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  1. 342681
    “…BACKGROUND: Narrow spectrum of action through limited molecular targets and unforeseen drug-related toxicities have been the main reasons for drug failures at the phase I clinical trials in complex diseases. Most plant-derived compounds with medicinal values possess poly-pharmacologic properties with overall good tolerability, and, thus, are appropriate in the management of complex diseases, especially cancers. …”
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    A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data
  2. 342682
    “…However, there are few randomized control trials studying medical cannabis indicating expert guidance on how to dose and administer medical cannabis safely and effectively is needed. …”
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    Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process
  3. 342683
    “…METHODS: This was a systematic review with searches carried out on 13 March 2021 through PubMed, Embase, MEDLINE and CINAHL plus, clinical trials registry and bibliography reviews. Eligibility criteria were: published in English; from 2000 onwards; included adult DM and/or HT patients; examined CoC as their main intervention/exposure; and utilised quantifiable outcome measures (categorised into health indicators and service utilisation). …”
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    Effects of continuity of care on health outcomes among patients with diabetes mellitus and/or hypertension: a systematic review
  4. 342684
    “…This has important implications to identify the eosinophilic and Th2 high endotype both for clinical trials of anti-eosinophil therapies, and to select patients who may respond well to glucocorticosteroids and anti-IL5 therapies.…”
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    Underestimation of airway luminal eosinophilia by quantitative sputum cytometry
  5. 342685
    “…However, most of the current COVID-19 clinical practices and trials do not take the sex factor into consideration. …”
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    Sex-based clinical and immunological differences in COVID-19
  6. 342686
    “…We also aimed to compare results from meta-analyses of observational studies against meta-analyses of randomized controlled trials (RCTs) and Mendelian randomization (MR) studies. …”
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    Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics
  7. 342687
    “…While in randomized clinical trials much effort concentrates on data monitoring, this is rarely the case in observational studies- due to high numbers of cases and often-restricted resources. …”
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    Implementing an automated monitoring process in a digital, longitudinal observational cohort study
  8. 342688
    “…METHODS: PubMed, Web of Science, OVID EMBASE, MEDLINE, The Cochrane database and Clinicaltrials.gov were systematically searched (from inception to 25 January 2021). Trials that randomized adult participants to extended-release formulation of metformin (met-XR), delayed-release (met-DR) or immediate-release metformin (met-IR) were included. …”
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    Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis
  9. 342689
    “…Currently, there are no systemic agents that have regulatory approval for these disorders, but the mTOR inhibitor sirolimus has been used for several years in clinical trials and off label to address symptoms. There are also other agents under investigation for PIK3CA-related disorders that act as inhibitors to target different components of the PI3K signaling pathway including AKT (miransertib) and PI3K alpha (alpelisib). …”
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    A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations
  10. 342690
    “…An alternative approach to insecticide use, based on blocking dengue transmission in mosquitoes by the endosymbiont Wolbachia, is being trialed in Jeddah following the success of this approach in Australia and Malaysia. …”
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    Voltage-sensitive sodium channel (Vssc) mutations associated with pyrethroid insecticide resistance in Aedes aegypti (L.) from two districts of Jeddah, Kingdom of Saudi Arabia: baseline information for a Wolbachia release program
  11. 342691
    “…CONCLUSIONS: In this real-world study, the observed effectiveness of COVID-19 vaccines in HCWs was in line with the efficacy reported in pivotal randomized trials.…”
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    Effectiveness of mRNA-BNT162b2, mRNA-1273, and ChAdOx1 nCoV-19 vaccines against COVID-19 in healthcare workers: an observational study using surveillance data
  12. 342692
    por Ding, Ting, Tang, Dan, Xi, Mingrong
    Publicado 2021
    “…METHODS: We searched EMBASE, MEDLINE, the Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials, from inception to April 2021. We used appropriate scales to assess the risk of bias. …”
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    The survival outcome and complication of secondary cytoreductive surgery plus chemotherapy in recurrent ovarian cancer: a systematic review and meta-analysis
  13. 342693
    “…METHODS: We searched 13 databases, including PubMed, Medline, Global Health, EMBASE, ADOLEC, Social Policy and Practice, Database of Promoting Health Effectiveness Reviews (DoPHER), Trials Register of Promoting Health Interventions (TRoPHI), EPPI-Centre database of health promotion research (Bibliomap), Web of Science, PsycINFO, Cochrane and Scopus for studies involving arts interventions aimed at reducing any or all components of mental-health-related stigma among youth (10–24-year-olds). …”
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    Effectiveness of arts interventions to reduce mental-health-related stigma among youth: a systematic review and meta-analysis
  14. 342694
    por Hober, Candice, Fredeau, Lisa, Pham-Ledard, Anne, Boubaya, Marouane, Herms, Florian, Celerier, Philippe, Aubin, François, Beneton, Nathalie, Dinulescu, Monica, Jannic, Arnaud, Meyer, Nicolas, Duval-Modeste, Anne-Bénédicte, Cesaire, Laure, Neidhardt, Ève-Marie, Archier, Élodie, Dréno, Brigitte, Lesage, Candice, Berthin, Clémence, Kramkimel, Nora, Grange, Florent, de Quatrebarbes, Julie, Stoebner, Pierre-Emmanuel, Poulalhon, Nicolas, Arnault, Jean-Philippe, Abed, Safia, Bonniaud, Bertille, Darras, Sophie, Heidelberger, Valentine, Devaux, Suzanne, Moncourier, Marie, Misery, Laurent, Mansard, Sandrine, Etienne, Maxime, Brunet-Possenti, Florence, Jacobzone, Caroline, Lesbazeilles, Romain, Skowron, François, Sanchez, Julia, Catala, Stéphanie, Samimi, Mahtab, Tazi, Youssef, Spaeth, Dominique, Gaudy-Marqueste, Caroline, Collard, Olivier, Triller, Raoul, Pracht, Marc, Dumas, Marc, Peuvrel, Lucie, Combe, Pierre, Lauche, Olivier, Guillet, Pierre, Reguerre, Yves, Kupfer-Bessaguet, Ingrid, Solub, David, Schoeffler, Amélie, Bedane, Christophe, Quéreux, Gaëlle, Dalac, Sophie, Mortier, Laurent, Maubec, Ève
    Publicado 2021
    “…SIMPLE SUMMARY: Prognosis of advanced cutaneous squamous-cell carcinoma (CSCC) is poor. Recent clinical trials have shown that immunotherapy achieves significantly improved survival of patients with advanced CSCCs. …”
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    Cemiplimab for Locally Advanced and Metastatic Cutaneous Squamous-Cell Carcinomas: Real-Life Experience from the French CAREPI Study Group
  15. 342695
    “…The aim of the study is to assess and synthesize available controlled trials investigating failures of fixed retainers. …”
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    What causes failure of fixed orthodontic retention? – systematic review and meta-analysis of clinical studies
  16. 342696
    “…Additional objectives were to further characterize the study sample regarding demographics, clinical parameters and medication usage, with particular reference to blood glucose-lowering agents (GLAs: glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors) with demonstrated cardiovascular benefit in randomized intervention trials. METHODS: Data were collected from adults with T2D managed in primary or specialist care in Australia, China, Japan, Czech Republic, France, Hungary, Italy, Argentina, Brazil, Mexico, Israel, Kingdom of Saudi Arabia, and Turkey in 2019, using standardized methodology. …”
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    CAPTURE: a multinational, cross-sectional study of cardiovascular disease prevalence in adults with type 2 diabetes across 13 countries
  17. 342697
    “…BACKGROUND: Treatment guidelines for generalized anxiety disorder (GAD) are based on a relatively small number of randomized controlled trials and do not consider patient-centered perceptions of treatment helpfulness. …”
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    Perceived helpfulness of treatment for generalized anxiety disorder: a World Mental Health Surveys report
  18. 342698
    “…However, evidence from appropriately designed randomized trials is needed prior to widespread adoption of PP on VV ECMO. …”
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    Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis
  19. 342699
    “…A Cochrane risk of bias assessment was applied to studies that performed randomized controlled trials and consistency of studies was analysed using I(2) as a test of heterogeneity. …”
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    Effects of Variations in Resistance Training Frequency on Strength Development in Well-Trained Populations and Implications for In-Season Athlete Training: A Systematic Review and Meta-analysis
  20. 342700
    “…This tool could be used in clinical practice and clinical trials after validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12969-021-00620-3.…”
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    Assessment of disease activity using a whole-body MRI derived radiological activity index in chronic nonbacterial osteomyelitis
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