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342241“…Future studies should conduct randomized controlled trials with clinical samples and assess clinical outcomes.…”
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342242por Schönecker, Sonja, Martinez-Murcia, Francisco J., Rauchmann, Boris-Stephan, Franzmeier, Nicolai, Prix, Catharina, Wlasich, Elisabeth, Loosli, Sandra V., Bochmann, Katja, Gorriz Saez, Juan-Manuel, Laforce, Robert, Ducharme, Simon, Tartaglia, Maria Carmela, Finger, Elizabeth, de Mendonça, Alexandre, Santana, Isabel, Sanchez-Valle, Raquel, Moreno, Fermin, Sorbi, Sandro, Tagliavini, Fabrizio, Borroni, Barbara, Otto, Markus, Synofzik, Matthis, Galimberti, Daniela, Vandenberghe, Rik, van Swieten, John, Butler, Christopher, Gerhard, Alexander, Graff, Caroline, Danek, Adrian, Rohrer, Jonathan D., Masellis, Mario, Rowe, James, Levin, Johannes“…These clinicogenetic associations can guide diagnostic evaluations and the design of clinical trials for new disease-modifying and preventive treatments.…”
Publicado 2022
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342243por Estabrooks, Carole, Song, Yuting, Anderson, Ruth, Beeber, Anna, Berta, Whitney, Chamberlain, Stephanie, Cummings, Greta, Duan, Yinfei, Hayduk, Leslie, Hoben, Matthias, Iaconi, Alba, Lanham, Holly, Perez, Janelle, Wang, Jing, Norton, Peter“…TREC data include the following: 5 waves of survey collection, 2 clinical trials, and regular ongoing outcome data for LTC residents. …”
Publicado 2022
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342244“…IMPORTANCE: Observational comparative effectiveness studies can inform the positioning of biologic therapies for older patients with inflammatory bowel disease (IBD) who are underrepresented in clinical trials. OBJECTIVE: To compare the effectiveness and safety of vedolizumab vs tumor necrosis factor (TNF) for older patients with IBD. …”
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342245“…Randomized controlled trials (RCTs) were included to compare high-intensity and moderate-intensity exercise training on cardiopulmonary function in patients with CAD. …”
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342246“…BACKGROUND: The current out-of-Africa 2022 outbreak of Monkeypox requires a coordinated, international response through the rapid sharing of data and research results, as we have seen with COVID-19 and the previous Ebola and Zika outbreaks, which demonstrated how important real-world data are to inform public health, to create surveillance systems, to determine policy decisions and to improve clinical trials. OBJECTIVES: To support global response efforts by providing public access to real-time Monkeypox-related data for effective use of open data that could accelerate scientific knowledge and discoveries in terms of understanding, preventing, and treating the disease. …”
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342247por Giampaolino, Pierluigi, Cafasso, Valeria, Boccia, Dominga, Ascione, Mario, Mercorio, Antonio, Viciglione, Francesco, Palumbo, Mario, Serafino, Paolo, Buonfantino, Cira, De Angelis, Maria Chiara, Verrazzo, Paolo, Grasso, Giovanna, Gullo, Giuseppe, Bifulco, Giuseppe, Della Corte, Luigi“…Further large series and randomized clinical trials are needed to confirm these results.…”
Publicado 2022
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342248por Báez Gutiérrez, Nerea, Rodríguez Ramallo, Héctor, Fernández González, Marcos, Abdel-Kader Martín, Laila“…None of the included apps proved clinical efficacy through clinical trials in patients with HMs. Statistically significant differences were found in the MARS scores between operating systems (+1.0, P=.003) in favor of iOS apps. …”
Publicado 2022
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342249“…In the zero-set vector analysis, the average change in ΔOxyHb and ΔDeoxyHb concentrations was utilized to calculate the APR percentage in 140 trials. The significant regions (z-score of ≥2.0) of the APR and ΔOxyHb in the task were compared. …”
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342250por Ständer, S., Bhatia, N., Gooderham, M. J., Silverberg, J. I., Thyssen, J. P., Biswas, P., DiBonaventura, M., Romero, W., Farooqui, S. A.“…Not only do a substantial proportion of abrocitinib‐treated patients achieve higher threshold efficacy end points but they also do so in a similar timeframe as the more commonly used thresholds for efficacy end points. CLINICAL TRIALS: NCT02780167, NCT03349060 and NCT03575871.…”
Publicado 2022
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342251por Motzer, Robert J., McDermott, David F., Escudier, Bernard, Burotto, Mauricio, Choueiri, Toni K., Hammers, Hans J., Barthélémy, Philippe, Plimack, Elizabeth R., Porta, Camillo, George, Saby, Powles, Thomas, Donskov, Frede, Gurney, Howard, Kollmannsberger, Christian K., Grimm, Marc‐Oliver, Barrios, Carlos, Tomita, Yoshihiko, Castellano, Daniel, Grünwald, Viktor, Rini, Brian I., McHenry, M. Brent, Lee, Chung‐Wei, McCarthy, Jennifer, Ejzykowicz, Flavia, Tannir, Nizar M.“…Efficacy, safety, and conditional survival outcomes were assessed in CheckMate 214 (ClinicalTrials.gov identifier NCT02231749) with a minimum follow‐up of 5 years. …”
Publicado 2022
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342252por Gauss, Tobias, Richards, Justin E., Tortù, Costanza, Ageron, François-Xavier, Hamada, Sophie, Josse, Julie, Husson, François, Harrois, Anatole, Scalea, Thomas M., Vivant, Valentin, Meaudre, Eric, Morrison, Jonathan J., Galvagno, Samue, Bouzat, Pierre“…CONCLUSIONS AND RELEVANCE: The findings of this study suggest that early norepinephrine infusion was not associated with 24-hour or in-hospital mortality among patients with blunt trauma and hemorrhagic shock. Randomized clinical trials that study the effect of early norepinephrine administration among patients with trauma and hypotension are warranted to further assess whether norepinephrine is safe for patients with hemorrhagic shock.…”
Publicado 2022
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342253por Golhen, Klervi, Winskill, Carolyn, Theiler, Martin, Buettcher, Michael, Yeh, Yu-Hsin, Zhang, Nancy, Welzel, Tatjana, Pfister, Marc“…To better understand the efficacy-safety profile of biologics in children with moderate-to-severe psoriasis, this study aimed to analyze efficacy and safety data of randomized controlled trials (RCTs) performed in pediatric psoriasis and to compare efficacy outcomes in children with those in adults. …”
Publicado 2022
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342254“…PATIENTS AND METHODS: Twenty-nine dialysis patients (mean age 62 years) and 40 diabetic patients (mean age 57 years, 88% type 2) were included in two different single-center open-label uncontrolled clinical trials. All patients presented skin dryness according to the Scaling Roughness Redness and Cracks (SRRC) scale, and pruritus and/or insomnia. …”
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342255por Rana, Ameena, Yu, Siyuan, Reid-Herrera, Savina, Kamen, Scott, Hunter, Krystal, Shaikh, Hamza, Jovin, Tudor, Thon, Olga R., Patel, Parth, Siegler, James E., Thon, Jesse M.“…Randomized prospective trials are needed to determine the safety and efficacy of EPT in this population.…”
Publicado 2022
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342256por Klein, Piers, Shu, Liqi, Nguyen, Thanh N., Siegler, James E., Omran, Setareh Salehi, Simpkins, Alexis N., Heldner, Mirjam, de Havenon, Adam, Aparicio, Hugo J., Abdalkader, Mohamad, Psychogios, Marios, Vedovati, Maria Cristina, Paciaroni, Maurizio, von Martial, Rascha, Liebeskind, David S., de Sousa, Diana Aguiar, Coutinho, Jonathan M., Yaghi, Shadi“…Determining patients at highest risk of poor outcome in CVT could help in clinical decision making and identify patients for targeted therapy in future clinical trials.…”
Publicado 2022
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342257por Menghini, Danilo, Kaushal, Shankar G., Flannery, Sean W., Ecklund, Kirsten, Murray, Martha M., Fleming, Braden C., Kiapour, Ata M., Proffen, Benedikt, Sant, Nicholas, Portilla, Gabriela, Sanborn, Ryan, Freiberger, Christina, Henderson, Rachael, Barnett, Samuel, Yen, Yi-Meng, Kramer, Dennis E., Micheli, Lyle J.“…REGISTRATION: NCT 02664545 (ClinicalTrials.gov identifier).…”
Publicado 2022
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342258por BECKWÉE, David, CUYPERS, Lotte, LEFEBER, Nina, DE KEERSMAECKER, Emma, SCHEYS, Ellen, VAN HEES, Wout, PERKISAS, Stany, DE RAEDT, Sylvie, KERCKHOFS, Eric, BAUTMANS, Ivan, SWINNEN, Eva“…Longitudinal cohort studies or controlled interventional trials that report data about patients in the first 3 months after stroke were identified. …”
Publicado 2022
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342259por Carballo, Nuria, Pérez García, Carolina, Grau, Santiago, Monfort, Jordi, Durán-Jordà, Xavier, Echeverría-Esnal, Daniel, Ferrández, Olivia“…Although several randomized clinical trials have confirmed that there is no difference in efficacy between etanercept and its biosimilar versions in the treatment of rheumatoid arthritis (RA), limited real-world evidence is available. …”
Publicado 2022
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342260por Pulavarty, Anusha, Singh, Ankit, Smyth, David, Mehta, Jai Prakash, Horgan, Karina, Kakouli-Duarte, Thomais“…In laboratory tests, effectiveness of the MFPs was recorded in terms of PCN juveniles (J2) hatching from cysts, J2 mortality and their attraction toward potato roots using pluronic gel. Greenhouse trials were conducted to study the effect of the products on PCN infestation in potato plants and a pilot scale experiment was conducted to study the impact of these MFPs on nematode biodiversity in garden soil. …”
Publicado 2022
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