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  1. 342421
    “…CONCLUSIONS: Our work demonstrates the value of identifying HRD for therapeutic targeting by PARPi and platinum in individuals with the aggressive rare malignancy, uLMS and suggests that individuals with HRD uLMS should be included in trials of PARP1-specific PARPi. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-023-02687-0.…”
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    Targeting homologous recombination deficiency in uterine leiomyosarcoma
  2. 342422
    “…Our findings thus reinforce calls to better contextualize the relationship between FGM/C and measures of health and well-being among Somali women in the United States (regardless of their FGM/C status), taking psychosocial factors more centrally into account. Clinical Trials.Gov ID no. NCT03249649, Study ID no. 5252. …”
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    Health outcomes and female genital mutilation/cutting: how much is due to the cutting itself?
  3. 342423
    “…Cochrane Library, Embase, PubMed/MEDLINE, PsycINFO/PsycNet, LILACS/BVS, ERIC (ProQuest), Web of Science, OpenGrey, and Google Scholar were searched for randomized clinical trials published until March 2022, without time or language restrictions. …”
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    Effectiveness of training programs based on mindfulness in reducing psychological distress and promoting well-being in medical students: a systematic review and meta-analysis
  4. 342424
    “…There were few randomized controlled trials (n = 6; 18.2%), and tasks were mostly shifted for hypertension (n = 27; 81.8%) than for diabetes (n = 16; 48.5%). …”
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    Task shifting roles, interventions and outcomes for kidney and cardiovascular health service delivery among African populations: a scoping review
  5. 342425
    “…METHODS: A search of MEDLINE/PubMed, Cochrane Library, Embase and DOSS was conducted in March 2021 to identify randomized controlled trials (RCTs) using BG in the treatment of intrabony and furcation defects. …”
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    Bioactive glass for periodontal regeneration: a systematic review
  6. 342426
    “…RT/TMZ/PL or RT/TMZ/PL/αPD1 exacts effective immune cure in refractory GBM, deserving a priority for clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-023-02686-1.…”
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    Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8(+)-T cell immunity
  7. 342427
    por He, Yuewen, Zhuang, Xuhui, Liu, Hao, Ma, Wuhua
    Publicado 2023
    “…RESULTS: This NMA included 23 randomized controlled trials (RCTs) with 5774 patients. With NIV as the control, the HFNC_high group was significantly associated with lower intubation rates (odds ratio [OR] 0.72 95% credible interval [CrI] 0.56 to 0.93; moderate quality evidence) and short-term mortality (OR 0.81 95% CrI 0.69 to 0.96; moderate quality evidence). …”
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    Comparison of the efficacy and comfort of high-flow nasal cannula with different initial flow settings in patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis
  8. 342428
    “…METHODS: Pubmed, Embase, and Cochrane Library of Clinical Trials were searched from inception until August 2022. …”
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    Effect of pharmacogenomics testing guiding on clinical outcomes in major depressive disorder: a systematic review and meta-analysis of RCT
  9. 342429
    “…METHODS: We performed a phase 1b observational study (ClinicalTrials.gov ID NCT04542291; registered 09/09/2020) to test the safety and tolerability of dapagliflozin (5 mg p.o.…”
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    Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study
  10. 342430
    “…Randomized controlled trials are needed to verify our finding.…”
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    Comparison of antibiotic-impregnated bone cement coverage versus vacuum sealing drainage in semi-open bone grafting using for tibial fracture with infected bone and soft tissue defect: a retrospective analysis
  11. 342431
    “…BACKGROUND: Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. …”
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    Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
  12. 342432
    por Tang, Zijiao, Liu, Lu, Borlak, Jürgen
    Publicado 2023
    “…CONCLUSION: The combined decitabine/PBA/THU drug treatment improved drug potency considerably, and given their existing regulatory approval, our findings merit prospective clinical trials for the triple combination in COAD patients. …”
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    Combined inhibition of histone deacetylase and cytidine deaminase improves epigenetic potency of decitabine in colorectal adenocarcinomas
  13. 342433
    “…Although clinical studies and trials have shown that patients can benefit significantly after PD-1/PD-L1 blocking therapy, less than 20% of patients can benefit from ICIs therapy due to tumor heterogeneity and the complexity of immune microenvironment. …”
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    ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma
  14. 342434
    “…These results may be useful in improving disease stratification for future clinical trials and may help in clinical decision-making. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10979-z.…”
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    Circulating tumor cells (CTCs) and hTERT gene expression in CTCs for radiotherapy effect with lung cancer
  15. 342435
    “…METHODS: We will include randomized controlled trials (RCT) found through three search strategies, (i) exploratory, (ii) systematic, and (iii) other known sources. …”
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    The effectiveness of spinal manipulative therapy procedures for spine pain: protocol for a systematic review and network meta-analysis
  16. 342436
    “…Patients with better prognoses were more likely operated after chemoradiation, although there is no evidence of OS benefit in previous randomized trials. On the other hand, the prognosis was poor for patients with poor general health and advanced cancers, despite the chemoradiation. …”
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    Chemoradiation for oesophageal cancer: the choice of treatment modality
  17. 342437
    “…There is significant overlap in physiological parameters for mobilisation versus non-mobilisation groups, suggesting a comprehensive physiological assessment is vital in decision making rather than relying on arbitrary time points. Clinical Trials registration: NCT05281705 Registered March 16, 2022. …”
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    Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK
  18. 342438
    “…This finding may have significant impact on the design of clinical trials with disease modifying therapies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-023-01251-4.…”
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    APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia
  19. 342439
    “…METHODS: A broad SLR was conducted to identify randomised controlled trials to ensure all relevant potential comparators were captured. …”
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    Efficacy and Safety of Brolucizumab, Aflibercept, and Ranibizumab for the Treatment of Patients with Visual Impairment Due to Diabetic Macular Oedema: A Systematic Review and Network Meta-Analysis
  20. 342440
    “…Relevant English and Chinese literature were searched in the PubMed, Embase, Cochrane Central Register of Controlled Trials (COCHRANE), CNKI, WanFang Data, and VIP databases between January 1st, 1990 and April 18th, 2023, and the references of the included articles and relevant systematic reviews were reviewed to determine whether studies were missed. …”
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    Pregnancy feasibility in women with mild pulmonary arterial hypertension: a systematic review and meta-analysis
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