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  1. 343761
    “…CONCLUSION: We determined the prevalence of different LGMD subtypes in Southeast China, described the detailed clinical manifestations and distinct muscle MRI patterns of these LGMD subtypes and reported the frequent mutations and the cardiorespiratory involvement frequency in our cohort, all of which might facilitate the differential diagnosis of LGMDs, allowing more timely treatment and guiding future clinical trials. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-023-02897-x.…”
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    Clinical features, imaging findings and molecular data of limb-girdle muscular dystrophies in a cohort of Chinese patients
  2. 343762
    “…The drug molecules may play an important role for therapeutic development against delirium if they are investigated more extensively through clinical trials and various wet lab experiments. CONCLUSION: This study could possibly help future research on investigating the delirium-associated therapeutic target biomarker hub-proteins and repurposed drug compounds. …”
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    Exploration of key drug target proteins highlighting their related regulatory molecules, functional pathways and drug candidates associated with delirium: evidence from meta-data analyses
  3. 343763
    por feng, Juntao, Wei, Shisi, Pang, Lihong
    Publicado 2023
    “…RESULTS: A total of five studies, including three randomized controlled trials (RCTs) and two retrospective studies, with a combined participation of 2325 individuals, were included. …”
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    Mersilene tape versus conventional sutures in transvaginal cervical cerclage: a systematic review and meta-analysis
  4. 343764
    “…CONCLUSIONS: Prediction of severe AKI in pediatric septic shock is important to improve outcomes, allocate resources, and inform enrollment in clinical trials examining potential disease-modifying therapies. …”
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    External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
  5. 343765
    “…There was no synergistic interaction for growth inhibition with the humAbs tested here that target different epitopes or subdomains of PvDBP, suggesting little benefit in clinical trials using combinations of these humAbs.…”
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    Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein
  6. 343766
    “…The observation of transient acute effects in the oral mucosa of a number of glioma patients involved in the American clinical trials, suggests that radiation damage of the oral mucosa could be a potential complication in future BNCT clinical protocols, involving higher doses and larger irradiation field sizes. …”
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    Boron microlocalization in oral mucosal tissue: implications for boron neutron capture therapy
  7. 343767
    por Jenab, Mazda, Bueno-de-Mesquita, H Bas, Ferrari, Pietro, van Duijnhoven, Franzel J B, Norat, Teresa, Pischon, Tobias, Jansen, Eugène H J M, Slimani, Nadia, Byrnes, Graham, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Bergmann, Manuela M, Trichopoulou, Antonia, Misirli, Gesthimani, Trichopoulos, Dimitrios, Berrino, Franco, Vineis, Paolo, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Ros, Martine M, van Gils, Carla H, Peeters, Petra H, Brustad, Magritt, Lund, Eiliv, Tormo, María-José, Ardanaz, Eva, Rodríguez, Laudina, Sánchez, Maria-José, Dorronsoro, Miren, Gonzalez, Carlos A, Hallmans, Göran, Palmqvist, Richard, Roddam, Andrew, Key, Timothy J, Khaw, Kay-Tee, Autier, Philippe, Hainaut, Pierre, Riboli, Elio
    Publicado 2010
    “…Conclusions The results of this large observational study indicate a strong inverse association between levels of pre-diagnostic 25-(OH)D concentration and risk of colorectal cancer in western European populations. Further randomised trials are needed to assess whether increases in circulating 25-(OH)D concentration can effectively decrease the risk of colorectal cancer.…”
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    Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
  8. 343768
    “…They provide a stronger basis for the constitution of more homogeneous groups to be included in clinical trials. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13023-015-0335-5) contains supplementary material, which is available to authorized users.…”
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    Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood—a study of 155 patients
  9. 343769
    “…In this setting, recruitment into clinical trials is warranted, and studies driven by selection according to individual tumor molecular characteristics are expected to provide added value. …”
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    Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience
  10. 343770
    “…IMPORTANCE An effective AIDS vaccine continues to be of paramount importance for the control of the pandemic, and it has been proven to be an elusive target. Vaccine efficacy trials and macaque challenge studies indicate that protection may be the result of combinations of many parameters. …”
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    Control of Heterologous Simian Immunodeficiency Virus SIV(smE660) Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques
  11. 343771
    “…These results could be used in clinical trials to pre-screen subjects for anti-amyloid therapies. …”
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    MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study
  12. 343772
    “…CONCLUSIONS: Genetic factors identified as part of this pan-European project, PanCareLIFE, may contribute to future risk prediction models that can be incorporated in future clinical trials of platinum-based therapies for cancer and may help with the development of prevention strategies. …”
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    Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study
  13. 343773
    “…Development of a disease biomarker would augment observational studies seeking to further define the risk factors, natural history, and clinical features of LATE, as well as eventual subject recruitment for targeted therapies in clinical trials.…”
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    Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
  14. 343774
    “…These measures correlate with the presence of pre-existing structural complications and this has implications for the reporting of trials using a single measure as a primary outcome. …”
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    Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)
  15. 343775
    “…Our results should inform future clinical trials that aim to reduce the burden of type 2 diabetes through the modification of serum levels of leptin and adiponectin.…”
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    Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study
  16. 343776
    “…Studies were screened independently by two reviewers and were included if they (1) described an intervention that engaged patients in an initiative to reduce low-value care, (2) reported the use of low-value care with and without the intervention, and (3) were randomized clinical trials (RCTs) or quasi-experimental designs. Studies describing interventions solely focused on clinicians or published in a language other than English were excluded. …”
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    Engaging patients in de-implementation interventions to reduce low-value clinical care: a systematic review and meta-analysis
  17. 343777
    “…Task durations and the tension-time index of HGE did not differ between normoxic and hypoxic trials. CONCLUSION: Hypoxic compared to normoxic HGE decreased SmO(2) and induced lower mean power frequency in the FDS, during repetitive hand grip exercise however did not result in differences in task durations or tension-time indices. …”
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    The effects of hypoxia on muscle deoxygenation and recruitment in the flexor digitorum superficialis during submaximal intermittent handgrip exercise
  18. 343778
    “…We would suggest the use of CD3 + TIL as a stratifying factor for LA-NPC, which warrants further validation in prospective trials.…”
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    CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma
  19. 343779
    por Bertoluci, Marcello Casaccia, Salles, João Eduardo Nunes, Silva-Nunes, José, Pedrosa, Hermelinda Cordeiro, Moreira, Rodrigo Oliveira, da Silva Duarte, Rui Manuel Calado, da Costa Carvalho, Davide Mauricio, Trujilho, Fábio Rogério, dos Santos Raposo, João Filipe Cancela, Parente, Erika Bezerra, Valente, Fernando, de Moura, Fábio Ferreira, Hohl, Alexandre, Melo, Miguel, Araujo, Francisco Garcia Pestana, de Araújo Principe, Rosa Maria Monteiro Castro, Kupfer, Rosane, Costa e Forti, Adriana, Valerio, Cynthia Melissa, Ferreira, Hélder José, Duarte, João Manuel Sequeira, Saraiva, José Francisco Kerr, Rodacki, Melanie, Castelo, Maria Helane Costa Gurgel, Monteiro, Mariana Pereira, Branco, Patrícia Quadros, de Matos, Pedro Manuel Patricio, de Melo Pereira de Magalhães, Pedro Carneiro, Betti, Roberto Tadeu Barcellos, Réa, Rosângela Roginski, Trujilho, Thaisa Dourado Guedes, Pinto, Lana Catani Ferreira, Leitão, Cristiane Bauermann
    Publicado 2020
    “…METHODS: MEDLINE (via PubMed) was searched for randomized clinical trials, meta-analyses, and observational studies related to diabetes treatment. …”
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    Portuguese-Brazilian evidence-based guideline on the management of hyperglycemia in type 2 diabetes mellitus
  20. 343780
    “…Well-designed randomised controlled trials are needed to measure outcomes, durability of effect, and cost effectiveness.…”
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    A feasibility study of an exercise intervention to educate and promote health and well-being among medical students: the ‘MED-WELL’ programme
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