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342541por Calderon, Moises A, Demoly, Pascal, Gerth van Wijk, Roy, Bousquet, Jean, Sheikh, Aziz, Frew, Anthony, Scadding, Glenis, Bachert, Claus, Malling, Hans J, Valenta, Rudolph, Bilo, Beatrice, Nieto, Antonio, Akdis, Cezmi, Just, Jocelyne, Vidal, Carmen, Varga, Eva M, Alvarez-Cuesta, Emilio, Bohle, Barbara, Bufe, Albrecht, Canonica, Walter G, Cardona, Victoria, Dahl, Ronald, Didier, Alain, Durham, Stephen R, Eng, Peter, Fernandez-Rivas, Montserrat, Jacobsen, Lars, Jutel, Marek, Kleine-Tebbe, Jörg, Klimek, Ludger, Lötvall, Jan, Moreno, Carmen, Mosges, Ralph, Muraro, Antonella, Niggemann, Bodo, Pajno, Giovanni, Passalacqua, Giovanni, Pfaar, Oliver, Rak, Sabina, Senna, Gianenrico, Senti, Gabriela, Valovirta, Erkka, van Hage, Marianne, Virchow, Johannes C, Wahn, Ulrich, Papadopoulos, Nikolaos“…Years of basic science research, clinical trials, and systematic reviews and meta-analyses have convincingly shown that allergen specific immunotherapy can achieve substantial results for patients, improving the allergic individuals’ quality of life, reducing the long-term costs and burden of allergies, and changing the course of the disease. …”
Publicado 2012
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342542por Larenas-Linnemann, Désirée, Michels, Alexandra, Dinger, Hanna, Shah-Hosseini, Kijawasch, Mösges, Ralph, Arias-Cruz, Alfredo, Ambriz-Moreno, Marichuy, Barajas, Martín Bedolla, Javier, Ruth Cerino, de la Luz Cid del Prado, María, Moreno, Manuel Alejandro Cruz, Almaráz, Roberto García, García-Cobas, Cecilia Y, Garcia Imperial, Daniel A, Muñoz, Rosa Garcia, Hernández-Colín, Dante, Linares-Zapien, Francisco J, Luna-Pech, Jorge A, Matta-Campos, Juan J, Jiménez, Norma Martinez, Medina-Ávalos, Miguel A, Hernández, Alejandra Medina, Maldonado, Alberto Monteverde, López, Doris N, Pizano Nazara, Luis J, Sanchez, Emmanuel Ramirez, Ramos-López, José D, Rodríguez-Pérez, Noel, Rodríguez-Ortiz, Pablo G“…Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries.…”
Publicado 2014
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342543por Köbel, M, Madore, J, Ramus, S J, Clarke, B A, Pharoah, P D P, Deen, S, Bowtell, D D, Odunsi, K, Menon, U, Morrison, C, Lele, S, Bshara, W, Sucheston, L, Beckmann, M W, Hein, A, Thiel, F C, Hartmann, A, Wachter, D L, Anglesio, M S, Høgdall, E, Jensen, A, Høgdall, C, Kalli, K R, Fridley, B L, Keeney, G L, Fogarty, Z C, Vierkant, R A, Liu, S, Cho, S, Nelson, G, Ghatage, P, Gentry-Maharaj, A, Gayther, S A, Benjamin, E, Widschwendter, M, Intermaggio, M P, Rosen, B, Bernardini, M Q, Mackay, H, Oza, A, Shaw, P, Jimenez-Linan, M, Driver, K E, Alsop, J, Mack, M, Koziak, J M, Steed, H, Ewanowich, C, DeFazio, A, Chenevix-Trench, G, Fereday, S, Gao, B, Johnatty, S E, George, J, Galletta, L, Goode, E L, Kjær, S K, Huntsman, D G, Fasching, P A, Moysich, K B, Brenton, J D, Kelemen, L E“…BACKGROUND: Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. …”
Publicado 2014
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342544por Bis, Joshua C., Sitlani, Colleen, Irvin, Ryan, Avery, Christy L., Smith, Albert Vernon, Sun, Fangui, Evans, Daniel S., Musani, Solomon K., Li, Xiaohui, Trompet, Stella, Krijthe, Bouwe P., Harris, Tamara B., Quibrera, P. Miguel, Brody, Jennifer A., Demissie, Serkalem, Davis, Barry R., Wiggins, Kerri L., Tranah, Gregory J., Lange, Leslie A., Sotoodehnia, Nona, Stott, David J., Franco, Oscar H., Launer, Lenore J., Stürmer, Til, Taylor, Kent D., Cupples, L. Adrienne, Eckfeldt, John H., Smith, Nicholas L., Liu, Yongmei, Wilson, James G., Heckbert, Susan R., Buckley, Brendan M., Ikram, M. Arfan, Boerwinkle, Eric, Chen, Yii-Der Ida, de Craen, Anton J. M., Uitterlinden, Andre G., Rotter, Jerome I., Ford, Ian, Hofman, Albert, Sattar, Naveed, Slagboom, P. Eline, Westendorp, Rudi G. J., Gudnason, Vilmundur, Vasan, Ramachandran S., Lumley, Thomas, Cummings, Steven R., Taylor, Herman A., Post, Wendy, Jukema, J. Wouter, Stricker, Bruno H., Whitsel, Eric A., Psaty, Bruce M., Arnett, Donna“…Although large long-term clinical trials conducted in the last several decades have identified a number of effective antihypertensive treatments that reduce the risk of future clinical complications, responses to therapy and protection from cardiovascular events vary among individuals. …”
Publicado 2015
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342545por Ajayi, IkeOluwapo O., Nsungwa-Sabiiti, Jesca, Siribié, Mohamadou, Falade, Catherine O., Sermé, Luc, Balyeku, Andrew, Afonne, Chinenye, Sanou, Armande K., Kabarungi, Vanessa, Oshiname, Frederick O., Gansane, Zakaria, Kyaligonza, Josephine, Jegede, Ayodele S., Tiono, Alfred B., Sirima, Sodiomon B., Diarra, Amidou, Yusuf, Oyindamola B., Fouque, Florence, Castellani, Joëlle, Petzold, Max, Singlovic, Jan, Gomes, Melba“…This approach, recommended by the World Health Organization, improves malaria case management. Clinical Trials Registration. ISRCTN13858170.…”
Publicado 2016
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342546por Nyombayire, Julien, Anzala, Omu, Gazzard, Brian, Karita, Etienne, Bergin, Philip, Hayes, Peter, Kopycinski, Jakub, Omosa-Manyonyi, Gloria, Jackson, Akil, Bizimana, Jean, Farah, Bashir, Sayeed, Eddy, Parks, Christopher L., Inoue, Makoto, Hironaka, Takashi, Hara, Hiroto, Shu, Tsugumine, Matano, Tetsuro, Dally, Len, Barin, Burc, Park, Harriet, Gilmour, Jill, Lombardo, Angela, Excler, Jean-Louis, Fast, Patricia, Laufer, Dagna S., Cox, Josephine H.“…The prime-boost sequence appears to determine which arm of the immune response is stimulated. Clinical Trials Registration. NCT01705990.…”
Publicado 2017
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342547por Mijajlović, Milija D., Pavlović, Aleksandra, Brainin, Michael, Heiss, Wolf-Dieter, Quinn, Terence J., Ihle-Hansen, Hege B., Hermann, Dirk M., Assayag, Einor Ben, Richard, Edo, Thiel, Alexander, Kliper, Efrat, Shin, Yong-Il, Kim, Yun-Hee, Choi, SeongHye, Jung, San, Lee, Yeong-Bae, Sinanović, Osman, Levine, Deborah A., Schlesinger, Ilana, Mead, Gillian, Milošević, Vuk, Leys, Didier, Hagberg, Guri, Ursin, Marie Helene, Teuschl, Yvonne, Prokopenko, Semyon, Mozheyko, Elena, Bezdenezhnykh, Anna, Matz, Karl, Aleksić, Vuk, Muresanu, DafinFior, Korczyn, Amos D., Bornstein, Natan M.“…Lifestyle interventions, physical activity, and cognitive training have been recently tested, but large controlled trials are still missing.…”
Publicado 2017
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342548por Charman, Tony, Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, Caroline, Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Acqua, Flavio Dell’, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J, Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber N. V., Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San Jóse, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C. R., Zwiers, Marcel P., Spooren, Will, Murphy, Declan G. M., Buitelaar, Jan K.“…The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13229-017-0145-9) contains supplementary material, which is available to authorized users.…”
Publicado 2017
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342549por Schmid, Christoph, de Wreede, Liesbeth C., van Biezen, Anja, Finke, Jürgen, Ehninger, Gerhard, Ganser, Arnold, Volin, Liisa, Niederwieser, Dietger, Beelen, Dietrich, Alessandrino, Paolo, Kanz, Lothar, Schleuning, Michael, Passweg, Jakob, Veelken, Hendrik, Maertens, Johan, Cornelissen, Jan J., Blaise, Didier, Gramatzki, Martin, Milpied, Noel, Yakoub-Agha, Ibrahim, Mufti, Ghulam, Rovira, Montserrat, Arnold, Renate, de Witte, Theo, Robin, Marie, Kröger, Nikolaus“…The data enabled identification of patients benefiting from donor lymphocyte infusion and second transplantation, and may serve as a baseline for prospective trials.…”
Publicado 2018
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342550por Chen, Shu, Gong, Enying, Kazi, Dhruv S, Gates, Ann B, Bai, Rong, Fu, Hua, Peng, Weixia, De La Cruz, Ginny, Chen, Lei, Liu, Xianxia, Su, Qingjie, Girerd, Nicolas, Karaye, Kamilu M, Alhabib, Khalid F, Yan, Lijing L, Schwalm, JD“…Randomized controlled trials are needed to verify the findings.…”
Publicado 2018
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342551por Gordon, Brian A., Blazey, Tyler M., Su, Yi, Hari-Raj, Amrita, Dincer, Aylin, Flores, Shaney, Christensen, Jon, McDade, Eric, Wang, Guoqiao, Xiong, Chengjie, Cairns, Nigel J., Hassenstab, Jason, Marcus, Daniel S., Fagan, Anne M., Jack, Clifford R., Hornbeck, Russ C., Paumier, Katrina L., Ances, Beau M., Berman, Sarah B., Brickman, Adam M., Cash, David M., Chhatwal, Jasmeer P., Correia, Stephen, Förster, Stefan, Fox, Nick C., Graff-Radford, Neill R., la Fougère, Christian, Levin, Johannes, Masters, Colin L., Rossor, Martin N., Salloway, Stephen, Saykin, Andrew J., Schofield, Peter R., Thompson, Paul M., Weiner, Michael M., Holtzman, David M., Raichle, Marcus E., Morris, John C., Bateman, Randall J., Benzinger, Tammie L.S.“…Accrual of these pathologies varied throughout the brain, suggesting differential regional and temporal vulnerabilities to Aβ, metabolic decline, and structural atrophy, which should be taken into account when using biomarkers in a clinical setting as well as designing and evaluating clinical trials.…”
Publicado 2018
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342552por Commons, Robert J, Simpson, Julie A, Thriemer, Kamala, Humphreys, Georgina S, Abreha, Tesfay, Alemu, Sisay G, Añez, Arletta, Anstey, Nicholas M, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Borghini-Fuhrer, Isabelle, Chu, Cindy S, D'Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J, Erhart, Annette, Gomes, Margarete S M, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Heidari, Aliehsan, Hwang, Jimee, Kager, Piet A, Ketema, Tsige, Khan, Wasif A, Lacerda, Marcus V G, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M, Nosten, Francois, Pereira, Dhelio B, Phan, Giao T, Phyo, Aung P, Rowland, Mark, Saravu, Kavitha, Sibley, Carol H, Siqueira, André M, Stepniewska, Kasia, Sutanto, Inge, Taylor, Walter R J, Thwaites, Guy, Tran, Binh Q, Tran, Hien T, Valecha, Neena, Vieira, José Luiz F, Wangchuk, Sonam, William, Timothy, Woodrow, Charles J, Zuluaga-Idarraga, Lina, Guerin, Philippe J, White, Nicholas J, Price, Ric N“…METHODS: A systematic review done in MEDLINE, Web of Science, Embase, and Cochrane Database of Systematic Reviews identified P vivax clinical trials published between Jan 1, 2000, and March 22, 2017. …”
Publicado 2018
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342553por Swart, Joost, Giancane, Gabriella, Horneff, Gerd, Magnusson, Bo, Hofer, Michael, Alexeeva, Еkaterina, Panaviene, Violeta, Bader-Meunier, Brigitte, Anton, Jordi, Nielsen, Susan, De Benedetti, Fabrizio, Kamphuis, Sylvia, Staņēviča, Valda, Tracahana, Maria, Ailioaie, Laura Marinela, Tsitsami, Elena, Klein, Ariane, Minden, Kirsten, Foeldvari, Ivan, Haas, Johannes Peter, Klotsche, Jens, Horne, Anna Carin, Consolaro, Alessandro, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino“…REGISTRY REGISTRATION: The Pharmachild registry is registered at ClinicalTrials.gov (NCT01399281) and at the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) (http://www.encepp.eu/encepp/viewResource.htm?…”
Publicado 2018
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342554por Park, Sophie, Kosmider, Olivier, Maloisel, Frédéric, Drenou, Bernard, Chapuis, Nicolas, Lefebvre, Thibaud, Karim, Zoubida, Puy, Hervé, Alary, Anne Sophie, Ducamp, Sarah, Verdier, Frédérique, Bouilloux, Cécile, Rousseau, Alice, Jacob, Marie-Christine, Debliquis, Agathe, Charpentier, Agnes, Gyan, Emmanuel, Anglaret, Bruno, Leyronnas, Cecile, Corm, Selim, Slama, Borhane, Cheze, Stephane, Laribi, Kamel, Amé, Shanti, Rose, Christian, Lachenal, Florence, Toma, Andrea, Pica, Gian Matteo, Carre, Martin, Garban, Frédéric, Mariette, Clara, Cahn, Jean-Yves, Meunier, Mathieu, Herault, Olivier, Fenaux, Pierre, Wagner-Ballon, Orianne, Bardet, Valerie, Dreyfus, Francois, Fontenay, Michaela“…Erythroid response to epoetin zeta was similar to that obtained with other erythropoiesis-stimulating agents and was correlated with higher baseline hepcidin:ferritin ratio and lower RED score. ClinicalTrials.gov registration: NCT 03598582.…”
Publicado 2019
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342555por Turner, N C, Alarcón, E, Armstrong, A C, Philco, M, López Chuken, Y A, Sablin, M -P, Tamura, K, Gómez Villanueva, A, Pérez-Fidalgo, J A, Cheung, S Y A, Corcoran, C, Cullberg, M, Davies, B R, de Bruin, E C, Foxley, A, Lindemann, J P O, Maudsley, R, Moschetta, M, Outhwaite, E, Pass, M, Rugman, P, Schiavon, G, Oliveira, M“…Adding capivasertib to weekly paclitaxel did not prolong PFS in the overall population or PIK3CA+ sub-population of ER+/HER2− advanced/metastatic breast cancer patients. ClinicalTrials.gov: NCT01625286.…”
Publicado 2019
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342556por Massierer, Daniela, Sapir-Pichhadze, Ruth, Bouchard, Vanessa, Dasgupta, Kaberi, Fernandez, Nicolas, da Costa, Deborah, Ahmed, Sara, Fortin, Marie-Chantal, Langevin, Rosalie, Mayo, Nancy, Janaudis-Ferreira, Tania“…METHODS: We will use the Obesity-Related Behavioral Intervention Trials model for developing behavioral treatments for chronic diseases to guide the proposed project. …”
Publicado 2019
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342557por Kaura, Amit, Panoulas, Vasileios, Glampson, Benjamin, Davies, Jim, Mulla, Abdulrahim, Woods, Kerrie, Omigie, Joe, Shah, Anoop D, Channon, Keith M, Weber, Jonathan N, Thursz, Mark R, Elliott, Paul, Hemingway, Harry, Williams, Bryan, Asselbergs, Folkert W, O’Sullivan, Michael, Kharbanda, Rajesh, Lord, Graham M, Melikian, Narbeh, Patel, Riyaz S, Perera, Divaka, Shah, Ajay M, Francis, Darrel P, Mayet, Jamil“…STUDY REGISTRATION: ClinicalTrials.gov NCT03507309.…”
Publicado 2019
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342558por Voets, Erik, Paradé, Marc, Lutje Hulsik, David, Spijkers, Sanne, Janssen, Wout, Rens, Joost, Reinieren-Beeren, Inge, van den Tillaart, Gilbert, van Duijnhoven, Sander, Driessen, Lilian, Habraken, Maurice, van Zandvoort, Peter, Kreijtz, Joost, Vink, Paul, van Elsas, Andrea, van Eenennaam, Hans“…Although several CD47-targeting agents are currently in phase I clinical trials and demonstrate activity in combination therapy, high and frequent dosing was required and safety signals (acute anemia, thrombocytopenia) were recorded frequently as adverse events. …”
Publicado 2019
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342559por Workman, Michael J., Gomes, Bruno, Weng, Ju-Lin, Ista, Linnea K., Jesus, Camila P., David, Mariana R., Ramalho-Ortigao, Marcelo, Genta, Fernando A., Matthews, Scott K., Durvasula, Ravi, Hurwitz, Ivy“…However, a variety of health and environmental issues are associated with some of these. Laboratory trials of essential oils (EO) have established the larvicidal activity of these substances, but there are currently no commercially available EO-based larvicides. …”
Publicado 2020
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342560por Chan, Xin Hui S., Win, Yan Naung, Haeusler, Ilsa L., Tan, Jireh Y., Loganathan, Shanghavie, Saralamba, Sompob, Chan, Shu Kiat S., Ashley, Elizabeth A., Barnes, Karen I., Baiden, Rita, Bassi, Peter U., Djimde, Abdoulaye, Dorsey, Grant, Duparc, Stephan, Hanboonkunupakarn, Borimas, ter Kuile, Feiko O., Lacerda, Marcus V. G., Nasa, Amit, Nosten, François H., Onyeji, Cyprian O., Pukrittayakamee, Sasithon, Siqueira, André M., Tarning, Joel, Taylor, Walter R. J., Valentini, Giovanni, van Vugt, Michèle, Wesche, David, Day, Nicholas P. J., Huang, Christopher L-H, Brugada, Josep, Price, Ric N., White, Nicholas J.“…Study limitations include that it was not possible to assess the effect of other factors that may affect the QT interval but are not consistently collected in malaria clinical trials. CONCLUSIONS: Adjustment for malaria and fever-recovery–related QT lengthening is necessary to avoid misattributing malaria-disease–related QT changes to antimalarial drug effects. …”
Publicado 2020
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