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  1. 342281
    “…Participants were recruited from prior clinical trials where amyloid beta status (97 amyloid positive, 103 amyloid negative, as established via PET or CSF test) and clinical diagnostic status was known (94 cognitively unimpaired, 106 with mild cognitive impairment or mild Alzheimer’s disease). …”
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    Leveraging speech and artificial intelligence to screen for early Alzheimer’s disease and amyloid beta positivity
  2. 342282
    “…BACKGROUND: Over the past decade, antiretroviral therapy (ART) regimens that include integrase strand inhibitors (INSTIs) have become the most commonly used for people with HIV starting ART. Although trials and observational studies have compared virological failure on INSTI-based with other regimens, few data are available on mortality in people with HIV treated with INSTIs in routine care. …”
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    Associations of modern initial antiretroviral drug regimens with all-cause mortality in adults with HIV in Europe and North America: a cohort study
  3. 342283
    “…METHODS: Randomized controlled trials (RCTs) of HRW and pure water (PW) in the treatment of periodontal diseases published before March 2022 in the PubMed, Web of science, EMBASE, Cochrane, China Knowledge Resource Integrated, Wanfang, and Weipu databases were searched. …”
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    Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis
  4. 342284
    “…This study takes advantage of the BraTIoUS international database (ClinicalTrials.gov Identifier: NCT05062772), which is an international collaborative database of brain tumor IOUS images where MicroV images are stored and retrieved along with B-Mode images in order to be further analyzed by collaborating institutions. …”
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    Intraoperative Evaluation of Brain-Tumor Microvascularization through MicroV IOUS: A Protocol for Image Acquisition and Analysis of Radiomic Features
  5. 342285
    “…However, despite encouraging activity in preclinical models, clinical trials with TRAIL mimetics/death receptor agonists demonstrated insufficient activity, largely due to emerging resistance to these agents. …”
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    Activity and rational combinations of a novel, engineered chimeric, TRAIL-based ligand in diffuse large B-cell lymphoma
  6. 342286
    “…Over half (54.5%) of all trials were less than 100N (57.8% of surgeons, 51.8% trainees). …”
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    The Lateral Fibular Stress Test: High Variability of Force Applied May Lead to Under-Detection of Syndesmotic Instability
  7. 342287
    “…To investigate benefits and risks, randomized and quasi-randomized trials comparing oxytocin augmentation with placebo or no oxytocin were included. …”
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    Labor augmentation with oxytocin in low- and lower-middle-income countries: a systematic review and meta-analysis
  8. 342288
    “…The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. …”
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    Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals
  9. 342289
    “…METHODS: A prospective, single-arm, pre- (2016) and post-(2019) coverage survey (ClinicalTrials.gov #NCT02506413) was used to assess key maternal and newborn health (MNH) outcomes. …”
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    Evaluation of a comprehensive maternal newborn health intervention in rural Tanzania: single-arm pre-post coverage survey results
  10. 342290
    “…These patients often do not meet inclusion criteria for clinical trials, meaning clinical and virologic characteristics, and optimal management strategies are poorly evidence-based. …”
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    Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review
  11. 342291
    “…Results: We included 30 randomized controlled trials that included 13 interventions (TXA, EPO, progesterone, progesterone + vitamin D, atorvastatin, beta-blocker therapy, Bradycor, Enoxaparin, Tracoprodi, dexanabinol, selenium, simvastatin, and placebo). …”
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    Effect of drug therapy on nerve repair of moderate-severe traumatic brain injury: A network meta-analysis
  12. 342292
    “…These data support further evaluation of CRh into future response criteria and clinical trials.…”
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    Evaluating complete remission with partial hematologic recovery (CRh) as a response criterion in myelodysplastic syndromes (MDS)
  13. 342293
    “…Studies were eligible if they (1) were randomized controlled trials (RCTs) or pre-post studies of app-based interventions for adults (aged 18 years or above) with prehypertension or hypertension, without consideration of gender or sociodemographic characteristics; (2) used mobile phone apps alone or combined with another component, such as communication with others; (3) used or did not use any comparator; and (4) had the primary outcome measures of BP level and adherence to the DASH diet. …”
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    The Use of Dietary Approaches to Stop Hypertension (DASH) Mobile Apps for Supporting a Healthy Diet and Controlling Hypertension in Adults: Systematic Review
  14. 342294
    “…New-user studies and randomized trials are needed to assess early outpatient treatment and post-exposure prophylaxis with therapeutics that are safe in adults, children, pregnancy and available worldwide.…”
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    Diabetes medications and associations with Covid-19 outcomes in the N3C database: A national retrospective cohort study
  15. 342295
    por Li, Xiaoming, Yang, Xia, Ning, Zong
    Publicado 2022
    “…METHODS: Various academic databases were searched comprehensively for randomized controlled trials (RCTs) related to COVID-19 inactivated vaccines. …”
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    Efficacy and safety of COVID-19 inactivated vaccine: A meta-analysis
  16. 342296
    “…Taken together, our findings complement the mutation spectrum of DMD/BMD, benefit us understanding to the DMD disease, and lay foundations for the clinical trials.…”
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    Clinical and genetic characteristics of Chinese Duchenne/Becker muscular dystrophy patients with small mutations
  17. 342297
    “…Alzheimer’s disease biomarkers are becoming increasingly important for characterizing the longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and for recruitment and treatment monitoring in clinical trials. In this work, we develop and evaluate three methods for modelling the longitudinal course of amyloid accumulation in three cohorts using amyloid PET imaging. …”
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    Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts
  18. 342298
    “…METHODS: Literature search within PubMed, EMBASE, Web of Science, and Cochrane Library for observational studies and clinical trials that evaluated the effect of vedolizumab on GI-aGVHD was done through 17 May 2022. …”
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    Vedolizumab for acute gastrointestinal graft-versus-host disease: A systematic review and meta-analysis
  19. 342299
    “…Methods: Forty-eight medically healthy outpatients diagnosed with MDD were enrolled in one of two groups in two sequentially conducted clinical trials. In Group-E, patients received a 12-week regimen of escitalopram (n = 20). …”
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    Cardiolipin Antibody: A Potential Biomarker for Depression
  20. 342300
    “…Although our results demonstrated correlation, causality can only be assessed using studies with limited confounding factors, such as clinical trials. Our outcomes suggest that physicians should pay attention not only to the location of the fracture, but also past medical history and medication use when making treatment decisions and discussing prognosis with patients.…”
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    Determining the Key Predictive Factors for Non-Union in Fifth Metatarsal Fractures: A Machine Learning-Based Study
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