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344401“…METHODS: Articles were searched from eight Chinese and English databases. Randomized control trials (RCTs) published in English and Chinese, from inception to October 17, 2022, were included in this review. …”
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344402“…RESULTS: Sixty-eight case series studies, 29 comparative studies, and 3 randomized clinical trials were finally included. The union rate of Ilizarov methods was 99.29% (95% CI: 98.67% ~ 99.86%) in tibial defects and 98.81% (95% CI: 98.81% ~ 100.00%) in femoral defects. …”
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344403por Cordoba, Raul, Lopez-Garcia, Alberto, Morillo, Daniel, Perez-Saenz, Maria-Angeles, Askari, Elham, Prieto, Rosa Elena, Castillo Bazan, Eva, Llamas Sillero, Pilar, Herrero Gonzalez, Antonio, Short Apellaniz, Jorge, del Olmo, Marta, Arcos, Javier“…Variables such as age, sex, reason of the visit, use of the patient portal, changes in management, enrollment in clinical trials, and COVID-19 infection were recorded. RESULTS: In all, 290 patients visited the lymphoma clinic, totaling 437 appointments. …”
Publicado 2023
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344404por Sadat Larijani, Mona, Doroud, Delaram, Banifazl, Mohammad, Karami, Afsaneh, Bavand, Anahita, Ashrafian, Fatemeh, Ramezani, Amitis“…COVID-19 vaccines are available of different platforms and the primary clinical trials results presented acceptable safety profile of the approved vaccines. …”
Publicado 2023
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344405por Force, Lindsey, Blair, Chris, Duckworth, Joshua, Abdelghany, Mazin, Nguyen, Ngoc-Quyen, Hyland, Robert H, Davies, Santosh, Chen, Shuguang, Zhao, Yang, Fu, Olivia“…Because COVID-19 can impact hepatic function and Phase 1 RDV trials showed transient Grade 1-2 transaminase elevations, subsequent studies have aimed to assess the hepatic safety of RDV. …”
Publicado 2023
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344406por Kenny, Grace, O’Reilly, Sophie R, Kelly, Neil Wrigley, Negi, Riya, Gaillard, Colette Marie, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, García-León, Alejandro, Tinago, Willard, Feeney, Eoin R, Cotter, Aoife, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Cox, Rebecca J, O’Shea, Donal, Olesen, Ole, Landay, Alan, Hogan, Andrew, Lelièvre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A, Mallon, Patrick“…Although an NT50 ≥100 IU is considered sufficient protection in vaccine trials, as some VOC induce up to 6-fold reduction in NT50, we used NT50 ≥ 1000 IU as a cut off for WT neutralisation that would retain neutralisation against VOC. …”
Publicado 2023
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344407por Rodriguez, Lauren, Li, Jiani, Han, Dong, Martin, Ross, Moshiri, Jasmine, Peinovich, Nadine, Bilello, John P, Perry, Jason K, Hedskog, Charlotte“…Obeldesivir (ODV), an oral mono-5’-isobutyryl ester prodrug that is metabolized into the same active triphosphate as RDV, is being evaluated in Phase 3 clinical trials. The antiviral activity of RDV and ODV against previous Omicron subvariants (BA.1 to BQ.1.1) was maintained with respect to the ancestral WA1 strain. …”
Publicado 2023
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344408por Kelly, Colleen R, Kraft, Colleen S, Straub, Tim, Litcofsky, Kevin, Wortman, Jennifer R, Cohen, Stuart H, Berenson, Charles, McGovern, Barbara, Hasson, Brooke, Hot, Dina, Pardi, Darrell, Ford, Christopher, Henn, Matthew“…We report microbiome findings of patients (pts) with frCDI and mrCDI from a post hoc analysis of two phase 3 trials with fecal microbiota spores, live-brpk (FMS; formerly SER-109), an FDA-approved, microbiota-based therapeutic comprised of Firmicutes spores. …”
Publicado 2023
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344409“…BACKGROUND: Compassionate use is a system that provides patients with expedited access to drugs which has not yet been approved, but currently in clinical trials. The investigational drugs have been authorized for compassionate use in cases involving patients suffered from life-threatening diseases and with no alternative treatments. …”
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344410“…ELIGIBILITY CRITERIA: Randomised controlled trials, cross-sectional observational studies, case studies or any other study wherein RMR, measured by indirect calorimetry, was compared with RMR predicted via prediction equations in adult athletes were included. …”
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344411“…In recent years, three new classes of anti-cancer agents, each with a novel mechanism of action, have been brought forward to clinical trials. These are the topoisomerase I (topo I) poisons topotecan and irinotecan, which are both camptothecin derivatives, the taxane tubulin stabilizers taxol and taxotere and, finally, the antimetabolite gemcitabin, which is active in solid tumours. …”
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344412por Montazeri, Ali“…This paper presents an extensive overview on the topic ranging from descriptive findings to clinical trials. METHODS: This was a bibliographic review of the literature covering all full publications that appeared in English language biomedical journals between 1974 and 2007. …”
Publicado 2008
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344413por Schnell-Inderst, Petra, Kunze, Silke, Hessel, Franz, Grill, Eva, Siebert, Uwe, Nickisch, Andreas, von Voß, Hubertus, Wasem, Jürgen“…However, it is more difficult to prove the efficacy of early intervention to improve long-term outcomes. Randomized clinical trials of the efficacy of early intervention for children with CHL hearing losses are inappropriate because of ethical reasons. …”
Publicado 2006
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344414“…METHODS: We conducted a systematic review of published randomized and quasi-randomized trials on PubMed, Cochrane Library and WHO regional databases. …”
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344415por Zhang, Ruoyu, Bures, Maximilian, Höffler, Hans-Klaus, Zinne, Norman, Länger, Florian, Bisdas, Theodosios, Haverich, Axel, Krüger, Marcus“…The clinical benefits of this sealant should be confirmed by prospective, randomised controlled clinical trials. ABSTRAKT: HINTERGRUND: Die Wirksamkeit von chirurgischen Klebstoffen zur Prävention von alveolo-pleuralem Luftleck (APL) ist trotz zunehmenden klinischen Anwendungen in Lungenchirurgie immer noch kontrovers diskutiert. …”
Publicado 2012
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344416“…In 5 days, 5 different groups of 7 students selected randomly agreed to use and experiment the SapoFit app using the 7 devices available for trials. RESULTS: There were 35 users of SapoFit that participated in this study. …”
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344417“…Weaning was performed using either T-tube trials or pressure support weaning. The chi-square test was used for statistical analysis. …”
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344418por Freund, Patrick, Weiskopf, Nikolaus, Ashburner, John, Wolf, Katharina, Sutter, Reto, Altmann, Daniel R, Friston, Karl, Thompson, Alan, Curt, Armin“…New interventions targeting acute spinal cord injury have entered clinical trials but neuroimaging outcomes as responsive markers of treatment have yet to be established. …”
Publicado 2013
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344419por Schwab, Ursula, Lauritzen, Lotte, Tholstrup, Tine, Haldorsson, Thorhallur I., Riserus, Ulf, Uusitupa, Matti, Becker, Wulf“…Randomized controlled trials (RCT) and prospective cohort studies (PCS) were included as well as nested case–control studies. …”
Publicado 2014
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344420por Dragicevic, Elena, Poetschke, Christina, Duda, Johanna, Schlaudraff, Falk, Lammel, Stephan, Schiemann, Julia, Fauler, Michael, Hetzel, Andrea, Watanabe, Masahiko, Lujan, Rafael, Malenka, Robert C., Striessnig, Joerg, Liss, Birgit“…L-type Ca(2+) channel blockers protect SN DA neurons from degeneration in Parkinson’s disease and its mouse models, and they are in clinical trials for neuroprotective Parkinson’s disease therapy. …”
Publicado 2014
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