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  1. 342701
    “…These clinical data will be useful to inform mechanistic studies and stratification of patients in clinical trials.…”
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    Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance study
  2. 342702
    “…The purpose of this review is to discuss and explain the most recent advances in CAR T cell-based therapies targeting AML antigens and review the results of preclinical and clinical trials. Moreover, we will criticize the clinical challenges, side effects, and the different strategies for CAR T cell therapy.…”
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    Novel CAR T therapy is a ray of hope in the treatment of seriously ill AML patients
  3. 342703
    “…Databases including PubMed, Web of Science, Embase, Google Scholar and ClinicalTrials.gov database were searched for eligible studies published up to 12 July 2021. …”
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    Circulating retinol binding protein 4 levels in coronary artery disease: a systematic review and meta-analysis
  4. 342704
    “…RESULTS: The literature search found 751 articles from which nine studies were included; seven were randomized controlled trials (RCTs), and two were observational studies. …”
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    The impact of clinical pharmacist services on patient health outcomes in Pakistan: a systematic review
  5. 342705
    “…Individual study quality will be assessed according to the Oxford Evidence-based Medicine Scales of Evidence 2, and risk of bias using either the ‘Revised Cochrane risk of bias tool for randomized trials’ (Rob2), the ‘Risk of bias in non-randomized studies of interventions’ (ROBINS-I) tool, or the National Institute for Health Quality Assessment tool for Case Series. …”
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    Protocol for a systematic review of outcomes from microsurgical free-tissue transfer performed on short-term collaborative surgical trips in low-income and middle-income countries
  6. 342706
    “…The treatment with rosuvastatin reduced IL-6 mRNA and 3-nitrotyrosine concentration in the brains of the animals. In earlier trials, statin treatment did not reduce mortality in ARDS patients but seemed to improve quality of life in ARDS survivors. …”
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    Influence of rosuvastatin treatment on cerebral inflammation and nitro-oxidative stress in experimental lung injury in pigs
  7. 342707
    “…The definitive study has been registered in ClinicalTrials.gov (Identifier: NCT04083924). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40814-021-00910-3.…”
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    Pre-clinical medical student cardiac point-of-care ultrasound curriculum based on the American Society of Echocardiography recommendations: a pilot and feasibility study
  8. 342708
    “…BACKGROUND: Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well understood. …”
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    Reasons for canakinumab initiation among patients with periodic fever syndromes: a retrospective medical chart review from the United States
  9. 342709
    “…BACKGROUND: Trials show that antimicrobial stewardship (AMS) strategies, including communication skills training, point-of-care C-reactive protein testing (POC-CRPT) and delayed prescriptions, help optimise antibiotic prescribing and use in primary care. …”
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    Development of an intervention to support the implementation of evidence-based strategies for optimising antibiotic prescribing in general practice
  10. 342710
    “…The GP2 vaccine could elicit a strong immune response, but more trials are needed to confirm its clinical efficacy.…”
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    Application of HER2 peptide vaccines in patients with breast cancer: a systematic review and meta-analysis
  11. 342711
    “…Following from this, we discuss a potential use of the M50 latency in indicating “target engagement” acutely with administration of a GABA-B agonist, potentially distinguishing “responders” from “non-responders” with the implication of optimizing inclusion for clinical trials of such agents. Implications for future application, including potential evaluation of infants with genetic risk factors, are discussed. …”
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    Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG)
  12. 342712
    “…The study is registered with ClinicalTrials.gov, NCT04416256. FINDINGS: Transplant activity in all countries studied showed an overall decrease during the pandemic. …”
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    COVID-19 pandemic and worldwide organ transplantation: a population-based study
  13. 342713
    “…The primary outcome of interest in the stage one searches will be studies which use PROMs to investigate HR-QOL as defined by the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy, the secondary outcome will be to assess the frequency of use of the various PROMs. …”
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    Evaluating measures of quality of life in adult scoliosis: a protocol for a systematic review and narrative synthesis
  14. 342714
    “…Given the high overlap and low methodological quality of primary studies, the focus should be on the development of high-quality trials investigating the effectiveness of falls prevention interventions, rather than the publication of further systematic reviews. …”
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    Effectiveness of interventions to prevent falls for people with multiple sclerosis, Parkinson’s disease and stroke: an umbrella review
  15. 342715
    “…The study designs were randomized controlled trials (n = 3), quasi-experimental studies (n = 2), prospective cohort studies (n = 15), and cross-sectional studies (n = 29). …”
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    Electronic media use and sleep in children and adolescents in western countries: a systematic review
  16. 342716
    “…Finally, randomised controlled trials that investigate the effect of treating sleep disorders in people with type 2 diabetes are scarce, based on a small number of participants and sometimes inconclusive. …”
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    Sleep disorders in people with type 2 diabetes and associated health outcomes: a review of the literature
  17. 342717
    “…Sea urchins in control trials showed complex diffusive properties in an information-limited environment, with highly variable trajectories, ranging from Brownian motion to superdiffusion, and even marginal ballistic motion. …”
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    The scent of fear makes sea urchins go ballistic
  18. 342718
    “…A total of 6 randomized controlled trials were included in this study, including 192 patients. …”
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    Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis
  19. 342719
    “…CONCLUSION: This study reveals that differences in the timing of the defense reaction mediated by the Rpv3-, Rpv10- and Rpv12-loci, result in different degrees of natural resistance to downy mildew in field. Vineyard trials demonstrate that Rpv12/Rpv3- and Rpv3-cultivars are a powerful tool to reduce the dependence of grape production on fungicide applications. …”
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    Grapevine Rpv3-, Rpv10- and Rpv12-mediated defense responses against Plasmopara viticola and the impact of their deployment on fungicide use in viticulture
  20. 342720
    “…INTRODUCTION: Data regarding efficacy of second-generation basal insulins (BI) using continuous glucose monitoring (CGM) come from clinical trials. We evaluated the effectiveness of insulin glargine 300 U/ml (Gla-300) compared to insulin degludec 100 U/ml (IDeg-100) in terms of percentage of time in range (TIR); 70–180 mg/dl was obtained from CGM in sub-optimally controlled patients with type 1 diabetes (T1D) in routine clinical practice. …”
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    Effectiveness and Safety of Insulin Glargine 300 U/ml in Comparison with Insulin Degludec 100 U/ml Evaluated with Continuous Glucose Monitoring in Adults with Type 1 Diabetes and Suboptimal Glycemic Control in Routine Clinical Practice: The OneCARE Study
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