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  1. 344481
    “…Background: Hyperglycemia in hospitalized patients is a common occurrence and is associated with adverse outcomes. Randomized trials indicated that a basal-prandial Insulin regimen (BPI) is preferred over sliding-scale insulin (SSI) alone in hospitalized patients. …”
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    SAT-LB026 Basal-Prandial Insulin versus Basal-Sliding-Scale Insulin in the Management of Hyperglycemia in Non-Critically Ill Hospitalized Patients
  2. 344482
    “…BACKGROUND: The concept of sarcopenic obesity hasn’t been fully elucidated, due to the different muscle mass indexes (MMIs) as a dilemma in its definition. There are few trials about MMIs related to the clinical outcomes in young adults with severe obesity. …”
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    SAT-LB018 Different Definitions of Sarcopenia and Its Correlations with Anthropometric Measurements, Body Composition, Handgrip Strength, Metabolic Profile and Bone Mineral Density in Obese Women
  3. 344483
    “…RACE is an open-label study that assessed the long-term safety and efficacy of recombinant human parathyroid hormone 1-84 (rhPTH[1-84]) for the treatment of hypoparathyroidism in adults (ClinicalTrials.gov identifier NCT01297309). Patients initially received 25 or 50 µg/day of rhPTH(1-84) subcutaneously, once daily, with stepwise dose adjustments of 25 µg (up or down) to a maximum of 100 µg/day. rhPTH(1-84) could be titrated and oral calcium (Ca) and calcitriol doses adjusted at any time during the study to maintain albumin-corrected serum Ca levels in the target range of 8.0-9.0 mg/dL. …”
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    OR30-1 Safety and Efficacy of Recombinant Human Parathyroid Hormone 1-84 for the Treatment of Adults with Chronic Hypoparathyroidism: Six-Year Results of the RACE Study
  4. 344484
    “…In addition, transplantation studies using pig pluripotent stem (PS) cell derivatives may serve as a testbed for safety and efficacy prior to human trials. Recently, it has been shown that mouse and human PS cells cultured in LCDM (recombinant human LIF, CHIR 99021, (S)-(+)-dimethindene maleate, minocycline hydrochloride) medium exhibited extended developmental potential (designated as extended pluripotent stem cells, or EPS cells), which could generate both embryonic and extraembryonic tissues in chimeric mouse conceptus. …”
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    Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
  5. 344485
    “…ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised and matched controlled trials with participants allocated to a recreational football group or any other type of exercises or passive control group were included. …”
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    Broad-spectrum physical fitness benefits of recreational football: a systematic review and meta-analysis
  6. 344486
    por Aibana, Omowunmi, Huang, Chuan-Chin, Aboud, Said, Arnedo-Pena, Alberto, Becerra, Mercedes C., Bellido-Blasco, Juan Bautista, Bhosale, Ramesh, Calderon, Roger, Chiang, Silvia, Contreras, Carmen, Davaasambuu, Ganmaa, Fawzi, Wafaie W., Franke, Molly F., Galea, Jerome T., Garcia-Ferrer, Daniel, Gil-Fortuño, Maria, Gomila-Sard, Barbará, Gupta, Amita, Gupte, Nikhil, Hussain, Rabia, Iborra-Millet, Jesus, Iqbal, Najeeha T., Juan-Cerdán, Jose Vicente, Kinikar, Aarti, Lecca, Leonid, Mave, Vidya, Meseguer-Ferrer, Noemi, Montepiedra, Grace, Mugusi, Ferdinand M., Owolabi, Olumuyiwa A., Parsonnet, Julie, Roach-Poblete, Freddy, Romeu-García, Maria Angeles, Spector, Stephen A., Sudfeld, Christopher R., Tenforde, Mark W., Togun, Toyin O., Yataco, Rosa, Zhang, Zibiao, Murray, Megan B.
    Publicado 2019
    “…CONCLUSION: Our findings suggest vitamin D predicts TB disease risk in a dose-dependent manner and that the risk of TB disease is highest among HIV-positive individuals with severe vitamin D deficiency. Randomized control trials are needed to evaluate the possible role of vitamin D supplementation on reducing TB disease risk.…”
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    Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis
  7. 344487
    “…Participants can be invited to participate in trials aimed at testing strategies to improve the uptake of and engagement in these interventions. …”
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    A Web-Based Study of HIV Prevention in the Era of Pre-Exposure Prophylaxis Among Vulnerable HIV-Negative Gay and Bisexual Men, Transmen, and Transwomen Who Have Sex With Men: Protocol for an Observational Cohort Study
  8. 344488
    “…These results are consistent with those reported in clinical trials.…”
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    Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
  9. 344489
    “…However, T-cells can develop an exhausted phenotype characterized by up-regulated inhibitory receptors (PD-1, CTLA-4, LAG-3, TIM-3, CD-244, CD-160, BTLA) and decreased function, allowing for immune escape. Clinical trials using combined checkpoint inhibition with PD-L1 and CTLA-4 antibodies have been considered a breakthrough for patients with advanced HCC, as up to 25% show an objective tumor response. …”
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    3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo
  10. 344490
    “…The use of a single small molecule to readthrough various PTC mutations has been repeatedly effective for in vitro studies and some of these have progressed to clinical trials. Although there has been success in defining these small molecules, the field has discovered that every PTC is unique and likely requires a different small molecule. …”
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    2348 Lafora disease premature termination codons (PTCs) are likely candidates for suppression by aminoglycosides
  11. 344491
    “…While previous literature has consistently shown that chronic cannabis users exhibit marked cognitive impairments, mixed findings have been reported in the context of placebo-controlled experimental trials. It is therefore unclear whether these compounds inherently alter cognitive processes or whether individuals who are genetically predisposed to use cannabis may have underlying cognitive deficits. …”
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    The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species
  12. 344492
    “…METHODS: For this systematic review and meta-analysis, we searched for randomised and quasi-randomised controlled trials, outbreak investigations, and cohort and case-control studies without restriction on publication dates, in which MCV1 was administered to infants younger than 9 months. …”
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    Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis
  13. 344493
    “…Findings support future randomized controlled trials testing the efficacy of Calm for health, stress, and sleep. …”
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    Characteristics and Usage Patterns Among 12,151 Paid Subscribers of the Calm Meditation App: Cross-Sectional Survey
  14. 344494
    “…Measuring the change in PiB SUVR has implications for designing anti–β-amyloid randomized clinical trials for individuals with probable DLB.…”
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    Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia
  15. 344495
    “…A robust NEC biomarker that is not confounded by sepsis could improve bedside management, lead to lower morbidity and mortality, and permit patient selection in randomized clinical trials of possible therapeutic approaches. OBJECTIVE: To evaluate whether aberrant intestinal alkaline phosphatase (IAP) biochemistry in infant stool is a molecular biomarker for NEC and not associated with sepsis. …”
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    Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants
  16. 344496
    “…FUNDING: German Ministry of Research and Education, EU Horizon 2020, and Emerging Diseases Clinical Trials Partnership.…”
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    Enzootic patterns of Middle East respiratory syndrome coronavirus in imported African and local Arabian dromedary camels: a prospective genomic study
  17. 344497
    “…IMPORTANCE: Meta-analyses of randomized clinical trials suggest that the advantages and risks of surgery compared with conservative management as the initial treatment for proximal humerus fracture (PHF) vary, or are heterogeneous across patients. …”
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    Association of Surgical Treatment With Adverse Events and Mortality Among Medicare Beneficiaries With Proximal Humerus Fracture
  18. 344498
    “…Because of the strong effect of clinic site noted, further randomized controlled trials are needed in order to reliably determine the effect of embryo culture on IVF success rates and the growth and health of subsequent offspring. …”
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    The impact of selected embryo culture conditions on ART treatment cycle outcomes: a UK national study
  19. 344499
    “…We envisage that the recent shift towards a continuous therapeutic approach will benefit TNE patients in view of improved survival data demonstrated by a number phase 3 trials. When continuous therapy is not appropriate due to patient choice or toxicities, an efficacious (not limited to thalidomide and bortezomib) but tolerable first line FDT strategy, which can maximise TFI and maintain a good QoL, remains a reasonable alternative approach.…”
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    Treatment-free interval as an additional measure of efficacy in a large UK dataset of transplant ineligible myeloma patients
  20. 344500
    “…IMPORTANCE: Multiple randomized clinical trials have shown that definitive therapy improves overall survival among patients with high-risk prostate cancer. …”
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    Association of Sociodemographic and Health-Related Factors With Receipt of Nondefinitive Therapy Among Younger Men With High-Risk Prostate Cancer
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