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  1. 341601
    “…A ‘low risk of bias’ was observed in the randomized controlled trials included, with no study bias shown for both strength or architecture (N = 250 and 663, respectively; p < 0.001). …”
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    The Effect of Nordic Hamstring Exercise Intervention Volume on Eccentric Strength and Muscle Architecture Adaptations: A Systematic Review and Meta-analyses
  2. 341602
    “…Our findings showed that the AT(N) biomarker profiles have limited utility to predict AD progression rates and, thus, measure change and interpreting outcomes from clinical trials of future therapies.…”
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    Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer’s disease
  3. 341603
    “…We collected data from 12 randomized trials on low-carbohydrate diets including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, and blood pressure levels, as well as weight as the endpoints. …”
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    The effects of low-carbohydrate diets on cardiovascular risk factors: A meta-analysis
  4. 341604
    “…The results may inform the design of future combination therapy trials in patients with tumors harboring mutations in the PI3K and MAPK pathways.…”
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    Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations
  5. 341605
    “…REGISTRATION: ACTRN12616001655437 (Australian New Zealand Clinical Trials Registry).…”
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    A Prospective 2-Year Clinical Evaluation of Augmented Hip Abductor Tendon Repair
  6. 341606
    “…RESULTS: Seventeen randomized controlled trials (RCTs) involving 5204 participants were included in this meta-analysis. …”
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    Laparoscopic versus open gastrectomy for gastric cancer
  7. 341607
    “…These findings highlight the utility of artificial intelligence-based CDSS to improve diagnosis efficiency, but these results require confirmation in future randomized controlled trials.…”
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    Accuracy and Effects of Clinical Decision Support Systems Integrated With BMJ Best Practice–Aided Diagnosis: Interrupted Time Series Study
  8. 341608
    “…Finally, more sophisticated systems were evaluated less often in comparative trials than less sophisticated ones (OR 0.59). CONCLUSIONS: The findings indicate that when developers create systems, there is a greater focus on implementing therapeutic treatment than adherence support. …”
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    Technological State of the Art of Electronic Mental Health Interventions for Major Depressive Disorder: Systematic Literature Review
  9. 341609
    “…There is an unmet need for non-invasive biomarkers in non-alcoholic fatty liver disease (NAFLD) that can diagnose advanced disease and identify patients suitable for clinical trials. The PRO-C3 collagen neo-epitope is a putative direct marker of fibrogenesis. …”
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    Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease
  10. 341610
    “…These encouraging data deserve further evaluation in randomized controlled trials. LAY SUMMARY: Hydrothermal duodenal mucosal resurfacing (DMR) is an endoscopic technique designed to treat metabolic disease through ablation of the duodenal mucosa. …”
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    Endoscopic duodenal mucosal resurfacing improves glycaemic and hepatic indices in type 2 diabetes: 6-month multicentre results
  11. 341611
    “…Rituximab was associated with sustained improvements in serum liver tests, an absence of clinical disease flares, and a reduction in prednisolone dose. Controlled trials are warranted to further evaluate B cell-targeting therapies in patients with AIH. …”
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    Efficacy of rituximab in difficult-to-manage autoimmune hepatitis: Results from the International Autoimmune Hepatitis Group
  12. 341612
    “…Properly constructed prospective trials are required to better understand the efficacy of bracing in adult scoliosis.…”
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    A systematic literature review of spinal brace/orthosis treatment for adults with scoliosis between 1967 and 2018: clinical outcomes and harms data
  13. 341613
    “…CONCLUSIONS: Our meta-analysis indicates that allogeneic MSC could be instrumental for the prophylaxis and treatment of GvHD. Future trials should investigate the effect of the administration of MSC as an adjuvant therapy for the treatment of patients with GvHD from the onset of the disease.…”
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    Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease—a meta-analysis
  14. 341614
    “…METHODS: We searched MEDLINE, PsycINFO, Embase, and the Cochrane Controlled Clinical Register of Trials from Jan 1, 1983, to Aug 14, 2019, for studies comparing the characteristics of voluntary and involuntary psychiatric inpatients, and studies investigating the characteristics of involuntarily hospitalised individuals in general population samples. …”
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    Clinical and social factors associated with increased risk for involuntary psychiatric hospitalisation: a systematic review, meta-analysis, and narrative synthesis
  15. 341615
    “…Which surgical approach offers more advantages is still controversial due to a lack of evidence from randomized controlled trials (RCTs). This meta-analysis was conducted to compare the short-term outcomes between the two surgical approaches. …”
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    Comparison of the short-term outcomes between totally laparoscopic total gastrectomy and laparoscopic-assisted total gastrectomy for gastric cancer: a meta-analysis
  16. 341616
    “…METHODS: Since xenogeneic-free growth supplements are increasingly being used in the expansion of bmMSCs in clinical trials, we investigated the effects of human plasma and platelet lysate (P/PL) on the expression of neuromuscular markers and whether P/PL-expanded human bmMSCs could be differentiated towards a skeletal myogenic phenotype. …”
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    Lack of a skeletal muscle phenotype in adult human bone marrow stromal cells following xenogeneic-free expansion
  17. 341617
    “…However, these reported findings still need to be verified by large randomized clinical trials.…”
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    Comparison between Arm Port and Chest Port for Optimal Vascular Access Port in Patients with Breast Cancer: A Systematic Review and Meta-Analysis
  18. 341618
    “…These findings will help guide the direction of future research in digital rehabilitation therapy, including the impact of demographics on recovery outcomes and the design of large, randomized controlled trials.…”
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    Closing the Digital Divide in Speech, Language, and Cognitive Therapy: Cohort Study of the Factors Associated With Technology Usage for Rehabilitation
  19. 341619
    “…METHODS: We conducted a systematic literature search of the databases of Cochrane Library, PsycINFO, PubMed, and Embase to identify relevant randomized controlled trials in adult OSA populations. The risk of bias in included studies was examined using seven items of the Cochrane Collaboration risk-of-bias tool. …”
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    Effectiveness of eHealth Interventions in Improving Treatment Adherence for Adults With Obstructive Sleep Apnea: Meta-Analytic Review
  20. 341620
    “…INTRODUCTION: Stigma and disclosure concerns have been key barriers to oral pre‐exposure prophylaxis (PrEP) adherence for African adolescent girls and young women (AGYW) in efficacy trials. We aimed to understand the impact of these factors among African AGYW in an open‐label PrEP study. …”
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    The influence of HIV‐related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082: a qualitative study
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