 2021
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1045324por Choi, Yun, Caro, Jessica, Li, Xiaochun, Al-Obeidi, Arshed, Kurtz, Sharyn Lynn, Kim, Austin I., Chang, Julie E., Olszewski, Adam J., Zayac, Adam, Matthews, Andrew, Barta, Stefan K., Sundaram, Suchitra, Hernandez-Ilizaliturri, Francisco J., Leslie, Lori A., Caimi, Paolo, Carter, Jordan, David, Kevin A., Evens, Andrew M., Kim, Myung Sun, Nagle, Sarah J., Goldberg, Judith, Diefenbach, Catherine S.“…Patients in remission at the time of COVID-19 diagnosis had a lower risk of severe events (OR 0.42), mortality (0.36) and hospital admission (0.40) relative to those who were not in remission. …”
Publicado 2021
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1045325“…Traditional criminal justice strategies for combating this issue have evolved over time but have frequently demonstrated limited success. …”
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1045326por Attard, Gerhardt, Murphy, Laura, Clarke, Noel W, Cross, William, Jones, Robert J, Parker, Christopher C, Gillessen, Silke, Cook, Adrian, Brawley, Chris, Amos, Claire L, Atako, Nafisah, Pugh, Cheryl, Buckner, Michelle, Chowdhury, Simon, Malik, Zafar, Russell, J Martin, Gilson, Clare, Rush, Hannah, Bowen, Jo, Lydon, Anna, Pedley, Ian, O'Sullivan, Joe M, Birtle, Alison, Gale, Joanna, Srihari, Narayanan, Thomas, Carys, Tanguay, Jacob, Wagstaff, John, Das, Prantik, Gray, Emma, Alzoueb, Mymoona, Parikh, Omi, Robinson, Angus, Syndikus, Isabel, Wylie, James, Zarkar, Anjali, Thalmann, George, de Bono, Johann S, Dearnaley, David P, Mason, Malcolm D, Gilbert, Duncan, Langley, Ruth E, Millman, Robin, Matheson, David, Sydes, Matthew R, Brown, Louise C, Parmar, Mahesh K B, James, Nicholas D“…Eligible patients (no age restrictions) had high-risk (defined as node positive or, if node negative, having at least two of the following: tumour stage T3 or T4, Gleason sum score of 8–10, and prostate-specific antigen [PSA] concentration ≥40 ng/mL) or relapsing with high-risk features (≤12 months of total ADT with an interval of ≥12 months without treatment and PSA concentration ≥4 ng/mL with a doubling time of <6 months, or a PSA concentration ≥20 ng/mL, or nodal relapse) non-metastatic prostate cancer, and a WHO performance status of 0–2. …”
Publicado 2022
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1045327por Javed, Farhan, Fayyaz, Harris, Al-Abadi, Eslam, Pickering, Warren, Leandro, Maria, Jeffery, Rachel“…Patients should be able to continue study and in view of symptoms and the disruption due to illness, the hospital should offer support letters to schools/universities to enable flexibility with assignments and time extension. To conclude, jSLE is a challenging disease that is both difficult to diagnose and to treat. …”
Publicado 2021
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1045328por Becker, Christian M, Bokor, Attila, Heikinheimo, Oskari, Horne, Andrew, Jansen, Femke, Kiesel, Ludwig, King, Kathleen, Kvaskoff, Marina, Nap, Annemiek, Petersen, Katrine, Saridogan, Ertan, Tomassetti, Carla, van Hanegem, Nehalennia, Vulliemoz, Nicolas, Vermeulen, Nathalie“…DISCLAIMER: This guideline represents the views of ESHRE, which were achieved after careful consideration of the scientific evidence available at the time of preparation. In the absence of scientific evidence on certain aspects, a consensus between the relevant ESHRE stakeholders has been obtained. …”
Publicado 2022
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1045329por Ebrahimzadeh, Sanam, Islam, Nayaar, Dawit, Haben, Salameh, Jean-Paul, Kazi, Sakib, Fabiano, Nicholas, Treanor, Lee, Absi, Marissa, Ahmad, Faraz, Rooprai, Paul, Al Khalil, Ahmed, Harper, Kelly, Kamra, Neil, Leeflang, Mariska MG, Hooft, Lotty, Pol, Christian B, Prager, Ross, Hare, Samanjit S, Dennie, Carole, Spijker, René, Deeks, Jonathan J, Dinnes, Jacqueline, Jenniskens, Kevin, Korevaar, Daniël A, Cohen, Jérémie F, Van den Bruel, Ann, Takwoingi, Yemisi, de Wijgert, Janneke, Wang, Junfeng, Pena, Elena, Sabongui, Sandra, McInnes, Matthew DF“…For all 98 included studies, risk of bias was high or unclear in 52 (53%) studies with respect to participant selection, in 64 (65%) studies with respect to reference standard, in 46 (47%) studies with respect to index test, and in 48 (49%) studies with respect to flow and timing. Concerns about the applicability of the evidence to: participants were high or unclear in eight (8%) studies; index test were high or unclear in seven (7%) studies; and reference standard were high or unclear in seven (7%) studies. …”
Publicado 2022
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1045330por Popp, Maria, Reis, Stefanie, Schießer, Selina, Hausinger, Renate Ilona, Stegemann, Miriam, Metzendorf, Maria-Inti, Kranke, Peter, Meybohm, Patrick, Skoetz, Nicole, Weibel, Stephanie“…No trial investigated quality of life at any time point. Ivermectin for treating COVID‐19 in outpatient settings with asymptomatic or mild disease Ivermectin plus standard of care compared to standard of care plus/minus placebo probably has little or no effect on all‐cause mortality at day 28 (RR 0.77, 95% CI 0.47 to 1.25; 6 trials, 2860 participants; moderate‐certainty evidence) and little or no effect on quality of life, measured with the PROMIS Global‐10 scale (physical component mean difference (MD) 0.00, 95% CI ‐0.98 to 0.98; and mental component MD 0.00, 95% CI ‐1.08 to 1.08; 1358 participants; high‐certainty evidence). …”
Publicado 2022
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1045331“…The Ophiostomatales was erected in 1980. Since that time, several of the genera have been redefined and others have been described. …”
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1045332por Coward, S, Benchimol, E I, Bernstein, C, Avina-Zubieta, J A, Bitton, A, Hracs, L, Jones, J, Kuenzig, E, Lu, L, Murthy, S K, Nugent, Z, Otley, A R, Panaccione, R, Pena-Sanchez, J -N, Singh, H, Targownik, L E, Windsor, J W, Kaplan, G“…A high incidence of IBD, in conjunction with low mortality, leads to a steadily rising prevalence over time. By understanding historical epidemiological trends, we can forecast incidence and prevalence into the future to inform healthcare systems in Canada of the rising burden of IBD to society. …”
Publicado 2023
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1045333“…Paulescu has undoubtedly documented the Judeophobic ideology of the Romanian scientist, linked to his orthodox religious radicalism, manifested in multiple documents (mostly pamphlets) and interventions in collaboration with other relevant personalities of the Romanian intelligentsia of his time. Furthermore, Paulescu participated in the creation of political organizations of the most radical extreme right that played a fundamental role in the spread of antisemitism amongst the Romanian population and the university community. …”
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1045334por Smith-Jeffcoat, Sarah E, Biddle, Jessica E, Talbot, H Keipp, Olivo, Vanessa, Sano, Ellen, Goodman, Sara H, Petrie, Joshua, Ledezma, Karla I, Bullock, Ayla, Rao, Suchitra, Mellis, Alexandra, Johnson, Sheroi, Kirking, Hannah L, Rolfes, Melissa A, Zhu, Yuwei, Schmitz, Jonathan, Hart, Kimberly W, Battan-Wraith, Steph, Merrill, Lori S, McLaren, Son H, Vargas, Celibell, Sarnquist, Clea, Govindaranjan, Prasanthi, Belongia, Edward, Pryor, Kathleen, Lutrick, Karen, Yang, Amy, Haehnel, Quenla, Asturias, Edwin J, Bowman, Natalie M, Ellingson, Katherine, McLean, Huong, Maldonado, Yvonne A, Stockwell, Melissa, Morrissey, Kerry Grace, Grijalva, Carlos G, Salvatore, Phillip P“…Propensity score matching was performed by calculating propensity score of nirmatrelvir/ritonavir use based on age, sex, race/ethnicity, prior COVID-19, recruitment method, participant type, medical care access, COVID-19 vaccination history, comorbidities, and predominant variant at the time of index onset. The best covariate balance was achieved using nearest propensity score matching method with a ratio of 2:1 no treatment to N/R treated. …”
Publicado 2023
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1045335por Paulsen, Grant C, Sher, Lawrence, Sabharwal, Charu, Kitchin, Nicholas, Hill, Sungeen, Wasserman, Emily, Xu, Xia, Maldonado, Yvonne A, Barnett, Elizabeth, Englund, Janet A, Walter, Emmanuel, Munoz, Flor M, Simoes, Eric, Talaat, Kawsar R, Kamidani, Satoshi, Moyer, Lisa, Parikh, Vrunda, Ma, Hua, Wang, Xingbin, Koury, Kenneth, Anderson, Annaliesa S, Swanson, Kena A, Gurtman, Alejandra C, Gruber, William C“…RESULTS: Of the 113 children who received bivalent BNT162b2, 50% were female, 58% White, and 58% SARS-CoV-2 positive at baseline. Median (range) time from dose 3 of original BNT162b2 to bivalent BNT162b2 was 5.5 (2.6−8.6) months. …”
Publicado 2023
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1045336por Edwards, Philip James, Roberts, Ian, Clarke, Mike J, DiGuiseppi, Carolyn, Woolf, Benjamin, Perkins, Chloe“…The odds of response also increased with: personalised e‐questionnaires (OR 1.24; 95% CI 1.17 to 1.32; I(2) = 41%); using a simple header (OR 1.23; 95% CI 1.03 to 1.48); giving a deadline (OR 1.18; 95% CI 1.03 to 1.34); and by giving a longer time estimate for completion (OR 1.25; 95% CI 0.96 to 1.64). …”
Publicado 2023
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1045337“…There was then an increase of both lymphocytes and monocytes, the latter exceeding the former for a time. Later, usually after the 2nd month, the lymphocytes again became predominant over the monocytes, approaching the normal base line. …”
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1045338por Yan, Xinhua, Sasi, Sharath P., Gee, Hannah, Lee, Juyong, Yang, Yongyao, Song, Jin, Carrozza, Joseph, Goukassian, David A.“…Background: During the future Moon and Mars missions, astronauts will be exposed to space radiation (IR) for extended time. The majority of space flight-associated risks identified for the cardiovascular (CV) system to date were determined shortly after low Earth orbit (LEO) short- and long-duration space flights that include: serious cardiac dysrhythmias, compromised orthostatic CV response and manifestation of previously asymptomatic CV disease. …”
Publicado 2014
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1045339por Okokon, Enembe O, Verbeek, Jos H, Ruotsalainen, Jani H, Ojo, Olumuyiwa A, Bakhoya, Victor Nyange“…Of these, 45 trials assessed treatment outcomes at five weeks or less after commencement of treatment, and six trials assessed outcomes over a longer time frame. We believe that 24 trials had some form of conflict of interest, such as funding by pharmaceutical companies. …”
Publicado 2015
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1045340por Mbuagbaw, Lawrence, Mursleen, Sara, Irlam, James H, Spaulding, Alicen B, Rutherford, George W, Siegfried, Nandi“…The length of follow‐up time, study settings, and NRTI combination drugs varied greatly. …”
Publicado 2016
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