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  1. 344041
    “…OBJECTIVES: Patient reported outcomes (PRO) following surgery is vital to determining treatment efficacy and is valuable for executing comparative trials. Traditional legacy measures used to assess outcomes of patients undergoing arthroscopic hip surgery have included the modified Harris Hip Score (mHHS), the Non-arthritic Hip Score (NAHS) and the Hip Outcome Score (HOS), among others. …”
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    Correlation of PROMIS CAT with Validated Hip Outcome Scores in Patients Undergoing Hip Arthroscopy
  2. 344042
    “…BACKGROUND: MODIFY I/II were global trials of the efficacy and safety of bezlotoxumab (BEZ), a monoclonal antibody (mAb) against C. difficile toxin B, alone and with actoxumab (ACT), a mAb against C. difficile toxin A. …”
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    Endogenous Serum IgG Antibodies to Clostridium difficile Toxin B Are Associated with Protection against C. difficile Infection Recurrence
  3. 344043
    “…Patients receiving a single infusion of BEZ alone or with ACT in the MODIFY I/II trials showed a consistent reduction in the rate of rCDI over a 12-week period compared with a placebo (PBO) infusion. …”
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    Genome Wide Analysis Reveals Host Genetic Variants that Associate with Reduction in Clostridium difficile Infection Recurrence (rCDI) in Patients Treated with Bezlotoxumab
  4. 344044
    “…BACKGROUND: Cabotegravir (CAB) is an integrase inhibitor in phase 3 clinical trials for the treatment and prevention of HIV. CAB undergoes glucuronidation via UGT1A1 with <1% renal elimination of unchanged CAB. …”
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    Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment
  5. 344045
    “…METHODS: We retrospectively studied a cohort of patients with HM who received BTK (ibrutinib, acalabrutinib, spebrutinib) or PI3K (idelalisib, duvelisib, TGR-1202) inhibitors as part of clinical trials at our center between March 2008 and November 2016. …”
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    Opportunistic Infections (OIs) in Patients with Hematologic Malignancies (HM) Treated with Bruton’s Tyrosine Kinase (BTK) and Phosphoinositide 3 Kinase (PI3K) Inhibitors: An 8-Year Retrospective Cohort Study
  6. 344046
    “…BACKGROUND: Cabotegravir (CAB) is an integrase inhibitor in phase 3 clinical trials for the treatment and prevention of HIV. CAB undergoes hepatic metabolism primarily via UGT1A1; thus hepatic impairment has the potential to affect CAB exposure. …”
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    Pharmacokinetics of Cabotegravir in Subjects with Moderate Hepatic Impairment
  7. 344047
    “…RESULTS: 7 eligible studies (4 randomized trials and 3 observational studies) were identified following the screening of 1,816 studies. …”
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    Efficacy and Effectiveness of High-Dose Influenza Vaccine for Older Adults: A Systematic Review and Meta-Analysis
  8. 344048
    “…This may have implications for clinical diagnosis and for selecting subjects for participation in clinical trials.…”
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    Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia
  9. 344049
    por Dougherty, Bryn, Badawy, Sherif M
    Publicado 2017
    “…Searches included PubMed MEDLINE, Embase, INSPEC (Ebsco), Cochrane Central Register of Controlled Trials (CENTRAL), IEEE Explore, Web of Science, Scopus, and Compendex. …”
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    Using Google Glass in Nonsurgical Medical Settings: Systematic Review
  10. 344050
    “…BACKGROUND: Switch strategies based on rilpivirine/tenofovir/emtricitabine or on an integrase inhibitor (InSTI) plus tenofovir/emtricitabine have never been compared in randomized clinical trials. The main aim of the study was to investigate the durability of these two switch regimens in virologically suppressed, HIV-infected patients. …”
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    Durability of switch regimens based on rilpivirine or on integrase inhibitors, both in association with tenofovir and emtricitabine, in HIV-infected, virologically suppressed patients
  11. 344051
    “…However, the application of CDDP/5FU was associated with significantly more hematologic III°- toxicities compared to Carb/TAX. Future prospective trials should investigate if these results are reproducible in randomized patient cohorts.…”
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    Comparison of neoadjuvant chemoradiation with carboplatin/ paclitaxel or cisplatin/ 5-fluoruracil in patients with squamous cell carcinoma of the esophagus
  12. 344052
    “…This study is registered with ClinicalTrials.gov identifier NCT00114101; new patients are no longer being recruited, but some patients remain on treatment and in follow-up. …”
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    Updated analysis of CALGB 100104 (Alliance): a randomised phase III study evaluating lenalidomide vs placebo maintenance after single autologous stem cell transplant for multiple myeloma
  13. 344053
    “…These findings have potential implications for clinical trials targeting immune dysfunction in patients with FTD.…”
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    Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
  14. 344054
    “…STUDY ELIGIBILITY, PARTICIPANTS, AND INTERVENTIONS: We included cohort studies with comparator arm, and randomized controlled trials (RCTs) with >50% of adult patients (≥18 years) comparing any form of intensive HD (>4 sessions/wk or >5.5 h/session) with any form of chronic dialysis (PD, HD ≤4 sessions/wk or ≤5.5 h/session), that reported at least 1 predefined outcome (mortality or hospitalization). …”
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    Mortality and Hospitalizations in Intensive Dialysis: A Systematic Review and Meta-Analysis
  15. 344055
    “…This study evaluated differences in dosing and clinical outcomes before and after Gla-300 treatment initiation in patients with type 2 diabetes starting or switching to treatment with Gla-300 to assess whether the benefits observed in clinical trials translate into real-world settings. METHODS: This was a retrospective observational study using medical record data obtained by physician survey for patients starting treatment with insulin glargine at a strength of 100 units per milliliter (Gla-100) or Gla-300, or switching to treatment with Gla-300 from treatment with another basal insulin (BI). …”
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    Treatment Dosing Patterns and Clinical Outcomes for Patients with Type 2 Diabetes Starting or Switching to Treatment with Insulin Glargine (300 Units per Milliliter) in a Real-World Setting: A Retrospective Observational Study
  16. 344056
    “…Included studies were randomized controlled trials (RCTs) and large (more than 1,000 participants) prospective cohort studies with greater than or equal to one-year follow-up comparing outcomes of women delivering by cesarean delivery and by vaginal delivery. …”
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    Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis
  17. 344057
    “…The growing use of the Internet offers new ways of collecting data, but trials using Web-based questionnaires have so far seen mixed results. …”
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    Paper- or Web-Based Questionnaire Invitations as a Method for Data Collection: Cross-Sectional Comparative Study of Differences in Response Rate, Completeness of Data, and Financial Cost
  18. 344058
    “…Going forward, further rigorously controlled randomised human trials with well-defined dietary substrates and utilizing omic-based technologies to characterise and measure the IM and their functional activities will advance the field. …”
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    Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients
  19. 344059
    “…More collaboration is required between relevant stakeholders to ensure development of high quality and relevant adherence apps with well-powered and robust clinical trials investigating the effectiveness of these interventions. …”
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    Medication Adherence Apps: Review and Content Analysis
  20. 344060
    “…Although reports of brain plasticity in older adults and the service needs of chronic mid-aged and older patients with schizophrenia are increasing, very few randomized controlled trials of CR have been conducted in mid-aged and older inpatients with schizophrenia. …”
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    F55. EFFICACY OF COMPUTER ASSISTED COGNITIVE REMEDIATION IN MID-AGED AND OLDER INPATIENTS WITH CHRONIC SCHIZOPHRENIA IN KOREA
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