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  1. 342481
    “…Identifying high-risk individuals will amplify prevention efforts and selection for clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12911-023-02244-x.…”
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    Dementia prediction in the general population using clinically accessible variables: a proof-of-concept study using machine learning. The AGES-Reykjavik study
  2. 342482
    “…Studies were included if they were randomized control trials (RCTs) assessing a non-pharmacological intervention in adults with MS and measured QoL using the MSQOL-54, SF-36 or MSQLI tools for at least two time points. …”
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    A systematic review and meta-analysis of the effects of non-pharmacological interventions on quality of life in adults with multiple sclerosis
  3. 342483
    “…CASE PRESENTATION: In this case series, we report on four cases with non-tuberculosis abnormalities detected on CXR in TB TRIAGE + ACCURACY (ClinicalTrials.gov Identifier: NCT04666311), a study in adult presumptive tuberculosis cases at health facilities in Lesotho and South Africa to determine the diagnostic accuracy of two potential tuberculosis triage tests: computer-aided detection (CAD4TB v7, Delft, the Netherlands) and C-reactive protein (Alere Afinion, USA). …”
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    Incidental radiological findings during clinical tuberculosis screening in Lesotho and South Africa: a case series
  4. 342484
    “…Determining these predictors is an important step toward future randomized controlled trials to establish the efficacy of these interventions. …”
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    Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study
  5. 342485
    “…It is noteworthy that total neoadjuvant therapy (TNT) is predominantly performed outside of clinical trials. Moreover, across the centers, there is significant heterogeneity in handling clinical complete response and adopting the “watch and wait” approach. …”
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    A contemporary assessment of total neoadjuvant therapy (TNT) protocols for locally advanced rectal cancer: adoption and expert perspectives at German Cancer Society (DKG)-certified colorectal cancer centers
  6. 342486
    “…There were no controlled multi-armed trials. However, we provide observations comparing two interventional therapies (alloHSCT and arsa-cel) and each of these to standard/supportive care (natural history). …”
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    A systematic review of clinical effectiveness and safety for historical and current treatment options for metachromatic leukodystrophy in children, including atidarsagene autotemcel
  7. 342487
    “…CONCLUSION: This study provides information to understand the metabolism of zanubrutinib with concurrent use with isavuconazole or fluconazole, and further clinical trials are needed to validate the results in animals.…”
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    A novel UHPLC‒MS/MS method for quantitative analysis of zanubrutinib in rat plasma: application to an in vivo interaction study between zanubrutinib and triazole antifungal
  8. 342488
    “…METHODS: We initially identified relevant studies from previous meta-analyses and then conducted a comprehensive search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases to locate additional studies published between February 2020 and September 2021. …”
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    Comparative efficacy and safety of different combinations of three CDK4/6 inhibitors with endocrine therapies in HR+/HER-2 − metastatic or advanced breast cancer patients: a network meta-analysis
  9. 342489
    “…Future studies should account for the influences of the neighborhood environment to stimulate equitable improvements in adolescent health. CLINICAL TRIALS REGISTRATION: # NCT02784509.…”
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    An examination of the relationships between the neighborhood social environment, adiposity, and cardiometabolic disease risk in adolescence: a cross-sectional study
  10. 342490
    “…Two independent researchers performed an assessment of the methodological quality of trials according to the Newcastle–Ottawa scale and extracted data strictly based on the inclusion and exclusion criteria, and afterward, we carried out a meta-analysis using Stata 16.0. …”
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    Genital mycoplasma infection: a systematic review and meta-analysis
  11. 342491
    “…This persistently high mortality during the 5th Omicron wave highlights the importance of including older patients in clinical trials to confirm the benefit/risk balance of COVID-19 treatments in this fragile population. …”
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    In-hospital mortality of older patients with COVID-19 throughout the epidemic waves in the great Paris area: a multicenter cohort study
  12. 342492
    “…Further bioavailability, PK/PD and clinical trials are still needed to determine the final dosage regimen.…”
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    Development of an amoxicillin-radix scutellaria extract formulation and evaluation of its pharmacokinetics in pigs
  13. 342493
    “…Landmark studies such as the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation and Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation trials have shown conflicting results with respect to all-cause death and heart failure rehospitalisations. …”
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    One-year real-world outcomes for patients undergoing transcatheter mitral valve repair: the Gulf MTEER registry (GULF Mitral Transcatheter Edge to Edge Repair)
  14. 342494
    “…RESULTS: Seven records, three randomized controlled trials, and four non-randomized studies were included with a total of 883 patients. …”
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    Restrictive versus conventional ward fluid therapy in non-cardiac surgery patients and the effect on postoperative complications: a meta-analysis
  15. 342495
    “…METHODS: The following databases were searched for randomized controlled trials (RCTs) on acupuncture for the treatment of bronchial asthma from database inception to August 26, 2022: PubMed, Embase, The Cochrane Library, Web of Science, Chinese Journal Full-text Database (CNKI), Wanfang Database (Wanfang Date), VIP Database (VIP), China Biology Medicine disc (CBM). …”
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    A network meta-analysis of different acupuncture modalities in the treatment of bronchial asthma
  16. 342496
    “…CONCLUSIONS: Low pbtO(2), under 25 mmHg and particularly below 15 mmHg, for longer durations and in combination with disturbances in global cerebral physiological variables were associated with poor outcome and may indicate detrimental ischaemic hypoxia. Prospective trials are needed to determine if pbtO(2)-directed therapy is beneficial, at what individualised pbtO(2) threshold therapies are warranted, and how this may depend on the presence/absence of concurrent cerebral physiological disturbances.…”
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    Brain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome
  17. 342497
    “…However, for lisinopril and losartan, the most commonly used definitions of high or low were from pivotal clinical trials with a pre-defined definition of high or low. …”
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    How do we define high and low dose intensity of heart failure medications: a scoping review
  18. 342498
    “…METHODS: We searched MEDLINE, EMBASE, CINAHL, and references of included studies for systematic reviews and meta-analyses (SRMAs) of randomized controlled trials (RCTs) and observational studies in adults published in the past 10 years. …”
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    Saturated fat, the estimated absolute risk and certainty of risk for mortality and major cancer and cardiometabolic outcomes: an overview of systematic reviews
  19. 342499
    “…Therefore, to better guide future practice in the field of non-pharmacological smoking cessation, it is essential to improve the methodological quality of SRs and carry out high-quality randomized controlled trials (RCTs). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-03087-z.…”
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    Non-pharmacological interventions for smoking cessation: analysis of systematic reviews and meta-analyses
  20. 342500
    “…CONCLUSIONS: The identified candidate proteins reflect microglia activity and may be relevant for monitoring the microglial response in clinical practice and clinical trials modulating microglial activity and amyloid deposition. …”
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    A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls
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