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  1. 342661
    “…These results have important implications for ongoing human AD immunotherapy trials, as they indicate that underlying immune activation states within the brain, which may be highly variable, may influence the ability for passive immunotherapy to alter Aβ deposition.…”
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    Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
  2. 342662
    “…CONCLUSIONS: This study provides important information about the natural history of chronic ASMD and provides a longitudinal view of the spectrum of disease manifestations and major morbidities in children and adults and supports the selection of clinically meaningful endpoints in therapeutic trials.…”
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    Prospective study of the natural history of chronic acid sphingomyelinase deficiency in children and adults: eleven years of observation
  3. 342663
    “…This review describes the frequency and direction (increase/decrease) of recombinant-human FSH (r-hFSH) dose adjustment reported in clinical trials. METHODS: We evaluated the proportion of patients undergoing ART treatment who received ≥ 1 r-hFSH dose adjustments. …”
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    Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017)
  4. 342664
    “…To determine the potential utility of this treatment, large-scale sham-controlled trials comparing cMCS and burstMCS are highly recommended. …”
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    Burst Motor Cortex Stimulation Evokes Sustained Suppression of Thalamic Stroke Pain: A Narrative Review and Single-Case Overview
  5. 342665
    “…Due to the study limitation, more data are needed to confirm our observations before human trials.…”
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    Newly designed solid coupling medium for reducing trapped air pockets during extracorporeal shock wave lithotripsy_ a phantom study
  6. 342666
    “…INTRODUCTION: The effectiveness of telmisartan has been reported in Indian clinical trials; however, real-world data are limited. We aimed to provide real-world evidence regarding the effectiveness of telmisartan as monotherapy or in combination with other antihypertensive drugs (AHDs) in Indian patients with essential hypertension. …”
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    Effectiveness of Telmisartan on Blood Pressure Control in Hypertensive Patients in India: A Real-World Retrospective Study from Electronic Medical Records
  7. 342667
    “…Post-hoc analysis of two independent, randomised, placebo-controlled and double-blinded clinical trials. In a cross-over study where persons with type 2 diabetes and microalbuminuria (LIRALBU, n = 32) received liraglutide (1.8 mg/day) or placebo for 12 weeks in random order, separated by 4 weeks of wash-out. …”
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    The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes
  8. 342668
    “…Additionally, we provide a summary of randomized controlled clinical trials conducted on DBS in PD, together with expert commentary on potential applications of the GPi as target. …”
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    Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson’s Disease: Expert Review and Commentary
  9. 342669
    “…In two randomized-controlled trials, BHP was shown to improve breastfeeding initiation and duration of any and exclusive breastfeeding. …”
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    Promoting equity in breastfeeding through peer counseling: the US Breastfeeding Heritage and Pride program
  10. 342670
    “…We included published English-language randomized control trials and observational studies assessing pre- and post-bariatric surgery prevalence or severity of FI. …”
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    Does Bariatric Surgery Improve Faecal Incontinence? A Systematic Review and Meta-analysis
  11. 342671
    “…Further diagnoses will lead to increased information on natural history/mechanistic details, and likely increased therapies and clinical trials.…”
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    Diagnostic yield of rare skeletal dysplasia conditions in the radiogenomics era
  12. 342672
    “…METHODS: We systematically searched published literature from January 1945 until December 2018 for observational comparative and non-comparative studies and randomized trials examining any antibiotic option for CR-GNB. …”
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    The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies
  13. 342673
    por Novelo, M., Audsley, M. D., McGraw, E. A.
    Publicado 2021
    “…The insect endosymbiont Wolbachia pipientis is currently being trialed in field releases globally as a means of biological control because it reduces virus replication inside the mosquito. …”
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    The effects of DENV serotype competition and co-infection on viral kinetics in Wolbachia-infected and uninfected Aedes aegypti mosquitoes
  14. 342674
    “…Consistent with previous studies, a low level of early-phase transmission (3 days after the infectious blood meal) was detected in some trials. Transmission at later time points was also sporadic, and the incidence of proventricular blockage, required for this mode of transmission, was low in fleas infected using rat blood and never occurred in fleas infected using human blood. …”
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    Poor vector competence of the human flea, Pulex irritans, to transmit Yersinia pestis
  15. 342675
    “…There is a lack of clear consensus on when to switch patients from trials of noninvasive therapies to invasive mechanical ventilation. …”
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    Timing of Invasive Mechanical Ventilation and Mortality among Patients with Severe COVID-19-associated Acute Respiratory Distress Syndrome
  16. 342676
    “…METHODS: We searched MEDLINE, Embase, Cochrane and Scopus databases from 1 December 2019 to 10 January 2021 for observational studies or randomised clinical trials examining ECMO in adults with COVID-19 ARDS. …”
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    Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis
  17. 342677
    “…Searches were run in the Medline, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL databases. Results were presented to the group and discussed during video conferences every two weeks from April 2018 to July 2020. …”
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    Canadian Airway Focus Group updated consensus-based recommendations for management of the difficult airway: part 1. Difficult airway management encountered in an unconscious patient
  18. 342678
    “…Our result suggests the clinical need to screen for POLE driver mutations in endometrioid OC, which can guide enrollment in immunotherapy clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-021-01017-7.…”
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    Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing
  19. 342679
    “…OBJECTIVES: To examine whether topical use of TXA (tTXA) reduces postoperative drainage output and duration, hidden blood loss, hemoglobin level drop, hospital stay, and adverse event rate, we reviewed both randomized and non-randomized controlled trials that assessed the aforementioned efficacies of tTXA compared with placebo in patients undergoing cervical, thoracic, or lumbar spinal surgeries. …”
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    Tranexamic acid given into wound reduces postoperative drainage, blood loss, and hospital stay in spinal surgeries: a meta-analysis
  20. 342680
    por Wang, Shizhuo, Gu, Jiahui
    Publicado 2021
    “…Prophylactic bilateral salpingectomy might be a good method to prevent the development of ovarian cancer. Larger clinical trials with longer follow-up times are needed to further evaluate the risks and benefits.…”
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    The effect of prophylactic bilateral salpingectomy on ovarian reserve in patients who underwent laparoscopic hysterectomy
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