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341641por Bhatraju, Pavan K., Zelnick, Leila R., Chinchilli, Vernon M., Moledina, Dennis G., Coca, Steve G., Parikh, Chirag R., Garg, Amit X., Hsu, Chi-yuan, Go, Alan S., Liu, Kathleen D., Ikizler, T. Alp, Siew, Edward D., Kaufman, James S., Kimmel, Paul L., Himmelfarb, Jonathan, Wurfel, Mark M.“…The identification of different AKI recovery patterns may improve patient risk stratification, facilitate prognostic enrichment in clinical trials, and enable recognition of patients who may benefit from nephrology consultation.…”
Publicado 2020
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341642por Husson, Olga, de Rooij, Belle H., Kieffer, Jacobien, Oerlemans, Simone, Mols, Floortje, Aaronson, Neil K., van der Graaf, Winette T.A., van de Poll‐Franse, Lonneke V.“…BACKGROUND: Health‐related quality of life (HRQoL) has been shown to be a prognostic factor for cancer survival in randomized clinical trials and observational “real‐world” cohort studies; however, it remains unclear which HRQoL domains are the best prognosticators. …”
Publicado 2019
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341643“…BACKGROUND: At least 50% of triple negative breast cancer (TNBC) overexpress the epidermal growth factor receptor, EGFR, which paved the way for clinical trials investigating its blockade. Outcomes remained dismal stemming from mechanisms of resistance particularly the nuclear cycling of EGFR, which is enhanced by Src activation. …”
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341644por Lumbala, Crispin, Matovu, Enock, Sendagire, Hakim, Kazibwe, Anne J. N., Likwela, Joris L., Muhindo Mavoko, Hypolite, Kayembe, Simon, Lutumba, Pascal, Biéler, Sylvain, Van Geertruyden, Jean-Pierre, Ndung’u, Joseph M.“…However, there is a need to assess its accuracy using fresh samples in prospective clinical trials.…”
Publicado 2020
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341645“…The three review articles described the results of 10 clinical trials and feasibility studies that quantified engagement and met the inclusion criteria assessed through CASP. …”
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341646“…Randomized controlled trials (RCTs) published between January 2015 and November 2019 were eligible for inclusion. …”
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341647“…Besides randomized controlled trials (RCT), we included non-randomized prospective cohort studies, as well as retrospective cohort studies. …”
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341648por Marklund, Matti, Singh, Gitanjali, Greer, Raquel, Cudhea, Frederick, Matsushita, Kunihiro, Micha, Renata, Brady, Tammy, Zhao, Di, Huang, Liping, Tian, Maoyi, Cobb, Laura, Neal, Bruce, Appel, Lawrence J, Mozaffarian, Dariush, Wu, Jason H Y“…The models incorporated existing data and corresponding uncertainties from randomised trials, the China National Survey of Chronic Kidney Disease, the Global Burden of Disease Study, and the Chronic Kidney Disease Prognosis Consortium. …”
Publicado 2020
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341649por Tondo, Giacomo, Iaccarino, Leonardo, Caminiti, Silvia Paola, Presotto, Luca, Santangelo, Roberto, Iannaccone, Sandro, Magnani, Giuseppe, Perani, Daniela“…Investigating microglial activation and its influence on the development of synaptic dysfunction and neuronal loss in EOAD may contribute to the understanding of its pathophysiology and to subject selection in clinical trials. In our study, we aimed to assess the amount of neuroinflammation and neurodegeneration and their relationship in EOAD patients, through positron emission tomography (PET) measures of microglia activation and brain metabolic changes. …”
Publicado 2020
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341650por Aquino, Maria, Munce, Sarah, Griffith, Janessa, Pakosh, Maureen, Munnery, Mikayla, Seto, Emily“…A qualitative study, observational studies, and randomized controlled trials were included in this scoping review. RESULTS: Of the 3904 articles initially identified, 20 met the inclusion criteria. …”
Publicado 2020
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341651por Gong, Li, Gu, Yongzhe, Yu, Qiuyue, Wang, Haichao, Zhu, Xiaoping, Dong, Qiong, Xu, Rong, Zhao, Yanxin, Liu, Xueyuan“…Conclusion: In this cohort study of dementia-free survivors of ICH, our results show that one in three early PSCI survivors exhibit cognitive recovery, in relation to dominant-hemisphere hematoma, lobar ICH, educational history, and MCV levels. Future clinical trials including ICH survivors with cognitive dysfunction should assess these factors.…”
Publicado 2020
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341652por Maida, Marcello, Sinagra, Emanuele, Morreale, Gaetano Cristian, Sferrazza, Sandro, Scalisi, Giuseppe, Schillaci, Dario, Ventimiglia, Marco, Macaluso, Fabio Salvatore, Vettori, Giovanni, Conoscenti, Giuseppe, Di Bartolo, Concetta, Garufi, Serena, Catarella, Domenico, Manganaro, Michele, Virgilio, Clara Maria, Camilleri, Salvatore“…Recently, a 1 L polyethylene glycol plus ascorbate (PEG-ASC) solution (Plenvu; Norgine, Harefield, United Kingdom) has been introduced on the evidence of three phase-3 randomized controlled trials, but it had never been tested in the real-life. …”
Publicado 2020
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341653por Ahmed, Jahangir, Chard, Louisa S, Yuan, Ming, Wang, Jiwei, Howells, Anwen, Li, Yuenan, Li, Haoze, Zhang, Zhongxian, Lu, Shuangshuang, Gao, Dongling, Wang, Pengju, Chu, Yongchao, Al Yaghchi, Chadwan, Schwartz, Joel, Alusi, Ghassan, Lemoine, Nicholas, Wang, Yaohe“…CONCLUSIONS: These data provide a proof of concept for translation of the regime into clinical trials. VVΔTKΔN1L-IL12 is a promising agent for use as an adjuvant to surgical treatment of solid tumors.…”
Publicado 2020
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341654“…Methods: Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Scopus, Web of Science, and references of key articles were searched from inception to 2019. …”
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341655por Ansari, Mohammad Jamal Uddin, Ahmed, Mahreen, Parveen, Sanober, Mariam, Murtaza Ali, Jabri, Hadoun, Rehman, Anis, Jakoby, Michael G“…In a recent meta-analysis of 38 immune checkpoint inhibitor trials and over 7,500 patients, T1D was the least common endocrine irAE. …”
Publicado 2020
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341656por Violet, Pierre-Christian, Ebenuwa, Ifechukwude, Wang, Yu, Niyyati, Mahtab, Padayatty, Sebastian, Head, Brian, Wilkins, Kenneth, Chung, Stacey, Thakur, Varsha, Ulatowski, Lynn, Atkinson, Jeffery, Ghelfi, Mikel, Smith Smith, Sheila, Smith, Sheila, Tu, Hongbin, Bobe, Gerd, Liu, Chia-Ying, Herion, David, Shamburek, Robert, Manor, Danny, Traber, Maret, Levine, Mark Alan“…We hypothesized that excess liver fat in obesity-associated HS could act as a pathophysiologic chemical depot for fat-soluble vitamins and alter normal physiology. Because clinical trials with Vitamin E (α-T) have shown that NASH partially responds to this supplement, we selected α-T as a model vitamin to test the sequestration hypothesis. …”
Publicado 2020
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341657por Smith, Gabrielle, Liang, Raimunde, Chortis, Vasileios, Khan, Sana, Lippert, Juliane, Hantel, Constanze, Altieri, Barbara, Fassnacht, Martin, Foster, Paul Alexander, Ronchi, Cristina Lucia“…Some PLK1 inhibitors are under evaluation in clinical trials for other solid organ malignancies, and seem to be more effective in TP53 mutated tumours. …”
Publicado 2020
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341658“…Both BET domain and histone deacetylase inhibitors are in clinical trials, and next-generation BET and CDK9 inhibitors have shown preclinical activity. …”
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341659por Dunn, Julia Passyn, Lamicchane, Bidhan, Braver, Todd, Hershey, Tamara, Klein, Samuel“…A total of 5 runs, each with 24 trials were completed. Imaging analyses included preprocessing with fMRIprep including censoring excessive motion ≥ 0.5mm. …”
Publicado 2020
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341660por Solocinski, Kristen, Padget, Michelle R, Fabian, Kellsye P, Wolfson, Benjamin, Cecchi, Fabiola, Hembrough, Todd, Benz, Stephen C, Rabizadeh, Shahrooz, Soon-Shiong, Patrick, Schlom, Jeffrey, Hodge, James W“…The data presented here provide an additional mechanism of action for haNK cells that are currently being evaluated in clinical trials for several tumor types.…”
Publicado 2020
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