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  1. 342821
    “…METHODS: Five hundred twenty-three OPSCC patients with p16-status treated with primary RT (68.0 Gy to 73.1 Gy in 7 weeks, or 68.0 Gy in 4.5 weeks), with or without concurrent chemotherapy, within three prospective trials were included in the study. Local failure (LF), progression free survival (PFS) and overall survival (OS) in relationship to the size of the primary gross tumor volume (GTV-T) and other prognostic factors were investigated. …”
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    Primary tumor volume and prognosis for patients with p16-positive and p16-negative oropharyngeal squamous cell carcinoma treated with radiation therapy
  2. 342822
    “…Randomised, placebo-controlled trials show that erenumab treatment results in clinically meaningful responses, including significant reductions in monthly migraine days. …”
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    Real-world experience of erenumab in patients with chronic or episodic migraine in the UAE
  3. 342823
    “…Trail registration: ClinicalTrials.gov Identifier: NCT02914132, first posted September 26, 2016. …”
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    Safety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study
  4. 342824
    “…The initial evaluation of the GUI identified significant usability problems that need to be addressed before the start of a clinical evaluation. Prospective trials are also needed in the second step to prove the clinical benefits of the app.…”
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    A Yoga Exercise App Designed for Patients With Axial Spondylarthritis: Development and User Experience Study
  5. 342825
    “…Workload for reviewers was a concern, particularly for topics where there is a steady flow of publication of small trials. CONCLUSIONS: Our study found that participants felt that the vast majority of topics assessed in the Living Stroke Guidelines should be continually updated. …”
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    How frequently should “living” guidelines be updated? Insights from the Australian Living Stroke Guidelines
  6. 342826
    “…Whether this physiological observation could be associated with clinical benefit should be assessed in clinical trials.…”
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    Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the Acute Respiratory Distress Syndrome
  7. 342827
    “…Results from 7 new systematic reviews were presented, alongside 7 expert stakeholder presentations and interim data from the National Audit and from relevant ongoing Clinical Trials. This resulted in the generation of 35 statements for indicative voting by attendees which, following steering committee ratification, led to 30 statements entering the National Delphi exercise. …”
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    Methodology for the development of National Multidisciplinary Management Recommendations using a multi-stage meta-consensus initiative
  8. 342828
    “…Male sex and early-onset AD are associated with and are potential predictors of long-term treatment and treatment of potent topical corticosteroids, antihistamines and skin infections, which may have clinical utility for personalised prognosis, healthcare planning and future AD prevention trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13555-022-00754-6.…”
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    Treatment Patterns of Atopic Dermatitis Medication in 0–10-Year-Olds: A Nationwide Prescription-Based Study
  9. 342829
    “…COAs are easily understood by persons with PROS and caregivers and are appropriate for measuring symptoms and disease-related impacts across diverse PROS syndromes in clinical trials.…”
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    Qualitative research with patients and caregivers of patients with PIK3CA related overgrowth spectrum: content validity of clinical outcome assessments
  10. 342830
    “…CONCLUSIONS: Our study provides the first clinical evidence that ICIs combined with platinum-based doublet chemotherapy may be effective treatment options for overcoming resistance mediated by EGFR T790M-cis-C797S. Clinical trials are needed to evaluate the efficacy and safety of PD-1 inhibitors in the treatment of NSCLC patients harboring EGFR T790M-cis-C797S.…”
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    Two case reports of non-small cell lung cancer patients harboring acquired EGFR T790M-cis-C797S benefit from immune checkpoint inhibitor combined with platinum-based doublet chemotherapy
  11. 342831
    “…Metropolitan clinics utilised neuropsychological assessments for a broader range of cases and were more likely to offer clinical trials and access to research opportunities. CONCLUSIONS: In comparison to similar countries with comprehensive government-funded public healthcare systems (i.e., United Kingdom, Ireland and Canada), wait-times for Australian MCs are long, and post-diagnostic support or evidence-based strategies targeting cognition are not common practice. …”
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    Characterising Australian memory clinics: current practice and service needs informing national service guidelines
  12. 342832
    “…Increasing the power of tests to identify individuals at risk of disease development would be a considerable asset for type 1 diabetes prevention trials. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s00125-022-05703-8) contains peer-reviewed but unedited supplementary material.…”
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    Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
  13. 342833
    “…Oils showed higher larvicidal activity in the laboratory than semi-field trials. The LC(50) values for JVO/PRO were computed as 10.82–2.89/7.13–0.9 ppm and 10.75–9.06/13.63–8.98 ppm in laboratory and semi-field environments, respectively at exposure time of 24–72 h. …”
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    Anti-mosquito properties of Pelargonium roseum (Geraniaceae) and Juniperus virginiana (Cupressaceae) essential oils against dominant malaria vectors in Africa
  14. 342834
    “…A total of 3037 mother-infant pairs from eight randomized controlled trials were ultimately analyzed. The primary outcome was the risk of “asthma and/or wheeze”, and the secondary outcome was “Allergic asthma” in this dose-response meta-analysis. …”
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    A dose-response meta-analysis of the association between the maternal omega-3 long-chain polyunsaturated fatty acids supplement and risk of asthma/wheeze in offspring
  15. 342835
    “…This is the first real-world data reporting the promising efficacy and tolerable toxicities of lenvatinib combined with nivolumab in advanced HCC. Further randomized trials are prompted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10637-022-01248-0.…”
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    Lenvatinib combined with nivolumab in advanced hepatocellular carcinoma-real-world experience
  16. 342836
    “…BACKGROUND: The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II clinical trials. Recently, illudin M derivatives have shown improved in vitro selectivity towards cancer cells encouraging further investigation. …”
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    Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors
  17. 342837
    “…STUDY REGISTRATION: ClinicalTrials.gov Identifier NCT04998370. Date of registration: August 10, 2021.…”
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    The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury
  18. 342838
    “…However, these results still need further high-quality prospective randomized controlled trials confirmation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40001-022-00748-2.…”
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    Outcomes of laparoscopic versus open total gastrectomy with D2 lymphadenectomy for gastric cancer: a systematic review and meta-analysis
  19. 342839
    “…FMS mastery level was defined according to the correct performance of all criteria over two trials. The correlation between BMI and FMS and the interaction of environmental and ethnic on FMS were analyzed. …”
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    Fundamental motor skills of kindergarten children in different environments and ethnic groups in Northwest China
  20. 342840
    “…Understanding the natural history of STXBP1-DEE is important for prognostication and will inform future therapeutic trials.…”
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    Natural History Study of STXBP1-Developmental and Epileptic Encephalopathy Into Adulthood
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