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  1. 343241
    “…RESULTS: 56 accuracy studies and 25 participation trials were included. hrHPV assays based on polymerase chain reaction were as sensitive on self samples as on clinician samples to detect CIN2+ or CIN3+ (pooled ratio 0.99, 95% confidence interval 0.97 to 1.02). …”
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    Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses
  2. 343242
    “…STUDY REGISTRATION: ClinicalTrials.gov NCT02237…”
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    Early antiretroviral therapy and daily pre‐exposure prophylaxis for HIV prevention among female sex workers in Cotonou, Benin: a prospective observational demonstration study
  3. 343243
    “…If a subject was diagnosed with diabetes or GMD at least once during the period, then that subject’s data obtained in previous trials were classified into the risk group (y=1). …”
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    Prediction of Glucose Metabolism Disorder Risk Using a Machine Learning Algorithm: Pilot Study
  4. 343244
    “…Also, we will include case series with a minimum of 10 cases and clinical trials which have measured baseline biomarker levels. …”
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    CSF and blood biomarkers in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis
  5. 343245
    “…RESULTS: A total of 14 studies, including 13 randomized controlled trials (RCTs) and 1 open-label intervention, were included, from which 11 unique eHealth tools were identified. …”
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    The Use and Effects of Electronic Health Tools for Patient Self-Monitoring and Reporting of Outcomes Following Medication Use: Systematic Review
  6. 343246
    “…These results may inform the design of future prospective studies and trials and help practitioners calibrate their index of suspicion to ensure that patients are referred for timely surgical care.…”
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    Rates of Repeated Operation for Isolated Subdural Hematoma Among Older Adults
  7. 343247
    “…Parameter assumptions were based on large prospective CrAg screening studies in Uganda, and clinical trials from sub Saharan Africa. CrAg positive (CrAg+) persons could be: (a) asymptomatic and thus eligible for preemptive treatment with fluconazole; or (b) symptomatic with meningitis with hospitalization. …”
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    Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: A cost-effectiveness modeling analysis
  8. 343248
    “…METHODS: We searched PubMed or Medline, SciELO, Lilacs, PsychNet, and Web of Science up to July 2018, as well as references of previous reviews for randomized trials that compared Web-based digital health interventions to offline interventions. …”
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    Web-Based Digital Health Interventions for Weight Loss and Lifestyle Habit Changes in Overweight and Obese Adults: Systematic Review and Meta-Analysis
  9. 343249
    “…Despite improvements in management of ARDS on the critical care unit, this complex disease continues to be a major life-threatening event. Clinical trials of β(2)-agonists, statins, surfactants and keratinocyte growth factor (KGF) have been disappointing. …”
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    Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
  10. 343250
    “…RESULTS: A total of 31 trials met the criteria and were, therefore, included in the study. …”
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    A systematic review of analgesia practices in dogs undergoing ovariohysterectomy
  11. 343251
    “…STUDY REGISTRATION: ClinicalTrials.gov NCT03573765.…”
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    Serious adverse events and lifetime risk of reoperation after elective shoulder replacement: population based cohort study using hospital episode statistics for England
  12. 343252
    “…Thus, while sampling, study design and retention rates will remain key determining factors of reliability and validity, further research attention directed toward the development of guiding tools for community trials is warranted.…”
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    Weight Management in Young Adults: Systematic Review of Electronic Health Intervention Components and Outcomes
  13. 343253
    “…This observation, if confirmed, might be clinically relevant since the use of IGF1R and mTOR inhibitors are currently investigated in clinical trials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4072-8) contains supplementary material, which is available to authorized users.…”
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    The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors
  14. 343254
    “…We searched 7 major bibliographic databases from January 1990 to August 2017 and included randomized controlled trials (RCTs) or cluster RCTs. RESULTS: A total of 29 studies, including 3175 learners, met the inclusion criteria. …”
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    Mobile Digital Education for Health Professions: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration
  15. 343255
    “…These findings warrant the transition of H-Zt/g4-MMAE into clinical trials in the future. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40425-019-0525-0) contains supplementary material, which is available to authorized users.…”
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    Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
  16. 343256
    “…BACKGROUND: To compare the clinical performance of bifocal and trifocal intraocular lenses (IOLs) in cataract surgery, a meta-analysis on randomized controlled trials was conducted. METHODS: A comprehensive literature retrieval of PubMed, Science Direct and EMBASE was performed in this systematic review. …”
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    Comparison of postoperative visual performance between bifocal and trifocal intraocular Lens based on randomized controlled trails: a meta-analysis
  17. 343257
    “…METHODS: Integrated post hoc intent-to-treat (ITT) analysis of data from two large 24-week, randomized placebo (PBO)-controlled trials (NCT01313637, NCT01313650). Symptomatic patients with moderate-to-very-severe COPD with/without an exacerbation history were randomized (2:3:3:3) to once-daily: PBO, umeclidinium/vilanterol (UMEC/VI 62.5/25 μg [NCT01313650] or 125/25 μg [NCT01313637]), UMEC (62.5 [NCT01313650] or 125 μg [NCT01313637]) or VI (25 μg) via the ELLIPTA inhaler. …”
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    Impact of prior and concurrent medication on exacerbation risk with long-acting bronchodilators in chronic obstructive pulmonary disease: a post hoc analysis
  18. 343258
    “…Increased protein delivery may improve extubation rate which has positive patient-centred and financial implications, warranting larger confirmatory trials. This investigation adds weight to the ICU literature supporting VBF, and the growing evidence which advocates for enhanced protein delivery to improve patient outcomes. …”
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    Safety and efficacy of volume-based feeding in critically ill, mechanically ventilated adults using the ‘Protein & Energy Requirements Fed for Every Critically ill patient every Time’ (PERFECT) protocol: a before-and-after study
  19. 343259
    “…We searched seven major electronic databases from January 1990 to August 2017 for randomized controlled trials (RCTs) or cluster RCTs. Two authors independently screened studies, extracted data, and assessed the risk of bias. …”
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    Offline Digital Education for Medical Students: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration
  20. 343260
    “…There was a 1.29 log(10) decrease of sputum LAM concentration, corresponding to an increase of 221 hours for MGIT TTD during the first 14 days of treatment, a treatment duration often used in early bactericidal activity (EBA) trials. Major limitations of this study include a relatively small number of patients, treatment duration up to only 56 days, lack of quantitative sputum culture CFU count data, and no examination of the correlation of sputum LAM to clinical cure. …”
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    Lipoarabinomannan in sputum to detect bacterial load and treatment response in patients with pulmonary tuberculosis: Analytic validation and evaluation in two cohorts
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