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  1. 342601
    “…Our findings might entail relevant implications for the therapy of this disease and could boost the design of new clinical trials among subjects affected by severe COVID-19. …”
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    Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort)
  2. 342602
    “…The BGC was trained and validated on patients in the Airway Epithelial Gene Expression in the Diagnosis of Lung Cancer (AEGIS) trials. A modern patient cohort, the BGC Registry, showed differences in key clinical factors from the AEGIS cohorts, with less smoking history, smaller nodules and older age. …”
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    Improving lung cancer risk stratification leveraging whole transcriptome RNA sequencing and machine learning across multiple cohorts
  3. 342603
    por Klarin, Derek, Verma, Shefali Setia, Judy, Renae, Dikilitas, Ozan, Wolford, Brooke N., Paranjpe, Ishan, Levin, Michael G., Pan, Cuiping, Tcheandjieu, Catherine, Spin, Joshua M., Lynch, Julie, Assimes, Themistocles L., Åldstedt Nyrønning, Linn, Mattsson, Erney, Edwards, Todd L., Denny, Josh, Larson, Eric, Lee, Ming Ta Michael, Carrell, David, Zhang, Yanfei, Jarvik, Gail P., Gharavi, Ali G., Harley, John, Mentch, Frank, Pacheco, Jennifer A., Hakonarson, Hakon, Skogholt, Anne Heidi, Thomas, Laurent, Gabrielsen, Maiken Elvestad, Hveem, Kristian, Nielsen, Jonas Bille, Zhou, Wei, Fritsche, Lars, Huang, Jie, Natarajan, Pradeep, Sun, Yan V., DuVall, Scott L., Rader, Daniel J., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W.F., O’Donnell, Christopher J., Kathiresan, Sekar, Scali, Salvatore T., Berceli, Scott A., Willer, Cristen, Jones, Gregory T., Bown, Matthew J., Nadkarni, Girish, Kullo, Iftikhar J., Ritchie, Marylyn, Damrauer, Scott M., Tsao, Philip S.
    Publicado 2020
    “…Using this PRS, we identified a subset of the population with AAA prevalence greater than that observed in screening trials informing current guidelines. CONCLUSIONS: We identify novel AAA genetic associations with therapeutic implications and identify a subset of the population at significantly increased genetic risk of AAA independent of family history. …”
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    Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program
  4. 342604
    “…This European Scleroderma Trials and Research (EUSTAR) database analysis was undertaken to examine the importance of impaired functionality in dcSSc prognosis. …”
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    Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database
  5. 342605
    “…Pressure patterns were also acquired during barefoot level walking at self-selected speed, from which regional peak pressure and absolute and normalised pressure-time integral were worked out at hallux and at first, central and fifth metatarsals (LOAD variables) as averaged over five trials. Correlations with 3D alignments were searched also with arch index, contact time, age, BMI, years of disease and a neuropathy-related variable. …”
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    Correlations between weight-bearing 3D bone architecture and dynamic plantar pressure measurements in the diabetic foot
  6. 342606
    “…Prospective clinical trials using a priori immunophenotyping are needed to understand optimal hydrocortisone strategies in this population.…”
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    Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis
  7. 342607
    “…INTRODUCTION: The triple-combination (TC) cystic fibrosis transmembrane conductance regulator (CFTR) modulator regimen elexacaftor, tezacaftor, and ivacaftor was shown to be safe and efficacious in phase 3 trials of people with cystic fibrosis (pwCF) ≥ 12 years of age with ≥ 1 F508del-CFTR allele. …”
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    Physiologically Based Pharmacokinetic Modeling of CFTR Modulation in People with Cystic Fibrosis Transitioning from Mono or Dual Regimens to Triple-Combination Elexacaftor/Tezacaftor/Ivacaftor
  8. 342608
    “…Since the utility of cross-sectional studies for causal inference remains limited, both randomized controlled trials and prospective cohort studies are needed to better evaluate contributions of e-cigarettes as harm reduction tools for smokers.…”
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    How effective are electronic cigarettes for reducing respiratory and cardiovascular risk in smokers? A systematic review
  9. 342609
    “…Following PRISMA guidelines, articles were screened using inclusion (any study design reporting duration from initiation to death in adults palliative care services) and exclusion (paediatric/non-English language studies, trials influencing the timing of palliative care) criteria. …”
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    Duration of palliative care before death in international routine practice: a systematic review and meta-analysis
  10. 342610
    “…Combined administration of telmisartan/amlodipine 80/5 mg and rosuvastatin 20 mg for the treatment of hypertensive patients with dyslipidemia significantly reduces blood pressure and improves lipid control. ClinicalTrials.gov identifier: NCT03067688.…”
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    Efficacy and safety of co‐administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia
  11. 342611
    “…CONCLUSIONS: During hemodynamic monitoring with TPTD, both single-lumen 5Fr PICCs and triple-lumen 6Fr PICCs can be used for cold fluid bolus injection as an alternative to CICC (ClinicalTrials.gov NCT04241926).…”
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    Are single-lumen 5Fr and triple-lumen 6Fr PICCs suitable for hemodynamic assessment by trans-pulmonary thermodilution? A pilot study
  12. 342612
    “…METHODS: Studies were systematically identified through searches of peer-reviewed databases (Medline, Embase, Global Health, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) and grey literature. …”
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    Change in mean salt intake over time using 24-h urine versus overnight and spot urine samples: a systematic review and meta-analysis
  13. 342613
    “…Miltuximab(®) is a clinical stage anti-GPC-1 antibody that has proven safe in first in human trials. METHODS: The single chain variable fragment (scFv) of Miltuximab(®) and the CD3 binding sequence of Blinatumomab were combined in a standard BiTE format. …”
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    A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells
  14. 342614
    “…These evidences are also fundamental for the stratification of patients eligible for clinical trials. Our work reinforces the value of large genotype–phenotype studies to define criteria for clinical practice and genetic counseling in rare diseases.…”
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    Large genotype–phenotype study in carriers of D4Z4 borderline alleles provides guidance for facioscapulohumeral muscular dystrophy diagnosis
  15. 342615
    “…Therefore, completion of randomised trials investigating pre-exposure prophylactic use of hydroxychloroquine for prevention of severe outcomes from COVID-19 are warranted. …”
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    Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform
  16. 342616
    “…The novel Ng assays are robust and highly sensitive and may be valuable tools to study synaptic alteration in AD, as well as to monitor the effect on synaptic integrity of novel drug candidates in clinical trials.…”
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    Full-length and C-terminal neurogranin in Alzheimer’s disease cerebrospinal fluid analyzed by novel ultrasensitive immunoassays
  17. 342617
    “…We selected randomized control trials that compared the risk of major adverse cardiovascular events (MACE) and a composite of renal outcomes. …”
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    Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta-analysis
  18. 342618
    “…RESULTS: Of 733 searched studies, we included four randomized and eleven non-randomized trials. Five of the studies were unpublished. Those who received Janus kinase-inhibitor had significantly reduced odds of mortality (OR, 0.12; 95% CI, 0.03–0.39, p< 0.001) and ICU admission (OR, 0.05; 95% CI, 0.01–0.26, p< 0.001), and had significantly increased odds of hospital discharge (OR, 22.76; 95% CI, 10.68–48.54, p< 0.00001) when compared to standard treatment group. …”
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    JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis
  19. 342619
    “…BACKGROUND: Clinical trials provide consistent evidence for buprenorphine’s efficacy in treating opioid use disorder (OUD). …”
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    Systematic content analysis of patient evaluations of START NOW psychotherapy reveals practical strategies for improving the treatment of opioid use disorder
  20. 342620
    “…Especially a reduction of administered activity might allow for a lower radiation exposure and better health economics. Larger trials are warranted to confirm our results. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-020-07723-2.…”
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    Evaluation of (18)F-FDG PET/CT images acquired with a reduced scan time duration in lymphoma patients using the digital biograph vision
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