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  1. 343721
    “…The Mouth Handicap in the Scleroderma Scale and the University of California Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 also showed significant positive correlations to the ScleroID score (rho: 0.626, p < 0.001; rho: 0.646, p < 0.001, respectively). …”
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    Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis
  2. 343722
    “…Risk of bias was assessed using the Downs and Black checklist for non-randomised studies of interventions (NRSIs), and Cochrane RoB2 tool for randomised controlled trials (RCTs). Meta-analysis incorporated meta-regressions and a random-effects model. …”
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    Depression after stoma surgery: a systematic review and meta-analysis
  3. 343723
    por Büssgen, Melanie, Stargardt, Tom
    Publicado 2023
    “…OBJECTIVES: The German Pharmaceutical Market Restructuring Act (AMNOG, 2011) is a two-stage process to regulate the price of new pharmaceuticals in which price negotiations are conducted based on evidence-based medical benefit assessments using data from prior clinical trials. Although the act does not explicitly set a willingness-to-pay (WTP) threshold, the process itself implicitly establishes a WTP for health improvement. …”
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    10 Years of AMNOG: What is the Willingness-to-Pay for Pharmaceuticals in Germany?
  4. 343724
    “…Randomized controlled designed in vitro/clinical trials related to the efficacy of the seven therapies for WSLs were included. …”
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    Comparison of therapies of white spot lesions: a systematic review and network meta-analysis
  5. 343725
    “…RESULTS: A total of 7 randomized controlled trials (RCTs) with 428 patients were included, including 215 in the observation group and 213 in the control group. …”
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    Efficacy and safety of apatinib combined with radiotherapy in the treatment of advanced pancreatic cancer: a meta-analysis
  6. 343726
    “…INTRODUCTION: Clinical trials investigating efficacy of immune checkpoint inhibitors (ICI) revealed sex-specific divergent outcomes in urothelial cancer (UC), suggesting that sex hormones might play an important role in gender-specific dimorphisms of response upon ICI. …”
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    Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
  7. 343727
    “…BACKGROUND: Subgroup analyses of randomized trials suggest the superiority of immune checkpoint inhibitor-based therapy over chemotherapy in patients with mismatch-repair deficient (dMMR) and/or microsatellite instability-high (MSI-high) advanced gastric or gastroesophageal junction adenocarcinoma. …”
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    Outcomes and a prognostic classifier in patients with microsatellite instability-high metastatic gastric cancer receiving PD-1 blockade
  8. 343728
    “…This study supports ongoing clinical trials evaluating the safety and efficacy of tocilizumab (anti-IL-6R antibody) in combination with ICIs (NCT04940299, NCT03999749).…”
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    Selective immune suppression using interleukin-6 receptor inhibitors for management of immune-related adverse events
  9. 343729
    “…We searched six databases (PubMed, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, WHO COVID-19) using a peer-reviewed search string with citation tracking and grey literature screening. …”
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    Anxiety increased among children and adolescents during pandemic-related school closures in Europe: a systematic review and meta-analysis
  10. 343730
    “…If so, this bolsters the case for the commissioning of activity interventions and for including QoL as an outcome in trials of such interventions. METHODS: We assessed physical behaviours (total physical activity, moderate-to-vigorous physical activity (MVPA), light physical activity, total sedentary time and prolonged sedentary bout time) for 7 days using hip-worn accelerometers at baseline (2006–2011) and follow-up (2012–2016) and health-related quality-of-life (QoL) using EQ-5D questionnaires at follow-up in 1433 participants (≥ 60 years) of the EPIC (European Prospective Investigation into Cancer)-Norfolk study. …”
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    Associations between change in physical activity and sedentary time and health-related quality of life in older english adults: the EPIC-Norfolk cohort study
  11. 343731
    “…BACKGROUND: Retinal diseases, including wet or dry age-related macular degeneration, diabetic macular edema, and diabetic retinopathy (DR), are underdiagnosed and undertreated in the United States. Clinical trials support the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) therapies for several retinal conditions, but real-world data suggest underuse by clinicians, resulting in patients experiencing poorer visual outcomes over time. …”
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    Impact of an immersive, interactive medical education initiative on guideline-based retinal disease management knowledge/competence and effectual practice change
  12. 343732
    “…Estimated rates of new injection-related infections in the US are limited due to widely varying estimates of the number of PWID in the US, and in the absence of clinical trials and nationally representative longitudinal observational studies of PWID, simulation models provide important insights to policymakers for informed decisions. …”
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    A multimorbidity model for estimating health outcomes from the syndemic of injection drug use and associated infections in the United States
  13. 343733
    “…In orphan indications practical and ethical challenges in conducting clinical trials, particularly in paediatric patients, often limit the available evidence, rendering structured evaluation challenging. …”
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    Exploring the feasibility of using the ICER Evidence Rating Matrix for Comparative Clinical Effectiveness in assessing treatment benefit and certainty in the clinical evidence on orphan therapies for paediatric indications
  14. 343734
    “…Standard ECGs may help identify individuals with prodromal PD for cost-effective population-level early detection and inclusion in disease-modifying therapeutic trials.…”
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    Externally validated deep learning model to identify prodromal Parkinson’s disease from electrocardiogram
  15. 343735
    “…Furthermore, four short message service trials revealed a treatment success risk ratio ranging from 1.0 to 1.45 (95% CI fell within these values) with a cost-effectiveness of up to 350I$ compared to standard of care. …”
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    Mapping the effectiveness of the community tuberculosis care programs: a systematic review
  16. 343736
    “…Large scale randomised controlled trials are required to confirm whether exercise snacking is effective in the short and long term. …”
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    Exercise snacking to improve physical function in pre-frail older adult memory clinic patients: a 28-day pilot study
  17. 343737
    “…METHODS: Seven electronic databases were searched from inception to December 2022 for cross-sectional studies, cohort studies, case­­-­control studies, and randomized controlled trials (RCTs) on neck pain. The quality of the selected studies were assessed by American Agency for Healthcare Research and Quality (AHRQ) or the Newcastle-Ottawa Scale (NOS). …”
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    Risk factors for neck pain in college students: a systematic review and meta-analysis
  18. 343738
    “…However, regarding other herpesviruses (EBV and CMV), further research especially from observational studies and clinical trials is required to elucidate the interaction between COVID-19 vaccination and their reactivation. …”
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    Herpesviruses reactivation following COVID-19 vaccination: a systematic review and meta-analysis
  19. 343739
    “…Furthermore, evidence from clinical trials may not be generalizable to real-world settings. …”
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    Association between dietary supplement use and mortality among US adults with diabetes: a longitudinal cohort study
  20. 343740
    “…All English articles published as of October 2022 were searched in four electronic databases: PubMed, Scopus, Web of Science (WoS), and the Cochrane Central Register of Controlled Trials (CENTRAL). We computed pooled estimates of ASMR using random-effects meta-analysis. …”
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    The global estimate of premature cardiovascular mortality: a systematic review and meta-analysis of age-standardized mortality rate
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