“…The evaluation of CDK4/6i in the real-world facilitates treatment planning, insights into the incidence of drug toxicities, dose modifications including dose delays (DDs) and dose reductions (DRs) and improves prognostic accuracy in subgroups, for example geriatric patients, who are under-represented in clinical trials. METHODS: This multi-centre study analysed retrospective and prospective data from 456 patients treated with CDK4/6i between January 2015 and December 2020. …”
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“…We propose that NEO212 should be developed further and evaluated in clinical trials with AML patients. ABSTRACT: Many patients with acute myeloid leukemia (AML) are still dying from this disease. …”
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“…Future high-quality randomized trials are needed to further elucidate the interaction between COVID-19 and hepatitis B.…”
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“…In particular, in in vitro tests, at the highest concentration and exposure time, the whole plant and the leaf, achene and flower fractions returned acaricidal efficacies of 56% (flowers), 52% (achenes), 64% (leaves) and 68% (whole plant). In the semi-field trials, the EO of the whole plant at the highest concentration caused the death of 53% of the mites exposed to the vapours. …”
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“…Clinical trials have demonstrated the health benefits of intermittent fasting (IF). …”
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“…OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to assess the efficacy of internet-based ACT (iACT) for depressive symptoms, anxiety, stress, psychological distress, and quality of life (QoL). …”
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“…METHOD: We searched MEDLINE, Embase, the Cochrane Library, CINAHL, and PsycINFO from inception until August 2022 to identify randomized clinical trials (RCTs) evaluating treatments for depressive symptoms in cognitive impairment. …”
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“…Overall, our analysis points to the need for clinical trials on HFRT/SBRT for the treatment of these rare malignancies.…”
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“…OBJECTIVE: It is unclear whether aggressive treatment would benefit lupus nephritis (LN) with poor renal function, which has been excluded from most clinical trials. We aimed at demonstrating their clinicopathological features and prognosis. …”
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“…METHODS: Data from the open-label extension periods of the BLISS-52 and BLISS-76 trials of belimumab in SLE (NCT00724867; NCT00712933) were used (N = 973). …”
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“…Corresponding prognostic models help forecast the prognosis of STAD patients. m6A-genes and associated immune cell infiltration in the tumor microenvironment (TME) may serve as potential therapeutic targets in STAD, which requires further trials. In addition, the m6a-related gene signature offers a viable alternative to predict bladder cancer, and these m6A-genes show a prospective research area for STAD targeted treatment in the future.…”
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“…ABSTRACT: Purpose: Planning target volume (PTV) expansion for post-prostatectomy radiotherapy is typically ≥5 mm. Recent clinical trials have proved the feasibility of a reduced margin of 2–3 mm for treatments on MRI-linac. …”
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“…In addition, randomized controlled trials (RCT) were also included. A risk-of-bias assessment, with the revised Cochrane risk-of-bias tool regarding RCT and probability-based ranking, was established based on the surface under the cumulative rank (SUCRA) method via network meta-analysis. …”
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“…This hypothesis should be tested in future prospective clinical trials. ABSTRACT: The standard of care for metastatic disease is systemic therapy. …”
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“…Additionally, we collected randomized controlled trials (RCTs) on Google Scholar using the snowball technique. …”
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“…RESULTS: Of 180 studies that passed the search logic, 31 (17.2%) satisfied the inclusion criteria (6 randomized controlled trials, 4 purely quantitative studies, 9 focus groups, 2 observational studies, and 10 mixed methods studies). …”
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“…The muscle tissue O(2) saturation index did not differ between trials (P > 0.05). Ischaemic preconditioning expedited [Formula: see text] kinetics and appeared to prevent an increase in leak respiration through CI, when expressed proportional to E and P evoked by severe‐intensity exercise, but did not improve exercise performance.…”
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“…Therefore, these patients may be eligible for inclusion in future basket trials and future treatment regimens tailored to the more frequently occurring HPV‐positive carcinomas of other locations. …”
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“…Corresponding prognostic models help forecast the prognosis of LIHC patients. m7G-related genes and associated immune cell infiltration in the TME may serve as potential therapeutic targets in LIHC, which requires further trials. In addition, the m7G-related gene signature offers a viable alternative to predict LIHC, and these m7G-related genes show a prospective research area for LIHC targeted treatment in the future.…”
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“…However, these promising findings need to be confirmed in future clinical trials.…”
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