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344381por Ayala, Alejandro, LaCerte, Carl, Luo, Rosa, Davidson, Christopher, Wang, Jian, Trainer, Peter, Krasner, Alan“…Krasner: Employee; Self; Crinetics Pharmaceuticals Inc. Clinical trials of cortisol-lowering drug candidates would benefit from user-friendly methods to measure cortisol in an outpatient setting. …”
Publicado 2023
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344382por Kumar Kulkarni, Abhigna Uday, Mehta, Vidhi, Renzu, Mahvish, Pereira, Kristal, Rather, Manzoor A“…Discussion: GLP-1 RA are now being widely used due to low risk of hypoglycemia and weight loss. Clinical trials with GLP-1 RA have shown mild, asymptomatic increase in lipase, amylase levels as well as rare incidences of AP. …”
Publicado 2023
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344383“…It was FDA-approved in 2021, but is currently available in Canada only through clinical trials or special access programs. Case Presentations: The first five Canadian HoFH patients to receive evinacumab via special access are presented. …”
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344384por Fansa, Sima, Ghusn, Wissam, Nicolalde, Bryan, Anazco, Diego, Tama, Elif, Acosta, Andres, Hurtado, Maria Daniela“…Tirzepatide, a novel dual GIP/GLP-1 receptor agonist approved for T2D, has shown promising weight loss outcomes in clinical trials. To date, no study has assessed weight loss outcomes of tirzepatide in a real-world setting. …”
Publicado 2023
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344385por Antwan, Agnes S, Rico-Bautista, Elizabeth, Pontillo, Joe, Wang, Shimiao, Johns, Michael, Ramms, Bastian, Fowler, Melissa A, Nguyen, Julie B, Castellanos Gonzalez, Anel A, Fleck, Beth, Retting, Kelsey, Dalvie, Deepak, Betz, Stephen F, Markison, Stacy“…The culmination of these studies has led to a subset of candidate molecules that are being evaluated in safety studies to identify the compound(s) suitable for evaluation in human clinical trials. Support: Crinetics Pharmaceuticals. Presentation: Saturday, June 17, 2023…”
Publicado 2023
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344386por Imtiaz Rafiqi, Shafiya, Aldasouqi, Ahmad, faisal, sarah, Qureshi, Salauddin, Mahmood, Asif, Carlos Jaume, Juan, Imam, Shahnawaz“…The present study expands the concept of T cell plasticity and establishes the functional stability of plasticized T cells that can accelerate pre-clinical trials for therapeutic use in T1D and as an adjunct to immunotherapies. …”
Publicado 2023
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344387por Foss de Freitas, Maria Cristina, Chase, Colby, Henry, Marie-Louise, Neidert, Adam, Narla, Goutham, Uhlmann, Wendy, Lee, Kristen, Oral, Elif A“…Clinical management was altered, aiming for a more personalized approach in patients with these new findings, and two are participating in clinical trials for their condition. Cascade testing for family members is now being pursued. …”
Publicado 2023
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344388“…Significant WL response to GLP1RA was similar in RYGB and VSG groups, supporting previously demonstrated GLP1RA efficacy for post-bariatric WR. Larger prospective trials are needed for confirmation. Reports suggest both RYGB and VSG increase postprandial GLP-1. …”
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344389por Jhawar, Sakshi, Jumani, Sanjay, Sterrett, Yamini, Elenius, Henrik, Veeraraghavan, Padmasree, Ryan, Carrie, Del Rivero, Jaydira, Sadowski, Samira Mercedes, Nilubol, Naris, Verbalis, Joseph G, Nieman, Lynnette K, Globa, Evgenia, Zemskova, Marina S, Klubo-Gwiezdzinska, Joanna, Gubbi, Sriram“…Vandetanib and octreotide were previously trialed but discontinued due to financial constraints. …”
Publicado 2023
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344390por Riedl, David, Lehmann, Jens, Rothmund, Maria, Dejaco, Daniel, Grote, Vincent, Fischer, Michael J, Rumpold, Gerhard, Holzner, Bernhard, Licht, Thomas“…Electronic assessment of patient-reported outcomes (ePRO) has become increasingly popular in recent years in both clinical trials and practice. However, there is limited evidence on how well older patients with cancer can complete ePRO assessments. …”
Publicado 2023
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344391por Wang, Puze, Huang, Yin, Li, Jin, Cao, Dehong, Chen, Bo, Chen, Zeyu, Li, Jinze, Wang, Ruyi, Liu, Liangren“…OBJECTIVE: We conducted a meta-analysis involving cohort studies and randomized controlled trials (RCTs) to compare the influence of balanced crystalloid solutions and normal saline among patients in ICUs. …”
Publicado 2023
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344392por Plitzko, Gabriel A., Stüben, Björn-Ole, Giannou, Anastasios, Reeh, Matthias, Izbicki, Jakob R., Melling, Nathaniel, Tachezy, Michael“…Longer follow-up times are needed to accurately assess recurrence rates, and large prospective trials are needed to show superiority of robotic compared to standard open and minimally invasive hernia repair.…”
Publicado 2023
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344393por Laursen, Henrik Vitus Bering, Jørgensen, Emmelie Ploug, Vestergaard, Peter, Ehlers, Lars Holger“…Most of the modelled cohorts and treatment effects were sourced from randomised controlled trials. The following model assumptions varied depending on the class of the main comparator: choice of and reasoning behind risk equations, the time until the treatment switch, and how often the comparators were discontinued. …”
Publicado 2023
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344394por Ferriero, Mariaconsiglia, Prata, Francesco, Anceschi, Umberto, Astore, Serena, Bove, Alfredo Maria, Brassetti, Aldo, Calabrò, Fabio, Chiellino, Silvia, De Nunzio, Cosimo, Facchini, Gaetano, Franzese, Elisena, Izzo, Michela, Mastroianni, Riccardo, Misuraca, Leonardo, Naspro, Richard, Papalia, Rocco, Pappalardo, Annalisa, Tema, Giorgia, Tuderti, Gabriele, Turchi, Beatrice, Tubaro, Andrea, Simone, Giuseppe“…ABSTRACT: Registrative trials recommended the use of upfront chemotherapy in high-volume metastatic prostate cancer. …”
Publicado 2023
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344395por Zupo, Roberta, Castellana, Fabio, Piscitelli, Prisco, Crupi, Pasquale, Desantis, Addolorata, Greco, Enrico, Severino, Franca Paola, Pulimeno, Manuela, Guazzini, Andrea, Kyriakides, Tassos C., Vasiliou, Vasilis, Trichopoulou, Antonia, Soldati, Laura, La Vecchia, Carlo, De Gaetano, Giovanni, Donati, Maria Benedetta, Colao, Annamaria, Miani, Alessandro, Corbo, Filomena, Clodoveo, Maria Lisa“…Systematic literature reviews, with or without meta-analysis, of clinical trials and observational studies were screened by two independent investigators for eligibility, data extraction, and quality assessment. …”
Publicado 2023
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344396por Solmi, Marco, Soardo, Livia, Kaur, Simi, Azis, Matilda, Cabras, Anna, Censori, Marco, Fausti, Luigi, Besana, Filippo, Salazar de Pablo, Gonzalo, Fusar-Poli, Paolo“…We conducted a PRISMA/MOOSE-compliant systematic meta-analysis, searching PubMed/PsycInfo up to June 21st, 2021 for observational studies/randomized controlled trials reporting on comorbid DSM/ICD-mental disorders in CHR-P subjects (protocol). …”
Publicado 2023
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344397por He, Jiafa, Chen, Shengying, Ye, Lingling, Sun, Yang, Dai, Yan, Song, Xue, Lin, Xiaojie, Xu, Rui“…The quality of the randomised, controlled trials (RCTs) was assessed according to the PEDro scale. …”
Publicado 2023
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344398por De Giorgi, Riccardo, De Crescenzo, Franco, Cowen, Philip J., Harmer, Catherine J., Cipriani, Andrea“…However, the acceptability and tolerability of combining statins with antidepressants are unclear, and their add-on efficacy has only been shown in small, short-term clinical trials. Observational data can provide complementary information about treatment effects on larger samples over longer follow-ups. …”
Publicado 2023
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344399por Lanteri-Minet, M., Fabre, R., Martin, C., Pradat, K., Alchaar, A., Bozzolo, E., Duchene, M. L., Van Obberghen, E. K., Donnet, A., Fontaine, D.“…BACKGROUND: Randomized clinical trials have demonstrated efficacy and safety of erenumab. …”
Publicado 2023
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344400por Ghaem Maghami, Naghmeh, Helfenstein, Fabrice, Manegold-Brauer, Gwendolin, Amstad, Gabriela“…STUDY REGISTRATION: The study was registered under http://www.ClinicalTrials.gov (NCT05542043) on 15 September 2022. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-023-06103-5.…”
Publicado 2023
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