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  1. 343081
    “…Answers to those questions will be gathered in the very near future through large international clinical trials. Cost-effectiveness of implementing HPV testing is likely to exist in the management of borderline or unclear smears in triage treatment as well as in certain scenarios of primary screening within the German health care setting.…”
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    Assessment of effectiveness and cost-effectiveness of HPV testing in primary screening for cervical
  2. 343082
    “…Bleeding events and mortality are considerable higher in studies in the usual care setting compared to clinical trials. In a number of subgroup analyses, both retrospectively and prospectively performed, DAA was not significantly associated with improved survival. …”
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    Efficacy and effectiveness of recombinant human activated protein C in severe sepsis of adults
  3. 343083
    “…We included systematic reviews and randomized controlled trials (RCT). Appraisal of literature was done by two authors independently. …”
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    Mistletoe treatments for minimising side effects of anticancer chemotherapy
  4. 343084
    “…FUNDING: Foundation for Innovative New Diagnostics, Bill & Melinda Gates Foundation, European and Developing Countries Clinical Trials Partnership (TA2007.40200.009), Wellcome Trust (085251/B/08/Z), and UK Department for International Development.…”
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    Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
  5. 343085
    “…However, larger studies and trials are needed to evaluate the effects of ART on these abnormalities as well as to choose the best screening tool in HIV-seropositive women.…”
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    Lower genital tract infections in HIV-seropositive women in India
  6. 343086
    “…This finding might have impact on interpreting previous and designing future trials on diagnosing and modulating immunoendocrine dysregulation (for example, adrenal insufficiency) during systemic inflammation and sepsis.…”
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    Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients
  7. 343087
    “…Randomised controlled trials are needed to confirm a protective effect.…”
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    Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study
  8. 343088
    “…Although a number of HDAC inhibitors are being evaluated in preclinical cancer models and in clinical trials, little is known about the differences in their specific mechanism of action and about the unique determinants of cancer cell sensitivity to each of these inhibitors. …”
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    Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
  9. 343089
    “…However, these differences did not seem to impact the clinical outcomes in the two groups. (ClinicalTrials.gov Identifier: NCT00499343).…”
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    A randomized study comparing chemotherapy followed by G-CSF alone or in combination with GM-CSF for mobilization of peripheral blood stem cells in patients with non-Hodgkin’s lymphomas
  10. 343090
    “…Recognition of patients with ALS who carry an expanded repeat is likely to be important in the context of appropriate disease management, stratification in clinical trials, and in recognition of other related phenotypes in family members. …”
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    Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study
  11. 343091
    “…BACKGROUND: Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. …”
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    Risk of Cardiovascular Disease and Total Mortality in Adults with Type 1 Diabetes: Scottish Registry Linkage Study
  12. 343092
    “…Appropriate assessment of neurotoxicity will be critical as a prognostic factor and as suitable endpoints for future trials of neuroprotective agents. Current methods to assess the severity of chemotherapy-induced neuropathy utilise clinician-based grading scales which have been demonstrated to lack sensitivity to change and inter-observer objectivity(4). …”
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    Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
  13. 343093
    “…In addition, bezafibrate has important fibrinogen-related properties and anti-inflammatory effects. In clinical trials bezafibrate was highly effective for cardiovascular risk reduction in patients with metabolic syndrome and atherogenic dyslipidemia. …”
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    Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?
  14. 343094
    “…Due to the limitations of a retrospective and descriptive study the level of evidence remains low and prospective trials should be conducted.…”
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    Impaction grafting in the femur in cementless modular revision total hip arthroplasty: a descriptive outcome analysis of 243 cases with the MRP-TITAN revision implant
  15. 343095
    “…Every five successive trials were superimposed and the lowest latencies were used for comparison. …”
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    The use of bilateral blink reflexes in intraoperative monitoring of facial-trigeminal nerves in cerebello-pontine angle operations
  16. 343096
    “…This understanding should have implications for the optimization of clinical trials into new treatments and for the choice of treatment decision timescales.…”
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    Quantifying Short-Term Dynamics of Parkinson’s Disease Using Self-Reported Symptom Data From an Internet Social Network
  17. 343097
    “…Studies pooled were mainly small, non-randomized trials. CONCLUSION: Sleep apnea treatment with CPAP improves levels of inflammatory markers.…”
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    Treatment for sleep apnea by continuous positive airway pressure improves levels of inflammatory markers - a meta-analysis
  18. 343098
    por Chanpura, Trupesh, Yende, Sachin
    Publicado 2012
    “…DESIGN: DATA SOURCES: MEDLINE, Embase, Cochrane Register of Controlled Trials, and citation review of relevant primary and review articles. …”
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    Weighing risks and benefits of stress ulcer prophylaxis in critically ill patients
  19. 343099
    “…BACKGROUND: Bilastine is a novel second-generation H(1) antihistamine, which has not shown sedative or cardiotoxic effects in clinical trials and in post-marketing experience so far, developed for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. …”
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    Evaluation of the Single-dose Pharmacokinetics of Bilastine in Subjects with Various Degrees of Renal Insufficiency
  20. 343100
    “…Given the high prevalence of PIK3CA mutations in human carcinomas and the emerging role of PIK3CA mutation status in the treatment selection process, these findings might have a significant impact on the design of future trials evaluating the potential of combining metformin with targeted therapy.…”
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    Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin
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