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  1. 342581
    “…To substantiate these findings, further research from prospective randomized controlled trials is needed.…”
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    One anastomosis gastric bypass vs. Roux-en-Y gastric bypass, remedy for insufficient weight loss and weight regain after failed restrictive bariatric surgery
  2. 342582
    “…BACKGROUND: Long-acting (LA) injectable antiretroviral therapy (ART) has been found non-inferior to daily oral ART in Phase 3 trials. LA ART may address key barriers to oral ART adherence and be preferable to daily pills for some people living with HIV. …”
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    Examining adherence barriers among women with HIV to tailor outreach for long-acting injectable antiretroviral therapy
  3. 342583
    “…Interestingly, ICC values for Discrimination Threshold increased to 0.90 [0.77–0.96] (good to excellent) when the number of trials was reduced to the first 50. Most APM parameters had ICC’s above 0.80, (range, ICC = [0.86–0.88]) with the exception of variability (ICC = 0.30). …”
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    Robotic tests for position sense and movement discrimination in the upper limb reveal that they each are highly reproducible but not correlated in healthy individuals
  4. 342584
    por Stawicki, Stanislaw P, Jeanmonod, Rebecca, Miller, Andrew C, Paladino, Lorenzo, Gaieski, David F, Yaffee, Anna Q, De Wulf, Annelies, Grover, Joydeep, Papadimos, Thomas J., Bloem, Christina, Galwankar, Sagar C, Chauhan, Vivek, Firstenberg, Michael S., Di Somma, Salvatore, Jeanmonod, Donald, Garg, Sona M, Tucci, Veronica, Anderson, Harry L, Fatimah, Lateef, Worlton, Tamara J, Dubhashi, Siddharth P, Glaze, Krystal S, Sinha, Sagar, Opara, Ijeoma Nnodim, Yellapu, Vikas, Kelkar, Dhanashree, El-Menyar, Ayman, Krishnan, Vimal, Venkataramanaiah, S, Leyfman, Yan, Saoud Al Thani, Hassan Ali, WB Nanayakkara, Prabath, Nanda, Sudip, Cioè-Peña, Eric, Sardesai, Indrani, Chandra, Shruti, Munasinghe, Aruna, Dutta, Vibha, Dal Ponte, Silvana Teixeira, Izurieta, Ricardo, Asensio, Juan A, Garg, Manish
    Publicado 2020
    “…As the race to develop an effective vaccine intensifies, several clinical trials of antivirals and immune modulators are underway, though no reliable COVID-19-specific therapeutics (inclusive of some potentially effective single and multi-drug regimens) have been identified as of yet. …”
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    The 2019–2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of Academic International Medicine-World Academic Council of Emergency Medicine Multidisciplinary COVID-19 Working Group Consensus Paper
  5. 342585
    “…Neuropsychological assessments traditionally used in AD clinical trials may not evaluate the often-subtle concepts that are important to patients and care partners. …”
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    Assessing what matters most to patients with or at risk for Alzheimer’s and care partners: a qualitative study evaluating symptoms, impacts, and outcomes
  6. 342586
    “…The magnitude of the differences was clinically small, but given the high prevalence of GERD, further investigation is warranted to understand the potential disease-modifying role of GERD in COPD pathogenesis and progression. CLINICAL TRIALS REGISTRATION: NCT00608764.…”
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    Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort
  7. 342587
    “…Further evidence from randomised clinical trials and/or high-quality prospective studies is needed to better guide decision making.…”
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    ECCO(2)R therapy in the ICU: consensus of a European round table meeting
  8. 342588
    “…Evaluation of studies focused on randomised controlled trials (RCTs). In both reviews, initial (January 2018) and updated (November 2019) searches were conducted in EMBASE and PubMed databases. …”
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    Asthma control factors in the Gulf Cooperation Council (GCC) countries and the effectiveness of ICS/LABA fixed dose combinations: a dual rapid literature review
  9. 342589
    “…Those with relapsing–remitting MS demonstrated more demographic heterogeneity than the participants in six randomized phase 3 MS treatment trials. Across sites, a significant variation was observed in the follow-up frequency and the patterns of disease-modifying therapy use. …”
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    Harnessing Real-World Data to Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS)
  10. 342590
    “…However, more detailed experiments and clinical trials are needed to verify their drug targets role in clinical medical use.…”
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    Bioinformatic analysis revealing mitotic spindle assembly regulated NDC80 and MAD2L1 as prognostic biomarkers in non-small cell lung cancer development
  11. 342591
    “…These findings warrant the development of optimal alternative treatment in clinical trials.…”
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    A genetic predictive model for precision treatment of diffuse large B-cell lymphoma with early progression
  12. 342592
    “…In addition to S. pneumoniae, clinical trials suggest efficacy of PHiD-CV against NTHi AOM. …”
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    Cost-effectiveness evaluation of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine for children in Taiwan
  13. 342593
    “…METHODS: Electronic databases were searched to identify randomized controlled trials (RCTs) that compared DEB and UCB till November 2018. …”
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    Comparison of efficacy and safety of drug-eluting versus uncoated balloon angioplasty for femoropopliteal arterial occlusive disease: a meta-analysis
  14. 342594
    “…METHODS: A systematic literature review was conducted to identify randomized controlled trials of at least 10-week duration, including at least one fixed-dose or open combination triple therapy arm, in patients with moderate to very severe COPD. …”
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    Efficacy of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Versus Other Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting β(2)-Agonist (ICS/LAMA/LABA) Triple Combinations in COPD: A Systematic Literature Review and Network Meta-analysis
  15. 342595
    “…The primary endpoint was the target lesion failure (TLF) rate at 9 months (ClinicalTrials.gov Identifier NCT02554292). RESULTS: A total of 481 patients (496 lesions) were recruited to treat de novo lesions (78.4%, 377), BMS-ISR (4.0%, 19), and DES-ISR (17.6%, 85). …”
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    Systematic Scoring Balloon Lesion Preparation for Drug-Coated Balloon Angioplasty in Clinical Routine: Results of the PASSWORD Observational Study
  16. 342596
    “…BACKGROUND: The indoleamine 2, 3-dioxygenase (IDO) inhibitor 1-methyl-tryptophan (1-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors by inhibiting tumor immune escape. …”
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    1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function
  17. 342597
    “…The FRENCHIE cohort is registered with ClinicalTrials.gov, NCT04050956. FINDINGS: Between Feb 17 and April 12, 2020, 1167 patients were consecutively admitted within 48 h of acute myocardial infarction (583 with STEMI, 584 with NSTEMI) and were included in the study. …”
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    Hospital admissions for acute myocardial infarction before and after lockdown according to regional prevalence of COVID-19 and patient profile in France: a registry study
  18. 342598
    “…Their reliability was evidenced through numerous trials on a wide range of bacterial strains and plant samples. …”
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    Development and comparative validation of genomic-driven PCR-based assays to detect Xanthomonas citri pv. citri in citrus plants
  19. 342599
    “…METHODS: The following databases will be searched: Medline, Embase, PsycINFO, Cochrane Controlled Register of Trials, CINAHL, EconLit, and Sociological Abstracts. …”
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    A protocol for a scoping review of equity measurement in mental health care for children and youth
  20. 342600
    “…BACKGROUND: Second-generation FLT3-inhibitors (FLT3i) demonstrated single-agent composite CR rates (CRc) of 45–55% in patients with relapsed/refractory (R/R) FLT3-mutated AML in phase II/III trials. However, > 85% of patients treated were prior FLT3i naïve. …”
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    Outcomes with sequential FLT3-inhibitor-based therapies in patients with AML
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