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  1. 342081
    “…Recent shifts towards “test and treat” strategies have potential to reduce transmission in this age group but have not been widely studied outside of clinical trials. Using data from nationwide surveillance among pregnant women in Botswana, where a “test and treat” program was implemented in 2016, we describe trends in HIV prevalence over time and highlight opportunities for targeted prevention. …”
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    Cross‐sectional trends in HIV prevalence among pregnant women in Botswana: an opportunity for PrEP?
  2. 342082
    “…Finally, we discuss the future implications of this understanding from a therapeutic standpoint and in light of currently ongoing and completed CAF-based NIH clinical trials.…”
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    Bête Noire of Chemotherapy and Targeted Therapy: CAF-Mediated Resistance
  3. 342083
    “…Proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2RAs) are routinely used for stress ulcer prophylaxis in burn patients, however there are few comparative trials evaluating the efficacy of these therapies in the burn population. …”
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    703 Evaluation of a Stress Ulcer Prophylaxis Protocol in an Burn Intensive Care Unit
  4. 342084
    “…Due to these reasons, transbronchial cryobiopsy guided by RP-EBUS and fluoroscopy in peripheral lung lesions are under active investigation, but still, there is limited data as only a few clinical trials of transbronchial cryobiopsy are published around the world. …”
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    Diagnostic Yield of Transbronchial Cryobiopsy Guided by Radial Endobronchial Ultrasound and Fluoroscopy in the Radiologically Suspected Lung Cancer: A Single Institution Prospective Study
  5. 342085
    “…Introduction: There is clear evidence of a significant reduction in all major cardiovascular adverse events (MACE) by coronary artery bypass grafting (CABG) in left main coronary artery stenosis (LMCS), but revascularization by percutaneous coronary artery intervention (PCI) shows an increasingly important role as an alternative to CABG. Several recent trials aiming to test the difference in mortality between the two types of revascularization found conflicting data. …”
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    Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting for Non-Protected Left Main Coronary Artery Disease: 1-Year Outcomes in a High Volume Single Center Study
  6. 342086
    “…Future randomized control trials are needed for intensive studies on physical and neuropsychological prognosis in TBI patients.…”
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    Decompressive Craniectomy vs. Craniotomy Only for Traumatic Brain Injury: A Propensity-Matched Study of Long-Term Outcomes in Neuropsychology
  7. 342087
    “…PATIENTS AND METHODS: Participants with stage I-III breast cancer were prospectively included from CANTO (ClinicalTrials.gov identifier: NCT01993498), collecting longitudinal data at diagnosis (before the initiation of any cancer treatment) and 1 (T1), 2 (T2), and 4 (T3) years after diagnosis. …”
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    Development and Validation of a Predictive Model of Severe Fatigue After Breast Cancer Diagnosis: Toward a Personalized Framework in Survivorship Care
  8. 342088
    “…As these patients were originally not included in the registration trials, fear related to vaccine adverse events and disease worsening was one of the reasons for vaccine hesitancy. …”
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    mRNA-COVID19 Vaccination Can Be Considered Safe and Tolerable for Frail Patients
  9. 342089
    “…METHODS: We systematically searched several electronic databases for randomized controlled trials (RCTs) published from inception until January 25, 2022 with no language restriction. …”
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    Effects of Antidiabetic Drugs on Endothelial Function in Patients With Type 2 Diabetes Mellitus: A Bayesian Network Meta-Analysis
  10. 342090
    “…The putative targets identified could be validated through clinical trials.…”
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    Potential Therapeutic Targets of Rehmannia Formulations on Diabetic Nephropathy: A Comparative Network Pharmacology Analysis
  11. 342091
    “…DESIGN: Systematic review and meta-analysis of randomised controlled trials and non-randomised studies of interventions. …”
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    Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain: systematic review and meta-analysis
  12. 342092
    “…Only randomized controlled trials (RCT) where participants increased their daily protein intake and were healthy and non‐obese adults were included. …”
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    Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults
  13. 342093
    “…METHODS: Patients diagnosed with coronary heart disease and participated in drug-eluting stent (DES) clinical trials for stent implantation in a single center were included for this retrospective analysis. …”
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    Prognostic Value of Coronary Angiography-Derived Fractional Flow Reserve Immediately After Stenting
  14. 342094
    “…These comprised three randomized controlled trials and three retrospective studies. Enhanced recovery care group was associated with decreased hospital stay [standard mean difference (SMD) = −0.56, 95% confidence interval (CI) = −0.83~−0.28, p < 0.0001], shorter duration to functional recovery (SMD = −1.14, 95% CI = −1.92~−0.37, p = 0.004), and lower cost of hospitalization Mean Difference (MD) = −1,539.62, 95% CI = −1992.85~−1086.39, p < 0.00001). …”
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    Enhanced Recovery Care vs. Traditional Care in Laparoscopic Hepatectomy: A Systematic Review and Meta-Analysis
  15. 342095
    “…INCLUSION CRITERIA: All randomised controlled trials (RCTs) comparing DZC with placebo on the occurrence rate and severity of OIC. …”
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    Efficacy of dezocine on preventing opioid-induced cough during general anaesthesia induction: a PRISMA-compliant systematic review and meta-analysis
  16. 342096
    “…We searched Embase, Medline, Web of Science Core Collection, and Cochrane Central Register of controlled Trials, CINAHL and Google Scholar in December 2020 using a combination of MeSH terms and specific index terms related to orthopedic fractures and PROMIS questionnaires. …”
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    There are more things in physical function and pain: a systematic review on physical, mental and social health within the orthopedic fracture population using PROMIS
  17. 342097
    “…METHODS: A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and using the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases. Inclusion criteria were English-language articles that compared functional outcomes after screw fixation versus suture fixation for tibial avulsion fractures and had at least 1-year follow-up. …”
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    Functional Outcomes and Subsequent Surgical Procedures After Arthroscopic Suture Versus Screw Fixation for ACL Tibial Avulsion Fractures: A Systematic Review and Meta-analysis
  18. 342098
    “…In the case of primary failure on a first TNFi, it seems reasonable to switch to another class of drugs, i.e., an anti-IL-17 agent, as phase III trials showed that the response to IL-17 blockade was higher than to placebo in patients previously exposed to TNFi. …”
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    Treatment Failure in Axial Spondyloarthritis: Insights for a Standardized Definition
  19. 342099
    “…However, while prospective clinical trials have confirmed the benefit of including those agents into the regimes for advanced CRC, disease progression or therapy-related toxicities might require physicians to switch from anti-EGFR-based therapies to alternative treatments. …”
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    Anti-EGFR Reintroduction and Rechallenge in Metastatic Colorectal Cancer (mCRC): A Real-World Analysis
  20. 342100
    “…In addition to a low complication rate, significant improvement in pain score and radiographic parameters at final follow up were demonstrated. Future randomized trials with long term follow up are needed to validate the outcomes of minimally invasive techniques.…”
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    Early outcomes of Minimally Invasive Percutaneous Chevron/Akin Osteotomy for Symptomatic Hallux Valgus Deformity
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