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  1. 343741
    por Wu, Nan, Katz, David A., An, Guohua
    Publicado 2023
    “…METHODS: PK and PD data from the first-in-human (FIH) clinical trials, including single ascending dose (SAD) and multiple ascending dose (MAD) studies, were used for model development. …”
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    Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
  2. 343742
    “…The patients were managed prospectively by the Shoklo Malaria Research Unit (SMRU) on the Thailand-Myanmar border or were included in hospital-based clinical trials in six Southeast Asian countries. Fixed-effects multivariable penalised logistic regression was used for analysing maternal mortality. …”
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    Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
  3. 343743
    por Wu, Qing, Wang, Ziming, Luo, Yang, Xie, Xianhe
    Publicado 2023
    “…METHODS: Electronic databases were screened to identify relevant trials. The primary endpoints were pooled objective response rate (ORR) and disease control rate (DCR). …”
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    Efficacy and safety of immune checkpoint inhibitors in Proficient Mismatch Repair (pMMR)/ Non-Microsatellite Instability-High (non-MSI-H) metastatic colorectal cancer: a study based on 39 cohorts incorporating 1723 patients
  4. 343744
    “…CONCLUSIONS: In conclusion, four key genes, Tfcp2l1, Kcns3, Olfml2a and Arl4d, significantly associated with the treatment of OGD/R by breviscapine were identified, which provides a theoretical basis for clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-023-01651-3.…”
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    Identification of m(6)A methylation-related genes in cerebral ischaemia‒reperfusion of Breviscapus therapy based on bioinformatics methods
  5. 343745
    “…However, recently published large clinical trials (OPERAM and SENATOR) have shown negative results on the use of CDSSs and patient outcomes and strikingly low acceptance of recommendations. …”
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    Clinical Decision Support Systems in Hospitalized Older Patients: An Exploratory Analysis in a Real-Life Clinical Setting
  6. 343746
    “…METHODS: We conducted a longitudinal analysis of PLWH enrolled in two large multicenter clinical trials across China, and outpatients followed at the clinic of Peking Union Medical College Hospital. …”
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    Risk factors and longitudinal changes of dyslipidemia among Chinese people living with HIV receiving antiretroviral therapy
  7. 343747
    “…There must be more SRs/MAs and high-quality clinical trials conducted to confirm these findings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40359-023-01313-0.…”
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    A meta-analysis of systematic reviews and meta-analyses to evaluate the psychological consequences of COVID-19
  8. 343748
    “…All of the random controlled trials(RCTs) were evaluated and collected as eligible studies. …”
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    Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma after curative resection
  9. 343749
    “…However, further randomized controlled trials are required to verify these results. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13048-023-01277-0.…”
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    Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth?
  10. 343750
    por Hardison, Scott A., Senior, Brent A.
    Publicado 2023
    “…Initial studies have shown an acceptable safety profile, but trials assessing the use of dupilumab for a separate indication revealed a higher rate of conjunctivitis. …”
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    The argument against the use of dupilumab in patients with limited polyp burden in chronic rhinosinusitis with nasal polyposis (CRSwNP)
  11. 343751
    “…Further research is necessary to evaluate if PSMA-PET parameters can predict progression-free survival and overall survival and serve as novel endpoints in clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41824-023-00178-1.…”
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    Associations of quantitative whole-body PSMA-PET metrics with PSA progression status under long-term androgen deprivation therapy in prostate cancer patients: a retrospective single-center study
  12. 343752
    “…These results have implications for patient selection for upcoming clinical trials.…”
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    Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants
  13. 343753
    “…Some other items including patient involvement in clinical trials, HbA1c in long-acting rhGH therapy and adherence did not meet the MDS criteria but were considered to be important enough to be included and some of the items were merged into one item. …”
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    THU166 A Minimum Data Set For The Monitoring Of Recombinant Human Growth Hormone (rhGH) Therapy In Children With Growth Hormone Deficiency (GHD)—A GloBE-Reg Initiative
  14. 343754
    “…However, it is important to note that further randomized controlled trials are necessary to validate and authenticate these findings. …”
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    Association of serum uric acid with prognosis in patients with myocardial infarction: an update systematic review and meta-analysis
  15. 343755
    “…INTRODUCTION: Biosimilar CT-P13 was approved with limited data from clinical trials compared to the originator infliximab in biologic-naïve patients with rheumatoid arthritis. …”
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    Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
  16. 343756
    “…In addition, we explored the correlation between riskScores and clinical trials and immune-related factors (22 immune-infiltrating cells, tumor microenvironment, 13 immune-related pathways and 24 HLA genes). …”
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    Construction of ceRNA prognostic model based on the CCR7/CCL19 chemokine axis as a biomarker in breast cancer
  17. 343757
    “…While the vaccines were developed and tested through extensive human trials, historically vaccines have been known to evoke mixed sentiments among the generic demographics. …”
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    The impact of geo-political socio-economic factors on vaccine dissemination trends: a case-study on COVID-19 vaccination strategies
  18. 343758
    por Meca-Lallana, José E., Prieto González, José M., Caminero Rodríguez, Ana B., Olascoaga Urtaza, Javier, Alonso, Ana M., Durán Ferreras, Eduardo, Espinosa, Raúl, Dotor, Julio, Romera, Mercedes, Ares Luque, Adrián, Pérez Ruiz, Domingo, Calles, Carmen, Hernández, Miguel A., Hervás García, Miguel, Mendoza Rodríguez, Amelia, Berdei Montero, Yasmina, Téllez, Nieves, Herrera Varó, Nicolás, Sotoca, Javier, Presas-Rodríguez, Silvia, Querol Gutierrez, Luis A., Hervás Pujol, Mariona, Batlle Nadal, Jordi, Martín Ozaeta, Gisela, Gubieras Lillo, Laura, Martínez Yélamos, Sergio, Ramió-Torrentà, Lluís, Mallada Frechin, Javier, Belenguer Benavides, Antonio, Gascón-Giménez, Francisco, Casanova, Bonaventura, Landete Pascual, Lamberto, Berenguer, Leticia, Navarro, Laura, Gómez Gutierrez, Montserrat, Durán, Carmen, Rodríguez Regal, Ana, Álvarez, Elena, García-Estévez, Daniel A., López Real, Ana M., Llaneza González, Miguel A., Marzo Sola, María E., Sánchez-Menoyo, José L., Oterino, Agustín, Villaverde González, Ramón, Castillo-Triviño, Tamara, Álvarez de Arcaya, Amaya, Llarena, Cristina
    Publicado 2023
    “…INTRODUCTION: Teriflunomide is a once-daily oral immunomodulator approved for relapsing forms of multiple sclerosis (MS) or relapsing–remitting multiple sclerosis (RRMS; depending on the local label), based on extensive evidence from clinical trials and a real-world setting on efficacy, tolerability and patient-reported benefits. …”
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    Effectiveness and Safety of Teriflunomide in Relapsing–Remitting Multiple Sclerosis and Improvements in Quality of Life: Results from the Real-World TERICARE Study
  19. 343759
    “…Both in vitro cell imaging and in vivo tumor treatment trials proved that HTI was effectively served as a robust scaffold for tumor labeling and CRC cells clearance. …”
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    Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe
  20. 343760
    “…We searched electronic databases including Medline, Embase, Global Health, Scopus, WoS Science Citation Index, Wiley Cochrane Central Register of Controlled Trials, Africa-Wide Information, LILACS and WHO Global Index. …”
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    Accuracy of the direct agglutination test for diagnosis of visceral leishmaniasis: a systematic review and meta-analysis
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