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341901por Granata, Vincenza, Grassi, Roberta, Fusco, Roberta, Belli, Andrea, Palaia, Raffaele, Carrafiello, Gianpaolo, Miele, Vittorio, Grassi, Roberto, Petrillo, Antonella, Izzo, Francesco“…RESULTS: We found 30 studies (14 studies for RFA, 3 for microwave therapy, 10 for IRE, and 3 for electrochemotherapy), comprising 1047 patients, which were analysed further. Two randomized trials were found for IRE. Percutaneous and laparotomy approaches were performed. …”
Publicado 2021
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341902por Rapin, Lucile, Gamaoun, Rihab, El Hage, Cynthia, Arboleda, Maria Fernanda, Prosk, Erin“…Within the limited results from randomized controlled trials, and lack of trust in product quality and known clinical guidelines and dosages, real-world evidence (RWE) from countries with robust regulatory frameworks may fill a critical need for patients and healthcare professionals. …”
Publicado 2021
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341903“…Methods: A retrospective analysis of 199 eyes of 120 patients (63 male, 57 female) of the Erlanger Glaucoma Registry (EGR; ClinicalTrials.gov Identifier: NCT00494923; ISSN 2191-5008, CS-2011) was performed considering systemic therapy with statins, ASS or a combination of both: 107 eyes with ocular hypertension (OHT) and 92 eyes with pre-perimetric primary open-angle glaucoma (pre-POAG). …”
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341904por Velasco Bohórquez, Pilar, Rucco, Roberta, Zubizarreta-Macho, Álvaro, Montiel-Company, José María, de la Vega Buró, Susana, Madroño, Esther Cáceres, Marín, Lara San Hipólito, Hernández Montero, Sofía“…Results: Four randomized controlled trials, five prospective clinical studies, four retrospective studies, and three case series were included in the meta-analysis. …”
Publicado 2021
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341905por Hartikainen, Jani, Haapala, Eero A., Poikkeus, Anna-Maija, Lapinkero, Eero, Pesola, Arto J., Rantalainen, Timo, Sääkslahti, Arja, Gao, Ying, Finni, Taija“…Longitudinal studies utilizing randomized controlled trials are warranted.…”
Publicado 2021
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341906por Liu, Kang, Qin, Zhongke, Xu, Xueqiang, Li, Ting, Ge, Yifei, Mao, Huijuan, Xing, Changying“…METHODS: We carried out a network meta-analysis of randomized controlled trials (RCTs) to compare the risk of RAEs between ICI-based regimens and traditional cancer therapy, including chemotherapy and targeted therapy. …”
Publicado 2021
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341907por Olsen, T. Anders, Martini, Dylan J., Goyal, Subir, Liu, Yuan, Evans, Sean T., Magod, Benjamin, Brown, Jacqueline T., Yantorni, Lauren, Russler, Greta Anne, Caulfield, Sarah, Goldman, Jamie M., Harris, Wayne B., Kucuk, Omer, Carthon, Bradley C., Master, Viraj A., Nazha, Bassel, Bilen, Mehmet Asim“…This similarity in survival outcomes is reassuring for the use of ICI amongst real-world patient populations, however, the difference in treatment response is poorly represented in early outcomes data from clinical trials. Thus, the literature requires larger prospective studies to validate these findings.…”
Publicado 2021
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341908por Strik, Myrte, Cofré Lizama, L Eduardo, Shanahan, Camille J, van der Walt, Anneke, Boonstra, Frederique M C, Glarin, Rebecca, Kilpatrick, Trevor J, Geurts, Jeroen J G, Cleary, Jon O, Schoonheim, Menno M, Galea, Mary P, Kolbe, Scott C“…There is thus an urgent need for in vivo markers of axonal loss for use in patient monitoring or as end-points for trials of neuroprotective agents. Advanced diffusion MRI can provide markers of diffuse loss of axonal fibre density or atrophy within specific white matter pathways. …”
Publicado 2021
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341909“…A meta-analysis of case-control and randomized controlled trials (RCTs) was conducted using a random-effects model. …”
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341910por Wang, Yun-Yun, Huang, Qiao, Shen, Quan, Zi, Hao, Li, Bing-Hui, Li, Ming-Zhen, He, Shao-Hua, Zeng, Xian-Tao, Yao, Xiaomei, Jin, Ying-Hui“…Chemoprophylaxis, including SARS-CoV 2 vaccines and antiviral drugs of COVID-19, still require more trials to confirm this.…”
Publicado 2021
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341911por Mbroh, Joshua, Poli, Khouloud, Tünnerhoff, Johannes, Gomez-Exposito, Alexandra, Wang, Yi, Bender, Benjamin, Hempel, Johann-Martin, Hennersdorf, Florian, Feil, Katharina, Mengel, Annerose, Ziemann, Ulf, Poli, Sven“…Limited sample size and few randomized controlled trials (RCTs) with respect to PCLVO make the safety and efficacy of MT, which has been confirmed in ACLVO, difficult to assess in the posterior circulation. …”
Publicado 2021
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341912por Beyene, Yoseph, Gowda, Manje, Pérez-Rodríguez, Paulino, Olsen, Michael, Robbins, Kelly R., Burgueño, Juan, Prasanna, Boddupalli M., Crossa, Jose“…In maize, doubled haploid (DH) line production capacity of large-sized maize breeding programs often exceeds the capacity to phenotypically evaluate the complete set of testcross candidates in multi-location trials. The ability to partially select DH lines based on genotypic data while maintaining or improving genetic gains for key traits using phenotypic selection can result in significant resource savings. …”
Publicado 2021
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341913por Hang, Xiaoyi, Zhang, Yijie, Li, Jingjing, Li, Zhenzhen, Zhang, Yi, Ye, Xuanhao, Tang, Qisheng, Sun, Wenjun“…Methods: To identify eligible randomized clinical trials, four databases (i.e, the Cochrane Library, Web of Science, PubMed and Embase) were searched from inception date to May 31, 2020. …”
Publicado 2021
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341914por Zhang, Dafang, Heyworth, Benton E., Liotta, Elizabeth S., Hergott, Katelyn A., Earp, Brandon E.“…While adolescent midshaft clavicle fractures have historically been treated nonoperatively, recent randomized controlled trials of displaced midshaft clavicle fractures in the adult literature have raised the question of decreased symptomatic nonunion and malunion and improved functional outcomes with surgery. …”
Publicado 2021
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341915por Grifell, Marc, Mir Fuster, Guillem, Ventura Vilamala, Mireia, Galindo Guarín, Liliana, Carbón Mallol, Xoán, Hart, Carl L, Pérez Sola, Víctor, Colom Victoriano, Francesc“…This will allow bridging an evidence gap between online surveys, which do not provide substance confirmation, and clinical trials, which are too slow and expensive to keep up with the new substances appearing every week. …”
Publicado 2021
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341916por Boonpheng, Boonphiphop, Hansrivijit, Panupong, Thongprayoon, Charat, Mao, Shennen A, Vaitla, Pradeep K, Bathini, Tarun, Choudhury, Avishek, Kaewput, Wisit, Mao, Michael A, Cheungpasitporn, Wisit“…Inclusion criteria were: Original, published, randomized controlled trials or cohort studies (either prospective or retrospective), case–control, or cross-sectional studies; inclusion of odds ratio, relative risk, and standardized incidence ratio with 95% confidence intervals (CI), or sufficient raw data to calculate these ratios; and subjects without interventions (controls) being used as comparators in cohort and cross-sectional studies. …”
Publicado 2021
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341917“…In this study, we conduct a meta-analysis of randomized controlled trials (RCTs) to explore the superior anaesthetic for breast cancer surgery patients. …”
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341918por Attia, Ahmed Khalil, Taha, Tarek, Mahmoud, Karim, Hunt, Kenneth J., Labib, Sameh A., d’Hooghe, Pieter“…The operative time, complication rate, talar tilt, and anterior drawer tests were excellent and statistically comparable. Long-term clinical trials are required before recommending arthroscopic Broström as the new gold standard.…”
Publicado 2021
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341919“…We collated vitamin D(3) and 25(OH)D(3) plasma PK data from reported clinical trials and developed a physiologically‐based pharmacokinetic (PBPK) model to appropriately recapitulate training data. …”
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341920“…METHODS: Data were pooled from two randomised controlled phase 3 trials (AMAGINE-2 and -3) which included patients with moderate-to-severe plaque psoriasis treated with brodalumab 210 mg or ustekinumab 45 or 90 mg for 52 weeks. …”
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