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  1. 343341
    “…Cardiology determined his CoA to be hemodynamically insignificant and not the cause of his PH. Successive trials of 100% FiO2, Nitric Oxide (NO), and Sildenafil resulted in only minimal improvement of his PH. …”
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    SAT-075 Pulmonary Hypertension in a Patient with Neonatal Graves Disease
  2. 343342
    “…Background: Immune checkpoint blockade is now established as standard of care in several malignancies. Trials involving combined cytotoxic T lymphocyte associated protein 4 (CTLA4) and programmed cell death protein 1 (PD1) blockade demonstrate improved tumour responses in melanoma but at the cost of severe grade 3-4 immune related adverse events (irAEs) in 55%, and endocrine irAEs in up to 10% [1]. …”
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    SUN-127 Diagnostic Challenges Associated with the Rising Incidence of Endocrine Toxicity in the Era of Combination Immunotherapy
  3. 343343
    “…Abstract: Introduction: Thyrotropin (TSH) levels on average are higher and vary more widely among older adults.(1) Large meta-analyses and treatment trials for isolated elevated TSH in older adults did not demonstrate harm from no treatment or benefit from treatment in this population.(2) Isolated, elevated TSH can result from adaptations to aging, rather than primary thyroid disease, suggesting that thyroid hormone treatment could actually cause harm.(3) Objective:To determine if there is a survival effect from thyroid hormone treatment in adults aged 65+. …”
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    OR18-05 Thyroid Hormone Use and Survival among Older Adults - Longitudinal Analysis of the Baltimore Longitudinal Study of Aging (BLSA)
  4. 343344
    “…Importantly, a significant proportion of the aging population does not meet the recommended intake of many micronutrients.(17) Clinical trials on the benefits of micronutrient supplementation have not been conclusive, but adequate intake should be considered an essential component of comprehensive healthcare for older adults. …”
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    SUN-393 The Impact of Micronutrients on Cellular Metabolism and Healthy Aging
  5. 343345
    “…Therefore, we administered the Wnt inhibitor LGK974, currently used in human clinical trials, to the Rs1 mice to test if the FD lesions could be pharmacologically reversed. …”
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    SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia
  6. 343346
    “…Among these studies, 18 were randomized clinical trials and 5 were case-control studies. Compared with those being treated with TACE alone, patients receiving TACE plus apatinib showed significantly better half-year survival (OR, 2.741, 95% CI, 1.745–4.306) and 1-year survival (OR, 2.284, 95% CI, 1.442–3.620). …”
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    A comparison of transcatheter arterial chemoembolization used with and without apatinib for intermediate- to advanced-stage hepatocellular carcinoma: a systematic review and meta-analysis
  7. 343347
    “…More rigorous multi-center trials with standardized metrics for reporting functional outcomes as well as long-term cancer specific survival are necessary to validate these initial studies.…”
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    Single port robotic radical prostatectomy: a systematic review
  8. 343348
    “…HC reaction time outpaced SZ reaction time in trials requiring successful marshalling of proactive control. …”
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    S140. CHARACTERISTICS OF COGNITIVE CONTROL SPECIALIZATION IN HEALTHY AND PATIENT POPULATIONS
  9. 343349
    “…METHODS: We searched Pubmed, Embase and Psychinfo for randomized clinical trials of antipsychotics that reported 7% weight change in study populations aged 18 years or older. …”
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    T199. 7% WEIGHT CHANGE ASSOCIATED WITH ANTIPSYCHOTICS: A META-ANALYSIS
  10. 343350
    “…Therefore, it could be a new promising therapeutic cell source for OA after further clinical trials.…”
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    Multiple umbilical cord–derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis
  11. 343351
    “…At present, insufficient detailed data from trials have been made available.…”
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    The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies
  12. 343352
    “…Registration: ClinicalTrials.gov identifier numbers: NCT03070171, and NCT03143166…”
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    Bioequivalence of a Newly Developed Dabigatran Etexilate Tablet Versus the Commercial Capsule and Impact of Rabeprazole-Induced Elevated Gastric pH on Exposure in Healthy Subjects
  13. 343353
    “…These findings support early ERT initiation in Fabry disease. ClinicalTrials.gov identifier: NCT03289065.…”
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    Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age
  14. 343354
    “…METHODS: We included non-randomised studies of interventions (NRSI) and randomised controlled trials (RCTs), reporting on interventions to prevent or manage IWS in critically ill neonatal, paediatric and adult patients. …”
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    Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies
  15. 343355
    “…METHODS: SMS text messaging replies received from 2 clinical trials were manually coded (1) into “Is staff review required?” …”
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    Use of a Machine Learning Program to Correctly Triage Incoming Text Messaging Replies From a Cardiovascular Text–Based Secondary Prevention Program: Feasibility Study
  16. 343356
    “…Retrospective and prospective clinical trials are warranted.…”
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    Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor–Positive Breast Cancer
  17. 343357
    “…CONCLUSION: Rates of grade 3 ir-D/C were higher than reported in clinical trials. The 58-day median duration of CS therapy for grade 3 ir-D/C places a significant number of patients at risk of complications. …”
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    Five-year review of corticosteroid duration and complications in the management of immune checkpoint inhibitor-related diarrhoea and colitis in advanced melanoma
  18. 343358
    “…Background: Clinical trials showed that only a subset of patients benefits from immunotherapy, suggesting the need to identify new predictive biomarker of resistance. …”
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    Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1
  19. 343359
    “…CONCLUSION: The DI protocol enables automatic dosimetry with undiminished image quality and accuracy. CLINICAL TRIALS: The clinical study mentioned is registered with Clinicaltrials.gov (NCT02067988) on 20 February 2014.…”
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    Quantitative (166)Ho-microspheres SPECT derived from a dual-isotope acquisition with (99m)Tc-colloid is clinically feasible
  20. 343360
    “…Furthermore, the >400 nanomedicine formulations currently in clinical trials are expecting to bring novel clinical solutions (e.g. platforms for nucleic acid delivery), alone or in combination with other key enabling technologies to the market, including biotechnologies, microfluidics, advanced materials, biomaterials, smart systems, photonics, robotics, textiles, Big Data and ICT (information & communication technologies) more generally. …”
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    Delivering the power of nanomedicine to patients today
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