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  1. 344121
    “…We thus tested an AAV2/8 variant, which was selected based on its safety record in multiple clinical trials, adding a glial fibrillary acidic protein (GFAP) promoter and mCherry (red fluorescent protein) reporter. …”
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    Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia
  2. 344122
    “…ICBT has been found to be efficacious in research trials and routine care, but there is limited research of ICBT when it is recommended and funded by insurance companies for clients on or recently in receipt of disability benefits or accommodations. …”
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    An Internet-Delivered Cognitive Behavioral Therapy for Depression and Anxiety Among Clients Referred and Funded by Insurance Companies Compared With Those Who Are Publicly Funded: Longitudinal Observational Study
  3. 344123
    “…We searched PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and WANFANG DATA for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies that evaluated therapies (hydroxychloroquine, lopinavir/ritonavir-based therapy, and ribavirin-based therapy, etc.) for SARS, MERS, and COVID-19. …”
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    Efficacy and safety of current therapeutic options for COVID-19 - lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis
  4. 344124
    “…Testing the apps in a home setting gave rise to some new usability problems, and for Self-TUG and Self-STS, the rates of correctly performed trials were slightly reduced from the second version, while for Self-Tandem, the rate increased. …”
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    App-based Self-administrable Clinical Tests of Physical Function: Development and Usability Study
  5. 344125
    “…The effect of mild induced hypothermia on outcomes of patients after cardiac arrest: a systematic review and meta-analysis of randomized controlled trials. Zhang et al. Critical Care (2015) 19:417. 2. …”
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    AN ASSESSMENT OF CLINICAL EFFICACY OF HYPOTHERMIC THERAPY FOLLOWING MILD TRAUMATIC BRAIN INJURY IN THE ADOLESCENT ATHLETE AS COMPARED TO AN UNTREATED ACTIVE CONTROL POPULATION
  6. 344126
    “…All values were normalized to the product of height and weight and averaged across three trials. Participants were grouped into SS or MS groups, then sub-grouped by gender. …”
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    EFFECTS OF SPORTS SPECIALIZATION ON LOWER EXTREMITY SAGITTAL PLANE LOADING IN ADOLESCENT MALES AND FEMALES
  7. 344127
    “…All participants underwent an MRI scan that included 6 minutes of resting state and 4 runs (40 trials per run) of the AX-CPT task. A subject-specific mask of the bilateral thalamus was extracted using Freesurfer segmentation of the structural images to generate subject-specific seed regions for both rs-fMRI and task-based connectivity. …”
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    O5.4. THALAMIC CONNECTIVITY IN EARLY PSYCHOSIS DURING TASK AND AT REST
  8. 344128
    “…Clozapine was prescribed to all 25 patients after they had failed to improve in three different trials of other antipsychotic medications. Sublingual oxytocin (10 IU 2x per day; 20 IU 3x per day) was prescribed to 25 of the patients only after the improvement in positive symptoms on the PANSS with clozapine had plateaued. …”
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    T198. CAN AUGMENTED SUBLINGUAL OXYTOCIN DECREASE NEGATIVE SYMPTOMS WITHIN TREATMENT RESISTANT SCHIZOPHRENIC POPULATIONS: A PILOT STUDY
  9. 344129
    “…Psychophysical analysis: Motion sensitivity was estimated independently of lapses of attention, which were assessed by including trials in which the motion stimulus was easily discriminated. …”
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    M192. SENSITIVITY FOR MOTION IS WEAKENED IN FIRST EPISODE PSYCHOSIS
  10. 344130
    “…This distinct pharmacological profile may confer favorable tolerability with a low risk of adverse metabolic effects compared with SOC treatment. In 3 short-term trials in patients with acute exacerbation of schizophrenia, lumateperone was associated with minimal weight gain and few metabolic side effects. …”
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    M205. LONG-TERM SAFETY OF LUMATEPERONE (ITI-007): METABOLIC EFFECTS IN A 1-YEAR STUDY
  11. 344131
    “…The effects might be sustained by the prevention and interference on forming clots in lung capillary vessels and by modulating megakaryocytes’ function and platelet adhesion. Randomized clinical trials are urgently needed to confirm these results.…”
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    Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study
  12. 344132
    “…Two on-going clinical trials resulted from these efforts, one with (89)Zr (diagnosis) and one with (177)Lu (β-particle therapy). …”
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    (89)Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following α- and β-particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma
  13. 344133
    “…Further large-scale prospective randomized trials are required to validate these findings.…”
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    Conservative treatment for recurrent secondary spontaneous pneumothorax in patients with a long recurrence-free interval
  14. 344134
    “…CONCLUSIONS AND RELEVANCE: In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality. Prospective trials are needed to examine this impact.…”
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    Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19
  15. 344135
    por Kim, Cheorl-Ho
    Publicado 2020
    “…Under the current circumstances where reliable antiviral therapeutics or vaccination tools are lacking, several trials are underway to examine viral agents. As expected, structural and non-structural proteins of SARS-CoV-2 are currently being targeted for viral therapeutic designation and development. …”
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    SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host Interaction
  16. 344136
    “…REVIEW METHODS: Prospective cohort studies or post hoc analysis of clinical trials were included for analysis if they reported adjusted relative risks, odds ratios, or hazard ratios of all cause mortality or cardiovascular disease for prediabetes compared with normoglycaemia. …”
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    Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis
  17. 344137
    “…METHODS AND FINDINGS: We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). …”
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    Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
  18. 344138
    “…We looked for randomized controlled trials (RCTs) examining interventions delivered to adult cancer survivors via eHealth methods with a measure of health behavior change. …”
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    Impact of the Method of Delivering Electronic Health Behavior Change Interventions in Survivors of Cancer on Engagement, Health Behaviors, and Health Outcomes: Systematic Review and Meta-Analysis
  19. 344139
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    Increasing access to clinical research using an innovative mobile recruitment approach: The (MoRe) concept
  20. 344140
    “…The registry’s comprehensive patient-level data over multiyear periods provides a strong foundation for robust research addressing critical public health questions related to the full course and spectrum of alcohol problems, including recovery, which would complement other methods used in alcohol research (eg, population-based surveys, clinical trials).…”
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    The Kaiser Permanente Northern California Adult Alcohol Registry, an Electronic Health Records-Based Registry of Patients With Alcohol Problems: Development and Implementation
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