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  1. 342781
    por Wu, Qing, Luo, Shuimei, Xie, Xianhe
    Publicado 2022
    “…METHODS: Electronic databases were searched to identify relevant trials. The primary endpoints were severe disease and death of cancer patients treated with anti-tumor therapy before COVID-19 diagnosis. …”
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    The impact of anti-tumor approaches on the outcomes of cancer patients with COVID-19: a meta-analysis based on 52 cohorts incorporating 9231 participants
  2. 342782
    “…The studies included were Randomized Clinical Trials (RCTs) and non-RCT based on EXOs intervention on individuals with SCI. …”
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    Overground robotic training effects on walking and secondary health conditions in individuals with spinal cord injury: systematic review
  3. 342783
    “…METHODS: Data were pooled from six randomized controlled trials (TONADO 1/2, DYNAGITO, WISDOM, UPLIFT and TIOSPIR; LAMA/LABA: n = 3156, LAMA/LABA/ICS: n = 11,891). …”
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    A Pooled Analysis of Mortality in Patients with COPD Receiving Dual Bronchodilation with and without Additional Inhaled Corticosteroid
  4. 342784
    por Chen, Ruirong, Su, Sheng, Shu, Haihua
    Publicado 2022
    “…METHODS: The PubMed, Web of Science and Embase were searched from 2016 to 2021 for all available randomized controlled trials (RCTs) that evaluated the analgesic efficacy and safety of RIB after thoracic surgery and breast surgery. …”
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    Efficacy and safety of rhomboid intercostal block for analgesia in breast surgery and thoracoscopic surgery: a meta-analysis
  5. 342785
    “…Our results support the safety and efficacy of heterologous prime-boost vaccination using the ChAdOx1 and mRNA-1273 COVID-19 vaccines. (ClinicalTrials.gov number, NCT05074368).…”
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    Immune response and safety of heterologous ChAdOx1-nCoV-19/mRNA-1273 vaccination compared with homologous ChAdOx1-nCoV-19 or homologous mRNA-1273 vaccination
  6. 342786
    “…There is a need for high-quality randomised trials to determine the value of second opinion services for reducing spinal surgery. …”
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    Second opinions for spinal surgery: a scoping review
  7. 342787
    “…However, several randomized controlled trials have not shown the superiority of hypofractionated radiotherapy over conventionally fractionated radiotherapy. …”
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    Variability of α/β ratios for prostate cancer with the fractionation schedule: caution against using the linear-quadratic model for hypofractionated radiotherapy
  8. 342788
    “…METHODS: Nine electronic databases were searched: MEDLINE, PsycINFO, EMBASE, CINAHL, WHOLiS, AMED, ScieLo, ASSIA and Web of Science. Randomised control trials and quasi-experimental studies examining pregnancy yoga interventions were eligible. …”
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    The characteristics and effectiveness of pregnancy yoga interventions: a systematic review and meta-analysis
  9. 342789
    “…BACKGROUND: Acupuncture is a popular treatment for women’s health. Several trials and meta-analysis have been published in recent years on key women’s health conditions but it is unclear if this has led to any changes in clinical practice or referrals from other health professionals. …”
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    The changing clinical landscape in acupuncture for women’s health: a cross-sectional online survey in New Zealand and Australia
  10. 342790
    “…BACKGROUND: Although the detrimental effects of advanced chronic kidney disease (CKD) on prognosis in coronary artery disease is known, there are few data on the efficacy and safety of modern interventional therapies and medications in patients with advanced CKD, because this special patient cohort is often excluded or underrepresented in randomized trials. METHODS: In the present study all patients admitted with ST-elevation myocardial infarctions (STEMI) from the region of Bremen/Germany treated between 2006 and 2019 were analyzed. …”
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    Temporal trends in treatment strategies and clinical outcomes among patients with advanced chronic kidney disease and ST-elevation myocardial infarctions: results from the Bremen STEMI registry
  11. 342791
    “…Further assay optimizations are needed to faithfully amplify peripheral prions whose recognition could lead to a better diagnosis and selection of patients for future clinical trials.…”
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    PMCA-Based Detection of Prions in the Olfactory Mucosa of Patients With Sporadic Creutzfeldt–Jakob Disease
  12. 342792
    “…CONCLUSION: These synaptic panels have potential in the differential diagnosis of FTLD neuropathologic subtypes and as surrogate markers of cognitive performance in future clinical trials targeting TDP-43 or tau. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13024-022-00534-y.…”
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    Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration
  13. 342793
    “…Informants generated considerations related to: perceived benefits of CGT towards an HIV cure, perceived risks, considerations necessary to ensure an acceptable benefit/risk balance, CGT strategies considered unacceptable, additional ethical considerations, and considerations for first-in-human CGT HIV cure trials. Informants also proposed important safeguards to developing CGT approaches towards an HIV cure, such as the importance of mitigating off-target effects, mitigating risks associated with long-term duration of CGT interventions, and mitigating risks of immune overreactions. …”
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    Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States
  14. 342794
    “…As classically those patients are excluded from clinical trials, a dedicated prospective study would be of interest in order to define more precisely treatment response of those patients. …”
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    Combined obstructive airflow limitation associated with interstitial lung diseases (O-ILD): the bad phenotype ?
  15. 342795
    “…We provide applied examples of MR studies examining the role of nutritional factors in cancer to illustrate how this method can be used to help prioritise or deprioritise the evaluation of specific nutritional factors as intervention targets in randomised controlled trials. We describe possible biases when using MR, and methodological developments aimed at investigating and potentially overcoming these biases when present. …”
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    Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer
  16. 342796
    “…CONCLUSIONS: While the autophagy previously observed to correlate with PGCC formation is unlikely necessary for PGCCs to form, autophagy modulating drugs severely impair the ability of HGSC PGCCs to form colonies. Clinical trials which utilize hydroxychloroquine, nelfinavir, and/or rapamycin after chemotherapy may be of future interest. …”
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    Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)
  17. 342797
    “…Furthermore, (99m)Tc could be injected up to at least 126 MBq without compromising (166)Ho image quality. Clinical trials The clinical study mentioned is registered with Clinicaltrials.gov (NCT02067988) on February 20, 2014.…”
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    (166)Holmium–(99)(m)Technetium dual-isotope imaging: scatter compensation and automatic healthy-liver segmentation for (166)Holmium radioembolization dosimetry
  18. 342798
    “…Despite promising preclinical results and evidences of safety and efficacy in phases I/ II, inconsistencies in phase III trials have been reported. In a previous study, we have shown using MSC derived from the bone marrow of PPARβ/δ (Peroxisome proliferator-activated receptors β/δ) knockout mice that the acute cardioprotective properties of MSC during the first hour of reperfusion are PPARβ/δ-dependent but not related to the anti-inflammatory effect of MSC. …”
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    PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury
  19. 342799
    “…CONCLUSIONS: This study identified good practice households and these findings will be useful for designing intervention trials to improve the production and health outcomes evaluated in this study. …”
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    How can we compare multispecies livestock rearing households? – an analysis of the impact of health and production parameters on multispecies livestock rearing outcomes
  20. 342800
    “…The present findings can promote the development of clinical trials and future advanced molecular therapies in Iran. …”
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    Characteristics of disease progression and genetic correlation in ambulatory Iranian boys with Duchenne muscular dystrophy
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