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  1. 344021
    “…METHODS: The Austrian Azacitidine Registry is a multicentre database (ClinicalTrials.gov: NCT01595295). For this analysis, we selected 339 patients treated with azacitidine front-line. …”
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    Azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of French-American-British and World Health Organization classifications
  2. 344022
    “…Three Orthopedic surgeons performed the pivot shift test and one surgeon applied maximal anterior load at 30° of knee flexion and maximal rotatory torques (internal and external rotations) at 30° and 90° of knee flexion. Three trials of each examination were recorded in seven knee states (Table 1). …”
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    Effects of Anterolateral Capsular Injury and Extra-Articular Tenodesis on Knee Kinematics During Physical Examination
  3. 344023
    “…Strength was defined as the maximum isometric force generated over three trials. For each test, percentile rank was determined within the sample. …”
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    Strength of Dynamic Stabilizers of the Elbow in Professional Baseball Pitchers Decreases during Baseball Season
  4. 344024
    “…The inclusion criteria was all published peer-reviewed studies including randomized controlled trials, nonrandomized comparative studies, cohort studies, and case series (> 10 patients) with outcome data following primary ACLR with a LEAR with more than two years follow-up. …”
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    The Outcome of a Combined Lateral Extra-Articular Reconstruction and Anterior Cruciate Ligament Reconstruction: A Systematic Review of the Literature
  5. 344025
    “…Future randomized controlled trials are needed to further strengthen the results and to determine potential moderator variables. …”
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    Changing Mental Health and Positive Psychological Well-Being Using Ecological Momentary Interventions: A Systematic Review and Meta-analysis
  6. 344026
    “…Identifying functional outcomes sensitive to the early, subtle changes in muscle function has confounded clinical trials. Additionally, the alterations in disease progression secondary to corticosteroid therapy are not well described making it difficult to ascertain the benefits of novel agents, often taken concurrently with corticosteroids. …”
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    Can Quantitative Muscle Strength and Functional Motor Ability Differentiate the Influence of Age and Corticosteroids in Ambulatory Boys with Duchenne Muscular Dystrophy?
  7. 344027
    “…Increasing concerns about limitations of LLINs and IRS and encouraging results from large larvicide-based LSM trials make a strong case for using biological larviciding as a complementary tool to existing control measures. …”
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    Routine implementation costs of larviciding with Bacillus thuringiensis israelensis against malaria vectors in a district in rural Burkina Faso
  8. 344028
    “…Evidence for the relative efficacy of different devices was sparse but a statistically significant advantage was observed for rerouting speech signals using abutment-mounted bone conduction devices when compared with outcomes after preoperative trials of air conduction devices when speech and noise were colocated (mean benefit, 1.5 dB). …”
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    Hearing Instruments for Unilateral Severe-to-Profound Sensorineural Hearing Loss in Adults: A Systematic Review and Meta-Analysis
  9. 344029
    “…New approaches are therefore needed to use these existing data and derive new insights that can augment traditional smaller-group randomized controlled trials. OBJECTIVE: Our objective was to demonstrate how emerging big data approaches can help explore questions about the effectiveness and process of an Internet well-being intervention. …”
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    Seeing the “Big” Picture: Big Data Methods for Exploring Relationships Between Usage, Language, and Outcome in Internet Intervention Data
  10. 344030
    “…METHODS: Data from 31 parallel-group randomised controlled trials (RCTs) of ICS/LABA, of ≥8 weeks’ duration in patients aged ≥12 years with asthma, identified by systematic review, were analysed using covariate-adjusted Bayesian hierarchical models for four efficacy outcomes (primary analysis). …”
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    Once-daily fluticasone furoate/vilanterol versus twice daily combination therapies in asthma–mixed treatment comparisons of clinical efficacy
  11. 344031
    “…CONCLUSIONS: In designing clinical trials of novel TB regimens, investigators should consider that even small changes in treatment efficacy may have considerable impact on TB-related incidence and mortality. …”
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    Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model
  12. 344032
    “…These data indicate that effects of CCL2/CCR2 antagonists on the intratumoral leukocyte content should be monitored in ongoing clinical trials using these agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-017-3074-2) contains supplementary material, which is available to authorized users.…”
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    The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo
  13. 344033
    “…The doses of VitC used here correspond to plasma VitC levels reported in recently completed clinical trials. Prior to supplementation, a baseline sample was collected for analysis. …”
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    Impact of high dose vitamin C on platelet function
  14. 344034
    “…With thorough validation, quantification of inherited genetic variation may prove useful for stratifying AD risk and as an enrichment strategy in therapeutic trials.…”
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    Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
  15. 344035
    “…The ability to assess the distribution and extent of tau pathology in Alzheimer’s disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies. New radioligands for positron emission tomography have generated considerable interest, and controversy, in their potential as tau biomarkers. …”
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    (18)F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy
  16. 344036
    “…Bivalent rLP2086 was well tolerated and elicited substantial and broad bactericidal responses to diverse MnB strains in a high proportion of recipients after 2 vaccinations, and these responses were further enhanced after 3 vaccinations. ClinicalTrials.gov identifier NCT01323270…”
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    Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents
  17. 344037
    “…BACKGROUND: Achieving control of glycated hemoglobin (HbA1c), blood pressure (BP), and body weight (BW) remains a challenge for most patients with type 2 diabetes mellitus (T2DM). In clinical trials, canagliflozin (CANA), an inhibitor of sodium-glucose co-transporter 2, has shown significant improvement compared to some dipeptidyl peptidase-4 (DPP-4) inhibitors in the achievement of such quality measures. …”
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    Quality measure and weight loss assessment in patients with type 2 diabetes mellitus treated with canagliflozin or dipeptidyl peptidase-4 inhibitors
  18. 344038
    “…STUDYING THE GENETIC CONTROL OF GRAIN QUALITY IN SW84: As a case study, grain quality of SW84 was studied in replicated field trials. Transgressive segregation was observed for all studied grain quality traits by evaluating SW84 for two years at two locations under low and high nitrogen supply. …”
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    Exotic QTL improve grain quality in the tri-parental wheat population SW84
  19. 344039
    “…CONCLUSIONS: The renal decline in Alport syndrome patients is heterogeneous which has implications for designing clinical trials of interventions.…”
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    The Variability of Estimated Glomerular Filtration Rate Decline in Alport Syndrome
  20. 344040
    “…Subjects completed an instrumented drop vertical landing assessment with the ground reaction forces recorded while the subjects performed a drop vertical jump task off a 30.48 cm high box. Three trials were taken and the data were analyzed using custom Labview code and Visual 3D software during the period of time from foot contact until initial impact peak. …”
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    Kinesiophobia is Strongly Associated with Altered Loading after an ACL Reconstruction: Implications for Re-injury Risk
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